EKS-MEG-00108

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00108

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/Akt	280.8	9.2E-84	357	628	272

Status

Unreviewed

Ensembl Protein

ENSMGAP00000000800

UniProt Accession

G1MRI6;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCD

Gene Synonyms/Alias

PRKCD;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000001305	ENSMGAP00000000800	ENSMGAT00000001446

Organism

Meleagris gallopavo

Functional Description

Protein Length

701

Protein Sequence
(FASTA)

MAPFLRISFN SFELGPVQNQ GEQLQPFCAI KMKEALTTER GKTLVQKKPT MYPEWKSTFD 60

AHIYEGRVIQ IVLMKAAEEP LSEVTVGVSV LAERCKKGSG KAEFWLDLQP QGKVLMAVQY 120

FLEDADCRQS MREEEGTVTI NRRGAIKQAK IHYIKNHEFI ATFFGQPTFC SVCKEFVWGL 180

NKQGYKCRQC NAAIHKKCID KIIGRCTGTA ANSRDTMFQK ERFNIDMPHR FKVYNYMSPT 240

FCDHCGSLLW GLVKQGLKCE ECAMNVHHKC QKKVANLCGI NQKLLAEALT QVSQKSTRRS 300

DSGSVENVGI YQDFDKKPRG PGGDTTADSQ YDKLWEGSTA KPAPRIASRR KFNIDSFVFH 360

KVLGKGSFGK VLLAELKGKN EFFAIKALKK DVVLIDDDVE CTMVEKRVLA LAWENPFLTH 420

LYCTFQTKDH LFFVMEFLNG GDLMFHIQDK GRFDLYRATF YGAEILCGLQ FLHSKGIIYR 480

KLTNIITEHN WSSFRDLKLD NVMLDKEGHI KIADFGMCKE NVVGENKAST FCGTPDYIAP 540

ENKILQGLKY TFSVDWWSFG VLLYEMLIGQ SPFHGDDEDE LFESIRVDTP HYPRWITKES 600

KDILEKLFER DPTRRLGVTG NIRAHPFFKT INWTTLEKRE VDPPFKPKVK SASDYNNFDR 660

EFLNEKPKLS YSDKNLIDSM DQSAFDGFSF TNPKFEQILE K 701

Nucleotide Sequence
(FASTA)

