EKS-LOA-00061

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00061

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	373.7	6.8E-112	647	939	293

Status

Unreviewed

Ensembl Protein

ENSLAFP00000018566

UniProt Accession

G3TJV5;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK13

Gene Synonyms/Alias

CDK13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000017946	ENSLAFP00000018566	ENSLAFT00000027964
ENSLAFG00000017946	ENSLAFP00000015044	ENSLAFT00000017947

Organism

Loxodonta africana

Functional Description

Protein Length

1455

Protein Sequence
(FASTA)

MPSSSDTALG GGGGLSWAEK KLEERRKRRR FLSPQPSSCF SPGPPLEVKR LARGKRRPGG 60

RQQEAEKRRV FSLPQPQQDG GGGASSGGGV TPLVEYEDVS SQSEQGLLLG GASAATAATA 120

AGGTGGSGGS LASSSGTQRR GEGSERRPRR DRRSGSGRSK ERHREHRRRD GQRGGSEASK 180

SRSRHSHSGE ERPEAASRKS ASATSSSSSS RKDRDLKAHR SRTKSSKEPP SAYKEPPKAY 240

REDKTEPKAY RRRQRSLSPL GGRDDSPVSH RASQSLRSRK SPSPAGGGSS PYSRRLPRSP 300

SPYNRRRSPS YSRHSSYERD GDVSPSPYSS SSWRRSRSPY SPVISRRSAK SRSRSPYSSR 360

HSRSRSRHRL SRSRSRHSSI SPSTLTLKSS LAAELNKNKK ARAAEAARAA EAAKAAETAK 420

AAEAAAKAAK ASNTSTPTKG NTEAGVSALQ TNHVKDVKKL KTEHAPSPSS GGTLKNDKVK 480

TKPPVQVTKV DNNLIVDKVA KKAVVAGKES KPAATKEEPV SVKEKTKSLT PSIGAKEKEQ 540

HVTIVTSTLP PLPLPPMLPE DKDADSLRGN ISVKAVKKEV EKKLRCLLAD LPLPPELPGG 600

DDLSKSPEEK KAATQLHSKR RPKICGPRYG EIKEKDIDWG KRCVDKFDII GIIGEGTYGQ 660

VYKARDKDTG EMVALKKVRL DNEKEGFPIT AIREIKILRQ LTHQSIINMK EIVTDKEDAL 720

DFKKDKGAFY LVFEYMDHDL MGLLESGLVH FNENHIKSFM RQLMEGLDYC HKKNFLHRDI 780

KCSNILLNNR GQIKLADFGL ARLYSSEESR PYTNKVITLW YRPPELLLGE ERYTPAIDVW 840

SCGCILGELF TKKPIFQANQ ELAQLELISR ICGSPCPAVW PDVIKLPYFN TMKPKKQYRR 900

KLREEFVFIP AAALDLFDYM LALDPSKRCT AEQALQCDFL RDVEPSKMPP PDLPLWQDCH 960

ELWSKKRRRQ KQMGMTDDVS TIKAPRKDLS LGLDDSRTST PQGVPPSSQL KSQGSSSVAP 1020

VKTGPGQQLN HSELAILLNL LQSKTSVNMA DFVQVLNIKV NSETQQQHLS KINLPAGILA 1080

TGEKQTDAST PQQESSKPLG GIQVPSQTVQ PKVETDAAQA AVQSAFAVLL TQLIKAQQSK 1140

QKDMLLEERE NGSGHEASLQ LRPPPEPSTP VSGQDDLIQH QDVRRLELTP EPDRPRILPP 1200

DQRPPEPPEP PPVTDEDLDY RTENQHAPST SSSLTDPHAG VKAALLQLLA QHQPQDDPKR 1260

EGGIDYQAGD TYVPAADYKD NFGSSSFSSA PYVSNDGLGG SSAPPLERRS FIGNSDIQSL 1320

DNYSTASSHS AGPPQPAAFS ESFASSVAGY GDIYLNTGPM LFSGDKDHRF EYSHGPIAVL 1380

ANSNDPSTGP ESTHPLPAKM HNYNYGGNLQ ENPGGPGLMH GQTWTSPAQG PGYSQGYRGH 1440

ISTSTGRGRG RGLPY 1455

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vyka+dk+tge+vAlKk+rl++ekeg+pita+rEi++l++l+h+ i

Q: 647   FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSI  706

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         ++++e+v+         kdk  +yLvfe++++dL+ ll++    +++++++ks+++ql+e

Q: 707   INMKEIVTdkedaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-HFNENHIKSFMRQLME  765

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170

         gl+y+H++++lHRD+K++N+L++++g++klaDfGlar +ss+++  yt++v+TlwYr+Pe

Q: 766   GLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESrPYTNKVITLWYRPPE  825

         ***************************************7665527**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         lLlg+++Y+ a+D+Ws+gcil el+t+kp+fq+++e  qle i++++g+p  +vwp+v k

Q: 826   LLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIK  885

         ************************************************************

S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhky  283

         lp +++  pkk+++ kl+e++  +  +aldl++ +laldp+kR++a++alq ++

Q: 886   LPYFNTMKPKKQYRrKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCDF  939

         *****7777777777******999999***********************9987

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKARD KDTGEMVALK KVRLDNEKEG FPITAIREIK ILRQLTHQSI 60

INMKEIVTDK EDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVHFNENHI KSFMRQLMEG 120

LDYCHKKNFL HRDIKCSNIL LNNRGQIKLA DFGLARLYSS EESRPYTNKV ITLWYRPPEL 180

LLGEERYTPA IDVWSCGCIL GELFTKKPIF QANQELAQLE LISRICGSPC PAVWPDVIKL 240

PYFNTMKPKK QYRRKLREEF VFIPAAALDL FDYMLALDPS KRCTAEQALQ CDF 293

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0019908	; C:nuclear cyclin-dependent protein kinase holoenzyme complex
GO:0016607	; C:nuclear speck
GO:0005524	; F:ATP binding
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0000380	; P:alternative mRNA splicing, via spliceosome
GO:0030097	; P:hemopoiesis
GO:0070816	; P:phosphorylation of RNA polymerase II C-terminal domain

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013