EPS-LOA-00023

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-LOA-00023

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	200.7	4.3E-59	88	342	255

Status

Unreviewed

Ensembl Protein

ENSLAFP00000014931

UniProt Accession

G3U2T9;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1F

Gene Synonyms/Alias

PPM1F;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000017804	ENSLAFP00000022147	ENSLAFT00000028468
ENSLAFG00000017804	ENSLAFP00000014931	ENSLAFT00000017804

Organism

Loxodonta africana

Functional Description

Protein Length

354

Protein Sequence
(FASTA)

RRAPLVLASA LAYASVSQLL QMDLSEFRKP PGHEEEEEGD EEEDKARVTL LDAGDLARSF 60

FTQLWNVCSQ WQKQVPSAAS TPQRQWLVSV HAIRNTRRKM EDRHVSMPAF NQLFGLSDPV 120

DRAYFAVFDG HGGVDAAKFA ATHVHANAAR QPGLTLDPAG ALREAFRLTD EMFLRKAKRE 180

RLQSGTTGVC ALIAGSTLYI AWLGDSQVIL VQQGEVVKLM EPHRPERQDE RERIEALGGF 240

VSHMDCWRVN GTLAVSRAIG DVFQKPYVSG EADTTSRELT GSEDYLLLAC DGFFDFVPPQ 300

EVTGLVQSHL AWHQGCGLRV AEELVAAARE RGSRDNITVL VVFLRDPQDL LEDG 354

Nucleotide Sequence
(FASTA)

AGGAGGGCTC CGCTGGTGCT GGCCTCAGCC CTGGCCTATG CGTCCGTTTC CCAGCTGCTG 60

CAGATGGATC TCTCAGAGTT CAGGAAGCCA CCCGGGCACG AGGAGGAGGA GGAGGGTGAC 120

GAGGAAGAGG ACAAGGCCCG TGTGACCCTG CTGGATGCCG GGGACCTGGC ACGGAGCTTC 180

TTTACCCAGC TCTGGAATGT GTGTAGCCAG TGGCAGAAAC AGGTGCCATC AGCTGCCAGT 240

ACTCCCCAGC GACAGTGGCT GGTCTCTGTC CACGCCATCC GGAACACACG CCGCAAGATG 300

GAGGATCGGC ATGTGTCAAT GCCGGCATTC AACCAGCTCT TCGGCCTGTC TGACCCTGTA 360

GACCGTGCCT ACTTTGCTGT GTTTGACGGT CACGGAGGGG TGGATGCTGC AAAGTTTGCT 420

GCAACGCACG TGCACGCCAA CGCTGCCCGC CAGCCAGGGC TGACCTTGGA CCCTGCAGGT 480

GCCCTCAGGG AAGCCTTCCG GCTCACCGAC GAGATGTTCC TCCGGAAAGC CAAGCGAGAG 540

CGGCTGCAGA GTGGCACCAC AGGTGTGTGT GCACTCATCG CAGGAAGCAC CCTGTACATC 600

GCCTGGCTTG GGGACTCCCA GGTCATCCTG GTGCAGCAGG GAGAGGTGGT GAAGCTGATG 660

GAGCCCCACA GGCCCGAGCG ACAGGACGAG AGGGAGCGCA TTGAAGCACT GGGTGGCTTT 720

GTGTCCCACA TGGACTGCTG GCGAGTCAAC GGGACCCTGG CCGTCTCCAG AGCCATTGGG 780

GATGTTTTCC AGAAGCCCTA CGTGTCCGGG GAGGCGGACA CGACCTCGAG GGAGCTGACC 840

GGCTCAGAGG ACTACCTGCT GCTCGCCTGT GACGGCTTCT TTGACTTCGT GCCCCCCCAG 900

GAGGTCACTG GCCTCGTCCA GAGCCACTTG GCCTGGCACC AAGGCTGTGG GCTTCGTGTT 960

GCTGAGGAGC TGGTGGCTGC CGCCCGGGAA CGGGGTTCCC GTGACAACAT CACCGTCCTG 1020

GTGGTCTTCC TCAGGGACCC CCAGGACCTG CTGGAGGACG GG 1062

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklhei  60

         v+v ++ + r++med++ s+p f +  + +d    a+f+v+DGhgg ++akf+++++h

Q: 88    VSVHAIRNTRRKMEDRHVSMPAFNQLFGLSDPvdRAYFAVFDGHGGVDAAKFAATHVHAN  147

         6788999*****************99888888778*************************

S: 61    laeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyva  120

          a++       + +   al++aF  tde +  l +++ +  +sG+t v+ali +s+ly+a

Q: 148   AARQPG----LTLDPAGALREAFRLTDEMF--LRKAKRERLQSGTTGVCALIAGSTLYIA  201

         ****77....555666799***********..8888889999******************

S: 121   nvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRalGd  180

          +GdS+++L ++g++v+l + H+p+r+dE+eRie+ gg v   d+ Rv+G LavsRa+Gd

Q: 202   WLGDSQVILVQQGEVVKLMEPHRPERQDERERIEALGGFVSHMDCWRVNGTLAVSRAIGD  261

         ********************************************99**************

S: 181   lylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqeaa  239

         ++ kpyv+ e ++ts +lt ++++l La+DG +d v+++e+  lv+++l  ++     +a

Q: 262   VFQKPYVSGEADTTSRELTGSEDYLLLACDGFFDFVPPQEVTGLVQSHLAwHQGCGLRVA  321

         **************************************************44445578**

S: 240   kkLvklalargskdnvsaivv  260

         ++Lv+ a++rgs+dn++++vv

Q: 322   EELVAAARERGSRDNITVLVV  342

         ****************99987

Domain Sequence
(FASTA)

VSVHAIRNTR RKMEDRHVSM PAFNQLFGLS DPVDRAYFAV FDGHGGVDAA KFAATHVHAN 60

AARQPGLTLD PAGALREAFR LTDEMFLRKA KRERLQSGTT GVCALIAGST LYIAWLGDSQ 120

VILVQQGEVV KLMEPHRPER QDERERIEAL GGFVSHMDCW RVNGTLAVSR AIGDVFQKPY 180

VSGEADTTSR ELTGSEDYLL LACDGFFDFV PPQEVTGLVQ SHLAWHQGCG LRVAEELVAA 240

ARERGSRDNI TVLVV 255

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0043234	; C:protein complex
GO:0033192	; F:calmodulin-dependent protein phosphatase activity
GO:0046872	; F:metal ion binding
GO:0035690	; P:cellular response to drug
GO:0097193	; P:intrinsic apoptotic signaling pathway
GO:0033137	; P:negative regulation of peptidyl-serine phosphorylation
GO:0044387	; P:negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045892	; P:negative regulation of transcription, DNA-dependent
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0050921	; P:positive regulation of chemotaxis
GO:0043280	; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0051894	; P:positive regulation of focal adhesion assembly
GO:0010628	; P:positive regulation of gene expression
GO:0045927	; P:positive regulation of growth
GO:0051496	; P:positive regulation of stress fiber assembly

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013