EKS-LOA-00091
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00091
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/PIKK407.17.5E-12221242448325
StatusUnreviewed
Ensembl ProteinENSLAFP00000015623
UniProt AccessionG3TL75;
Protein Name
Protein Synonyms/Alias
Gene NameSMG1
Gene Synonyms/Alias SMG1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000018634ENSLAFP00000015623ENSLAFT00000018637
ENSLAFG00000018634ENSLAFP00000021919ENSLAFT00000025614
OrganismLoxodonta africana
Functional Description
Protein Length3662
Protein Sequence
(FASTA)
MSRRAPGSRL SSGGGGTKYP RSWNDWQPRT DSASADPDNL KYSSTRDRGG SYGLQSSHSA 60
VVSRQRHDDT RVHADIQNDE KGGYGVNGGS GENTYGRKSL GQELRVNNVT SPEFTSVQHG 120
SRALANKDMR KSQERSMSYS DESRLSNLLR RITREDDRDR RLATVKQLKE FIQQPENKLV 180
LVKQLDNILA AVHDVLNESS KLLQELRQEG ACCLGLLCAS LSYEAEKIFK WIFSKFSSSA 240
KDEVKLLYLC ATYKALETVG EKKAFSSVMQ LVMTSLQSIL ENVDTPELLC RCVKCILLVA 300
RCYPHIFSTN FRDTVDILVG WHIDHTQKPS LTQQVSGWLQ SLEPFWVADL AFSTTLLGQF 360
LEDMEAYAED LSHVASGESV DEDVPPPSVS LPKLAALLRV FSTVVRSIGE RFSPVRGPPI 420
TEAYVTDVLY RVMRCVTAAN QVFFSEAVLT AANECVGVLL GSLDPSMTIH CDMVITYGLD 480
QLENCQTCGT DYIISVLNLL TLIVEQINTK LPSSFVEKLF IPSSKLLFLR YHKEKEVVAV 540
AHAVYQAVLG LKNIPVLETA YKLILGEMTC ALNNLLHSLQ LPDACSEIKH EAFKNHVFNV 600
DNAKFVVIFD LSALTTIGNA KNSLIGMWAL SPTVFALLSK NLMIVHGDLA VHFPAIQYAV 660
LYTLYSHCTR HDHFISSSLS SSSPSLFDGA VISTVTTATK KHFSIILNLL GILLKKDNLN 720
QDTRKLLMTW ALEVAVLMKK SETYAPLFSL SCFHKFCKGL LANTLVEDVN ICLQACSSLH 780
ALSSSLPDDL LHRCVDVCRV QLVHSGTRIR QAFGKLLKSI PLDVVLSNNN HTEIQEISLA 840
LRSHMSKAPS NTFHPQDFSD VISFILYGNS HRTGKDNWLE RLFYSCQRLD KRDQSTIPRN 900
LLKTDAVLWQ WAIWEAAQFT VLSKLRTPLG RAQDTFQTIE GIIRSLAAHT LNPDQDVSQW 960
TTADNDEGHS SNQLRLVLLL QYLENLEKLM YNAYEGCANA LTSPPKVIRT FFYTNRQTCQ 1020
DWLTRIRLSI MRVGLLAGQP AVTVRHGFDL LTEMKTNNVS QGNELEVTIM MVVEALCELH 1080
CPEAIQGIAV WSSSVVGKNL LWINSVAQQA EGRFEKASVE YQEHLCAMTG VDCCISGFDK 1140
SVLTLANSGR NSASPKHSLN GESRKTVLSK PTDSSPEVIN YLGNKACECY ISIADWAAVQ 1200
DWQNAIHDLK KSTSSTSLNL KADFNYIKSL SSFESGEFVE CTEQLELLPG ENINLLAVGS 1260
KEKIDMKKLL PNMLSPDPRE LQKSIEVQLL RSSVCLATAL NHIEQDQKWQ SITENVVKYL 1320
KQTSRIAIGP LRLSTLTVSQ SLPVLSTLQL YCSSALENTV SNRLSTEDCL IPLFSEALRS 1380
CKQHDVRPWM QALRYTMYQS QLLEKIKEQA VPIRSHLMEL GLTAAKFARK RGNVSLATRL 1440
LAQCSEVQLG KTTTAQDLVQ HFKKLSTQGQ VDEKWGPELD IEKTKLLYTA GQSAHAMEML 1500
SSCAISFCKS AKAEYAVAKS ILTLAKWIQA EWKEISGQLK QVYRAQQQQN FTGLSTLSKN 1560
ILTLIELPTL NTVDVNTMEE VYPRIESEST VHIGVGEPDF ILGQLYHLSS VQAPEVAKSW 1620
AALASWAYRW GRKVVDNASQ GEGVRLLPRE KSEVQNLLPD TITDEEKERI YGILGQAVCR 1680
PAGIQDEDIT LQITESEDNE EDDMVDVIWR QLISSCPWLS ELDESATEGV IKVWRKVVDR 1740
IFSLYKLSCS AYFTFLKLNA GQVPLDEDDP RLHLSNRAEQ STDDVIVMAT LRLLRLLVKH 1800
