EKS-MEG-00125

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00125

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	623.5	3.2E-188	464	743	280

Status

Unreviewed

Ensembl Protein

ENSMGAP00000000739

UniProt Accession

G1MRD6;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK2

Gene Synonyms/Alias

TLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000001264	ENSMGAP00000000739	ENSMGAT00000001385

Organism

Meleagris gallopavo

Functional Description

Protein Length

774

Protein Sequence
(FASTA)

MMEELHSLDP RRQELLEARF TGVGVAKGPL NSESSNQSLC SVGSLSDKEL ETPEKKQNDQ 60

RNRKRKAEAY ETSQGKGTPR GHKISDYFEF AGGSGPGTSP GRSVPPVARS SPQHSLSNPL 120

PRRVEQPLYG VDGSTAKEPQ EDHSALPTLM SVMLAKQRLE NEQLAQRGGG LCFTFVSAQQ 180

GSPSSTGSGN TEHSCTSQKQ ISIQHKQSQS DLTMEKISAL ENSKNSDLEK KEGRIDDLLR 240

ANCDLRRQID EQQKMLEKYK ERLNRCVTMS KKLLIEKSKQ EKMACRDKSM QDRLRLGHFT 300

TVRHGASFTE QWTDGYAFQN LIKQQERINS QREEIERQRK MLAKRKPPAM GQTPPASNEQ 360

KQRKNKTNGA ENETCSKGGT WLATSTKDLN IWESLLGRLT LAEYHEQEEI FKLRLGHLKK 420

EEAEIQAELE RLERVRNLHI RELKRIHNED NSQFKDHPTL NDRYLLLHLL GRGGFSEVYK 480

AFDLTEQRYV AVKIHQLNKN WRDEKKENYH KHACREYRIH KELDHPRIVK LYDYFSLDTD 540

SFCTVLEYCE GNDLDFYLKQ HKLMSEKEAR SIIMQIVNAL KYLNEIKPPI IHYDLKPGNI 600

LLVNGTACGE IKITDFGLSK IMDDDSYNSV DGMELTSQGA GTYWYLPPEC FVVGKEPPKI 660

SNKVDVWSVG VIFYQCLYGR KPFGHNQSQQ DILQENTILK ATEVQFPPKP VVTPEAKAFI 720

RRCLAYRKED RIDVQQLACD PYLLPHIRKS VSTSSPAGAA IASTSGSSNN SSSN 774

Nucleotide Sequence
(FASTA)

