EKS-MEG-00377

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00377

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	423.4	3.2E-127	27	310	284

Status

Unreviewed

Ensembl Protein

ENSMGAP00000000205

UniProt Accession

G1MQ62;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK13

Gene Synonyms/Alias

MAPK13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000000797	ENSMGAP00000000205	ENSMGAT00000000839

Organism

Meleagris gallopavo

Functional Description

Protein Length

367

Protein Sequence
(FASTA)

RAMNIARRRG FYRQELNRTV WELPRRYISL HPVGSGAYGS VCSAIDKKTG EKVAIKKLCR 60

PFQTEIFAKR AYRELILLKQ MQHENVIGLL DVFTSAPSYH GFQDFYLVMP YMRTDLQKIM 120

GHEFSDEKIQ YLVYQMLKGL KYIHSAGIVH RDLKPGNLAV NEDCQLKILD FGLARHADAE 180

MTGYVVTRWY RAPEVILNWM HYNQTVDIWS IGCIMAEMLT GKTLFKGKDY LDQLTQILKV 240

TGHPGDDFVE KLEDKAAKSY IKSLPKMPKK DLSVLFPKAN PQAVDLLDKM LQLDVEKRLT 300

ATEALAHPYF DQFRDIEEET EAQQAYDDSL EHEKLSIEEW KKHIYKEILS FSPIARKDSK 360

KRSGMSL 367

Nucleotide Sequence
(FASTA)

CGGGCGATGA ACATCGCAAG GAGAAGAGGC TTTTACAGAC AGGAGCTGAA CAGAACCGTC 60

TGGGAGCTGC CCAGGAGGTA CATCTCCCTG CACCCCGTGG GCTCTGGGGC CTACGGTTCT 120

GTCTGTTCTG CCATAGACAA GAAGACAGGA GAGAAAGTGG CCATCAAGAA GCTGTGCCGC 180

CCGTTCCAGA CAGAGATCTT TGCCAAGAGA GCATACAGAG AGCTCATTCT CTTGAAGCAA 240

ATGCAGCATG AGAATGTCAT TGGGCTGCTC GATGTCTTCA CCTCCGCCCC TTCCTACCAC 300

GGATTTCAAG ACTTCTACCT GGTGATGCCA TACATGCGGA CAGATTTACA AAAGATCATG 360

GGACATGAGT TCAGTGATGA AAAGATCCAG TACCTGGTCT ACCAGATGCT GAAAGGGCTG 420

AAGTATATTC ATTCTGCCGG AATCGTCCAC AGGGACCTGA AGCCAGGCAA CCTGGCTGTC 480

AATGAAGACT GCCAGCTAAA GATCTTGGAC TTTGGCTTAG CAAGACATGC TGATGCTGAA 540

ATGACAGGCT ATGTGGTCAC ACGCTGGTAT AGAGCTCCAG AAGTCATTCT GAACTGGATG 600

CATTACAACC AGACAGTGGA TATCTGGTCT ATTGGTTGCA TCATGGCAGA AATGCTGACT 660

GGGAAAACAC TGTTTAAAGG AAAAGACTAC CTTGATCAGC TGACTCAGAT CCTGAAAGTA 720

ACAGGGCATC CGGGAGATGA CTTTGTGGAG AAGCTTGAGG ACAAGGCGGC TAAAAGTTAT 780

ATCAAGTCTC TTCCAAAAAT GCCCAAGAAG GATTTGTCTG TGCTTTTCCC CAAAGCCAAT 840

CCTCAGGCAG TGGACCTGCT GGACAAGATG CTGCAGCTGG ATGTGGAGAA GCGCCTTACG 900

GCCACAGAAG CATTAGCCCA CCCGTACTTC GATCAATTCC GAGACATCGA GGAGGAGACA 960

GAGGCACAAC AGGCCTACGA TGATTCTCTG GAGCATGAAA AGCTTTCAAT AGAAGAATGG 1020

AAAAAACATA TCTATAAGGA GATCTTATCC TTCAGTCCAA TTGCACGGAA GGACTCAAAG 1080

AAGCGAAGTG GAATGTCGCT GTAG 1104

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y sl+p+g+Gayg v+sa+dk+t+e+vaikkl rpfq+e+ akr++REl llk+++heN+

Q: 27    YISLHPVGSGAYGSVCSAIDKKTGEKVAIKKLCRPFQTEIFAKRAYRELILLKQMQHENV  86

         66889*******************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i lldvft++ +++ ++d+Ylv+ +m tdL+k++ ++ +sde+i++l+yq+l+glky+Hs

Q: 87    IGLLDVFTSAPSYHGFQDFYLVMPYMRTDLQKIMGHE-FSDEKIQYLVYQMLKGLKYIHS  145

         **********************************998.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a+++HrDlKP+Nl+vnedc+lkildFGlar+ad+e    +t+yv+trwYraPe++l++++

Q: 146   AGIVHRDLKPGNLAVNEDCQLKILDFGLARHADAE----MTGYVVTRWYRAPEVILNWMH  201

         ***********************************....*********************

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWs+GCI+aE+ltgk+lf+gkd++dql++il+v+g+p ++f++k+e++ a++yi

Q: 202   YNQTVDIWSIGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGHPGDDFVEKLEDKAAKSYI  261

         ************************************************************

S: 241   kslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         kslpk++kkd++ lfpka+++a+dLl+k+L+ld +kR++++eaL+hpY+

Q: 262   KSLPKMPKKDLSVLFPKANPQAVDLLDKMLQLDVEKRLTATEALAHPYF  310

         ************************************************6

Domain Sequence
(FASTA)

YISLHPVGSG AYGSVCSAID KKTGEKVAIK KLCRPFQTEI FAKRAYRELI LLKQMQHENV 60

IGLLDVFTSA PSYHGFQDFY LVMPYMRTDL QKIMGHEFSD EKIQYLVYQM LKGLKYIHSA 120

GIVHRDLKPG NLAVNEDCQL KILDFGLARH ADAEMTGYVV TRWYRAPEVI LNWMHYNQTV 180

DIWSIGCIMA EMLTGKTLFK GKDYLDQLTQ ILKVTGHPGD DFVEKLEDKA AKSYIKSLPK 240

MPKKDLSVLF PKANPQAVDL LDKMLQLDVE KRLTATEALA HPYF 284

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0032755	; P:positive regulation of interleukin-6 production
GO:0006970	; P:response to osmotic stress

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013