EKS-MEG-00138
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00138
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC439.34.1E-132252518267
StatusUnreviewed
Ensembl ProteinENSMGAP00000001831
UniProt AccessionG1MTR8;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCZ
Gene Synonyms/Alias PRKCZ;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000002228ENSMGAP00000001831ENSMGAT00000002500
OrganismMeleagris gallopavo
Functional Description
Protein Length592
Protein Sequence
(FASTA)
MPSRMGSKGN LNKDIIRVKA HYSGDILITN LDASISYEEL CDEVREMCNL QQEQPITLKW 60
IDDEGDPCTI SSQMELEEAF RLYCQNREEG LIIHVFPSIP EKPGMPCPGE DKSIYRRGAR 120
RWRKLYRVNG HLFQAKRFNR RAYCGQCSER IWGLSRQGYK CINCKLLVHK RCHILVPLTC 180
KRHMDSVMPS QEPQLGDKND EVDLPSEEND GIPYIPSNRK HDSIKDDSED IKPVIDGMDG 240
IKISQGLGLQ DFDLIRVIGR GSYAKVLLVR LKKNDQIYAM KVVKKELVHD DEDIDWVQTE 300
KHVFEQASSN PFLVGLHSCF QTTSRLFLVI EYVNGGDLMF HMQRQRKLPE EHARFYAAEI 360
CIALNFLHER GIIYRDLKLD NVLLDAEGHI KLTDYGMCKE GLGPGDTTST FCGTPNYIAP 420
EILRGEEYGF SVDWWALGVL MFEMMAGRSP FDIITDNPDM NTEDYLFQVI LEKPIRIPRF 480
LSVKASHVLK GFLNKDPKER LGCQPQTGFS DIKSHTFFRS IDWDLLEKKQ TTPPFQPQIT 540
DDYGLDNFDT QFTSEPVQLT PDDEDIIKRI DQSEFEGFEY INPLLLSTEE TV 592
Nucleotide Sequence
(FASTA)
ATGCCCAGCA GGATGGGCTC GAAAGGCAAT TTGAACAAAG ACATCATCAG GGTAAAGGCG 60
CACTACAGTG GGGACATCCT GATAACTAAC TTGGATGCAT CCATAAGCTA TGAGGAGCTT 120
TGTGATGAAG TGCGTGAGAT GTGTAATCTA CAACAGGAGC AGCCAATTAC CCTCAAGTGG 180
ATTGATGATG AAGGTGACCC ATGTACCATC TCATCTCAAA TGGAATTGGA AGAAGCCTTC 240
CGTTTGTACT GTCAAAACAG AGAGGAAGGG CTGATCATTC ATGTTTTCCC AAGTATTCCA 300
GAGAAACCCG GCATGCCTTG CCCAGGAGAA GACAAATCAA TCTACCGACG TGGAGCCAGA 360
AGATGGAGGA AGCTGTACCG AGTGAATGGG CATTTGTTTC AAGCCAAACG TTTTAACAGA 420
AGAGCATACT GTGGCCAGTG CAGTGAAAGG ATATGGGGTC TCAGCAGGCA AGGCTACAAG 480
TGTATCAACT GCAAATTGTT GGTCCATAAA CGTTGTCACA TACTTGTTCC ACTGACCTGC 540
AAAAGGCATA TGGATTCGGT CATGCCTTCC CAGGAACCTC AGTTAGGTGA TAAAAATGAT 600
GAAGTTGACC TCCCTTCAGA AGAAAATGAT GGAATTCCTT ACATTCCCTC AAACCGGAAG 660
CATGACAGCA TTAAAGATGA CTCTGAGGAT ATCAAACCAG TCATTGATGG AATGGATGGA 720
ATTAAGATTT CTCAGGGGCT TGGGCTACAG GACTTCGATT TAATCAGAGT TATTGGACGT 780
GGAAGCTATG CCAAAGTTCT TTTAGTTCGG TTAAAAAAGA ATGATCAAAT CTATGCGATG 840
AAAGTAGTGA AAAAAGAATT GGTCCATGAT GATGAGGATA TTGATTGGGT ACAGACAGAG 900
AAACACGTGT TTGAACAGGC ATCCAGCAAC CCATTCCTAG TTGGTTTACA TTCCTGCTTT 960
CAAACAACGA GTCGATTATT TCTTGTCATA GAGTATGTAA ATGGAGGAGA CCTTATGTTT 1020
CATATGCAAC GGCAAAGAAA ACTTCCTGAA GAACATGCAA GGTTTTATGC TGCTGAAATT 1080
TGTATTGCTC TGAACTTCCT ACATGAAAGA GGCATAATCT ACAGAGATTT AAAACTAGAC 1140
AATGTTCTTT TAGATGCAGA GGGTCATATC AAATTAACAG ATTATGGCAT GTGCAAGGAA 1200
GGATTGGGTC CTGGTGACAC TACGAGCACT TTCTGTGGAA CACCAAATTA CATTGCACCA 1260
GAAATCCTAA GGGGAGAAGA ATATGGGTTC AGCGTGGACT GGTGGGCTCT TGGTGTATTG 1320
ATGTTTGAAA TGATGGCAGG AAGGTCTCCA TTTGATATCA TTACTGACAA TCCAGACATG 1380
AACACTGAAG ATTACCTCTT CCAAGTTATC CTTGAGAAGC CCATCCGGAT TCCAAGGTTT 1440
CTTTCTGTCA AGGCCTCCCA TGTGTTAAAA GGATTTTTAA ACAAGGACCC CAAGGAAAGG 1500
CTTGGTTGTC AGCCACAAAC AGGATTTTCT GATATCAAGT CTCACACGTT TTTCCGCAGC 1560
ATAGACTGGG ATCTGCTGGA AAAGAAGCAA ACAACCCCTC CATTTCAGCC TCAGATCACA 1620
GATGATTATG GTTTGGACAA CTTTGATACG CAGTTCACCA GTGAACCTGT GCAGCTAACC 1680
CCAGATGATG AAGATATAAT AAAACGAATA GACCAGTCAG AATTTGAAGG ATTTGAATAC 1740
ATTAATCCAT TGTTGCTGTC AACGGAAGAA ACAGTATGA 1779
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f+l++v+G+Gs++kvll++lkk+d++ya+kv+kk++v++d+d++++++ek+v+++as++p
