EKS-LOA-00403
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00403
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl546.01.7E-164506771266
StatusUnreviewed
Ensembl ProteinENSLAFP00000014919
UniProt AccessionG3TJK5;
Protein Name
Protein Synonyms/Alias
Gene NameTYRO3
Gene Synonyms/Alias TYRO3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000017791ENSLAFP00000014919ENSLAFT00000017790
OrganismLoxodonta africana
Functional Description
Protein Length869
Protein Sequence
(FASTA)
MALRQSMERP GLGGSGALLL SEPAAAGLKL LGAPVKLTVS QGQPMKLNCS MEGMSEPEIH 60
WMKDGSLVQS VDQVFMPISE QHWISFLSLK SVERSDAGQY WCQVKNKGKI QTSQPVWLMV 120
EGVPFFTVEP KDLAVLPNAS FQLSCEALGP PEPVTIVWWR EGRKVGGPTP SPSVLNVTAG 180
VTQSTVFSCE AHNPKGLASS RPATVSLQVL PTAPSNITVT KLFSRNASVA WMPGADGQAL 240
LRSCTVQVTQ ALGGWEVLAV VVSVPPFTCL LRDLSPATNY RLRVRCTNAL GPSPYADWVP 300
FRTKGLGAAP ASAPQNLHAI LTDSGLILEW EDVKPEGPME GPLGTYKLSW AQDNGTQNEL 360
TVEGTRVNLT GWDPQKDLTV YVCVCNAVGC GPWSQPLVIS SHDHSGQQGP PHSRTSWVPV 420
VLGVLTALVT AAALALILLR KRRKDTRFGQ AFDSVMAQGE PAVHFRAARS FNRERPERIE 480
ATLDSLGVSD ELKDKLQDVL IPEQQFTLGR MLGKGEFGSV REAQLKQEDG SFVKVAVKML 540
KADIIASSDI EEFLREAACM KEFDHPHVAK LVGVSLRSRA KGRLPIPMVI LPFMKHGDLH 600
AFLLASRIGE NPFNLPLQTL IRFMVDIACG MEYLSSRNFI HRDLAARNCM LAEDMTVCVA 660
DFGLSRKIYS GDYYRQGCAS KLPVKWLALE SLADNLYTVH SDVWAFGVTM WEIMTRGQTP 720
YAGIENAEIY NYLIGGNRLK QPPECMEDVY ELMYQCWSAD PKRRPTFTCL RMELEHILGH 780
LSVLSSSQDP LYINIERAEG PGGDQASNGA GDGSGLGAVG GVPSDCRYIL SPEGLSEQPG 840
QEEQQPETPV SEGQRLLLQQ QGLLPHSSC 869
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         ++lg++lg+gefgsv+e+qlkqedgs++kvavk+lk+diia+s+ieefl+eaacmkefdh
Q: 506   FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDH  565
         68**********************************************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         p+v++lvgvsl+s++kgrlp+p+vilpfmk+gdlhafll+sr+genp++lplqtl++fmv
Q: 566   PHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMV  625
         ************************************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         dia+gmeylssrnfihrdlaarncmlaedmtvcvadfgls+kiysgdyyrqg+++klpvk
Q: 626   DIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVK  685
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         w+a+eslad++yt++sdvwafgvtmwei+trgqtpyag+enaeiy+yl++gnrlkqp++c
Q: 686   WLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPEC  745
         ************************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvlr  266
         ++++y+lmy+cw+adpk rp+f+ lr
Q: 746   MEDVYELMYQCWSADPKRRPTFTCLR  771
         ***********************998
Domain Sequence
(FASTA)
FTLGRMLGKG EFGSVREAQL KQEDGSFVKV AVKMLKADII ASSDIEEFLR EAACMKEFDH 60
PHVAKLVGVS LRSRAKGRLP IPMVILPFMK HGDLHAFLLA SRIGENPFNL PLQTLIRFMV 120
DIACGMEYLS SRNFIHRDLA ARNCMLAEDM TVCVADFGLS RKIYSGDYYR QGCASKLPVK 180
WLALESLADN LYTVHSDVWA FGVTMWEIMT RGQTPYAGIE NAEIYNYLIG GNRLKQPPEC 240
MEDVYELMYQ CWSADPKRRP TFTCLR 266
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00372
EKS-ANC-00384
EKS-BOT-00399
EKS-CAJ-00404
EKS-CAF-00400
EKS-CAP-00424
EKS-CIS-00152
EKS-DAR-00777
EKS-EQC-00387
EKS-FEC-00382
EKS-GAG-00338
EKS-GAA-00488
EKS-GOG-00387
EKS-HOS-00403
EKS-ICT-00375
EKS-MAM-00399
EKS-MEG-00329
EKS-MOD-00385
EKS-MUM-00432
EKS-MUP-00390
EKS-MYL-00393
EKS-NOL-00364
EKS-ORN-00511
EKS-ORA-00344
EKS-ORC-00374
EKS-ORL-00465
EKS-OTG-00402
EKS-PAT-00374
EKS-PES-00355
EKS-POA-00391
EKS-PTV-00110
EKS-RAN-00411
EKS-SAH-00365
EKS-SUS-00346
EKS-TAG-00471
EKS-TAR-00502
EKS-TAS-00046
EKS-XET-00511
EKS-XIM-00503
Gene Ontology
GO:0005789; C:endoplasmic reticulum membrane
GO:0016021; C:integral to membrane
GO:0005635; C:nuclear envelope
GO:0005524; F:ATP binding
GO:0043548; F:phosphatidylinositol 3-kinase binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043277; P:apoptotic cell clearance
GO:0021885; P:forebrain cell migration
GO:0001779; P:natural killer cell differentiation
GO:0050728; P:negative regulation of inflammatory response
GO:0045824; P:negative regulation of innate immune response
GO:0051250; P:negative regulation of lymphocyte activation
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0034122; P:negative regulation of toll-like receptor signaling pathway
GO:0070050; P:neuron homeostasis
GO:0042698; P:ovulation cycle
GO:0070527; P:platelet aggregation
GO:0046777; P:protein autophosphorylation
GO:0043491; P:protein kinase B signaling cascade
GO:0032940; P:secretion by cell
GO:0007283; P:spermatogenesis
GO:0034446; P:substrate adhesion-dependent cell spreading
GO:0060068; P:vagina development
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 2.
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 2.
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013