EPS-LOA-00008

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-LOA-00008

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	151.9	1.3E-44	133	278	146

Status

Unreviewed

Ensembl Protein

ENSLAFP00000015655

UniProt Accession

G3TLA0;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP27

Gene Synonyms/Alias

DUSP27;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000018677	ENSLAFP00000022222	ENSLAFT00000034418
ENSLAFG00000018677	ENSLAFP00000015655	ENSLAFT00000018677

Organism

Loxodonta africana

Functional Description

Protein Length

1150

Protein Sequence
(FASTA)

MATSGDPEEE QVVPSEEDEA DVRAVQARYL RSPSPSQYSM VSDAETESIF MEPIHLSSGV 60

AAKQIISEEL KPRGVGADSE CPGLLESAEQ LLVEDLYNRV KEKMDDTSLY NTPCVLDLQR 120

ALVQDRHEAP WNEVDEVWPN IFIAEKSVAV NKARLKRLGI THILNAAHGT GVYTGPEFYT 180

GLEIQYLGVE VDDFPEVDIS QHFRKAAEFL DEALLTYRGK ALVSSEMGIS RSAVLVVAYL 240

MIFHNMAILE ALMTVRKKRA IYPNDGFLKQ LRELNEKLME EREEDDGGEE GTDQGSTLGA 300

RVHGLTVEEE DDITSHLSGS SLGKASQASK PLTLIDEDEE ERLYEEWKKG QGLPTGKVPQ 360

GGDGRCLASS GQGGEELEDE DVESIIREWQ SRNERYQTEE HQRRGREEEE EVESEAGCFV 420

GRRRRHTLSE SSTSESVSSH DIRVLKQQLQ MSSLNRAGRR RSDSVSTEST WDMWNQRLLE 480

IEKEAARKYH SRSRREEADT GSEAGSRVPE DDEESVASEA SSFYNFCSRN KDKLTALERW 540

KIKRIQFGFH KKDSEAGDGS SEQGAEEAEG EKRNPSDVNL TAYQAWKLKH QKKLGSENKE 600

EVVELSKGED SASAKKRQRR LELLERSRQT LEESQSMGSW EAASSAASMS IPLSAFWSAT 660

PSVSADGDTG SVLSTQSHRS HLSQAASNSR GCSVSNPTTP LPTLPVGPGD TISIASIQNW 720

IANVVSETLA QKQNEMLLLS RSPSIASLKV APLAGCLGDD QASMLSGQSG SSLGGCLWPQ 780

SQTRPSCDTQ SVLSSNTTLS SRAEDTGSKV KGTSKPIYSL FADDVDLKEL GRKEKERQME 840

LREKMSEYKM EKLASDNKRS SLFKKKVKEE DDDVSDRDED TDSAIGSFRY SSHTNSQKPE 900

TDTSSSLAVS DCYGNDNRAD KEMDRSINKW LGGLRTEEKS PSQSDWSGSS RGKYTRSSTL 960

RETASKSSSY KFSKSQSEER DTSSYQEANG NSVRSTSRFS SSSTREGREM HKSSRSMFSE 1020

TSSSREESPE PYFFRRTPEP PEGAESPEQR RRDWARPKDW EDVEESSKSD FSEFGAKRKF 1080

TQSFARSEEE GERERVENRE EGRFASGRRS QYHRSTDREE EGEMDDEAII AAWRRRQEET 1140

WTKLQRRRED 1150

Nucleotide Sequence
(FASTA)

