EKS-LOA-00323

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00323

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	348.7	2.5E-104	16	273	258

Status

Unreviewed

Ensembl Protein

ENSLAFP00000014076

UniProt Accession

G3THL8;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

MAP4K3

Gene Synonyms/Alias

MAP4K3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000016771	ENSLAFP00000014076	ENSLAFT00000016786

Organism

Loxodonta africana

Functional Description

Protein Length

896

Protein Sequence
(FASTA)

MNPGFDLSRR NPQEDFELIQ RIGSGTYGDV YKARNVNTGE LAAIKVIKLE PGEDFAVVQQ 60

EIIMMKDCKH PNIVAYFGSY LRRDKLWICM EFCGGGSLQD IYHVTGPLSE LQIAYVSRET 120

LQGLYYLHSK GKMHRDIKGA NILLTDNGHV KLADFGVSAQ ITATIAKRKS FIGTPYWMAP 180

EVAAVERKGG YNQLCDLWAV GITAIELAEL QPPMFDLHPM RALFLMTKSN FQPPKLKDKM 240

KWSNSFHHFV KMALTKNPKK RPTAEKLLQH PFVTQPLTRS LAIELLDKVN NPDHSTYHCF 300

DDDDPEPLVA VPHRIHSTSR NVREEKTRSE INFGQVQFDA PLRKETEPHH ELPDSDGFLD 360

SSEEIYYTAR SNLDLQLEYG QGHQGSYFLG ANKSLLKSVE EELHQRGHVA HLEDDEGEDD 420

ESKHSTMKAK IPPPLPPKPK CISLPQEPHS AEDDNQGTIK RCPTSESPAK LSQVPPRPPP 480

PRLPPQKSVA LGNGTSSFQL NGERDGSLHQ QQTERRGTNL SRKEKKDVPK PISNGLPPTP 540

KVHMGACFSK VFNGCPLKIH CATSWINPDT RDQYLIFGAE EGIYTLNLNE LHETSMEQLF 600

PRRCTWLYVM NNCLLSISGK ASQLYSHNLP GLFDYARQMQ KLPVAIPAHK LPDRILPRKF 660

AVSAKIPETK WCQKCCVVRN PYTGHKYLCG ALHTSIVLLE WVEPMQKFML IKHIDFPIPC 720

PLRMFEMLVV PEQEYPLVCV GVSRGRDFNQ VVQFETVNPN STSSWFTESG LDSPQTSVTH 780

VTQLERDTIL VCLDCCIKIV NLQGRLKSSR KLSSELTFDF QIESIVCLQD SVLAFWKHGM 840

QGRSFRSNEV TQEISDSTRI FRLLGSDRVV VLESRPTDNP TANSNLYILA GHENSY 896

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +el+++ig+G++g+vy+ar+++tgel+aik+i+le  e+ + +q+ei ++k++khpniv+

Q: 16    FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVA  75

         899*********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y++s+l++++lw++me++ gGsl+d+++  ++ +l+E qiay+ re+l++L ylHsk+++

Q: 76    YFGSYLRRDKLWICMEFCGGGSLQDIYH--VTGPLSELQIAYVSRETLQGLYYLHSKGKM  133

         ****************************..******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179

         Hrdik++niLlt++g+VkL+dfgv+aq+++t +krk+++gtpywmAPEv a+e + gY++

Q: 134   HRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVErKGGYNQ  193

         ****************************************************98889***

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237

          +D+w++GItaielae +pP++dl+p++al++++k++  ppklk+k k+s++f++fv+ +

Q: 194   LCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNfqPPKLKDKMKWSNSFHHFVKMA  253

         ******************************999999888*********************

S: 238   lqknpekRpsasellkhkFl  257

         l+knp+kRp+a++ll+h+F+

Q: 254   LTKNPKKRPTAEKLLQHPFV  273

         *******************7

Domain Sequence
(FASTA)

FELIQRIGSG TYGDVYKARN VNTGELAAIK VIKLEPGEDF AVVQQEIIMM KDCKHPNIVA 60

YFGSYLRRDK LWICMEFCGG GSLQDIYHVT GPLSELQIAY VSRETLQGLY YLHSKGKMHR 120

DIKGANILLT DNGHVKLADF GVSAQITATI AKRKSFIGTP YWMAPEVAAV ERKGGYNQLC 180

DLWAVGITAI ELAELQPPMF DLHPMRALFL MTKSNFQPPK LKDKMKWSNS FHHFVKMALT 240

KNPKKRPTAE KLLQHPFV 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0006950	; P:response to stress

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013