AGELRQFLER GLERTPTAPW RGIIPQLFSR LNHPEVYVRQ SICNLLCRVA QDSPHLILYP 1860
AIVGTISLSS ESQASGNKFS SAIPTLLGNI QGEELLVSEC EGGSPPASQD SSKDEPKSGL 1920
NEDQAMMQDC YSKIVDKLSS ANPTMVLQVQ MLVAELRRVT VLWDELWLGV LLQQHMYVLR 1980
RIQQLEDEVK RVQNNNTLRK EEKIAIMREK HTALMKPIVF ALEHVKSITA APAETPHEKW 2040
FQDNYGDAIE NALEKLKTPS NPAKPGSSWI PFKEIMLSLQ QRAQKRASYI LRLEEISPWL 2100
AAMTNTEIAL PGEVSARDTV TIHSVGGTIT ILPTKTKPKK LLFLGSDGKS YPYLFKGLED 2160
LHLDERIMQF LSIVNTMFAT INRQETPRFH ARHYSVTPLG TRSGLIQWVD GATPLFGLYK 2220
RWQQREAALQ AQKAQDSYQT PQNPGIVPRP SELYYSKIGP ALKAVGLSLD VSRRDWPLHV 2280
MKAVLEELME ATPPNLLAKE LWSSCTTPDE WWRVTQSYAR STAVMSMVGY IIGLGDRHLD 2340
NVLIDMTTGE VVHIDYNVCF EKGKSLRVPE KVPFRMTQNI ETALGVTGVE GVFRLSCEQV 2400
LHIMRRGRET LLTLLEAFVY DPLVDWTAGG EAGFAGAVYG GGGQQAESKQ SKREMEREIT 2460
RSLFSSRVAE IKVNWFKNRD EMLVVLPKLD SSLDEYLSLQ EQLTDVEKLQ GKLLEEIEFL 2520
EGAEEVDHPS HTLQHRYSEH TQLQTQQRAV QEAIQVKLNE FEQWITHYQA AFNNLEATQL 2580
ASLLQEISTQ MDLGPPSYVP ATAFLQNAGQ AHLISQCEQL EGEVGSFLQQ RRSVLRGCLE 2640
QLHHYATVAL QYPKAIFQKH RIEQWKTWME ELICNTTVER CQELYRKYEM QYAPQPPPTV 2700
CQFITATEMT LQRYAADINS RLIRQVERLK QEAVTVPVCE DQLKEIERCI KVFLHENGEE 2760
GSLSLASVII SALCTLTRRN LMMEGAASSA GEQLVDLTSR DGAWFLEELC SMSGNVTCLV 2820
QLLKQCRLVP QDLDIPNPAE ASEAVHLANG VYTSLQELNS NFRQIIFPEA LRCLMKGEYT 2880
LESMLHELDT LIEQTTDGVP LQTLVESLQA YLRNAAMGLE EETHAHYIDV ARILHAQYGE 2940
LIQPRNGSVD ETPKMSAGQM LLVAFDGMFA QVETAFGLLV EKLNKMEIPI AWRKIDIIRE 3000
ARSTQVNFFD DDNHRQVLEE IFFLKRLQTI KEFFRLCGTF SKTLSGSSSL EDQNTVNGPV 3060
QIVNVKTLFR NSCFSEDQMA KPIKAFTADF VRQLLIGLPN QALGLTLCSF ISALGVDIIA 3120
QVEAKDFGAE SKVSVDDLCK KAVEQNIQVG KFSQLVMNRA TVLASSYDTA WKKHDLVRRL 3180
ETSISSCKTS LQRVQLHIAM FQWQHEDLLI NRPQAMSVTP PPRSAILTSM KKKLHTLSQI 3240
ETSIATVQEK LATLEASIEQ RLKWAGGANP ALAPVLQDFE ATIAERRNLV LKESQRASQV 3300
TFLCSNIIHF ESLRTRTAEA LNLDAALFEL IKRCQQMCSF ASQFNSSVSE LELRLLQRVD 3360
TSLEHPIGSS EWLLSAHKQL TQDMSTQRAV QTEKEQQIET ICETIQNLVD NIKTVLTGHN 3420
RQLGDVKHLL KAMAKDEEAA LADGEDVPYE NSVRQFLGEY KSWQDNIQTV LFTLVQAMGQ 3480
VRSQEHVEML QEITPTLKEL KTQSQSIYNN LVSFASPLVT DATNECSSPT SSATYQPSFA 3540
AAVRSNTGQK TQPDVMSQNA KKLIQKNLAT SADTPPSAVP GTGKSVACSP KKAVRDPKTG 3600
KAVQERNSYA VSVWKRVKAK LEGRDVDPNR RMSVAEQVDY VIKEATNLDN LAQLYEGWTA 3660
WV 3662
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 3     gfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdke  62
         ++  +++il++k+kpkkll++Gsdgk+ypyL+kg+eDl+ der++q++s+vNt++a+ ++
Q: 2124  SVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINR  2183
         566789******************************************************
S: 63    tsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpi..syrykdl  120
         ++++++++r+y+V+pl+trsgli+wv+++++L+ l+k++++++a+l++q++  sy+++++
