EKS-MEG-00218

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00218

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	467.4	1.4E-140	180	467	288

Status

Unreviewed

Ensembl Protein

ENSMGAP00000001585

UniProt Accession

G1MT75;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1

Gene Synonyms/Alias

TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000002050	ENSMGAP00000001585	ENSMGAT00000002248

Organism

Meleagris gallopavo

Functional Description

Protein Length

478

Protein Sequence
(FASTA)

AALQCYCHLC TKDNFTCVTD GLCFTSVTRI ADRVIHNSMC IAEIDLIPRD RPFVCAPSSR 60

DGVTTLPHCC DKDHCNKIEL PIPTPGPTPG RPASSLGPVE LAAVIAGPVC FVCISLMLIL 120

YLCHNRTVIH HRVPSEEDPS LDRPFISEGT TLKDLIYDMT TSGSGSGLPL LVQRTIARTI 180

VLQESIGKGR FGEVWRGKWR GEEVAVKIFS SREERSWFRE AEIYQTVMLR HENILGFIAA 240

DNKDNGTWTQ LWLVSDYHEH GSLFDYLNRY TVTVEGMIKL ALSTASGLAH LHMEIVGTQG 300

KPAIAHRDLK SKNILVKKNG TCCIADLGLA VRHDSATDTI DIAPNHRVGT KRYMAPEVLD 360

DSINMKHFES FKRADIYAMG LVFWEIARRC SIGGIHEDYQ LPYYDLVPSD PSVEEMKKVV 420

CEQKLRPNIP NRWQSCEALR VMAKIMRECW YANGAARLTA LRIKKTLSQL SQQEGIKM 478

Nucleotide Sequence
(FASTA)

GCAGCATTAC AGTGTTACTG CCATCTATGC ACAAAAGACA ACTTTACCTG TGTAACAGAT 60

GGGCTTTGTT TTACCTCAGT AACACGGATT GCAGATAGAG TCATACACAA TAGCATGTGT 120

ATAGCAGAAA TCGATCTGAT TCCCCGGGAC AGACCATTTG TTTGTGCACC ATCCTCCAGA 180

GATGGAGTTA CTACTTTGCC TCATTGCTGT GACAAAGACC ACTGCAATAA AATAGAACTT 240

CCAATTCCAA CACCAGGTCC TACTCCAGGA AGACCAGCTT CTAGTCTAGG TCCTGTGGAA 300

CTGGCAGCTG TTATTGCTGG ACCTGTCTGC TTTGTCTGCA TTTCATTGAT GCTGATTCTG 360

TATCTTTGTC ATAACCGTAC TGTAATTCAT CATCGTGTGC CAAGTGAAGA AGATCCTTCA 420

TTGGATCGTC CCTTTATATC TGAAGGAACT ACATTAAAGG ATTTAATTTA TGATATGACA 480

ACTTCAGGCT CTGGGTCAGG TTTACCTTTA CTTGTGCAAA GAACAATTGC ACGAACTATA 540

GTACTCCAAG AAAGTATTGG TAAGGGTCGC TTTGGGGAAG TATGGAGGGG AAAATGGAGA 600

GGAGAAGAAG TTGCTGTGAA GATCTTTTCT TCAAGAGAAG AGCGCTCATG GTTTCGAGAG 660

GCAGAAATTT ATCAAACAGT TATGCTACGA CATGAAAACA TTCTTGGATT CATAGCTGCC 720

GACAATAAAG ACAATGGTAC ATGGACACAG CTGTGGTTGG TGTCAGATTA TCACGAACAT 780

GGGTCACTCT TTGATTACCT GAACAGGTAT ACAGTAACCG TGGAAGGAAT GATAAAATTA 840

GCCTTGTCTA CTGCCAGTGG CCTTGCTCAT CTTCACATGG AAATTGTAGG CACACAAGGC 900

AAACCAGCGA TTGCCCACAG AGATTTGAAA TCAAAAAACA TATTGGTAAA AAAGAATGGA 960

ACATGCTGCA TTGCAGATCT GGGGTTGGCA GTTCGGCATG ATTCAGCTAC AGACACAATT 1020

GACATTGCCC CCAACCACAG AGTGGGAACA AAAAGGTACA TGGCACCTGA AGTTTTAGAT 1080

GATTCCATAA ATATGAAACA TTTTGAGTCA TTCAAACGAG CAGACATCTA TGCAATGGGA 1140

TTAGTATTTT GGGAAATTGC TCGTCGATGT TCAATCGGTG GAATCCATGA AGATTACCAG 1200

TTGCCATATT ATGACCTAGT TCCTTCAGAT CCTTCTGTTG AAGAAATGAA AAAAGTTGTT 1260

TGTGAGCAGA AGTTGAGGCC CAATATCCCA AACAGATGGC AGAGCTGTGA GGCATTACGA 1320

GTAATGGCAA AAATCATGCG GGAATGCTGG TATGCCAACG GAGCTGCTAG GCTAACAGCT 1380

TTGCGTATTA AGAAAACACT ATCACAGCTT AGTCAACAGG AGGGGATAAA GATGTAA 1437

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 180   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  239

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+

Q: 240   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  299

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 300   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  357

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem

Q: 358   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEEM  416

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         k+vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 417   KKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  467

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMKKV 240

VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0044459	; C:plasma membrane part
GO:0043235	; C:receptor complex
GO:0005923	; C:tight junction
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0000186	; P:activation of MAPKK activity
GO:0071560	; P:cellular response to transforming growth factor beta stimulus
GO:0030199	; P:collagen fibril organization
GO:0043542	; P:endothelial cell migration
GO:0006917	; P:induction of apoptosis
GO:0043066	; P:negative regulation of apoptotic process
GO:0032331	; P:negative regulation of chondrocyte differentiation
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0030307	; P:positive regulation of cell growth
GO:0008284	; P:positive regulation of cell proliferation
GO:0051272	; P:positive regulation of cellular component movement
GO:0051491	; P:positive regulation of filopodium assembly
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0060391	; P:positive regulation of SMAD protein import into nucleus
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0043393	; P:regulation of protein binding
GO:0031396	; P:regulation of protein ubiquitination
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013