EPS-LOA-00069

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-LOA-00069

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP2A	419.5	2.0E-126	51	243	193

Status

Unreviewed

Ensembl Protein

ENSLAFP00000014120

UniProt Accession

G3THP9;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP2CA

Gene Synonyms/Alias

PPP2CA;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000016840	ENSLAFP00000014120	ENSLAFT00000016838

Organism

Loxodonta africana

Functional Description

Protein Length

309

Protein Sequence
(FASTA)

MDEKVFTKEL DQWIEQLNEC KQLSESQVKS LCEKAKEILT KESNVQEVRC PVTVCGDVHG 60

QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER ITILRGNHES 120

RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI 180

RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA 240

HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV 300

TRRTPDYFL 309

Nucleotide Sequence
(FASTA)

ATGGACGAGA AAGTGTTCAC CAAGGAGCTA GACCAGTGGA TCGAGCAGCT GAACGAGTGC 60

AAGCAGCTGT CCGAGTCCCA GGTCAAGAGC CTCTGCGAGA AGGCTAAAGA AATCCTGACA 120

AAAGAATCCA ACGTGCAGGA GGTTCGATGT CCAGTCACTG TCTGTGGAGA TGTACATGGG 180

CAATTTCATG ATCTCATGGA ACTGTTTAGA ATTGGTGGCA AATCACCAGA TACAAATTAC 240

TTGTTTATGG GAGATTATGT TGACAGAGGA TATTATTCAG TTGAAACAGT TACACTGCTG 300

GTAGCTCTTA AGGTTCGTTA CCGTGAACGC ATCACCATTC TTCGAGGGAA TCATGAGAGC 360

AGACAGATAA CACAAGTATA TGGTTTCTAT GATGAATGTT TAAGGAAATA TGGAAATGCG 420

AATGTGTGGA AATATTTTAC AGATCTTTTT GACTATCTCC CTCTCACTGC CTTGGTGGAT 480

GGGCAGATCT TCTGTCTACA TGGTGGCCTC TCACCATCCA TAGATACACT GGATCACATC 540

AGAGCACTTG ATCGCCTACA AGAAGTTCCC CATGAGGGCC CAATGTGTGA CTTGCTGTGG 600

TCAGATCCAG ATGACCGAGG TGGTTGGGGT ATATCTCCTC GAGGAGCTGG TTACACCTTT 660

GGACAAGATA TTTCTGAGAC ATTTAATCAT GCCAATGGCC TCACGTTGGT ATCTAGAGCT 720

CACCAGCTGG TAATGGAGGG TTATAACTGG TGCCATGACC GGAACGTAGT AACAATTTTC 780

AGTGCTCCAA ACTATTGTTA TCGTTGTGGT AACCAAGCTG CAATCATGGA ACTTGATGAT 840

ACTCTAAAAT ACTCTTTCTT GCAGTTTGAC CCAGCGCCTC GCAGAGGCGA ACCACATGTT 900

ACTCGTCGTA CTCCAGACTA CTTCCTGTAA 930

Domain Profile

S: 1     pvtvcgdvhgqfhdllelfriggkspdtnylflgdyvdrgyysvetvtllvalkvryrer  60

         pvtvcgdvhgqfhdl+elfriggkspdtnylf+gdyvdrgyysvetvtllvalkvryrer

Q: 51    PVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRER  110

         9***********************************************************

S: 61    itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdgkifclhggl  120

         itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdg+ifclhggl

Q: 111   ITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGL  170

         ************************************************************

S: 121   spsidtldeiraldrlqevphegplcdllwsdpddregwgisprgagytfgqdiseqfnh  180

         spsidtld+iraldrlqevphegp+cdllwsdpddr+gwgisprgagytfgqdise+fnh

Q: 171   SPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNH  230

         ************************************************************

S: 181   angleliarahql  193

         angl+l++rahql

Q: 231   ANGLTLVSRAHQL  243

         ************8

Domain Sequence
(FASTA)

PVTVCGDVHG QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER 60

ITILRGNHES RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL 120

SPSIDTLDHI RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH 180

ANGLTLVSRA HQL 193

Keyword

Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000775	; C:chromosome, centromeric region
GO:0005829	; C:cytosol
GO:0005886	; C:plasma membrane
GO:0000159	; C:protein phosphatase type 2A complex
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0007498	; P:mesoderm development
GO:0010719	; P:negative regulation of epithelial to mesenchymal transition
GO:0071902	; P:positive regulation of protein serine/threonine kinase activity

KEGG

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125

; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013