EKS-MEG-00113
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00113
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Csk416.22.9E-125195430236
StatusUnreviewed
Ensembl ProteinENSMGAP00000001978
UniProt AccessionG3UP76;
Protein Name
Protein Synonyms/Alias
Gene NameCSK
Gene Synonyms/Alias CSK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000002394ENSMGAP00000017366ENSMGAT00000020922
ENSMGAG00000002394ENSMGAP00000001978ENSMGAT00000002649
OrganismMeleagris gallopavo
Functional Description
Protein Length440
Protein Sequence
(FASTA)
MSGMQAVWPS GTECIAKYNF HGTAEQDLPF SKGDVLTIVA VTKDPNWYKA KNKVGREGII 60
PANYVQKREG VKAGIKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 120
SCEGKVEHYR IIYSSSKLSI DEEVYFENLM QLVEHYTTDA DGLCTRLIKP KVMEGTVAAQ 180
DEFSRSGWAL NMKDLKLLQI IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM 240
TQLRHSNLVQ LLGVIVEEKS GLYIVTEYMA KGSLVDYLRS RGRSVLGADC LLKFSLDVCE 300
AMEYLEANNF VHRDLAARNV LVSEDNIAKV SDFGLTKEAS STQDTEALRE KKFSTKSDVW 360
SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPAIVYEVMK KCWTLDPGHR 420
PSFHQLREQL VHIKEKELYL 440
Nucleotide Sequence
(FASTA)
ATGTCAGGGA TGCAGGCCGT TTGGCCATCC GGTACGGAAT GTATCGCCAA GTACAACTTC 60
CACGGTACCG CCGAGCAGGA CCTGCCGTTC AGCAAGGGAG ACGTCCTCAC CATCGTTGCT 120
GTCACCAAGG ACCCCAACTG GTACAAGGCG AAGAACAAGG TGGGCCGGGA GGGCATCATC 180
CCCGCTAACT ACGTGCAGAA ACGGGAAGGA GTGAAGGCTG GCATCAAGCT CAGCCTCATG 240
CCGTGGTTCC ATGGGAAGAT CACACGGGAG CAGGCAGAGC GGCTGCTGTA CCCACCTGAA 300
ACGGGGCTGT TCCTGGTGCG GGAGAGCACC AACTACCCTG GGGACTACAC CCTGTGTGTG 360
AGCTGTGAGG GCAAGGTGGA GCACTACCGC ATCATTTACT CCTCCAGCAA GCTGAGCATC 420
GACGAGGAGG TCTACTTTGA GAACCTGATG CAGCTTGTGG AGCATTACAC CACGGATGCT 480
GACGGGCTCT GCACGCGCCT CATCAAGCCG AAGGTGATGG AGGGGACGGT GGCAGCTCAG 540
GACGAGTTCT CCCGCAGTGG CTGGGCCCTC AACATGAAGG ACCTCAAGCT GCTGCAGATC 600
ATTGGCAAAG GGGAATTTGG AGACGTGATG CTGGGTGATT ACCGGGGGAA CAAAGTCGCC 660
GTCAAGTGCA TTAAAAACGA CGCCACAGCG CAGGCTTTCC TGGCAGAAGC GTCCGTGATG 720
ACGCAGCTCC GACACAGCAA CCTGGTGCAG CTGCTGGGGG TGATCGTGGA GGAGAAGAGC 780
GGCCTCTACA TTGTCACTGA GTATATGGCC AAGGGCAGCC TAGTAGATTA CCTGCGGTCG 840
CGCGGGAGGT CGGTCCTAGG TGCAGACTGC CTGCTCAAGT TTTCCTTAGA TGTCTGTGAA 900
GCCATGGAGT ACCTGGAAGC CAACAACTTT GTCCATCGGG ACCTGGCGGC GAGGAACGTG 960
TTGGTCTCAG AGGACAACAT TGCCAAGGTC AGCGATTTTG GGCTGACAAA GGAAGCGTCG 1020
TCCACTCAGG ACACCGAAGC ACTTAGAGAA AAGAAATTCT CCACCAAATC GGACGTGTGG 1080
AGCTTCGGGA TCCTCCTGTG GGAAATCTAT TCCTTCGGGC GAGTGCCTTA TCCGAGAATC 1140
CCCCTGAAGG ACGTGGTGCC CCGGGTGGAG AAGGGCTACA AGATGGACGC GCCCGACGGC 1200
TGCCCAGCCA TCGTCTACGA GGTGATGAAG AAGTGCTGGA CGCTGGACCC AGGGCACCGG 1260