ATGGCCCCCT TCTTGCGGAT ATCTTTCAAC TCATTCGAGC TGGGACCCGT GCAGAATCAA 60

GGGGAACAAC TACAGCCTTT CTGCGCTATC AAGATGAAGG AGGCATTGAC TACAGAGAGA 120

GGAAAAACTC TGGTTCAGAA GAAACCCACC ATGTATCCGG AATGGAAGTC CACTTTTGAC 180

GCCCACATTT ACGAAGGACG CGTGATTCAG ATTGTTCTCA TGAAAGCAGC AGAAGAGCCA 240

TTATCCGAAG TGACTGTAGG TGTGTCTGTC CTGGCAGAGC GCTGCAAGAA GGGCAGTGGC 300

AAAGCAGAAT TCTGGCTTGA CCTACAACCT CAGGGGAAGG TGCTGATGGC TGTGCAGTAT 360

TTTTTAGAAG ATGCAGATTG CAGACAGTCA ATGAGGGAAG AAGAGGGAAC AGTAACTATC 420

AACAGGAGAG GAGCTATCAA GCAAGCAAAG ATCCACTACA TCAAAAATCA TGAATTTATT 480

GCTACCTTCT TTGGACAGCC CACATTTTGT TCTGTCTGCA AAGAGTTTGT ATGGGGACTG 540

AACAAACAAG GATACAAATG TAGGCAATGC AACGCTGCTA TTCATAAGAA ATGTATTGAT 600

AAAATCATTG GGAGGTGTAC TGGTACTGCA GCCAACAGCA GAGACACAAT GTTTCAGAAG 660

GAACGTTTCA ACATTGACAT GCCTCACCGC TTCAAAGTTT ACAACTACAT GAGCCCTACT 720

TTCTGTGACC ACTGCGGCAG CCTGCTCTGG GGGCTGGTCA AGCAAGGACT CAAATGTGAA 780

GAATGTGCAA TGAATGTGCA TCATAAATGC CAAAAGAAGG TGGCCAACCT GTGTGGAATT 840

AACCAGAAGT TGCTAGCTGA AGCCTTAACT CAAGTCAGCC AGAAGTCCAC ACGAAGGTCT 900

GATTCTGGAT CTGTAGAAAA TGTTGGTATT TACCAGGATT TTGATAAGAA ACCTCGAGGT 960

CCAGGAGGGG ATACAACAGC AGATAGCCAG TATGATAAAC TCTGGGAGGG AAGCACTGCC 1020

AAGCCAGCAC CACGAATTGC AAGCAGGAGA AAATTCAATA TAGACAGCTT TGTCTTCCAT 1080

AAAGTACTGG GGAAAGGAAG TTTTGGAAAG GTCCTGCTTG CTGAGCTAAA AGGAAAGAAT 1140

GAGTTCTTTG CTATCAAAGC TCTGAAAAAA GATGTGGTGC TAATTGATGA TGATGTGGAA 1200

TGTACCATGG TGGAGAAGCG GGTCCTAGCA CTTGCATGGG AAAATCCATT TCTCACACAC 1260

CTTTATTGCA CGTTCCAGAC AAAGGATCAC CTGTTTTTTG TTATGGAGTT CCTGAATGGG 1320

GGAGACCTGA TGTTTCACAT ACAAGACAAG GGGCGTTTTG ACCTCTACAG AGCAACGTTT 1380

TATGGAGCTG AAATTTTATG TGGGCTACAG TTTCTTCACA GCAAAGGCAT TATTTATAGG 1440

AAGTTGACCA ATATAATCAC AGAACACAAC TGGAGCAGTT TTAGAGACCT AAAACTGGAC 1500

AACGTTATGC TCGATAAAGA AGGCCACATC AAAATAGCTG ACTTTGGAAT GTGCAAAGAA 1560

AATGTAGTTG GTGAGAACAA GGCAAGCACT TTCTGTGGGA CCCCAGATTA CATTGCTCCA 1620

GAGAACAAGA TTCTACAAGG CTTGAAGTAC ACATTCTCTG TGGACTGGTG GTCATTTGGG 1680

GTCCTGCTAT ACGAGATGCT CATTGGGCAG TCCCCTTTCC ATGGGGATGA TGAAGATGAG 1740

TTGTTTGAGT CGATCCGAGT GGACACACCT CACTACCCAC GCTGGATCAC CAAGGAATCA 1800

AAAGATATAT TAGAAAAGCT ATTTGAAAGA GATCCAACAA GAAGACTTGG TGTCACTGGG 1860

AATATCAGAG CTCATCCTTT CTTCAAAACC ATCAACTGGA CAACCCTGGA GAAGAGGGAG 1920

GTAGACCCTC CTTTCAAGCC AAAAGTGAAG TCAGCGAGTG ACTACAACAA CTTCGACAGA 1980

GAATTTCTGA ATGAGAAGCC GAAGCTCTCC TACAGTGACA AAAACCTGAT TGACTCCATG 2040

GACCAGTCTG CGTTCGATGG CTTCTCCTTC ACCAACCCTA AGTTTGAACA GATCTTAGAA 2100

AAATAG 2106

Domain Profile

S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrt.khp  59

         f + k+lGkG+fGkv+l   k  + ++a+k+lkk+v++  d+v  t+ e+rvl+ + ++p

Q: 357   FVFHKVLGKGSFGKVLLAELKGKNEFFAIKALKKDVVLIDDDVECTMVEKRVLALAwENP  416

         5688*************************************************965278*

S: 60    flvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskd  119

         fl++l  +fqtk++l++v+e++nGG+l+fh++ +++f+  ra fygaei++ l++lhsk

Q: 417   FLTHLYCTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFDLYRATFYGAEILCGLQFLHSKG  476

         ************************************************************

S: 120   vvyr...............dlklenllldkdGhikitdfGlckeeikdgdktktfcGtpe  164

         ++yr               dlkl+n++ldk+Ghiki+dfG+cke++  ++k +tfcGtp+

Q: 477   IIYRkltniitehnwssfrDLKLDNVMLDKEGHIKIADFGMCKENVVGENKASTFCGTPD  536

         **9544444444444444499***************************************

S: 165   ylape..vlededygkavdwwglGvvlyemlcGrlpfynkdheklfelilleelkfprkl  222

         y+ape  +l++  y+ +vdww+ Gv+lyeml+G++pf+ +d+++lfe i ++  ++pr +

Q: 537   YIAPEnkILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWI  596

         ****8779****************************************************

S: 223   seeaksllsGllkkdpkkrlGggkddakeireheff  258

         ++e+k++l+ l+++dp++rlG     + +ir+h+ff

Q: 597   TKESKDILEKLFERDPTRRLGV----TGNIRAHPFF  628

         *********************6....6778999988

Domain Sequence
(FASTA)

FVFHKVLGKG SFGKVLLAEL KGKNEFFAIK ALKKDVVLID DDVECTMVEK RVLALAWENP 60

FLTHLYCTFQ TKDHLFFVME FLNGGDLMFH IQDKGRFDLY RATFYGAEIL CGLQFLHSKG 120

IIYRKLTNII TEHNWSSFRD LKLDNVMLDK EGHIKIADFG MCKENVVGEN KASTFCGTPD 180

YIAPENKILQ GLKYTFSVDW WSFGVLLYEM LIGQSPFHGD DEDELFESIR VDTPHYPRWI 240

TKESKDILEK LFERDPTRRL GVTGNIRAHP FF 272

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005911	; C:cell-cell junction
GO:0005829	; C:cytosol
GO:0005783	; C:endoplasmic reticulum
GO:0016363	; C:nuclear matrix
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0008047	; F:enzyme activator activity
GO:0046872	; F:metal ion binding
GO:0004697	; F:protein kinase C activity
GO:0006915	; P:apoptotic process
GO:0042100	; P:B cell proliferation
GO:0090398	; P:cellular senescence
GO:0016064	; P:immunoglobulin mediated immune response
GO:0035556	; P:intracellular signal transduction
GO:0030837	; P:negative regulation of actin filament polymerization
GO:0051490	; P:negative regulation of filopodium assembly
GO:0034351	; P:negative regulation of glial cell apoptotic process
GO:0046627	; P:negative regulation of insulin receptor signaling pathway
GO:0043407	; P:negative regulation of MAP kinase activity
GO:0050732	; P:negative regulation of peptidyl-tyrosine phosphorylation
GO:0090331	; P:negative regulation of platelet aggregation
GO:0042119	; P:neutrophil activation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:2000304	; P:positive regulation of ceramide biosynthetic process
GO:2000753	; P:positive regulation of glucosylceramide catabolic process
GO:1900163	; P:positive regulation of phospholipid scramblase activity
GO:0035307	; P:positive regulation of protein dephosphorylation
GO:2001022	; P:positive regulation of response to DNA damage stimulus
GO:2000755	; P:positive regulation of sphingomyelin catabolic process
GO:0032930	; P:positive regulation of superoxide anion generation
GO:0023021	; P:termination of signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR014376	; Prot_kin_PKC_delta.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00130	; C1_1; 2.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013