EKS-LOA-00147
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00147
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR555.12.8E-167487763277
StatusUnreviewed
Ensembl ProteinENSLAFP00000015289
UniProt AccessionG3TKE5;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR1
Gene Synonyms/Alias FGFR1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000018249ENSLAFP00000015289ENSLAFT00000018253
OrganismLoxodonta africana
Functional Description
Protein Length831
Protein Sequence
(FASTA)
MWSWKCLLFW AVLVTATLCT ARPAPTLPEQ ASSSRPLWVA AAQPWGAPVE VESFLVHPGD 60
LLQLRCRLRD DVQSINWLRD GVQLVESNRT RITGEEVEVR DSVPADSGLY ACVTSSPSGS 120
DTTYFSVNVS DALPSSEDDD DDDDSSSEEK ETDNTKPNPV APYWTSPEKM EKKLHAVPAA 180
KTVKFKCPSS GTPNPTLRWL KNGKEFKPDH RIGGYKVRYA TWSIIMDSVV PSDKGNYTCI 240
VENEYGSINH TYQLDVVERS PHRPILQAGL PANKTVALGS NVEFMCKVYS DPQPHIQWLK 300
HIEVNGSKIG PDNLPYVQIL KTAGVNTTDK EMEVLHLRNV SFEDAGEYTC LAGNSIGLSH 360
HSAWLTVLEA LEERPAVMTS PLYLEIIIYC TGAFLISCMV GSVIIYKMKS GTKKSDFHSQ 420
MAVHKLAKSI PLRRQVTVSA DSSASMNSGV LLVRPSRLSS SGTPMLAGVS EYELPEDPRW 480
ELPRDRLVLG KPLGEGCFGQ VVLAEAIGLD KDKPNRVTKV AVKMLKSDAT EKDLSDLISE 540
MEMMKMIGKH KNIINLLGAC TQDGPLYVIV EYASKGNLRE YLQARRPPGL EYCYNPSHNP 600
EEQLSSKDLV SCAYQVARGM EYLASKKCIH RDLAARNVLV TEDNVMKIAD FGLARDIHHI 660
DYYKKTTNGR LPVKWMAPEA LFDRIYTHQS DVWSFGVLLW EIFTLGGSPY PGVPVEELFK 720
LLKEGHRMDK PSNCTNELYM MMRDCWHAVP SQRPTFKQLV EDLDRIVALT SNQEYLDLSM 780
PLDQYSPSFP DTRSSTCSSG EDSVFSHEPL PEEPCLPRHP AQLANGGLKR R 831
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         lvlgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+
Q: 487   LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  546
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g e+++++s+++eeql++
Q: 547   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS  606
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt
Q: 607   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  666
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh
Q: 667   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  726
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl
Q: 727   RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  763
         ***********************************97
Domain Sequence
(FASTA)
LVLGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60
IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGLEYCYNP SHNPEEQLSS 120
KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180
TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240
RMDKPSNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00140
EKS-ANC-00142
EKS-BOT-00147
EKS-CAJ-00152
EKS-CAF-00156
EKS-CAP-00148
EKS-CII-00090
EKS-CIS-00182
EKS-DAR-00434
EKS-DRM-00072
EKS-EQC-00147
EKS-FEC-00138
EKS-GAM-00076
EKS-GAG-00126
EKS-GAA-00173
EKS-GOG-00148
EKS-HOS-00154
EKS-ICT-00142
EKS-LAC-00157
EKS-MAM-00145
EKS-MOD-00148
EKS-MUM-00153
EKS-MUP-00152
EKS-MYL-00157
EKS-NOL-00142
EKS-ORA-00126
EKS-ORC-00139
EKS-ORL-00171
EKS-OTG-00153
EKS-PAT-00139
EKS-PES-00133
EKS-PEM-00079
EKS-POA-00144
EKS-RAN-00147
EKS-SAH-00143
EKS-SUS-00129
EKS-TAG-00177
EKS-TAR-00192
EKS-TEN-00184
EKS-XET-00136
EKS-XIM-00177
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008201; F:heparin binding
GO:0001525; P:angiogenesis
GO:0060117; P:auditory receptor cell development
GO:0060445; P:branching involved in salivary gland morphogenesis
GO:0048469; P:cell maturation
GO:0002062; P:chondrocyte differentiation
GO:0030326; P:embryonic limb morphogenesis
GO:0035607; P:fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0001701; P:in utero embryonic development
GO:0042472; P:inner ear morphogenesis
GO:0060484; P:lung-associated mesenchyme development
GO:0048762; P:mesenchymal cell differentiation
GO:0030901; P:midbrain development
GO:0042474; P:middle ear morphogenesis
GO:0043066; P:negative regulation of apoptotic process
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0001759; P:organ induction
GO:0042473; P:outer ear morphogenesis
GO:0048339; P:paraxial mesoderm development
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0045787; P:positive regulation of cell cycle
GO:0043406; P:positive regulation of MAP kinase activity
GO:0090080; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0002053; P:positive regulation of mesenchymal cell proliferation
GO:0045666; P:positive regulation of neuron differentiation
GO:0010976; P:positive regulation of neuron projection development
GO:0010863; P:positive regulation of phospholipase C activity
GO:0046777; P:protein autophosphorylation
GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0048378; P:regulation of lateral mesodermal cell fate specification
GO:0007605; P:sensory perception of sound
GO:0001657; P:ureteric bud development
GO:0021847; P:ventricular zone neuroblast division
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 3.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013