EKS-LOA-00412

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00412

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	598.7	4.7E-180	585	920	336

Status

Unreviewed

Ensembl Protein

ENSLAFP00000018370

UniProt Accession

G5E7C2;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

KIT

Gene Synonyms/Alias

KIT;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000022078	ENSLAFP00000026144	ENSLAFT00000034154
ENSLAFG00000022078	ENSLAFP00000019967	ENSLAFT00000033936
ENSLAFG00000022078	ENSLAFP00000017394	ENSLAFT00000022306
ENSLAFG00000022078	ENSLAFP00000020652	ENSLAFT00000031886
ENSLAFG00000022078	ENSLAFP00000018370	ENSLAFT00000027209

Organism

Loxodonta africana

Functional Description

Protein Length

968

Protein Sequence
(FASTA)

MILSRPLTFF FFPLQIIIHK QAGSSQPSVS PEDLSPPSIH PAKPQLIVNV GDEIRLLCTD 60

SGFVKWTFEI LGQVSENKHN EWITEKAVAT NTGNYTCTNE GGLSSSIYVF VRDPNKLFLV 120

SQLLYGKEGN DALVRCPLTD PEVSNYSLKG CKGKPLPKDL VFVSDPKAGI TIRSVKRTYH 180

QLCVHCSADR EGKSVLSEKF ILKVRAAIKA VPSVSVSKAS YLLREGEEFA VTCTIKDEAS 240

SVLSMWIREN SQIKAQVQST SRHKGDFYYE RQETLTVSSA RVNDSGVFMC YANNTFGSAN 300

VTTTLKVVDK GFIHISPIMN TTIFVNDGEN LDLIVEYEAY PKPEHQQWIY MNRTSTDKWE 360

DYPKSENESN IRYVSELHLT RLKGTEGGIY TFLVSNSDAN SSVTFNVYVN TKPEILTSDR 420

LVNGKLQCVA AGFPEPTIEW YFCPGTEQRC SPPIVPVDVQ IQNSSVSPFG RLVVQSSIDS 480

SAFKHNGTFE CKAYNDVGKN SAYFNFAFKE QIQSHTLFTP LLIGFVIAAG MMCIIVMILT 540

YKYLQKPMYE VQWKVVEEIN GNNYVYIDPT QLPYDHKWEF PRNRLSFGKT LGAGAFGKVV 600

EATAYGLIKS DAAMTVAVKM LKPSAHLTER EALMSELKVL SYLGNHMNIV NLLGACTVGG 660

PTLVITEYCC YGDLLNFLRR KRDSFICAKQ EDHAEAALYK NLLHSKESSS CDSTNEYMDM 720

KPGVSYVVPT KADRRRSGRI GSYIEHDVTP AIMEDDELAL DLEDLLSFSY QVAKGMAFLA 780

SKNCIHRDLA ARNILLTHGR ITKICDFGLA RDIKNDSNYV VKGNARLPVK WMAPESIFNC 840

VYTFESDVWS YGIFLWELFS LGSSPYPGMP VDSKFYKMIK EGFRMFSPEH APAEMYDIMK 900

TCWDADPLKR PTFKQMVQLI EKQISDSTNH IYSNFANPSP IPADHSVRIN SVGSSASSTQ 960

PLLVHEDV 968

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         l++Gk+lG+GafGkvveatayGl+ksda+++vavkmlk++a+ +e+ealmselk+ls+lG

Q: 585   LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLG  644

         79**********************************************************

S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120

         +h+nivnllGact+gGp++viteyccyGdlln+lrrkr+sf+   + k+++++e++ +k+

Q: 645   NHMNIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDSFI---CAKQEDHAEAALYKN  701

         ******************************************...889999********9

S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180

         l     l+sk+s+s +s++ey+d+k++vs+v ++kad+++s ++ s++e++v++a++e+d

Q: 702   L-----LHSKESSSCDSTNEYMDMKPGVSYVVPTKADRRRSGRIGSYIEHDVTPAIMEDD  756

         9.....9*****************************************************

S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240

         + +l+ledllsfsyqvakGm+flasknc+hrdlaarn+llt+G+++kicdfGlardi++d

Q: 757   ELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKND  816

         ************************************************************

S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300

         snyvvkGnarlpvkwmapesif+++yt++sdvwsyGi+lwe+fslGs+pypg++vdskfy

Q: 817   SNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFY  876

         ************************************************************

S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344

         k+ikeG+rm +p++a++e+y+im++cw+a+p krp+fkq+v+l+

Q: 877   KMIKEGFRMFSPEHAPAEMYDIMKTCWDADPLKRPTFKQMVQLI  920

         *****************************************996

Domain Sequence
(FASTA)

LSFGKTLGAG AFGKVVEATA YGLIKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG 60

NHMNIVNLLG ACTVGGPTLV ITEYCCYGDL LNFLRRKRDS FICAKQEDHA EAALYKNLLH 120

SKESSSCDST NEYMDMKPGV SYVVPTKADR RRSGRIGSYI EHDVTPAIME DDELALDLED 180

LLSFSYQVAK GMAFLASKNC IHRDLAARNI LLTHGRITKI CDFGLARDIK NDSNYVVKGN 240

ARLPVKWMAP ESIFNCVYTF ESDVWSYGIF LWELFSLGSS PYPGMPVDSK FYKMIKEGFR 300

MFSPEHAPAE MYDIMKTCWD ADPLKRPTFK QMVQLI 336

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0009897	; C:external side of plasma membrane
GO:0005615	; C:extracellular space
GO:0016021	; C:integral to membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0005020	; F:stem cell factor receptor activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0000187	; P:activation of MAPK activity
GO:0097067	; P:cellular response to thyroid hormone stimulus
GO:0048066	; P:developmental pigmentation
GO:0038093	; P:Fc receptor signaling pathway
GO:0035234	; P:germ cell programmed cell death
GO:0006687	; P:glycosphingolipid metabolic process
GO:0007243	; P:intracellular protein kinase cascade
GO:0002320	; P:lymphoid progenitor cell differentiation
GO:0008584	; P:male gonad development
GO:0002551	; P:mast cell chemotaxis
GO:0032762	; P:mast cell cytokine production
GO:0043303	; P:mast cell degranulation
GO:0002573	; P:myeloid leukocyte differentiation
GO:0002318	; P:myeloid progenitor cell differentiation
GO:0043069	; P:negative regulation of programmed cell death
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0008284	; P:positive regulation of cell proliferation
GO:0010628	; P:positive regulation of gene expression
GO:0043410	; P:positive regulation of MAPK cascade
GO:0051091	; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0042511	; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523	; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777	; P:protein autophosphorylation
GO:0048070	; P:regulation of developmental pigmentation
GO:0009314	; P:response to radiation
GO:0007286	; P:spermatid development

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.

Pfam

PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

Created Date

20-Feb-2013