ATGGCGACCA GTGGGGACCC AGAGGAGGAG CAGGTAGTCC CGAGTGAAGA GGATGAAGCT 60

GATGTGAGGG CAGTGCAGGC CCGGTACCTC CGGAGCCCCT CGCCCAGCCA GTATTCAATG 120

GTCTCAGATG CAGAAACAGA AAGCATTTTC ATGGAGCCCA TTCACCTCTC CTCAGGCGTT 180

GCAGCCAAAC AGATCATCAG TGAAGAACTC AAGCCGCGAG GGGTCGGAGC AGACTCAGAG 240

TGTCCAGGCC TGCTGGAGTC CGCTGAGCAG CTGCTGGTGG AGGACCTGTA CAACCGTGTC 300

AAGGAGAAGA TGGACGACAC CAGCCTGTAC AATACTCCCT GCGTCCTGGA CCTGCAGCGG 360

GCCCTGGTCC AGGACCGCCA TGAGGCCCCC TGGAATGAGG TGGATGAGGT CTGGCCCAAC 420

ATCTTCATAG CTGAGAAGAG CGTGGCTGTG AACAAGGCGA GGCTGAAGAG GCTGGGGATT 480

ACCCACATCC TGAACGCTGC TCATGGCACT GGTGTTTACA CTGGTCCAGA ATTCTACACT 540

GGCCTGGAGA TACAGTACCT GGGTGTGGAA GTGGATGACT TCCCCGAGGT GGACATCTCT 600

CAGCATTTCC GGAAGGCTGC TGAGTTCCTC GACGAAGCCC TGCTGACCTA CAGAGGGAAA 660

GCCCTGGTCA GTAGTGAAAT GGGCATCAGC CGGTCAGCAG TGCTTGTGGT GGCCTACCTG 720

ATGATCTTCC ACAACATGGC CATCCTGGAG GCCTTGATGA CCGTGCGCAA GAAGCGGGCC 780

ATCTACCCCA ACGACGGCTT CCTGAAGCAG CTCCGCGAGC TCAACGAGAA GCTGATGGAG 840

GAGAGAGAAG AGGACGATGG CGGGGAGGAG GGCACAGACC AGGGGAGCAC ACTAGGGGCC 900

AGAGTGCATG GCCTCACCGT GGAGGAGGAG GATGACATCA CCAGCCACCT AAGTGGATCC 960

TCCTTGGGGA AGGCCAGCCA GGCCTCCAAG CCCCTCACCC TTATAGACGA GGATGAGGAG 1020

GAGAGGCTGT ATGAGGAGTG GAAGAAGGGG CAAGGCCTCC CCACAGGCAA GGTCCCCCAG 1080

GGTGGAGATG GCCGGTGCTT AGCCTCCTCT GGCCAGGGCG GGGAGGAATT GGAGGATGAG 1140

GACGTGGAGA GCATCATCCG GGAATGGCAG AGCCGAAATG AGCGGTACCA GACAGAAGAG 1200

CACCAGAGAC GGGGCAGGGA GGAGGAAGAG GAGGTGGAGA GTGAGGCTGG CTGCTTCGTG 1260

GGGAGAAGAC GGAGGCACAC CCTGAGTGAG AGCAGCACCT CAGAGAGCGT CAGCAGCCAT 1320

GACATACGGG TCCTGAAGCA GCAGCTGCAG ATGAGCAGCC TGAACCGAGC TGGGAGGCGC 1380

CGCTCGGACT CAGTGTCCAC AGAGAGCACC TGGGACATGT GGAACCAGAG GCTGCTGGAG 1440

ATTGAGAAGG AGGCCGCCCG GAAGTATCAC TCCAGGAGCA GGAGAGAGGA GGCAGACACA 1500

GGCTCAGAGG CAGGGAGCAG GGTGCCAGAG GATGATGAGG AGAGTGTGGC TTCAGAGGCC 1560

AGCTCCTTCT ACAACTTCTG CAGCAGGAAC AAGGACAAGC TCACTGCCCT AGAGAGGTGG 1620

AAGATCAAGA GAATCCAATT TGGATTTCAC AAAAAAGACT CGGAGGCAGG AGATGGCAGC 1680

AGTGAGCAAG GGGCAGAGGA GGCAGAGGGG GAGAAAAGGA ACCCCTCCGA TGTCAACCTG 1740

ACGGCCTACC AGGCCTGGAA GCTGAAACAC CAGAAGAAGC TGGGCAGTGA GAACAAGGAG 1800

GAGGTGGTGG AGCTCAGCAA GGGAGAGGAC TCAGCCTCAG CCAAGAAGAG GCAGCGGAGG 1860

CTGGAGCTGC TGGAGAGGAG CCGGCAGACG CTGGAGGAGA GCCAGTCCAT GGGAAGCTGG 1920

GAGGCAGCCA GCTCGGCAGC CAGCATGAGC ATCCCCCTGT CAGCATTCTG GTCTGCAACC 1980

CCCTCAGTCA GTGCTGATGG GGACACAGGG TCAGTACTCA GCACCCAGAG CCACCGCTCC 2040

CACCTGTCTC AGGCCGCAAG CAACTCAAGG GGATGCTCTG TCTCCAACCC CACCACACCC 2100

CTGCCCACCC TGCCAGTGGG GCCTGGAGAC ACAATTTCCA TTGCCAGTAT CCAGAACTGG 2160

ATCGCCAACG TGGTCAGCGA GACCCTTGCC CAGAAGCAGA ATGAAATGTT GCTGTTGTCC 2220

