EKS-MEG-00116
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00116
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR408.58.4E-123519719201
StatusUnreviewed
Ensembl ProteinENSMGAP00000001522
UniProt AccessionG1MT22;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR1
Gene Synonyms/Alias FGFR1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000002004ENSMGAP00000001522ENSMGAT00000002184
OrganismMeleagris gallopavo
Functional Description
Protein Length786
Protein Sequence
(FASTA)
MFTWRSLILW AVLVTATLSA ARPAPTLPDQ ALPKTNIEVE SHSAHPGDLL QLRCRLRDDV 60
QSINWVRDGV QLPENNRTRI TGEEVEVRDA VPEDSGLYAC MTNSPSGSET TYFSVNVSDA 120
LPSAEDDDDE DDSSSEEKEA DNTKPNQAVA PYWTYPEKME KKLHAVPAAK TVKFKCPSGG 180
TPNPTLRWLK NGKEFKPDHR IGGYKVRYAT WSIIMDSVVP SDKGNYTCIV ENKYGSINHT 240
YQLDVVERSP HRPILQAGLP ANKTVALGSN VEFVCKVYSD PQPHIQWLKH IEVNGSKIGP 300
DNLPYVQILK TAGVNTTDKE MEVLHLRNVS FEDAGEYTCL AGNSIGISHH SAWLTVLEAI 360
EDSPAMMTSP LYLEIIIYCT GAFLISCMVV TVIIYKMKST TKKTDFNSQL AVHKLAKSIP 420
LRRQVTESRE GVSWLLLPLP KELPFPWVGL GWMVHHGFPS PCCVRGPVAT RVTRRIYGEE 480
HVLSTDDPQA VCFVVSASRK SIADDTVVSR HTAQPHSPTG PLYVIVEYAS KGNLREYLQA 540
RRPPGMEYCY NPTRVPEEQL SFKDLVSCAY QVARGMEYLA SKKCIHRDLA ARNVLVTEDN 600
VMKIADFGLA RDIHHIDYYK KTTNGRLPVK WMAPEALFDR IYTHQSDVWS FGVLLWEIFT 660
LGGSPYPGVP VEELFKLLKE GHRMDKPSNC TNELYMMMRD CWHAVPSQRP TFKQLVEDLD 720
RIVAMTSNQE YLDLSVPLDQ YSPGFPATRS STCSSGEDSV FSHDPLPDEP CLPRCPPHSQ 780
GVLKRH 786
Nucleotide Sequence
(FASTA)
ATGTTTACCT GGAGGTCCCT CATCCTTTGG GCTGTGCTGG TCACAGCCAC GCTGTCAGCT 60
GCCAGACCGG CCCCCACGCT TCCTGACCAA GCTCTTCCCA AAACGAACAT CGAGGTGGAA 120
TCCCACTCTG CACACCCCGG AGATCTCCTC CAGCTGCGCT GCCGGCTGCG CGATGACGTG 180
CAGAGCATCA ACTGGGTGCG TGATGGAGTG CAGCTGCCTG AGAACAACCG CACACGCATC 240
ACCGGCGAGG AGGTAGAGGT GCGGGATGCG GTGCCTGAGG ATTCGGGGCT CTATGCCTGC 300
ATGACCAACA GCCCCTCGGG GAGTGAGACC ACCTACTTCT CCGTCAATGT CTCAGACGCA 360
CTCCCTTCTG CAGAGGATGA TGATGATGAA GATGATTCCT CCTCAGAGGA GAAGGAGGCG 420
GATAACACCA AGCCGAACCA GGCTGTAGCT CCTTACTGGA CCTATCCTGA GAAGATGGAG 480
AAGAAGCTGC ACGCCGTCCC TGCTGCCAAA ACAGTGAAAT TCAAGTGCCC CTCAGGTGGG 540
ACGCCCAACC CCACGCTGCG CTGGCTGAAG AATGGCAAGG AATTCAAGCC TGACCACCGC 600
ATCGGGGGGT ACAAGGTCCG CTATGCCACC TGGAGCATCA TCATGGACTC GGTGGTGCCG 660
TCAGATAAAG GCAACTACAC GTGCATCGTG GAGAACAAAT ACGGGAGCAT CAACCACACC 720
TATCAGCTGG ATGTTGTGGA GCGCTCCCCA CACCGGCCCA TCCTGCAGGC AGGGCTCCCT 780
GCCAACAAAA CGGTGGCCCT GGGCAGCAAC GTGGAGTTCG TCTGCAAGGT CTACAGCGAC 840
CCGCAGCCCC ACATCCAATG GCTGAAACAC ATCGAGGTGA ACGGCAGCAA GATCGGCCCC 900
GACAACTTGC CCTACGTGCA GATCCTGAAG ACGGCTGGCG TTAACACGAC AGACAAAGAG 960
ATGGAAGTCC TTCACTTAAG GAATGTCTCA TTTGAGGATG CTGGGGAGTA TACATGTTTG 1020
GCGGGTAATT CTATTGGGAT CTCCCATCAC TCTGCATGGT TGACAGTTCT CGAAGCTATT 1080
GAGGACTCAC CAGCCATGAT GACGTCCCCT CTTTACCTGG AGATCATCAT TTACTGCACC 1140
GGCGCGTTCC TCATCTCCTG CATGGTGGTG ACAGTCATCA TCTATAAGAT GAAGAGCACC 1200
ACCAAGAAGA CAGATTTCAA CAGCCAGCTG GCCGTGCACA AGCTGGCCAA GAGCATCCCA 1260
CTGCGCAGAC AGGTAACAGA AAGTAGAGAG GGGGTTTCTT GGCTCCTACT GCCCCTCCCC 1320
AAAGAATTGC CCTTTCCCTG GGTTGGGTTG GGATGGATGG TGCACCATGG CTTCCCCTCG 1380
CCATGCTGTG TGCGTGGCCC CGTGGCAACG AGAGTAACCA GGAGGATTTA TGGTGAAGAG 1440
CACGTGCTGA GCACCGACGA CCCCCAGGCT GTGTGTTTTG TGGTATCAGC AAGCAGGAAA 1500
TCAATTGCAG ATGATACAGT CGTGTCCCGG CACACGGCTC AGCCCCATTC TCCCACAGGA 1560
