EKS-MEG-00311

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00311

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	319.1	1.7E-95	173	410	238

Status

Unreviewed

Ensembl Protein

ENSMGAP00000001861

UniProt Accession

G1MTU4;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K13

Gene Synonyms/Alias

MAP3K13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000002279	ENSMGAP00000001861	ENSMGAT00000002530

Organism

Meleagris gallopavo

Functional Description

Protein Length

955

Protein Sequence
(FASTA)

MASTQDRLSL SSSPNSISKA FCEDKDFGRL HDERGPTGNH PSPELIEDMR EKGLLQSDLM 60

DNMSSPVTAA VLTSISEDSR DQFENSVLQL REQDEPETAI PQGNRSTMDG ESNSGADDVK 120

VQFNRSGSGS GGFLEGLFGC LRPVWNIIGK AYSTDYKLQQ QDTWEVPFEE ISELQWLGSG 180

AQGAVFLGKF RAEEVAIKKV RDQNETDIKH LRKLKHPNII AFKGVCTQAP CYCIIMEYCA 240

HGQLYEVLRA GRKVTPRLLV DWSTGIASGM NYLHLHKIIH RDLKSPNVLV THTDAVKISD 300

FGTSKELSDK STKMSFAGTV AWMAPEVIRN EPVSEKVDIW SFGVVLWELL TGEIPYKDVD 360

SSAIIWGVGS NSLHLPVPST CPDGFKILMK QTWQSKPRNR PSFRQTLMHL DIASADVLAT 420

PQETYFKSQA EWREEVKKHF EKIKSEGTCI HRLDEELIRR RREELRHALD IREHYERKLE 480

RANNLYMELS AIMLQLEVRE KELIKREQAV EKKYPGTYKR HPVRPIIHPN TVEKLMKRKG 540

VSHKPGSQTK RPDLLKSEGI PSAEAASNGS PVSGSPKMST LSGKSRYRSK PRHRRGNSKG 600

SYNDFAGILK NQPVQDDALP PPPHNHSHQP GLPQQHGHGH PHGHHSRLHA HGQDIANCAN 660

NLRYFGPAAA LRSPLSNHAQ RRMSGSSPDL ISTAMEADCR RNLESKESKD DHWECCKTDQ 720

YNSCLQCREE DSGQVQMSSV ETGVSRSQSP TAVSLYENAQ FIEKMEEEDF SNCTSASALG 780

TPQHMASSAL PCKARPIQKS GDDSSEEEEG EVDSEVEFPR RQRPHRCISS CQSYSTFSSE 840

NFSVSDGEEG NTSDHSNSPD ELAAKLEDEL AEKLEDMLSQ TPEIPIEIST QSDGLSDKEC 900

AVRRVKTQMS LGKLCADEHS CENPAQFGES DCDSSEGECS DATVRTNKPC SSATW 955

Nucleotide Sequence
(FASTA)

