EKS-MEG-00090

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00090

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	390.6	2.9E-117	46	309	264

Status

Unreviewed

Ensembl Protein

ENSMGAP00000000022

UniProt Accession

G1MPR6;

Protein Name

Protein Synonyms/Alias

Gene Name

AAK1

Gene Synonyms/Alias

AAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000000645	ENSMGAP00000000022	ENSMGAT00000000650

Organism

Meleagris gallopavo

Functional Description

Protein Length

951

Protein Sequence
(FASTA)

MKKFFDSRRE QGGSGPGSGT SGGGGGSGGP GSGYIGRVFG IGRRQVTVDE VLAEGGFAIV 60

FLVRTNNGMK CALKRMYVNN EYDLQVCKRE IQIMRDLSGH KNIVGYIDSS INSVSSGDVW 120

EVLILMDFCR GGQVVNLMNQ RLQTGFTENE VLQIFCDTCE AVARLHQCKT PIIHRDLKVE 180

NILLHDRGHY VLCDFGSATN KFQNPQTEGV NAVEEEIKKY TTLSYRAPEM VNLYSGKLIT 240

TKADIWALGC LLYKLCYFTL PFGESQVAIC DGNFTIPDNS RHSQDMHCLI RYMLEPDPDK 300

RPDIYQVSYF AFKLAKKECP VQNVQNSPIP AKLPDPVKAS EAAAKKSQPK ARLTDPIPTT 360

ETSIAPRQRP KAGQTQPNPG ILPIQPALTP RKRPTAQAAI QPQGPTALGS GQPSLPASVP 420

QQKAAPQPTS VQPQAKQAPA LQQASQAQPQ VPSAQPQATL MQAQQLFVMQ WKKQDNEASC 480

PGGRFRTNKN GLTHFPAEQQ VSQLLLVSQF PVMQQGAPAQ QQLMQNYYQQ QQMMAQQTAM 540

QQKTAAAAVQ QKQQAPAAPQ PQAQQSAAQP TPQQEQAMQA QIRQQQKPQT TPPTAVQGQK 600

LGSLTPPSSP KTQRAGHRRI LSDVTHSAVF GVPASKSTQL LQAAAAEASL NKSKSASTTP 660

SGSPRTSQQN VYNPPDVSTW NPFDDDNFSK LTAEELLNKD FAKLGDGKAP EKMGSSTENL 720

IPGFQPASSA AQADAFGGSS SFTAGSAEKM KDILSLDTSP PLLTVPDPFI SLPLSDPPEK 780

LIEGLKSPET ALLLPDILPL TDPFGSTSDA VNGKPDVAVE SLIPGLEAPL PQCLVSQTES 840

IASNRTDSLT GEDSLLDCSL LSNPAADLLD EFAPVAFTAQ PHKDAEDTNL IAGFDAPEGS 900

EKVTEDEFDP IPVLISKNSQ GGHSRNNSGS SESSLPNIAR SLLLVDQLID L 951

Nucleotide Sequence
(FASTA)

