EKS-LOA-00102
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00102
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec489.52.1E-147404654251
StatusUnreviewed
Ensembl ProteinENSLAFP00000014568
UniProt AccessionG3TIS4;
Protein Name
Protein Synonyms/Alias
Gene NameBTK
Gene Synonyms/Alias BTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000017369ENSLAFP00000014568ENSLAFT00000017372
OrganismLoxodonta africana
Functional Description
Protein Length661
Protein Sequence
(FASTA)
MASVILESIF LKRSQQKKKT SPLNFKKRLF LLTGQKLSYY EYDFERGRRG SKKGSIDVEK 60
ITCVETVVPE KNPPPERQIP RRGEESGEME QISIIERFPY PFQVVYDEGP LYVFSPTEDL 120
RKRWIHQLKN ATVIRYNSDL VQKYHPCFWI DGQYLCCSQT AKNAMGCQIL ENRNGSLKPG 180
SSHRKTKKPL PPTPEEDQIL KKPLPPEPTA APVSTSELKK VVALYDYMPM NANDLQLRKG 240
EEYFILEQSN LPWWRARDKN GEEGYIPSNY VTEAEDSIEM YEWYSKHMTR SQAEQLLKQE 300
GKEGGFIVRD SSKAGKYTVS VFAKSTGDPQ GVIRHYVVCS TPQSQYYLAE KHLFSTIPEL 360
INYHQHNSAG LISRLKYPVS QQNKNAPSTA GLGYGSWEID PKDLTFLKEL GTGQFGVVKY 420
GKWRGQYDVA IKMIKEGSMS EDEFIEEAKV MMNLSHEKLV QLYGVCTKQR PIFIITEYMA 480
NGCLLNYLRE MRHRFQTQQL LEMCKDVCEA MEYLESKQFL HRDLAARNCL VNDQGVVKVS 540
DFGLSRYVLD DEYTSSVGSK FPVRWSPPEV LMYSKFSSKS DIWAFGVLMW EIYSLGKMPY 600
ERFTNSETAE HIAQGLRLYR PHLASERVYT IMYSCWHEKA DERPTFKILL SNILDVMDEE 660
S 661
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+lkelg+gqfgvvk+gkwr+++dvaik+ikeg+mse++fieeakvmm+lsh+klvqly
Q: 404   LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLY  463
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc+kq+pi+i+tey++ngcllnylre+++++++++llemckdvce+meyle+k+f+hrd
Q: 464   GVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRD  523
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+++ vvkvsdfgl+ryvldd+y+ssvg+kfpv+wsppevl+ysk+ssksd+w
Q: 524   LAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIW  583
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         afgvlmwe++s+gk+pye+++nse++e++++glrlyrp+las++vy++m+scw+ek++er
Q: 584   AFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHEKADER  643
         ************************************************************
S: 241   ptfkellsale  251
         ptfk lls++ 
Q: 644   PTFKILLSNIL  654
         ********996
Domain Sequence
(FASTA)
LTFLKELGTG QFGVVKYGKW RGQYDVAIKM IKEGSMSEDE FIEEAKVMMN LSHEKLVQLY 60
GVCTKQRPIF IITEYMANGC LLNYLREMRH RFQTQQLLEM CKDVCEAMEY LESKQFLHRD 120
LAARNCLVND QGVVKVSDFG LSRYVLDDEY TSSVGSKFPV RWSPPEVLMY SKFSSKSDIW 180
AFGVLMWEIY SLGKMPYERF TNSETAEHIA QGLRLYRPHL ASERVYTIMY SCWHEKADER 240
PTFKILLSNI L 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00098
EKS-ANC-00100
EKS-BOT-00108
EKS-CAJ-00109
EKS-CAF-00109
EKS-CAP-00103
EKS-DAR-00355
EKS-EQC-00104
EKS-FEC-00102
EKS-GAM-00052
EKS-GAG-00088
EKS-GAA-00127
EKS-GOG-00108
EKS-HOS-00110
EKS-ICT-00102
EKS-LAC-00112
EKS-MAM-00103
EKS-MEG-00083
EKS-MOD-00109
EKS-MUM-00109
EKS-MUP-00110
EKS-MYL-00121
EKS-NOL-00100
EKS-ORN-00132
EKS-ORA-00087
EKS-ORC-00099
EKS-ORL-00124
EKS-OTG-00109
EKS-PAT-00098
EKS-PES-00092
EKS-PEM-00054
EKS-POA-00100
EKS-PTV-00097
EKS-RAN-00109
EKS-SAH-00100
EKS-SOA-00057
EKS-SUS-00094
EKS-TAR-00136
EKS-TEN-00126
EKS-XET-00090
EKS-XIM-00130
Gene Ontology
GO:0031410; C:cytoplasmic vesicle
GO:0005829; C:cytosol
GO:0045121; C:membrane raft
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0004713; F:protein tyrosine kinase activity
GO:0048469; P:cell maturation
GO:0007249; P:I-kappaB kinase/NF-kappaB cascade
GO:0018108; P:peptidyl-tyrosine phosphorylation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013