Q: 2184  QETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQAQKAqdSYQTPQN  2243
         **************************************************999*******
S: 121   stvqar.........kpklkhlkls.........levfkevlenlv...pkdllkkllle  159
         + +++r         +p+lk++ ls         l+v+k+vle+l+   p++ll+k+l++
Q: 2244  PGIVPRpselyyskiGPALKAVGLSldvsrrdwpLHVMKAVLEELMeatPPNLLAKELWS  2303
         ***************999999999999*****************99999***********
S: 160   kfpspeewfelrkaytrslAvislvgyiLgLgdrhlenllidqetgevvhidfgvafeka  219
         ++++p+ew++++++y+rs+Av+s+vgyi+gLgdrhl+n+lid++tgevvhid++v+fek+
Q: 2304  SCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKG  2363
         ************************************************************
S: 220   ktqlkvpekvPFRLTrnivnalgvtgveGvfrasceavlrvlreskeklltiLevflydp  279
         k+ l+vpekvPFR+T+ni++algvtgveGvfr sce+vl+++r+ +e+llt+Le+f+ydp
Q: 2364  KS-LRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDP  2422
         **.*********************************************************
S: 280   lvdwkk...................k  286
         lvdw+                    +
Q: 2423  LVDWTAggeagfagavyggggqqaeS  2448
         *****988777777666555522222
Domain Sequence
(FASTA)
SVGGTITILP TKTKPKKLLF LGSDGKSYPY LFKGLEDLHL DERIMQFLSI VNTMFATINR 60
QETPRFHARH YSVTPLGTRS GLIQWVDGAT PLFGLYKRWQ QREAALQAQK AQDSYQTPQN 120
PGIVPRPSEL YYSKIGPALK AVGLSLDVSR RDWPLHVMKA VLEELMEATP PNLLAKELWS 180
SCTTPDEWWR VTQSYARSTA VMSMVGYIIG LGDRHLDNVL IDMTTGEVVH IDYNVCFEKG 240
KSLRVPEKVP FRMTQNIETA LGVTGVEGVF RLSCEQVLHI MRRGRETLLT LLEAFVYDPL 300
VDWTAGGEAG FAGAVYGGGG QQAES 325
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00085
EKS-BOT-00096
EKS-CAE-00083
EKS-CAJ-00097
EKS-CAF-00095
EKS-CAP-00092
EKS-DAR-00347
EKS-DRM-00044
EKS-FEC-00089
EKS-GAG-00076
EKS-GAA-00115
EKS-GOG-00094
EKS-HOS-00098
EKS-ICT-00087
EKS-MAM-00093
EKS-MEG-00071
EKS-MOD-00093
EKS-MUM-00094
EKS-MUP-00095
EKS-MYL-00106
EKS-NOL-00088
EKS-ORN-00122
EKS-ORA-00076
EKS-ORC-00088
EKS-OTG-00099
EKS-PAT-00087
EKS-PES-00080
EKS-PEM-00049
EKS-POA-00091
EKS-RAN-00091
EKS-SAH-00087
EKS-TAG-00125
EKS-TAR-00128
EKS-XIM-00119
Gene Ontology
GO:0005524; F:ATP binding
GO:0016301; F:kinase activity
GO:0016773; F:phosphotransferase activity, alcohol group as acceptor
KEGG
InterPros
IPR011989; ARM-like.
IPR016024; ARM-type_fold.
IPR003152; FATC.
IPR011009; Kinase-like_dom.
IPR000403; PI3/4_kinase_cat_dom.
IPR018936; PI3/4_kinase_CS.
IPR014009; PIK_FAT.
Pfam
PF02260; FATC; 1.
PF00454; PI3_PI4_kinase; 1.
SMARTs
SM00146; PI3Kc; 1.
Prosites
PS51189; FAT; 1.
PS51190; FATC; 1.
PS00916; PI3_4_KINASE_2; 1.
PS50290; PI3_4_KINASE_3; 1.
Prints
Created Date20-Feb-2013