EKS-LOA-00471
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00471
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK408.02.4E-1224277274
StatusUnreviewed
Ensembl ProteinENSLAFP00000015006
UniProt AccessionG3UNI7;
Protein Name
Protein Synonyms/Alias
Gene NameMAPK3
Gene Synonyms/Alias MAPK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000017904ENSLAFP00000029396ENSLAFT00000026253
ENSLAFG00000017904ENSLAFP00000015006ENSLAFT00000017903
OrganismLoxodonta africana
Functional Description
Protein Length326
Protein Sequence
(FASTA)
GPLSSAYDHV RKIRVAIKKI SPFEHQTYCQ RTLREIQILL RFRHENVIGI RDILRAPTLE 60
AMRDVYIVQD LMETDLYKLL KSQQLSNDHV CYFLYQILRG LKYIHSANVL HRDLKPSNLL 120
INTTCDLKIC DFGLARIADP EHDHTGFLTE YVATRWYRAP EIMLNSKGYT KSIDIWSVGC 180
ILAEMLSNRP IFPGKHYLDQ LNHILSILGS PSQEDLNCII NMKARNYLQS LPAKTKVAWA 240
KLFPKSDPKA LELLDRMLTF NPNKRITVEE ALAHPYLEQY YDPTDEPVAE EPFTFDMELD 300
DLPKERLKAL IFQETARFQP EALEAT 326
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 16    vsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiiklldvftpeeelee  75
          sa+d+ ++ rvaikk+s pf+++t ++rtlRE+++l +++heN+i + d++++ + le+
Q: 4     SSAYDHVRKIRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPT-LEA  61
         6899*************9.***********************************99.***
S: 76    lkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHsanviHrDlKPsNllv  135
         ++dvY+v++lmetdL+k++ksq+ls++h+ ++lyqilrglky+Hsanv+HrDlKPsNll+
Q: 62    MRDVYIVQDLMETDLYKLLKSQQLSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLI  121
         ************************************************************
S: 136   nedcelkildFGlarsadkekekk..lteyvatrwYraPeillslkeytkavDiWsvGCI  193
         n++c+lki+dFGlar+ad+e++++  lteyvatrwYraPei+l++k ytk++DiWsvGCI
Q: 122   NTTCDLKICDFGLARIADPEHDHTgfLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCI  181
         ********************99999***********************************
S: 194   laElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyikslpkkkkkdfee  253
         laE+l+++p+fpgk+++dql++il++lg+ps+e+l++i + +arny++slp k+k  +++
Q: 182   LAEMLSNRPIFPGKHYLDQLNHILSILGSPSQEDLNCIINMKARNYLQSLPAKTKVAWAK  241
         ************************************************************
S: 254   lfpkaseealdLleklLvldpdkRisveeaLehpYl  289
         lfpk++++al+Ll+++L+++p+kRi+veeaL+hpYl
Q: 242   LFPKSDPKALELLDRMLTFNPNKRITVEEALAHPYL  277
         ***********************************7
Domain Sequence
(FASTA)
SSAYDHVRKI RVAIKKISPF EHQTYCQRTL REIQILLRFR HENVIGIRDI LRAPTLEAMR 60
DVYIVQDLME TDLYKLLKSQ QLSNDHVCYF LYQILRGLKY IHSANVLHRD LKPSNLLINT 120
TCDLKICDFG LARIADPEHD HTGFLTEYVA TRWYRAPEIM LNSKGYTKSI DIWSVGCILA 180
EMLSNRPIFP GKHYLDQLNH ILSILGSPSQ EDLNCIINMK ARNYLQSLPA KTKVAWAKLF 240
PKSDPKALEL LDRMLTFNPN KRITVEEALA HPYL 274
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00436
EKS-ANC-00449
EKS-BOT-00462
EKS-CAJ-00472
EKS-CAF-00465
EKS-CAP-00493
EKS-DAR-00867
EKS-DAN-00034
EKS-DIO-00097
EKS-ECT-00064
EKS-EQC-00449
EKS-ERE-00049
EKS-FEC-00445
EKS-GOG-00456
EKS-ICT-00441
EKS-LAC-00477
EKS-MAM-00463
EKS-MAE-00072
EKS-MOD-00453
EKS-MUM-00493
EKS-MUP-00452
EKS-MYL-00457
EKS-ORA-00408
EKS-ORC-00440
EKS-ORL-00529
EKS-POA-00449
EKS-PTV-00167
EKS-RAN-00475
EKS-SAH-00430
EKS-TAS-00069
EKS-TEN-00572
EKS-TUT-00168
EKS-SAC-00101
EKS-SCP-00101
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0031143; C:pseudopodium
GO:0005524; F:ATP binding
GO:0004707; F:MAP kinase activity
GO:0051216; P:cartilage development
GO:0071260; P:cellular response to mechanical stimulus
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0031663; P:lipopolysaccharide-mediated signaling pathway
GO:0000165; P:MAPK cascade
GO:2000657; P:negative regulation of apolipoprotein binding
GO:0009887; P:organ morphogenesis
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity
GO:0006974; P:response to DNA damage stimulus
GO:0043330; P:response to exogenous dsRNA
GO:0019233; P:sensory perception of pain
GO:0006351; P:transcription, DNA-dependent
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR003527; MAP_kinase_CS.
IPR008349; MAPK_ERK1/2.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS01351; MAPK; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR01770; ERK1ERK2MAPK.
Created Date20-Feb-2013