ATGAAGAAGT TCTTCGACTC GCGCCGGGAA CAGGGCGGCT CTGGGCCCGG ATCGGGCACC 60

AGCGGCGGCG GCGGAGGCAG CGGAGGGCCC GGCAGCGGTT ACATCGGCAG AGTGTTCGGC 120

ATCGGCCGCC GCCAGGTGAC GGTGGACGAG GTGCTGGCGG AAGGTGGATT TGCCATAGTG 180

TTTCTTGTGA GGACAAACAA TGGGATGAAA TGTGCCCTGA AGCGAATGTA CGTCAATAAT 240

GAGTATGACT TGCAAGTATG CAAAAGAGAA ATCCAAATCA TGCGAGATCT GTCTGGCCAC 300

AAGAACATTG TAGGATACAT TGATTCCAGT ATAAACTCAG TAAGCAGCGG TGATGTGTGG 360

GAAGTGCTGA TATTAATGGA CTTCTGCCGA GGAGGACAGG TGGTGAACCT CATGAATCAA 420

CGACTTCAGA CAGGGTTCAC AGAGAATGAA GTCCTGCAGA TCTTCTGTGA CACCTGTGAA 480

GCTGTAGCAA GGCTGCATCA GTGTAAAACA CCAATAATCC ACAGGGATCT GAAGGTTGAA 540

AATATCTTGC TACATGATCG TGGTCACTAT GTCCTCTGTG ACTTTGGAAG TGCTACCAAC 600

AAATTCCAGA ACCCTCAAAC AGAAGGGGTG AATGCGGTGG AGGAGGAGAT CAAGAAGTAC 660

ACTACGTTAT CTTACAGAGC ACCAGAAATG GTCAACCTGT ATAGTGGCAA ACTTATCACT 720

ACAAAAGCAG ACATATGGGC CCTCGGCTGT TTGCTGTACA AGCTGTGTTA CTTCACTTTG 780

CCATTTGGGG AGAGTCAGGT GGCAATCTGT GATGGCAACT TCACCATTCC AGATAACTCC 840

CGGCATTCAC AGGACATGCA CTGCCTCATC CGGTATATGC TTGAGCCAGA CCCTGATAAG 900

AGACCTGATA TTTATCAAGT CTCCTACTTT GCATTCAAAC TGGCAAAGAA GGAATGCCCA 960

GTCCAGAACG TCCAGAACTC TCCAATCCCT GCTAAACTCC CAGACCCAGT CAAAGCAAGT 1020

GAAGCTGCGG CGAAGAAGAG TCAACCAAAG GCCAGGTTGA CAGATCCCAT TCCTACAACA 1080

GAAACTTCCA TAGCACCTCG CCAGAGACCT AAAGCAGGAC AGACACAACC CAACCCTGGA 1140

ATTTTACCAA TTCAGCCAGC CTTGACACCT AGGAAGAGAC CCACAGCCCA AGCAGCAATT 1200

CAGCCTCAAG GGCCTACTGC CCTGGGCAGT GGTCAGCCTT CACTCCCTGC AAGTGTCCCC 1260

CAGCAAAAAG CAGCACCGCA ACCAACTTCA GTGCAGCCAC AAGCCAAGCA GGCGCCAGCA 1320

CTCCAGCAGG CATCACAGGC ACAGCCCCAG GTCCCTTCTG CTCAGCCACA AGCCACACTG 1380

ATGCAAGCTC AGCAGCTTTT TGTGATGCAA TGGAAGAAGC AGGATAATGA AGCTTCTTGT 1440

CCTGGGGGAA GGTTTAGAAC AAATAAAAAT GGACTAACCC ACTTCCCAGC TGAGCAGCAG 1500

GTGTCTCAAC TACTGCTTGT TTCCCAGTTC CCAGTGATGC AGCAGGGAGC ACCAGCACAG 1560

CAGCAGCTGA TGCAAAACTA CTACCAGCAG CAGCAGATGA TGGCCCAGCA GACAGCCATG 1620

CAGCAGAAGA CAGCAGCAGC AGCAGTTCAG CAAAAGCAAC AGGCTCCAGC AGCACCACAG 1680

CCCCAGGCCC AGCAAAGTGC AGCCCAGCCA ACACCACAGC AGGAACAAGC GATGCAGGCA 1740

CAAATAAGGC AACAGCAAAA ACCTCAAACC ACACCACCTA CAGCAGTTCA GGGGCAGAAG 1800

CTGGGTTCTC TCACACCTCC GTCCTCCCCC AAGACGCAGC GTGCAGGACA CAGGAGGATT 1860

CTGAGTGATG TGACCCACAG TGCTGTTTTT GGGGTTCCAG CCAGCAAATC TACCCAGCTC 1920

CTGCAGGCAG CTGCTGCTGA AGCCAGTCTC AACAAGTCCA AATCGGCTTC CACTACGCCC 1980

TCGGGTTCCC CAAGGACTTC ACAGCAGAAC GTCTATAATC CGCCCGATGT CTCCACCTGG 2040

AATCCGTTTG ATGATGATAA CTTCTCCAAA CTCACAGCTG AGGAGCTGCT GAACAAGGAC 2100

TTTGCAAAGC TGGGTGATGG GAAAGCTCCA GAAAAGATGG GCAGTTCCAC AGAGAACTTG 2160

ATTCCAGGTT TCCAACCAGC TTCATCTGCA GCCCAGGCAG ATGCGTTTGG TGGCTCATCT 2220

TCCTTCACTG CTGGATCGGC TGAAAAAATG AAAGACATTC TGAGTCTGGA CACTAGCCCT 2280