ATGATGGAAG AATTGCATAG CCTGGACCCA CGAAGGCAGG AACTACTGGA GGCCAGGTTT 60

ACTGGAGTTG GTGTTGCTAA GGGTCCATTA AATAGCGAGT CTTCCAACCA GAGCTTATGC 120

AGCGTGGGTT CTCTCAGTGA TAAAGAACTG GAGACTCCTG AGAAAAAACA GAATGACCAG 180

CGGAATAGAA AAAGGAAAGC AGAAGCATAT GAGACCAGTC AAGGAAAAGG CACTCCTAGA 240

GGACATAAAA TTAGTGACTA TTTTGAGTTT GCTGGGGGAA GCGGCCCAGG AACCAGTCCT 300

GGTAGAAGTG TGCCACCAGT TGCCAGATCA TCACCGCAGC ATTCCTTATC CAACCCCTTA 360

CCACGGCGAG TGGAGCAGCC GCTGTATGGG GTAGACGGCA GCACAGCAAA GGAACCACAG 420

GAGGATCACT CTGCTCTGCC AACGCTGATG TCGGTGATGC TGGCGAAACA GCGGCTAGAG 480

AATGAGCAGC TGGCACAGAG GGGAGGTGGC CTCTGCTTTA CTTTTGTCTC GGCCCAGCAA 540

GGCAGCCCAT CTTCTACGGG ATCAGGGAAC ACTGAGCATT CCTGCACTTC CCAAAAACAG 600

ATTTCCATCC AGCACAAACA GTCACAGTCG GACCTCACAA TGGAAAAAAT ATCTGCACTA 660

GAAAACAGTA AGAACTCTGA CTTGGAGAAG AAGGAAGGGA GGATAGATGA CTTACTAAGA 720

GCCAACTGCG ATTTGAGACG GCAGATAGAT GAACAACAAA AGATGCTGGA GAAGTACAAG 780

GAGAGGTTGA ATAGATGTGT AACGATGAGC AAGAAGCTCC TTATAGAAAA GTCAAAACAG 840

GAGAAGATGG CGTGCAGAGA TAAGAGCATG CAGGATCGAT TGAGGCTGGG TCACTTCACC 900

ACGGTGCGGC ACGGGGCGTC CTTCACTGAG CAGTGGACAG ATGGCTATGC CTTCCAGAAT 960

CTCATCAAGC AACAGGAAAG GATAAATTCC CAGCGGGAAG AAATAGAAAG GCAACGAAAA 1020

ATGTTAGCAA AACGGAAGCC ACCTGCAATG GGCCAGACCC CCCCAGCAAG CAATGAGCAG 1080

AAGCAACGCA AGAACAAAAC CAACGGAGCA GAAAATGAAA CCTGCAGCAA AGGTGGCACA 1140

TGGTTGGCAA CATCAACCAA AGACCTAAAC ATCTGGGAAA GCCTTTTAGG CAGGTTAACG 1200

CTAGCAGAAT ACCATGAACA GGAAGAAATC TTCAAACTCC GACTGGGTCA TCTGAAAAAG 1260

GAAGAAGCAG AGATCCAGGC AGAGCTGGAA CGGCTAGAGA GGGTTAGAAA TCTACATATC 1320

AGGGAATTGA AAAGGATACA CAATGAAGAT AACTCACAAT TTAAAGACCA TCCAACGCTA 1380

AACGATAGAT ATTTGTTGCT ACATCTTCTG GGTCGAGGAG GCTTCAGTGA AGTATATAAG 1440

GCATTTGATT TAACAGAACA GAGATATGTA GCTGTGAAAA TACACCAGTT AAATAAAAAC 1500

TGGAGGGATG AGAAGAAAGA AAACTATCAC AAACATGCGT GTAGAGAGTA CAGAATTCAC 1560

AAAGAACTGG ATCATCCTCG AATAGTTAAG CTATATGACT ACTTTTCACT GGATACTGAC 1620

TCGTTTTGTA CAGTGTTAGA ATACTGTGAG GGAAACGATC TGGACTTCTA CCTGAAGCAG 1680

CACAAGTTAA TGTCGGAGAA AGAGGCGCGA TCCATTATCA TGCAGATTGT GAATGCTTTA 1740

AAATACTTAA ATGAAATCAA ACCTCCCATC ATACACTATG ACCTTAAACC AGGTAACATT 1800

CTTCTAGTCA ATGGTACTGC ATGTGGAGAG ATAAAAATCA CAGATTTTGG GCTTTCCAAA 1860

ATCATGGATG ATGACAGCTA CAACTCTGTT GATGGCATGG AGCTGACATC GCAGGGGGCT 1920

GGTACTTACT GGTATTTGCC ACCAGAATGT TTCGTGGTTG GGAAAGAACC TCCAAAGATT 1980

TCAAATAAAG TTGATGTCTG GTCAGTAGGG GTCATCTTCT ATCAGTGTCT GTACGGCAGA 2040

AAGCCCTTTG GCCACAACCA GTCACAACAA GATATTCTCC AGGAGAACAC GATTCTGAAA 2100

GCTACCGAGG TGCAGTTCCC TCCAAAGCCA GTAGTCACAC CAGAAGCAAA GGCATTTATC 2160

AGGCGTTGTT TGGCCTACCG AAAGGAGGAT CGGATAGATG TCCAGCAGCT GGCCTGTGAC 2220

CCGTACTTGC TGCCTCACAT CCGCAAATCT GTATCCACAA GCAGCCCAGC TGGAGCTGCA 2280

ATTGCATCAA CCTCTGGATC ATCCAATAAC AGCTCTTCAA ACTGA 2325

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqryvavkihqlnk+w+dekkeny+kha+reyrihkel

Q: 464   YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL  523

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtdsfctvley+egndldfylkqhkl+sekearsiimqiv+alkyl

Q: 524   DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL  583

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy+s+dg+eltsqgagty

Q: 584   NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY  643

         ************************************************************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvifyqclyg+kpfghnqsqqdil+entilkate

Q: 644   WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE  703

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvv++eakafirrclayrkedridvqqla+d+yl

Q: 704   VQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL  743

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LTEQRYVAVK IHQLNKNWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDSFC TVLEYCEGND LDFYLKQHKL MSEKEARSII MQIVNALKYL 120

NEIKPPIIHY DLKPGNILLV NGTACGEIKI TDFGLSKIMD DDSYNSVDGM ELTSQGAGTY 180

WYLPPECFVV GKEPPKISNK VDVWSVGVIF YQCLYGRKPF GHNQSQQDIL QENTILKATE 240

VQFPPKPVVT PEAKAFIRRC LAYRKEDRID VQQLACDPYL 280

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005882	; C:intermediate filament
GO:0005634	; C:nucleus
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction
GO:0001672	; P:regulation of chromatin assembly or disassembly

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013