EPS-MEG-00035

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MEG-00035

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	181.9	1.5E-53	96	351	256

Status

Unreviewed

Ensembl Protein

ENSMGAP00000000443

UniProt Accession

G1MQR9;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1F

Gene Synonyms/Alias

PPM1F;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000001043	ENSMGAP00000000443	ENSMGAT00000001083

Organism

Meleagris gallopavo

Functional Description

Protein Length

360

Protein Sequence
(FASTA)

ALLSLPFVTS RGVSPLLAAS VIHTAVDEVL RTDLTEFKRE SVEKQGEGEE ERFTLLSVLD 60

GESLQRCFFN KLRDVCFEWQ KQLPPLRPLK RFLLVSIHAI RNTRRKMEDR HVILMEFNQL 120

FGLAGKDDID RAYFAIFDGH GGVDAANYSA THLHVNVGLH REIVKNPAEA LKCSFQKTDE 180

MFIFKAKRER LRSGTTGVSA LIVGNKLHIA WLGDSQVMLV QQGNAVTLME PHKPEREDER 240

ARIEALGGCV TYMDCWRVNG TLAVSRAIGD VCQKPYISGD ADGDSFDLTG SEDYLLLACD 300

GFFDAVKPYE VVDLVLDHLM QTKGVGLKAA ERLVAAAKEN GSNDNITVLV VFLRDPQDIL 360

Nucleotide Sequence
(FASTA)

GCTCTTCTTT CCCTTCCTTT TGTTACCAGC AGAGGTGTTT CGCCACTCCT TGCAGCGTCA 60

GTGATCCACA CTGCAGTCGA TGAAGTTCTC CGAACAGACC TGACTGAGTT TAAGAGGGAA 120

AGTGTGGAAA AACAGGGAGA AGGAGAGGAG GAAAGATTCA CCTTGCTGTC AGTGCTGGAT 180

GGAGAGTCGC TGCAGCGCTG CTTCTTTAAC AAACTTCGGG ATGTCTGCTT TGAATGGCAG 240

AAGCAGTTGC CACCGCTGAG ACCACTGAAG CGTTTCCTGC TTGTTTCCAT CCATGCCATC 300

CGTAACACTC GGCGGAAAAT GGAGGACCGC CATGTTATCC TTATGGAGTT CAATCAGCTG 360

TTTGGCTTAG CAGGAAAGGA TGACATCGAT CGCGCTTACT TTGCGATATT TGATGGCCAT 420

GGTGGAGTGG ATGCTGCCAA CTATTCAGCA ACCCATTTAC ATGTAAATGT GGGGCTACAC 480

AGGGAGATTG TTAAGAATCC AGCTGAGGCC TTGAAATGCT CTTTCCAGAA GACTGATGAA 540

ATGTTTATTT TCAAAGCCAA AAGAGAGAGG CTGCGGAGTG GTACAACAGG TGTATCTGCA 600

TTGATTGTAG GGAACAAGCT ACACATAGCA TGGCTAGGGG ACTCGCAGGT AATGCTTGTG 660

CAGCAAGGAA ATGCTGTGAC GTTAATGGAA CCTCACAAAC CAGAGAGAGA AGATGAGAGA 720

GCACGCATTG AGGCTCTGGG TGGATGTGTA ACCTACATGG ACTGCTGGCG GGTTAATGGC 780

ACTTTGGCTG TTTCCAGAGC AATTGGTGAT GTGTGTCAAA AACCTTACAT CTCTGGTGAT 840

GCAGATGGAG ATTCGTTTGA CCTGACTGGT TCTGAAGATT ACTTGCTTCT AGCCTGTGAT 900

GGATTCTTTG ATGCTGTCAA GCCCTATGAG GTTGTAGACT TAGTCCTAGA TCATTTAATG 960

CAAACCAAAG GAGTGGGTCT CAAAGCAGCA GAAAGACTGG TGGCTGCTGC GAAGGAAAAT 1020

GGATCCAATG ACAACATTAC TGTTTTAGTG GTGTTCTTGA GGGATCCACA GGACATCTTG 1080

Domain Profile

S: 4     gvvsvngrrnemedavtsspnflkspekkdr....laffgvyDGhggsevakfcseklhe  59

         ++ ++ + r++med++ +  +f +  +   +     a+f+++DGhgg ++a++ +++lh

Q: 96    SIHAIRNTRRKMEDRHVILMEFNQLFGLAGKddidRAYFAIFDGHGGVDAANYSATHLHV  155

         5678999*********99999888765544455679************************

S: 60    ilaeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyv  119

          +    e      ++  +al+ +F++tde + ++++k  +  +sG+t v ali ++kl++

Q: 156   NVGLHRE----IVKNPAEALKCSFQKTDEMF-IFKAK-RERLRSGTTGVSALIVGNKLHI  209

         9999866....999999**************.66666.67778*****************

S: 120   anvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRalG  179

         a +GdS+++L ++g+av+l + Hkp+redE++Rie+ gg v++ d+ Rv+G LavsRa+G

Q: 210   AWLGDSQVMLVQQGNAVTLMEPHKPEREDERARIEALGGCVTYMDCWRVNGTLAVSRAIG  269

         *********************************************99*************

S: 180   dlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqea  238

         d+  kpy++ + +  s++lt ++++l La+DG +d v++ e+v+lv d+l  +k    +a

Q: 270   DVCQKPYISGDADGDSFDLTGSEDYLLLACDGFFDAVKPYEVVDLVLDHLMqTKGVGLKA  329

         ***********************************************998846667889*

S: 239   akkLvklalargskdnvsaivv  260

         a++Lv+ a ++gs+dn++++vv

Q: 330   AERLVAAAKENGSNDNITVLVV  351

         *****************99987

Domain Sequence
(FASTA)

SIHAIRNTRR KMEDRHVILM EFNQLFGLAG KDDIDRAYFA IFDGHGGVDA ANYSATHLHV 60

NVGLHREIVK NPAEALKCSF QKTDEMFIFK AKRERLRSGT TGVSALIVGN KLHIAWLGDS 120

QVMLVQQGNA VTLMEPHKPE REDERARIEA LGGCVTYMDC WRVNGTLAVS RAIGDVCQKP 180

YISGDADGDS FDLTGSEDYL LLACDGFFDA VKPYEVVDLV LDHLMQTKGV GLKAAERLVA 240

AAKENGSNDN ITVLVV 256

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0043234	; C:protein complex
GO:0033192	; F:calmodulin-dependent protein phosphatase activity
GO:0046872	; F:metal ion binding
GO:0035690	; P:cellular response to drug
GO:0097193	; P:intrinsic apoptotic signaling pathway
GO:0033137	; P:negative regulation of peptidyl-serine phosphorylation
GO:0044387	; P:negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045892	; P:negative regulation of transcription, DNA-dependent
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0050921	; P:positive regulation of chemotaxis
GO:0043280	; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0051894	; P:positive regulation of focal adhesion assembly
GO:0010628	; P:positive regulation of gene expression
GO:0045927	; P:positive regulation of growth
GO:0051496	; P:positive regulation of stress fiber assembly

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013