CCTCTTCTGA CTGTGCCTGA TCCTTTCATC TCTCTCCCAT TATCTGACCC TCCAGAAAAA 2340

CTGATTGAGG GACTCAAATC TCCTGAGACT GCGCTTCTGC TCCCTGATAT CCTGCCTCTC 2400

ACTGACCCTT TTGGTAGCAC ATCAGATGCT GTGAATGGAA AACCTGATGT AGCCGTTGAG 2460

AGCCTCATAC CGGGCCTTGA GGCTCCACTG CCCCAATGCC TCGTGTCACA GACTGAGTCG 2520

ATTGCTTCCA ACAGGACAGA CTCTCTCACT GGGGAAGACT CTCTGCTTGA CTGTTCTCTG 2580

CTTTCTAACC CTGCTGCTGA CCTCTTGGAT GAGTTTGCTC CTGTGGCTTT CACGGCTCAA 2640

CCTCACAAAG ATGCAGAAGA TACTAACCTG ATAGCAGGCT TTGATGCTCC TGAGGGCTCT 2700

GAAAAAGTGA CAGAAGATGA GTTTGACCCA ATTCCAGTGT TGATATCCAA AAATTCACAA 2760

GGTGGGCATT CTAGAAACAA CAGTGGAAGC TCTGAGTCCA GTCTTCCCAA CATAGCCAGG 2820

TCTTTACTGC TGGTGGATCA GCTCATAGAC CTGTAG 2856

Domain Profile

S: 1     vriekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghkniv  60

         v++++vlaeGGfa+v+l++ +++g k+alKr++vn+e dl+ +krEi+im++lsghkniv

Q: 46    VTVDEVLAEGGFAIVFLVR-TNNGMKCALKRMYVNNEYDLQVCKREIQIMRDLSGHKNIV  104

         6899***************.9999************************************

S: 61    klvdssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrava  120

          ++dss+++ ++++++evl+l+++c+ g++v+l+n+rl++g ++e+e+l+i++d+++ava

Q: 105   GYIDSSINSVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG-FTENEVLQIFCDTCEAVA  163

         ************9***************************9.******************

S: 121   alHalsvpliHRDlkveNillsdegelvlcDlGSattaileveskqelsalqeeiekntt  180

         +lH++++p+iHRDlkveNill+d+g++vlcD+GSat+++++++ +++++a++eei+k+tt

Q: 164   RLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQ-TEGVNAVEEEIKKYTT  222

         *******************************************.9***************

S: 181   lsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiPensr  240

         lsyr+PE+++lys++ i++k+DiWaLGcllYklc+f+ Pf+es ++ai++g+++iP+nsr

Q: 223   LSYRAPEMVNLYSGKLITTKADIWALGCLLYKLCYFTLPFGES-QVAICDGNFTIPDNSR  281

         *******************************************.****************

S: 241   yseklkslikkmlevdpeeRptiaqvle  268

         +s+++++li++mle+dp++Rp+i+qv++

Q: 282   HSQDMHCLIRYMLEPDPDKRPDIYQVSY  309

         **************************87

Domain Sequence
(FASTA)

VTVDEVLAEG GFAIVFLVRT NNGMKCALKR MYVNNEYDLQ VCKREIQIMR DLSGHKNIVG 60

YIDSSINSVS SGDVWEVLIL MDFCRGGQVV NLMNQRLQTG FTENEVLQIF CDTCEAVARL 120

HQCKTPIIHR DLKVENILLH DRGHYVLCDF GSATNKFQNP QTEGVNAVEE EIKKYTTLSY 180

RAPEMVNLYS GKLITTKADI WALGCLLYKL CYFTLPFGES QVAICDGNFT IPDNSRHSQD 240

MHCLIRYMLE PDPDKRPDIY QVSY 264

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045747	; P:positive regulation of Notch signaling pathway
GO:0050821	; P:protein stabilization
GO:2000369	; P:regulation of clathrin-mediated endocytosis
GO:0032880	; P:regulation of protein localization

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013