EKS-MEG-00140

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00140

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/SRPK	692.8	2.3E-208	16	592	577

Status

Unreviewed

Ensembl Protein

ENSMGAP00000000104

UniProt Accession

G1MPY2;

Protein Name

Protein Synonyms/Alias

Gene Name

SRPK1

Gene Synonyms/Alias

SRPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000000715	ENSMGAP00000000104	ENSMGAT00000000735

Organism

Meleagris gallopavo

Functional Description

Protein Length

594

Protein Sequence
(FASTA)

GGYHLVKIGD LFNGRYHVIR KLGWGHFSTV WLAWDIQGKR FVAMKVVKSA EHYTETALDE 60

IKLLKSVRNS DPNDPNKERV VQLLDDFKIS GVNGSHICMV FEVLGHHLLK WIIKSNYQGL 120

PLPCVKKIIK QPLLTLTIPH KCKYVGTVFP ISPQDITDFT RENFCTEHSG TITEVTIEKA 180

NANSVSTAPQ PKPADKMSKN KKKKLKKKQK RQAELLEKRM QEIEEMEKEA SPGQAHPEEE 240

EEAQGPLKML IKVSPPNENA DKKKAEVIVH EQSVLMESSI EKCVAEINCN GVIRMSDFPD 300

SGSQGSVRLE DDLHNANDCG DHPHTQENFH SCNYSQRNGD VENGPRAAVS DCFVPLVSED 360

SMVCQPTSSE EQSFNQQEIS HLQESIRTEM PSEDENENNS PADNKGKSTA GNFLLNPLEP 420

KNADKLKVKI ADLGNACWVH KHFTEDIQTR QYRSLEVLIG SGYSTPADIW STACMAFELA 480

TGDYLFEPHS GEDYSRDEEK NADHIALIIE LLGKIPRKLI LAGKYSKEFF TKKGDLKHIT 540

KLKPWGLFEV LVEKYEWSQD EAAAFTDFLL PMLELIPEKR ATAAECLRHP WLLS 594

Nucleotide Sequence
(FASTA)

