EKS-MEG-00362
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00362
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Syk465.92.3E-140369616248
StatusUnreviewed
Ensembl ProteinENSMGAP00000001386
UniProt AccessionG1MSR6;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameZAP70
Gene Synonyms/Alias ZAP70;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000001863ENSMGAP00000001386ENSMGAT00000002042
OrganismMeleagris gallopavo
Functional Description
Protein Length632
Protein Sequence
(FASTA)
TRAAMPDAAA HLPFYYGSIA RSEAEEYLKL AGMSDGLFLL RQCLRSLGGY VLSMVCNLQF 60
YHYAIERQMN GTYAIAGGKA HCGPEELCEF YSKDADGLCC TLRKPCNRPS GVEPQPGVFD 120
SMRDNMVREY VRQTWRLEGD ALEQAIISQA PQVEKLIATT AHERMPWYHG NIARDEAERR 180
LYSGAQPDGK FLLRDKKESG TYALSLVYGK TVYHYRIDQD KSGKYSIPEG TKFDTLWQLV 240
EYLKLKPDGL IFYLRESCPN PSMPGVREMW LGSGNAQPHC WLLATASLCA SSAFPALGKV 300
HAQCPAVLKP ASLRCECPAE PNTSGTWRNE HAGKSRMLPM DTSVYESPYS DPEELKDKKL 360
FLKRDHLMID EVELGAGNFG CVKKGVYKMR KKQIDVAIKV LKSNNEKTVR DEMMTEAQIM 420
HQLDNPYIVR MIGVCEAESL MLVMEMASGG PLNKFLSSKK DEITVSNIVE LMHQVSMGMK 480
YLEEKNFVHR DLAARNVLLV NQHYAKISDF GLSKALGADD SYYKARTAGK WPLKWYAPEC 540
ILYHKFSSKS DVWSYGVTMW EAFSYGQKPY KKMKGPEVIS FIEQGKRMDC PTECPAEIYT 600
LMMQCWTYRW EERPGFFTVE NTIRTYYYSI AT 632
Nucleotide Sequence
(FASTA)
ACGCGTGCAG CAATGCCGGA TGCTGCCGCT CACCTTCCCT TCTACTATGG CAGCATTGCC 60
AGGTCGGAGG CTGAGGAGTA CCTGAAGCTG GCTGGCATGT CAGATGGGCT GTTCCTGCTG 120
CGGCAGTGCC TGCGCAGCCT CGGGGGCTAT GTCCTTTCCA TGGTGTGCAA CCTGCAGTTC 180
TATCATTATG CCATCGAGCG CCAGATGAAT GGAACCTACG CCATCGCGGG TGGCAAAGCG 240
CACTGTGGGC CTGAGGAACT TTGTGAGTTT TATTCCAAGG ATGCCGATGG GCTCTGCTGC 300
ACCCTCCGCA AACCCTGCAA CCGCCCCAGT GGCGTGGAAC CCCAGCCTGG GGTCTTTGAC 360
AGCATGAGGG ACAACATGGT GCGCGAGTAT GTCCGACAGA CATGGAGACT GGAGGGGGAT 420
GCCCTTGAAC AGGCCATTAT AAGCCAGGCC CCTCAGGTGG AGAAGCTCAT TGCAACCACA 480
GCCCATGAGA GGATGCCCTG GTATCATGGC AACATTGCCC GGGATGAAGC TGAGCGGAGG 540
CTTTACTCTG GGGCACAACC CGATGGGAAA TTCCTGCTGA GAGACAAAAA GGAAAGCGGC 600
ACTTATGCTC TGTCCCTTGT CTATGGCAAA ACAGTTTATC ACTATCGGAT CGACCAGGAC 660
AAGTCTGGCA AGTACTCCAT CCCCGAGGGG ACCAAGTTTG ACACGCTCTG GCAGCTGGTG 720
GAATATTTGA AGCTCAAACC AGACGGGCTG ATTTTCTACC TGAGGGAAAG CTGCCCCAAC 780
CCCAGCATGC CAGGAGTGAG GGAGATGTGG TTGGGTTCTG GGAATGCTCA GCCCCACTGC 840
TGGCTATTGG CCACAGCATC TCTTTGTGCT TCCTCTGCAT TCCCAGCCCT GGGGAAAGTC 900
CACGCTCAGT GCCCAGCTGT GCTGAAACCA GCAAGTTTGC GCTGTGAGTG CCCAGCAGAG 960
CCTAACACGT CTGGGACCTG GAGGAACGAA CATGCAGGGA AGTCACGCAT GCTGCCCATG 1020
GACACCAGTG TTTATGAGAG CCCATACAGT GACCCTGAGG AACTGAAGGA CAAGAAACTC 1080
TTCCTGAAAA GGGATCACCT GATGATTGAC GAAGTAGAAC TGGGAGCAGG AAACTTTGGC 1140
TGTGTCAAGA AGGGAGTCTA CAAAATGAGA AAGAAGCAGA TCGATGTGGC CATCAAGGTA 1200
CTGAAGAGCA ACAATGAGAA AACAGTGAGG GATGAAATGA TGACAGAAGC TCAGATCATG 1260
CACCAGCTGG ACAACCCCTA CATCGTCCGC ATGATTGGGG TCTGTGAGGC AGAGTCCCTG 1320
ATGCTCGTGA TGGAGATGGC TTCTGGTGGA CCACTCAACA AGTTCTTATC TTCCAAGAAA 1380
GACGAGATTA CAGTCAGCAA TATTGTGGAG CTGATGCATC AAGTATCCAT GGGGATGAAG 1440
TACTTGGAAG AAAAAAACTT TGTCCACAGG GACTTGGCAG CAAGAAATGT CCTGCTGGTC 1500
AATCAGCATT ATGCCAAGAT CAGTGACTTT GGCCTCTCAA AGGCTCTCGG TGCTGATGAC 1560
AGCTATTACA AGGCCAGGAC AGCAGGAAAG TGGCCTTTGA AATGGTACGC GCCAGAGTGC 1620
ATCCTTTATC ACAAGTTCTC CAGCAAGAGT GATGTATGGA GCTACGGTGT GACCATGTGG 1680