Q: 252   FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNP  311
         89**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         flv l+scfqt++rlf+v+eyvnGGdlmfh+q++rkl+ee+arfyaaei++al+flhe+g
Q: 312   FLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERG  371
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnvlldaeGhikl+d+G+cke++  g+ttstfcGtP+yiaPeil++eeyg+s
Q: 372   IIYRDLKLDNVLLDAEGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFS  431
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfe.......gededelfesilekevlyPkslskeaveilkg  233
         vdwwalGvl++em+ag+sPf+       +++ed+lf++ilek +++P+ ls++a+++lkg
Q: 432   VDWWALGVLMFEMMAGRSPFDiitdnpdMNTEDYLFQVILEKPIRIPRFLSVKASHVLKG  491
         **************************999*******************************
S: 234   lltkdpekrlGvk.eegeedikehaff  259
         +l+kdp++rlG++ ++g +dik+h+ff
Q: 492   FLNKDPKERLGCQpQTGFSDIKSHTFF  518
         ************989***********9
Domain Sequence
(FASTA)
FDLIRVIGRG SYAKVLLVRL KKNDQIYAMK VVKKELVHDD EDIDWVQTEK HVFEQASSNP 60
FLVGLHSCFQ TTSRLFLVIE YVNGGDLMFH MQRQRKLPEE HARFYAAEIC IALNFLHERG 120
IIYRDLKLDN VLLDAEGHIK LTDYGMCKEG LGPGDTTSTF CGTPNYIAPE ILRGEEYGFS 180
VDWWALGVLM FEMMAGRSPF DIITDNPDMN TEDYLFQVIL EKPIRIPRFL SVKASHVLKG 240
FLNKDPKERL GCQPQTGFSD IKSHTFF 267
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00165
EKS-ANC-00167
EKS-BOT-00174
EKS-CAE-00132
EKS-CAJ-00178
EKS-CAF-00181
EKS-CAP-00175
EKS-CII-00115
EKS-CIS-00206
EKS-DAR-00466
EKS-DIO-00088
EKS-DRM-00085
EKS-EQC-00172
EKS-ERE-00041
EKS-FEC-00166
EKS-GAM-00090
EKS-GAG-00149
EKS-GAA-00210
EKS-GOG-00173
EKS-HOS-00179
EKS-ICT-00168
EKS-LAC-00182
EKS-LOA-00172
EKS-MAM-00174
EKS-MOD-00171
EKS-MUM-00178
EKS-MUP-00178
EKS-MYL-00182
EKS-NOL-00166
EKS-OCP-00108
EKS-ORN-00218
EKS-ORC-00159
EKS-ORL-00205
EKS-OTG-00179
EKS-PAT-00164
EKS-PES-00153
EKS-POA-00172
EKS-RAN-00170
EKS-SAH-00165
EKS-TAG-00201
EKS-TAS-00058
EKS-TEN-00219
EKS-TUT-00155
EKS-XET-00161
EKS-XIM-00213
Gene Ontology
GO:0045179; C:apical cortex
GO:0016324; C:apical plasma membrane
GO:0035748; C:myelin sheath abaxonal region
GO:0005635; C:nuclear envelope
GO:0016363; C:nuclear matrix
GO:0043234; C:protein complex
GO:0005923; C:tight junction
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0008270; F:zinc ion binding
GO:0035556; P:intracellular signal transduction
GO:0000226; P:microtubule cytoskeleton organization
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation
GO:0031333; P:negative regulation of protein complex assembly
GO:0018105; P:peptidyl-serine phosphorylation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:2001181; P:positive regulation of interleukin-10 secretion
GO:2000667; P:positive regulation of interleukin-13 secretion
GO:0032753; P:positive regulation of interleukin-4 production
GO:2000664; P:positive regulation of interleukin-5 secretion
GO:2000553; P:positive regulation of T-helper 2 cell cytokine production
GO:0045630; P:positive regulation of T-helper 2 cell differentiation
GO:0072659; P:protein localization to plasma membrane
KEGG
mgp:100538756;
InterPros
IPR000961; AGC-kinase_C.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR000270; OPR_PB1.
IPR012233; PKC_zeta.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF00564; PB1; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 1.
SM00666; PB1; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013