CCGTCCTTCC ACCAGCTCCG TGAACAGCTA GTGCATATCA AAGAGAAGGA GCTCTACCTG 1320
TGA 1323
Domain Profile
S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60
         lkl + igkgefgdv+lg+yrg+kvavk+ikndataqafl+easvmt+l+h+nlv+llgv
Q: 195   LKLLQIIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGV  254
         6899********************************************************
S: 61    ileek.glylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrd  119
         i+eek gly+vtey+akgslvdylrsrgr++l+ ++llkf+ldv+e+meyle++++vhrd
Q: 255   IVEEKsGLYIVTEYMAKGSLVDYLRSRGRSVLGADCLLKFSLDVCEAMEYLEANNFVHRD  314
         ****999*****************************************************
S: 120   laarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgi  179
         laarnvlvsed++akvsdfgl+ke+s+++d+          eal+ekkfstksdvwsfgi
Q: 315   LAARNVLVSEDNIAKVSDFGLTKEASSTQDT----------EALREKKFSTKSDVWSFGI  364
         *****************************97..........9******************
S: 180   llweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfa  239
         llwei+sfgrvpypriplkdvv++vekgykm+ap+gcp+ vye+mk++w l++ +rpsf+
Q: 365   LLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPAIVYEVMKKCWTLDPGHRPSFH  424
         ************************************************************
S: 240   klkekl  245
         +l+e+l
Q: 425   QLREQL  430
         ***997
Domain Sequence
(FASTA)
LKLLQIIGKG EFGDVMLGDY RGNKVAVKCI KNDATAQAFL AEASVMTQLR HSNLVQLLGV 60
IVEEKSGLYI VTEYMAKGSL VDYLRSRGRS VLGADCLLKF SLDVCEAMEY LEANNFVHRD 120
LAARNVLVSE DNIAKVSDFG LTKEASSTQD TEALREKKFS TKSDVWSFGI LLWEIYSFGR 180
VPYPRIPLKD VVPRVEKGYK MDAPDGCPAI VYEVMKKCWT LDPGHRPSFH QLREQL 236
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00137
EKS-ANC-00139
EKS-BOT-00146
EKS-CAE-00119
EKS-CAJ-00150
EKS-CAF-00152
EKS-CAP-00145
EKS-CII-00089
EKS-CIS-00181
EKS-DAR-00430
EKS-DRM-00070
EKS-EQC-00143
EKS-FEC-00136
EKS-GAM-00074
EKS-GAG-00123
EKS-GAA-00170
EKS-GOG-00145
EKS-HOS-00150
EKS-ICT-00139
EKS-LAC-00154
EKS-LOA-00144
EKS-MAM-00143
EKS-MAE-00056
EKS-MOD-00144
EKS-MUM-00149
EKS-MUP-00149
EKS-MYL-00155
EKS-ORN-00178
EKS-ORL-00168
EKS-OTG-00150
EKS-PAT-00135
EKS-PES-00130
EKS-POA-00141
EKS-PRC-00025
EKS-PTV-00137
EKS-RAN-00143
EKS-SAH-00139
EKS-SOA-00023
EKS-SUS-00127
EKS-TAR-00188
EKS-TEN-00180
EKS-TUT-00144
EKS-XET-00133
EKS-XIM-00172
Gene Ontology
GO:0005911; C:cell-cell junction
GO:0005813; C:centrosome
GO:0005794; C:Golgi apparatus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0008285; P:negative regulation of cell proliferation
GO:0042997; P:negative regulation of Golgi to plasma membrane protein transport
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013