ATGGCCAGTA CTCAGGATCG CCTGAGCTTG TCTTCCTCTC CAAACTCCAT CAGCAAAGCT 60

TTCTGTGAGG ATAAAGACTT TGGCAGGCTA CACGATGAAC GTGGGCCTAC TGGAAACCAC 120

CCGTCCCCCG AGCTCATAGA GGATATGCGT GAGAAGGGCT TGCTGCAGTC AGACCTCATG 180

GACAACATGA GCAGCCCGGT CACTGCGGCC GTGCTGACCA GCATCAGTGA GGACTCTAGG 240

GACCAATTTG AGAACAGCGT GCTGCAGCTA CGAGAGCAGG ATGAACCCGA AACGGCCATT 300

CCTCAGGGCA ACAGGAGCAC TATGGATGGA GAGAGCAACA GCGGGGCGGA CGATGTTAAA 360

GTGCAGTTCA ACAGATCAGG CAGTGGGAGC GGTGGGTTTC TGGAGGGACT TTTTGGCTGT 420

CTCAGGCCTG TGTGGAACAT CATAGGCAAG GCGTACTCCA CGGACTACAA ACTGCAGCAG 480

CAAGATACGT GGGAGGTCCC GTTTGAGGAG ATCTCGGAGC TGCAGTGGCT GGGCAGTGGT 540

GCACAGGGAG CCGTCTTCTT GGGCAAGTTC CGAGCTGAGG AGGTGGCCAT CAAGAAAGTG 600

AGAGACCAGA ATGAAACAGA TATCAAGCAC CTGCGGAAAC TCAAACACCC CAACATCATT 660

GCCTTCAAAG GAGTCTGCAC ACAAGCCCCA TGCTACTGTA TTATCATGGA GTACTGTGCA 720

CATGGGCAAC TCTACGAAGT CTTGCGAGCG GGGCGGAAAG TCACTCCTCG GCTGCTTGTG 780

GATTGGTCCA CTGGGATTGC TAGTGGGATG AATTATCTGC ACCTTCACAA AATCATCCAT 840

CGAGACCTCA AGTCACCAAA TGTTTTAGTT ACACACACGG ATGCAGTTAA AATCTCAGAT 900

TTTGGTACGT CTAAAGAACT CAGTGATAAA AGTACCAAAA TGTCTTTTGC GGGAACCGTG 960

GCTTGGATGG CCCCAGAGGT GATACGCAAT GAGCCTGTTT CTGAAAAAGT GGATATCTGG 1020

TCATTTGGAG TAGTTTTGTG GGAGCTGCTT ACAGGAGAGA TTCCCTACAA AGATGTGGAC 1080

TCCTCCGCCA TCATTTGGGG AGTGGGCAGT AACAGCTTGC ACCTTCCTGT TCCTTCCACC 1140

TGCCCAGATG GCTTCAAAAT TCTCATGAAG CAGACCTGGC AGAGCAAGCC CCGGAATCGT 1200

CCCTCCTTCC GACAGACACT GATGCACCTG GATATTGCAT CTGCTGATGT GCTGGCTACT 1260

CCTCAGGAAA CCTACTTCAA ATCACAGGCT GAATGGAGGG AAGAGGTGAA GAAGCATTTT 1320

GAGAAGATTA AAAGTGAAGG AACCTGCATC CACCGGCTAG ATGAAGAATT GATTCGCCGT 1380

CGAAGAGAAG AGCTGAGGCA CGCCTTGGAT ATCCGTGAGC ACTACGAGAG GAAGCTGGAG 1440

CGAGCCAACA ACTTATACAT GGAGCTCAGT GCTATTATGC TGCAGCTGGA GGTCCGTGAG 1500

AAGGAGCTCA TAAAGAGGGA GCAAGCAGTG GAAAAGAAAT ATCCTGGGAC TTACAAACGC 1560

CACCCGGTCA GACCAATAAT CCACCCCAAT ACTGTGGAGA AGCTGATGAA GAGGAAAGGG 1620

GTCTCCCATA AACCAGGCAG CCAGACTAAA CGACCAGATC TGCTGAAGTC GGAGGGCATA 1680

CCCAGTGCAG AAGCAGCATC CAATGGCTCA CCAGTCTCAG GAAGTCCTAA AATGTCAACA 1740

CTGAGTGGCA AAAGTCGCTA CCGCAGTAAG CCACGTCACC GCCGAGGGAA CAGCAAAGGC 1800

AGCTACAACG ATTTTGCAGG GATCTTGAAA AACCAGCCTG TGCAAGATGA TGCACTCCCA 1860

CCTCCACCTC ATAATCATTC TCATCAGCCC GGTCTGCCAC AGCAGCATGG CCACGGCCAT 1920

CCCCACGGCC ATCACTCACG GCTCCATGCC CACGGACAGG ATATTGCCAA CTGTGCAAAC 1980

AACTTACGGT ACTTTGGCCC TGCAGCAGCG CTGCGGAGCC CGCTCAGTAA CCATGCACAA 2040

AGGAGGATGT CTGGTTCCAG CCCCGACCTC ATCTCCACTG CCATGGAAGC AGATTGCCGG 2100

AGGAATCTAG AAAGCAAAGA GAGCAAAGAT GATCACTGGG AGTGTTGCAA AACAGATCAG 2160

TACAACTCCT GTCTCCAGTG CAGGGAAGAG GACAGCGGTC AGGTACAGAT GTCATCTGTT 2220

