EKS-LOA-00256

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00256

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	288.1	6.6E-86	9	265	257

Status

Unreviewed

Ensembl Protein

ENSLAFP00000017097

UniProt Accession

G3TP32;

Protein Name

Protein Synonyms/Alias

Gene Name

CHEK1

Gene Synonyms/Alias

CHEK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000022165	ENSLAFP00000017097	ENSLAFT00000022776

Organism

Loxodonta africana

Functional Description

Protein Length

475

Protein Sequence
(FASTA)

MAVPFVEDWD LVQTLGEGAY GEVQLAVNRR TEEAVAVKIV DMKRAIDCPE NIKKEICINK 60

MLNHENVVKF YGHRREGNIQ YLFLEYCSGG ELFDRIEPDI GMPEQDAQRF FHQLMAGVVY 120

LHGIGITHRD IKPENLLLDE RDNLKISDFG LATVFRHNNR ERLLNKMCGT LPYVAPELLK 180

RKEFHAEPVD VWSCGIVLTA MLAGELPWDQ PSDSCQEYSD WKEKKTYLNP WKKIDSAPLA 240

LLHKILVENP SVRITIPDIK KDRWYNKPLK KGTRRPQVTS GGVSESPSGF SKHIQSNLDF 300

SPLNSASSET IKHSSSQPEP RTGLSLWDTS PSYIDKLVQG ISFSQPTCPD HMLLNSQLLG 360

TPGSSQNPWQ RLVKRMTRFF TKLDADKSYH CLKETCEKLG YQWKKSCMNQ VTVSTTDRRN 420

NKLIFKVNLV EMDEKILVDF RLSKGDGLEF KRHFLKIKGK LSDVVSSQKV WLPAT 475

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         ++l++tlGeg++g+V+la++++t+e+vavKi++ k++  +  e+ik+Ei i k+l+h+n+

Q: 9     WDLVQTLGEGAYGEVQLAVNRRTEEAVAVKIVDMKRAI-DCPENIKKEICINKMLNHENV  67

         7899******************************7764.5579*****************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +k++   ++ +  yl+ley+sggeLfd+ie +  ++e++a+++f+ql+++v Ylh  gi+

Q: 68    VKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEQDAQRFFHQLMAGVVYLHGIGIT  127

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkeg...klletfcGsppYaaPellkgkkYegp  177

         HrD+KpeNllld+++n+ki+DFGla++f+++   +ll+++cG++pY+aPellk+k+++++

Q: 128   HRDIKPENLLLDERDNLKISDFGLATVFRHNnreRLLNKMCGTLPYVAPELLKRKEFHAE  187

         **************************9988877799************************

S: 178   kvDvWslGvvLyalvtgklPfdee..nlkellekilkgkleipkk.lskelesLlrklLv  234

         +vDvWs+G+vL a+++g+lP+d++  +++e++++ +k+++  p k +++    Ll+k+Lv

Q: 188   PVDVWSCGIVLTAMLAGELPWDQPsdSCQEYSDWKEKKTYLNPWKkIDSAPLALLHKILV  247

         ***********************97679999999999999888778**************

S: 235   vdpekRatieeilkhewl  252

         ++p+ R+ti +i+k++w+

Q: 248   ENPSVRITIPDIKKDRWY  265

         *****************5

Domain Sequence
(FASTA)

WDLVQTLGEG AYGEVQLAVN RRTEEAVAVK IVDMKRAIDC PENIKKEICI NKMLNHENVV 60

KFYGHRREGN IQYLFLEYCS GGELFDRIEP DIGMPEQDAQ RFFHQLMAGV VYLHGIGITH 120

RDIKPENLLL DERDNLKISD FGLATVFRHN NRERLLNKMC GTLPYVAPEL LKRKEFHAEP 180

VDVWSCGIVL TAMLAGELPW DQPSDSCQEY SDWKEKKTYL NPWKKIDSAP LALLHKILVE 240

NPSVRITIPD IKKDRWY 257

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0000785	; C:chromatin
GO:0000781	; C:chromosome, telomeric region
GO:0000794	; C:condensed nuclear chromosome
GO:0005657	; C:replication fork
GO:0005524	; F:ATP binding
GO:0035402	; F:histone kinase activity (H3-T11 specific)
GO:0071260	; P:cellular response to mechanical stimulus
GO:0048096	; P:chromatin-mediated maintenance of transcription
GO:0000077	; P:DNA damage checkpoint
GO:0006281	; P:DNA repair
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0045839	; P:negative regulation of mitosis
GO:0010569	; P:regulation of double-strand break repair via homologous recombination
GO:2000615	; P:regulation of histone H3-K9 acetylation
GO:0046602	; P:regulation of mitotic centrosome separation
GO:0010767	; P:regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013