GGAGGTTATC ACCTTGTGAA AATTGGAGAT CTCTTTAATG GACGCTACCA TGTGATTCGG 60

AAGCTCGGAT GGGGCCACTT CTCCACTGTC TGGCTGGCAT GGGACATCCA AGGGAAGAGA 120

TTTGTGGCGA TGAAAGTGGT GAAGAGTGCG GAGCACTACA CAGAAACAGC ACTGGATGAA 180

ATCAAGTTGC TAAAATCGGT TCGCAACAGT GATCCAAATG ATCCAAATAA AGAGAGAGTT 240

GTTCAGTTAT TAGATGACTT CAAGATTTCA GGAGTTAATG GTTCTCATAT CTGTATGGTG 300

TTTGAAGTTT TAGGGCATCA TCTCCTGAAG TGGATCATCA AGTCAAATTA TCAGGGGCTC 360

CCACTCCCTT GTGTCAAAAA GATCATCAAG CAGCCTCTTC TTACCCTGAC TATTCCTCAC 420

AAATGCAAGT ACGTTGGTAC TGTTTTCCCC ATCTCTCCCC AAGACATAAC TGATTTCACT 480

AGGGAAAACT TCTGCACTGA GCACAGTGGA ACAATAACGG AAGTAACTAT TGAAAAGGCA 540

AATGCAAATT CAGTGAGTAC TGCACCACAG CCAAAACCAG CTGACAAAAT GTCAAAGAAT 600

AAGAAAAAGA AGTTGAAAAA GAAGCAGAAG CGTCAGGCGG AGCTATTAGA GAAGCGAATG 660

CAAGAGATAG AGGAAATGGA GAAGGAAGCA AGCCCTGGGC AGGCACATCC TGAGGAGGAG 720

GAAGAAGCTC AGGGCCCTCT GAAAATGCTC ATAAAAGTTA GTCCACCCAA TGAAAATGCA 780

GACAAAAAGA AAGCTGAAGT CATCGTACAT GAACAGTCCG TTCTAATGGA AAGCAGCATA 840

GAAAAATGTG TAGCAGAAAT AAATTGCAAT GGTGTGATAC GAATGTCGGA CTTCCCAGAC 900

TCTGGCAGTC AAGGGTCTGT GCGACTTGAG GATGACCTTC ACAATGCCAA CGACTGCGGC 960

GATCACCCTC ACACACAGGA GAACTTCCAT AGCTGTAATT ACAGCCAACG TAATGGTGAT 1020

GTAGAGAACG GGCCTCGGGC TGCAGTGTCG GACTGTTTCG TGCCCTTAGT TTCAGAAGAT 1080

TCCATGGTGT GTCAGCCTAC TTCCAGCGAA GAGCAATCAT TCAACCAGCA GGAGATCAGC 1140

CATTTGCAAG AAAGCATCCG GACAGAGATG CCATCAGAGG ATGAGAATGA GAATAATAGC 1200

CCAGCAGACA ACAAAGGAAA ATCAACTGCT GGGAATTTCC TTCTTAATCC TCTTGAGCCC 1260

AAGAATGCAG ATAAGCTTAA GGTGAAGATA GCTGACCTTG GAAATGCCTG CTGGGTGCAC 1320

AAGCACTTCA CTGAAGACAT CCAGACCAGA CAGTACCGAT CCCTGGAGGT GCTGATAGGG 1380

TCGGGGTACA GCACCCCTGC TGACATCTGG AGCACGGCTT GTATGGCCTT TGAATTAGCA 1440

ACAGGAGACT ATCTGTTTGA GCCTCATTCT GGGGAAGACT ACTCACGAGA TGAAGAAAAA 1500

AATGCAGATC ACATTGCTCT GATCATAGAA CTTCTGGGGA AAATACCTCG CAAGCTCATT 1560

TTGGCAGGAA AGTATTCCAA GGAGTTTTTC ACCAAAAAAG GTGATCTGAA GCACATCACT 1620

AAACTGAAGC CCTGGGGCCT TTTCGAAGTC TTGGTGGAAA AATACGAATG GTCCCAGGAT 1680

GAGGCAGCTG CATTCACAGA CTTCTTACTA CCGATGTTGG AGCTGATCCC AGAGAAGCGA 1740

GCCACAGCAG CAGAATGTCT CAGGCACCCC TGGCTTCTCT CTTAG 1785

Domain Profile

S: 1     yhvirkLGWGhfstvWLawdlqekrfvalkvvksaehytetaldeikllksvresdpsdp  60

         yhvirkLGWGhfstvWLawd+q+krfva+kvvksaehytetaldeikllksvr+sdp+dp

Q: 16    YHVIRKLGWGHFSTVWLAWDIQGKRFVAMKVVKSAEHYTETALDEIKLLKSVRNSDPNDP  75

         9***********************************************************

S: 61    krekvvqllddfkisGvnGvhvclvfevLGenLlkliiksnyrGlpleqvkkiirqvLeg  120

         ++e+vvqllddfkisGvnG h+c+vfevLG++Llk+iiksny+Glpl++vkkii+q L +

Q: 76    NKERVVQLLDDFKISGVNGSHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIKQPLLT  135

         ************************************************************

S: 121   LdylhekCkiiht..dikPenvLlavddeyirrlaaeatewqkagakppsgsavstapqk  178

         L   h kCk + t   i P+++   + +++    +   t   +++ +   ++ vstapq+

Q: 136   LTIPH-KCKYVGTvfPISPQDITDFTRENFCTEHSGTIT---EVTIEKANANSVSTAPQP  191

         *9877.8****995559*****98888886665555555...55555666788*******

S: 179   kaieklsknkkkklkkkqkrqaellekrlqeleele........................  214

         k+++k+sknkkkklkkkqkrqaellekr+qe+ee+e

Q: 192   KPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEkeaspgqahpeeeeeaqgplkmli  251

