EKS-LOA-00352

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00352

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	293.1	2.6E-87	249	505	257

Status

Unreviewed

Ensembl Protein

ENSLAFP00000015597

UniProt Accession

G3TL54;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK2

Gene Synonyms/Alias

EIF2AK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000018604	ENSLAFP00000015597	ENSLAFT00000018604

Organism

Loxodonta africana

Functional Description

Protein Length

521

Protein Sequence
(FASTA)

MASGLSAGFF MEELNKYSQK HDVPVKYLEL SKTGPPHDLR FTFQVIIKDR EFPAAEGKTK 60

KIAKNAAAKI AYEIINKENK TVSSISLLTA DTSEGLSIGN YIGLVNRFAQ KTQLSVNYVQ 120

CFVSEPRESD VRRFHYTCRI GSKEYGIAAG STKQEAKQFA AKLAYDEITG EKTSETSTSS 180

IELVPENGLS ASESEQKHSS DSSKDSSSSS VTHRGSGLGE VKRKARIRVI AGAVGNTKHT 240

MDSRFVKDFE EIEPIGSGGY GDVFKAKHRI DKKTYVIKRV KYNNEKVERE VKALANLNHA 300

NIVHYHYCWD GYDYDPENST NNSRSRSVTK CLFIQMEFCD KGTLEQWIES RRGKQSDKDL 360

ALDLFEQITK GVAYIHSQRL IHRDLKPSNI FLVHIKQVKI GDFGLVTSLK NDEKRTVDKG 420

TWRYMSPEQM SLQEYGNEVD IFALGLILAE LLHICTTVQE TVKIFNDLRQ GIFPDVFDTK 480

EKNLLQKLLS KDPKERLKAP EILKTLKKWK NDPEEKKSKS C 521

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60

         feei+ +G+Gg+g+V+kak+++dkk+y ikr+k+n+     ekverevkaLa+l+h niv

Q: 249   FEEIEPIGSGGYGDVFKAKHRIDKKTYVIKRVKYNN-----EKVEREVKALANLNHANIV  303

         899********************************9.....78*****************

S: 61    rYfaawleekeesltdsseveaeaeleesesseesdtkllyiqmelceketLkdwiderk  120

         +Y+++w   ++++             ++ +s ++s tk+l+iqme+c+k tL++wi++r+

Q: 304   HYHYCWDGYDYDPE-----------NSTNNSRSRSVTKCLFIQMEFCDKGTLEQWIESRR  352

         **********9888...........455667788999**********************9

S: 121   llesrselvmrlfkqllegleylHskgliHrdLkpsniFldsddqvKigDFgLatalaea  180

          ++s + l ++lf+q+ +g++y+Hs+ liHrdLkpsniFl + +qvKigDFgL+t+l+++

Q: 353   GKQSDKDLALDLFEQITKGVAYIHSQRLIHRDLKPSNIFLVHIKQVKIGDFGLVTSLKND  412

         9999999988**********************************************9999

S: 181   lkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGlilfeLlypfstem  240

         +k+             t + gt +ymsPeq++ ++Y+++vDif+LGlil+eLl+ + t +

Q: 413   EKR-------------TVDKGTWRYMSPEQMSLQEYGNEVDIFALGLILAELLHICTTVQ  459

         886.............8999****************************************

S: 241   ervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasellks  289

         e+v+++++lr+g +p+ fd    kek+llqklls+dpkeR++a e+lk+

Q: 460   ETVKIFNDLRQGIFPDVFDT---KEKNLLQKLLSKDPKERLKAPEILKT  505

         ********************...9**********************986

Domain Sequence
(FASTA)

FEEIEPIGSG GYGDVFKAKH RIDKKTYVIK RVKYNNEKVE REVKALANLN HANIVHYHYC 60

WDGYDYDPEN STNNSRSRSV TKCLFIQMEF CDKGTLEQWI ESRRGKQSDK DLALDLFEQI 120

TKGVAYIHSQ RLIHRDLKPS NIFLVHIKQV KIGDFGLVTS LKNDEKRTVD KGTWRYMSPE 180

QMSLQEYGNE VDIFALGLIL AELLHICTTV QETVKIFNDL RQGIFPDVFD TKEKNLLQKL 240

LSKDPKERLK APEILKT 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0003725	; F:double-stranded RNA binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030968	; P:endoplasmic reticulum unfolded protein response
GO:0033689	; P:negative regulation of osteoblast proliferation
GO:0046777	; P:protein autophosphorylation
GO:0006412	; P:translation
GO:0006926	; P:virus-infected cell apoptotic process

KEGG

InterPros

IPR001159	; Ds-RNA-bd.
IPR014720	; dsRNA-bd-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00035	; dsrm; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00358

; DSRM; 2.

Prosites

PS50137	; DS_RBD; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013