GAGGCCTTCA GCTATGGGCA GAAACCATAC AAGAAAATGA AAGGCCCAGA GGTCATCAGC 1740
TTCATAGAGC AAGGGAAGCG CATGGACTGT CCCACCGAGT GCCCGGCAGA GATTTACACC 1800
CTCATGATGC AATGCTGGAC CTATAGATGG GAGGAGCGTC CAGGATTTTT TACAGTGGAA 1860
AACACGATCC GCACCTACTA CTACAGCATT GCCACC 1896
Domain Profile
S: 2     vedkelGsGnfGsvkkGyyrmkkkrlevaikvlkeadekadkdellreasvmqqldnkyi  61
         + + elG+GnfG+vkkG+y+m+kk+++vaikvlk ++ek+ +de++ ea++m+qldn+yi
Q: 369   IDEVELGAGNFGCVKKGVYKMRKKQIDVAIKVLKSNNEKTVRDEMMTEAQIMHQLDNPYI  428
         6789********************************************************
S: 62    vrliGiakaealmlvmelaelGpllkylldkreeikaknvlelvhqvamGmkyleeknfv  121
         vr+iG+++ae+lmlvme+a++Gpl+k+l  k++ei+++n++el+hqv+mGmkyleeknfv
Q: 429   VRMIGVCEAESLMLVMEMASGGPLNKFLSSKKDEITVSNIVELMHQVSMGMKYLEEKNFV  488
         ************************************************************
S: 122   hrdlaarnvllvarhyakisdfGlskalradesyykarsaGkwpvkwyapecinlrkfss  181
         hrdlaarnvllv++hyakisdfGlskal+ad+syykar+aGkwp+kwyapeci ++kfss
Q: 489   HRDLAARNVLLVNQHYAKISDFGLSKALGADDSYYKARTAGKWPLKWYAPECILYHKFSS  548
         ************************************************************
S: 182   ksdvwsfGvtlweafsyGqkpykelkgsevlalvekGerlecpaecpaelyalmsscwky  241
         ksdvws+Gvt+weafsyGqkpyk++kg+ev++++e+G+r++cp+ecpae+y lm +cw+y
Q: 549   KSDVWSYGVTMWEAFSYGQKPYKKMKGPEVISFIEQGKRMDCPTECPAEIYTLMMQCWTY  608
         ************************************************************
S: 242   kvedrpdf  249
         ++e+rp+f
Q: 609   RWEERPGF  616
         *******9
Domain Sequence
(FASTA)
IDEVELGAGN FGCVKKGVYK MRKKQIDVAI KVLKSNNEKT VRDEMMTEAQ IMHQLDNPYI 60
VRMIGVCEAE SLMLVMEMAS GGPLNKFLSS KKDEITVSNI VELMHQVSMG MKYLEEKNFV 120
HRDLAARNVL LVNQHYAKIS DFGLSKALGA DDSYYKARTA GKWPLKWYAP ECILYHKFSS 180
KSDVWSYGVT MWEAFSYGQK PYKKMKGPEV ISFIEQGKRM DCPTECPAEI YTLMMQCWTY 240
RWEERPGF 248
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00407
EKS-BOT-00437
EKS-CAP-00470
EKS-CII-00250
EKS-CIS-00192
EKS-DAR-00833
EKS-DIO-00086
EKS-EQC-00428
EKS-ERE-00039
EKS-GAG-00368
EKS-GAA-00534
EKS-GOG-00429
EKS-LAC-00453
EKS-MAM-00436
EKS-MIM-00075
EKS-MOD-00427
EKS-MUM-00469
EKS-MUP-00431
EKS-NOL-00398
EKS-ORN-00558
EKS-ORC-00410
EKS-ORL-00508
EKS-OTG-00441
EKS-PAT-00413
EKS-POA-00428
EKS-PRC-00042
EKS-RAN-00450
EKS-SAH-00406
EKS-TAG-00504
EKS-TAR-00548
EKS-TEN-00552
EKS-XET-00547
EKS-XIM-00548
Gene Ontology
GO:0005829; C:cytosol
GO:0001772; C:immunological synapse
GO:0042101; C:T cell receptor complex
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0006955; P:immune response
GO:0035556; P:intracellular signal transduction
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0046638; P:positive regulation of alpha-beta T cell differentiation
GO:0046641; P:positive regulation of alpha-beta T cell proliferation
GO:0050850; P:positive regulation of calcium-mediated signaling
GO:0046777; P:protein autophosphorylation
GO:0050852; P:T cell receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR023420; Kinase_SYK/ZAP-70_inter-SH2.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR012234; Tyr_kinase_non-rcpt_SYK/ZAP70.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 2.
SMARTs
SM00252; SH2; 2.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 2.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013