         ************************************9***********************

S: 215   ..........aaeanseaedqelkedae.kgeleeieadveeevanedeaseeee.....  258

                    ++a+ ++++q++ ++++ ++ ++ei+++ ++ +    ++ ++++

Q: 252   kvsppnenadKKKAEVIVHEQSVLMESSiEKCVAEINCNGVIRMSDFPDSGSQGSvrled  311

         ***999999877777777777765554415567889999998888887774444445555

S: 259   .............essltsssdaesksgel........seastellsesleqlacgsvls  297

                       ++  +s ++++ +g+         s+  ++l+se  ++++c+ ++s

Q: 312   dlhnandcgdhphTQENFHSCNYSQRNGDVengpraavSDCFVPLVSE--DSMVCQPTSS  369

         566666677777644455566667777766444444444444455554..4444444444

S: 298   .............................................vnplepknadkikvk  312

                                                      +nplepknadk+kvk

Q: 370   eeqsfnqqeishlqesirtempsedenennspadnkgkstagnflLNPLEPKNADKLKVK  429

         7799999999999999999999999999999999**************************

S: 313   iadLGnaCwvhkhftediqtrqyrslevliGagygtpadiWstaClafeLatGdyLfeph  372

         iadLGnaCwvhkhftediqtrqyrslevliG+gy+tpadiWstaC+afeLatGdyLfeph

Q: 430   IADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYSTPADIWSTACMAFELATGDYLFEPH  489

         ************************************************************

S: 373   sgedysrde....dhiakiiellGkiPrklilkGkysreffnkkgeLrhitkLkpwsLle  428

         sgedysrde    dhia iiellGkiPrklil+Gkys+eff+kkg+L+hitkLkpw+L+e

Q: 490   SGEDYSRDEeknaDHIALIIELLGKIPRKLILAGKYSKEFFTKKGDLKHITKLKPWGLFE  549

         ********977778**********************************************

S: 429   vLvekyewskeeaaefsdfLlPmleldpekrasaaeclkhpwL  471

         vLvekyews++eaa f+dfLlPmlel+pekra+aaecl+hpwL

Q: 550   VLVEKYEWSQDEAAAFTDFLLPMLELIPEKRATAAECLRHPWL  592

         ******************************************8

Domain Sequence
(FASTA)

YHVIRKLGWG HFSTVWLAWD IQGKRFVAMK VVKSAEHYTE TALDEIKLLK SVRNSDPNDP 60

NKERVVQLLD DFKISGVNGS HICMVFEVLG HHLLKWIIKS NYQGLPLPCV KKIIKQPLLT 120

LTIPHKCKYV GTVFPISPQD ITDFTRENFC TEHSGTITEV TIEKANANSV STAPQPKPAD 180

KMSKNKKKKL KKKQKRQAEL LEKRMQEIEE MEKEASPGQA HPEEEEEAQG PLKMLIKVSP 240

PNENADKKKA EVIVHEQSVL MESSIEKCVA EINCNGVIRM SDFPDSGSQG SVRLEDDLHN 300

ANDCGDHPHT QENFHSCNYS QRNGDVENGP RAAVSDCFVP LVSEDSMVCQ PTSSEEQSFN 360

QQEISHLQES IRTEMPSEDE NENNSPADNK GKSTAGNFLL NPLEPKNADK LKVKIADLGN 420

ACWVHKHFTE DIQTRQYRSL EVLIGSGYST PADIWSTACM AFELATGDYL FEPHSGEDYS 480

RDEEKNADHI ALIIELLGKI PRKLILAGKY SKEFFTKKGD LKHITKLKPW GLFEVLVEKY 540

EWSQDEAAAF TDFLLPMLEL IPEKRATAAE CLRHPWL 577

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0007059	; P:chromosome segregation
GO:0045071	; P:negative regulation of viral genome replication
GO:0045070	; P:positive regulation of viral genome replication

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013