GAAACAGGAG TGAGCCGTTC TCAGTCGCCG ACGGCTGTTT CCCTATATGA AAATGCACAG 2280

TTCATTGAGA AGATGGAGGA AGAGGACTTC AGCAACTGCA CGTCAGCATC TGCTCTAGGC 2340

ACACCACAGC ACATGGCTTC CTCAGCACTA CCTTGCAAAG CAAGACCCAT TCAAAAGAGT 2400

GGCGATGACT CCTCAGAAGA GGAAGAGGGC GAAGTCGACA GTGAAGTGGA GTTTCCTCGT 2460

AGACAAAGAC CTCACCGCTG CATTAGTAGC TGCCAGTCCT ACTCAACCTT CAGCTCGGAG 2520

AACTTCTCCG TGTCAGATGG AGAGGAGGGG AACACCAGTG ATCACTCCAA CAGCCCGGAT 2580

GAGCTGGCTG CCAAGCTGGA AGATGAGCTG GCTGAGAAGC TGGAGGACAT GTTGTCCCAG 2640

ACTCCAGAGA TCCCCATTGA AATCTCCACC CAGTCTGATG GGCTTTCAGA CAAAGAGTGC 2700

GCTGTGCGGA GAGTCAAGAC TCAGATGTCT CTGGGGAAAC TTTGTGCAGA TGAACATAGC 2760

TGTGAGAACC CAGCACAGTT TGGAGAATCA GACTGTGACT CTTCTGAAGG GGAGTGTTCT 2820

GATGCCACAG TCAGGACCAA TAAGCCCTGC AGCTCTGCTA CTTGGTAA 2868

Domain Profile

S: 3     leeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiell  62

         + +++gsga+g+v+ +k+r++eva+Kk+r+++e+         ++k+l+kl+hpnii+++

Q: 173   ELQWLGSGAQGAVFLGKFRAEEVAIKKVRDQNET---------DIKHLRKLKHPNIIAFK  223

         6789**************************9999.........*****************

S: 63    GvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkki  122

         Gvc++ p+++++mey+++g+L++vl++   r+++++ lv+w++ iA+Gm+YLh +   ki

Q: 224   GVCTQAPCYCIIMEYCAHGQLYEVLRA--GRKVTPRLLVDWSTGIASGMNYLHLH---KI  278

         ***************************..99************************...9*

S: 123   ihrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseks  181

         ihrdLks+nvL+ ++++ +ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+

Q: 279   IHRDLKSPNVLV-THTDAVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKV  337

         ************.999***************99***************************

S: 182   DvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedp  241

         D+wS+gvvLWellt+e+Pykd+++ ai+++v++++l+lp+ps+cp+ +k Lmk++w+++p

Q: 338   DIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKP  397

         ************************************************************

S: 242   ekRpsfseivksl  254

         ++Rpsf++ +++l

Q: 398   RNRPSFRQTLMHL  410

         *******998775

Domain Sequence
(FASTA)

ELQWLGSGAQ GAVFLGKFRA EEVAIKKVRD QNETDIKHLR KLKHPNIIAF KGVCTQAPCY 60

CIIMEYCAHG QLYEVLRAGR KVTPRLLVDW STGIASGMNY LHLHKIIHRD LKSPNVLVTH 120

TDAVKISDFG TSKELSDKST KMSFAGTVAW MAPEVIRNEP VSEKVDIWSF GVVLWELLTG 180

EIPYKDVDSS AIIWGVGSNS LHLPVPSTCP DGFKILMKQT WQSKPRNRPS FRQTLMHL 238

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008385	; C:IkappaB kinase complex
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0007254	; P:JNK cascade
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017419	; MAP3K12_MAP3K13.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013