CCCCTCTATG TCATCGTGGA GTACGCCAGC AAAGGCAACC TGCGTGAGTA CCTGCAGGCA 1620
CGGCGCCCAC CGGGCATGGA GTACTGCTAC AACCCCACCC GTGTCCCCGA GGAGCAGCTC 1680
TCCTTCAAGG ACCTGGTGTC CTGTGCATAC CAGGTGGCGC GTGGCATGGA GTACCTGGCC 1740
TCCAAAAAGT GCATCCACAG GGACCTGGCA GCCAGGAACG TGCTGGTGAC CGAGGACAAC 1800
GTGATGAAGA TCGCTGACTT TGGGCTGGCC CGTGACATCC ACCACATCGA TTATTACAAG 1860
AAGACGACAA ATGGTCGCTT GCCAGTGAAG TGGATGGCCC CAGAGGCTCT GTTCGACCGA 1920
ATATACACTC ATCAGAGTGA TGTTTGGTCC TTCGGCGTGC TGCTTTGGGA GATCTTCACT 1980
CTGGGCGGTT CGCCGTACCC CGGTGTGCCT GTGGAGGAGC TTTTCAAGCT GCTGAAGGAG 2040
GGCCACAGGA TGGACAAGCC CAGCAACTGC ACCAACGAGC TGTACATGAT GATGCGCGAC 2100
TGCTGGCACG CCGTGCCCTC CCAGCGCCCC ACTTTCAAAC AGCTGGTGGA GGACCTGGAC 2160
AGGATCGTGG CCATGACATC CAACCAGGAA TACCTGGACC TGTCGGTGCC GTTGGATCAG 2220
TACTCACCCG GCTTCCCAGC CACACGCAGC TCCACCTGCT CTTCTGGGGA GGACTCAGTG 2280
TTCTCCCACG ACCCACTGCC CGATGAGCCC TGCCTGCCAC GCTGCCCCCC GCACAGCCAA 2340
GGGGTGCTAA AGCGGCACTG A 2361
Domain Profile
S: 77    eGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqltekdlvsfayqvarGmey  136
          Gplyviveya+kGnlre+l+arrp+g+e+++++++++eeql++kdlvs+ayqvarGmey
Q: 519   TGPLYVIVEYASKGNLREYLQARRPPGMEYCYNPTRVPEEQLSFKDLVSCAYQVARGMEY  578
         7***********************************************************
S: 137   laskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkttnGrlpvkwmapealf  196
         laskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkttnGrlpvkwmapealf
Q: 579   LASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALF  638
         ************************************************************
S: 197   drvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGhrmekpakctkelyvlm  256
         dr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGhrm+kp++ct+ely++m
Q: 639   DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMM  698
         ************************************************************
S: 257   recwhakaserptfkqlvedl  277
         r+cwha++s+rptfkqlvedl
Q: 699   RDCWHAVPSQRPTFKQLVEDL  719
         *******************97
Domain Sequence
(FASTA)
TGPLYVIVEY ASKGNLREYL QARRPPGMEY CYNPTRVPEE QLSFKDLVSC AYQVARGMEY 60
LASKKCIHRD LAARNVLVTE DNVMKIADFG LARDIHHIDY YKKTTNGRLP VKWMAPEALF 120
DRIYTHQSDV WSFGVLLWEI FTLGGSPYPG VPVEELFKLL KEGHRMDKPS NCTNELYMMM 180
RDCWHAVPSQ RPTFKQLVED L 201
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Gallus gallus"; ?>
EKS-ANC-00142
EKS-GAG-00126
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008201; F:heparin binding
GO:0043066; P:negative regulation of apoptotic process
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0001759; P:organ induction
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0045787; P:positive regulation of cell cycle
GO:0043406; P:positive regulation of MAP kinase activity
GO:0090080; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0002053; P:positive regulation of mesenchymal cell proliferation
GO:0010863; P:positive regulation of phospholipase C activity
GO:0046777; P:protein autophosphorylation
GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0048378; P:regulation of lateral mesodermal cell fate specification
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 3.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013