EKS-LOA-00411

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00411

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	600.6	1.3E-180	604	962	359

Status

Unreviewed

Ensembl Protein

ENSLAFP00000014108

UniProt Accession

G3THN9;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

PDGFRB

Gene Synonyms/Alias

PDGFRB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000016816	ENSLAFP00000014108	ENSLAFT00000016826

Organism

Loxodonta africana

Functional Description

Protein Length

1102

Protein Sequence
(FASTA)

LQDIMKPPGV MPAMVLKGQL LLLPLLLLMG PQASQGLVIT PPGPELVLNI SSTFILTCSG 60

PAPVVWERLS QKPPQEVIRT QDGNFSSMLT LTNVTGLDTG EYFCTYNDSH GLEHDERKRL 120

YIFVPDPTVG FLPTKPEDLF IFLVEVPETI PCRVTDPQLV VTLHEKKVDI PLPIPYDHQR 180

GFSGIFEDKT YICKTTIGDR EVDSDPYYVY SLQVSSINVS VNAVQTVVRQ GENITVMCIV 240

TGSEVVNFGW TYPRMESGRL VEPVTDFLLD VPSHIRSILH IPNAELGDSG TYVCNVSESV 300

NEHQDEKAIN VTVVESGYLR LLGEMDPVQF ADLHRSRTLR VVFEAYPPPT VMWFKDNRTL 360

GDSGTGEISL SIRNVSETRY VTELTLVRVK VAEAGHYTVR AFHEDAELQL SFQLQVNVPV 420

RVLELSESHP ASGEQTVRCR GRGMPQPYLT WSTCSDLKSR CPHELPPTSL GNSSEEESQL 480

ETNVTYWAEE QEFEVVSTLR LHRVDQPLSV RCTLHNPLGY HMQEVIVVPH SLPFKVVVIS 540

AILALVVLTV ISLIILIMLW QKKPRYEIRW KVIESVSSDG HEYIYVDPMQ LPYDSTWELP 600

RDQLVLGRTL GSGAFGQVVE ATAHGLSHSQ ATMKVAVKML KSTARSSEKQ ALMSELKIMS 660

HLGPHLNVVN LLGACTKGGP IYIITEYCRY GDLVDYLHRN KHTFLQHCSD KRHPPSAELY 720

SNALPVGLPL PSHVSLTGES DGGYMDMSKD ELVDYVPMLD MKGDVKYADI ESSNYTAPYD 780

NYVPSAPERT CRATLINESP VLSYMDLVGF SYQVANGMEF LASKNCVHRD LAARNVLICE 840

GKLVKICDFG LARDIMRDSN YISKGSTFLP LKWMAPESIF NSLYTTLSDV WSFGVLLWEI 900

FTLGGTPYPE LPMNEQFYNA IKRGYRMAQP AHASDEIYEI MQKCWEEKFE IRPPFSQLVL 960

LLERLLGEGY KKKYQQVDEE FLRSDHPAIL RSQARLPGSR GLHSSLDSSV LYTAVQPNEG 1020

DNDYIIPLPD PKPEVADEGP LEGSPSLASS TLNEVNTSST ISCDSPLEPQ EEPEPPEPEP 1080

EPEQPLGSGC PGPRAQAADS FL 1102

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         l+lG++lGsGafG+vveata+Gls+s+a++kvavkmlkstarssek+almselki+shlG

Q: 604   LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG  663

         78**********************************************************

S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120

         +h+n+vnllGactkgGpiy+iteyc+yGdl++yl+r++++fl++ ++k++++++el+s+a

Q: 664   PHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHCSDKRHPPSAELYSNA  723

         ************************************************************

S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklasekk  164

         l+++  l s++sl+ es++ y+d++kd                ++d++ss++++++++++

Q: 724   LPVGLPLPSHVSLTGESDGGYMDMSKDelvdyvpmldmkgdvkYADIESSNYTAPYDNYV  783

         ************************************************************

S: 165   ksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGk  224

          sa er+++a+l++e s vl+++dl+ fsyqva+Gmeflaskncvhrdlaarnvl++eGk

Q: 784   PSAPERTCRATLINE-SPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGK  842

         **************9.9*******************************************

S: 225   vvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifs  284

         +vkicdfGlardim+dsny++kG+++lp+kwmapesif+slyt+ sdvws+G+llweif+

Q: 843   LVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGVLLWEIFT  902

         ************************************************************

S: 285   lGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344

         lG+tpyp+l+++++fy++ik+Gyrmaqpa+a++eiyeimqkcwe+++e rp+f+qlv ll

Q: 903   LGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLL  962

         ********************************************************9986

Domain Sequence
(FASTA)

LVLGRTLGSG AFGQVVEATA HGLSHSQATM KVAVKMLKST ARSSEKQALM SELKIMSHLG 60

PHLNVVNLLG ACTKGGPIYI ITEYCRYGDL VDYLHRNKHT FLQHCSDKRH PPSAELYSNA 120

LPVGLPLPSH VSLTGESDGG YMDMSKDELV DYVPMLDMKG DVKYADIESS NYTAPYDNYV 180

PSAPERTCRA TLINESPVLS YMDLVGFSYQ VANGMEFLAS KNCVHRDLAA RNVLICEGKL 240

VKICDFGLAR DIMRDSNYIS KGSTFLPLKW MAPESIFNSL YTTLSDVWSF GVLLWEIFTL 300

GGTPYPELPM NEQFYNAIKR GYRMAQPAHA SDEIYEIMQK CWEEKFEIRP PFSQLVLLL 359

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005019	; F:platelet-derived growth factor beta-receptor activity
GO:0005021	; F:vascular endothelial growth factor-activated receptor activity
GO:0030325	; P:adrenal gland development
GO:0060326	; P:cell chemotaxis
GO:0001701	; P:in utero embryonic development
GO:0001822	; P:kidney development
GO:0006807	; P:nitrogen compound metabolic process
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0046488	; P:phosphatidylinositol metabolic process
GO:0048015	; P:phosphatidylinositol-mediated signaling
GO:0030335	; P:positive regulation of cell migration
GO:0038091	; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0043552	; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863	; P:positive regulation of phospholipase C activity
GO:0032516	; P:positive regulation of phosphoprotein phosphatase activity
GO:0046777	; P:protein autophosphorylation
GO:0050730	; P:regulation of peptidyl-tyrosine phosphorylation
GO:0048705	; P:skeletal system morphogenesis
GO:0048745	; P:smooth muscle tissue development
GO:0001894	; P:tissue homeostasis
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.
IPR009134	; Tyr_kinase_VEGFR_rcpt_N.

Pfam

PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 2.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

PR01832

; VEGFRECEPTOR.

Created Date

20-Feb-2013