CGCTCACCGT CCATTGCAAG CCTGAAGGTG GCACCGCTGG CTGGCTGCCT GGGGGATGAC 2280

CAAGCGTCCA TGCTCAGTGG ACAGAGCGGC TCCTCCCTGG GTGGCTGCCT GTGGCCTCAG 2340

AGCCAGACAA GACCTAGCTG TGACACGCAG TCTGTGCTGT CCTCCAACAC CACACTGAGC 2400

TCGAGGGCCG AGGACACAGG GAGTAAGGTG AAGGGGACAA GCAAGCCTAT CTATAGCCTC 2460

TTTGCCGATG ATGTGGACCT AAAGGAGCTT GGTCGGAAGG AGAAGGAGAG GCAAATGGAG 2520

TTGAGGGAGA AGATGTCTGA GTACAAAATG GAGAAGCTGG CCTCAGACAA CAAACGCAGC 2580

TCCCTTTTCA AGAAGAAGGT CAAGGAAGAG GATGATGACG TTAGTGACAG GGATGAGGAC 2640

ACTGACAGTG CCATAGGGAG CTTCCGATAC TCTTCCCACA CTAATTCCCA AAAACCGGAA 2700

ACAGACACCT CCTCTTCCCT GGCTGTCTCT GATTGTTATG GAAATGACAA CAGAGCTGAC 2760

AAAGAGATGG ATAGAAGCAT TAATAAGTGG CTAGGTGGCC TCAGGACAGA GGAAAAATCT 2820

CCTTCCCAAA GTGATTGGTC TGGAAGCTCC AGAGGGAAGT ACACCAGATC CTCCACGCTC 2880

CGGGAGACTG CGTCTAAATC CTCCAGTTAC AAATTCTCCA AGTCGCAGTC AGAGGAACGG 2940

GATACCTCCT CCTACCAGGA GGCAAATGGC AACTCGGTCA GAAGCACTTC CCGGTTCTCC 3000

TCTTCCTCCA CCAGAGAGGG CAGAGAGATG CACAAGTCCT CCAGGTCCAT GTTCAGTGAG 3060

ACCTCAAGCT CCCGAGAGGA AAGCCCAGAG CCCTACTTCT TCCGTAGGAC CCCCGAGCCC 3120

CCTGAAGGGG CAGAGTCCCC TGAACAGCGA CGTCGGGATT GGGCCAGGCC CAAGGACTGG 3180

GAAGATGTGG AAGAATCATC CAAATCAGAC TTTTCTGAAT TTGGAGCCAA GAGGAAGTTC 3240

ACACAGAGCT TCGCGAGGTC TGAAGAGGAG GGAGAAAGAG AAAGGGTGGA AAACAGGGAG 3300

GAAGGGAGGT TTGCCTCGGG GCGGCGGTCC CAGTATCACA GAAGCACTGA CAGGGAGGAA 3360

GAGGGGGAAA TGGACGATGA AGCCATCATT GCCGCCTGGA GACGTCGACA AGAAGAAACC 3420

TGGACTAAGT TGCAGAGAAG GAGGGAGGAT 3450

Domain Profile

S: 1     evteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipv  60

         ev+e++p+++++++ +a+++  L++lgit+++na++++    ++Pe+++  +i+y++++v

Q: 133   EVDEVWPNIFIAEKSVAVNKARLKRLGITHILNAAHGTGV-YTGPEFYTGLEIQYLGVEV  191

         69**********************************8765.79*****************

S: 61    dDsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdA  119

         dD ++ d++q+f++aaef+dea  + +gk lv +++G+sRSa+lv+aYLm+++++++ +A

Q: 192   DDFPEVDISQHFRKAAEFLDEAlLTYRGKALVSSEMGISRSAVLVVAYLMIFHNMAILEA  251

         **********************8999**********************************

S: 120   ieavkrkrpsiepnegfleQLlelekkl  147

         +++v++kr +i+pn+gfl+QL+el++kl

Q: 252   LMTVRKKR-AIYPNDGFLKQLRELNEKL  278

         ********.***************9987

Domain Sequence
(FASTA)

EVDEVWPNIF IAEKSVAVNK ARLKRLGITH ILNAAHGTGV YTGPEFYTGL EIQYLGVEVD 60

DFPEVDISQH FRKAAEFLDE ALLTYRGKAL VSSEMGISRS AVLVVAYLMI FHNMAILEAL 120

MTVRKKRAIY PNDGFLKQLR ELNEKL 146

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR020417	; Atypical_DUSP.
IPR020405	; Atypical_DUSP_famA.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

PR01908	; ADSPHPHTASE.
PR01909	; ADSPHPHTASEA.

Created Date

20-Feb-2013