EKS-MEG-00005
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00005
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph513.46.6E-155608867260
StatusUnreviewed
Ensembl ProteinENSMGAP00000002139
UniProt AccessionG1MUE3;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB1
Gene Synonyms/Alias EPHB1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000002399ENSMGAP00000002139ENSMGAT00000002813
OrganismMeleagris gallopavo
Functional Description
Protein Length973
Protein Sequence
(FASTA)
SPETLMDTRT ATAELGWTAN PPSGWEEVSG YDENLNTIRT YQVCNVFEPN QNNWLLTTFI 60
NRRGAHRIYT EMRFTVRDCS SLPNVPGSCK ETFNLYYYET DSVIATKKSA FWTEAPYLKV 120
DTIAADESFS QVDFGGRLMK VNTEVRSFGP LTRNGFYLAF QDYGACMSLL SVRVFFKKCP 180
SVVQNFAIFP ETMTGAESTS LVTARGTCIP NAEEVDVPIK LYCNGDGEWM VPIGRCTCKA 240
GYEPENNVAC KECELGWFKA NLPSWDIQSQ SGCRAVCPCP HSRSSAEASP LCACRNGYFR 300
ADLDPPTAAC TSVPSGPRNV ISIVNETSII LEWNPPRETG GRDDVTYNIV CKKCRADRRA 360
CSRCDDNVDF VPRQLGLTET RVFISSLWAH TPYTFEIQAV NGVSNKSPFP PQHVSVNITT 420
NQAAPSTVPI MHQVSATMRS ITLSWPQPEQ PNGIILDYEL RYYEKDHNEY NSSMARSQTN 480
TARLEGLRPG MVYVVQVRAR TVAGYGKYSG KMCFQTLTDA DDYKSELREQ LPLIAGSAAA 540
GVVFIVSLVA ISIVCSRKRA YSKEAVYSDK LQHYSTGRGM KIYIDPFTYE DPNEAVREFA 600
KEIDVSFVKI EEVIGAGEFG EVYKGRLKLP GKREIYVAIK TLKAGYSEKQ RRDFLSEASI 660
MGQFDHPNII RLEGVVTKSR PVMIITEFME NGALDSFLRQ NDGQFTVIQL VGMLRGIAAG 720
MKYLAEMNYV HRDLAARNIL VNSNLVCKVS DFGLSRYLQD DTSDPTYTSS LGGKIPVRWT 780
APEAIAYRKF TSASDVWSYG IVMWEVMSFG ERPYWDMSNQ DVINAIEQDY RLPPPMDCPA 840
ALHQLMLDCW QKDRNTRPRF AEIVNTLDKM IRNPASLKTV ATITAVPSQP LLDRSIPDFT 900
AFTSVEDWLS AVKMSQYRDN FLSAGFTSLQ LVAQMTSEDL LRIGVTLAGH QKKILNSIQS 960
MRVQMSQSPT SMA 973
Nucleotide Sequence
(FASTA)
TCCCCAGAAA CCCTGATGGA CACACGGACG GCGACGGCCG AGCTGGGCTG GACTGCCAAC 60
CCTCCGTCAG GGTGGGAAGA AGTGAGTGGC TACGACGAAA ACCTGAACAC CATCCGTACG 120
TACCAGGTGT GCAACGTCTT CGAGCCAAAC CAGAACAACT GGCTCCTCAC CACCTTCATC 180
AACCGGCGTG GAGCCCATCG CATCTACACC GAGATGCGCT TCACTGTGCG GGACTGCAGC 240
AGCCTCCCCA ACGTTCCTGG CTCCTGCAAG GAGACCTTCA ATCTCTATTA CTACGAGACA 300
GACTCTGTCA TTGCCACCAA GAAGTCGGCC TTCTGGACGG AGGCACCCTA CCTCAAAGTG 360
GACACCATTG CTGCTGACGA GAGCTTTTCC CAGGTGGACT TTGGTGGCAG GTTGATGAAG 420
GTGAACACAG AAGTGAGAAG TTTTGGGCCC CTGACCCGCA ATGGCTTTTA CCTGGCTTTC 480
CAGGACTACG GGGCTTGCAT GTCTCTGCTC TCCGTCAGGG TTTTCTTCAA GAAATGCCCA 540
AGCGTGGTGC AGAACTTTGC TATCTTCCCT GAGACCATGA CGGGGGCAGA GAGCACCTCT 600
CTGGTGACAG CACGGGGCAC CTGCATCCCC AATGCTGAGG AGGTGGACGT GCCCATCAAG 660
CTGTACTGTA ACGGGGATGG GGAGTGGATG GTACCCATAG GTCGCTGTAC CTGCAAGGCT 720
GGTTATGAGC CAGAAAACAA CGTGGCTTGC AAAGAGTGTG AATTGGGATG GTTTAAGGCA 780
AACCTGCCCA GCTGGGACAT TCAAAGCCAG TCAGGGTGCA GGGCTGTGTG CCCGTGTCCC 840
CACAGCCGCT CCAGTGCTGA GGCCTCACCG CTCTGCGCCT GTCGCAATGG CTACTTTCGG 900
GCTGACCTGG ACCCACCGAC AGCTGCCTGC ACCAGCGTCC CCTCCGGTCC ACGCAACGTC 960
ATCTCCATTG TCAACGAGAC CTCCATCATC CTGGAGTGGA ACCCACCGCG GGAGACGGGA 1020
GGCCGGGATG ATGTCACTTA CAACATCGTC TGCAAGAAGT GCCGGGCGGA CCGGCGTGCC 1080
TGCTCCCGCT GTGACGACAA CGTGGACTTT GTGCCCCGAC AGCTGGGGCT GACAGAGACC 1140
CGTGTCTTCA TCAGCAGCCT CTGGGCACAC ACGCCCTACA CCTTTGAGAT CCAGGCGGTC 1200
AACGGGGTTT CCAACAAGAG CCCCTTCCCA CCCCAGCATG TCTCTGTGAA CATCACCACC 1260
AACCAAGCTG CACCCTCCAC TGTCCCCATC ATGCACCAGG TGAGTGCCAC CATGAGGAGC 1320
ATCACGCTGT CCTGGCCACA GCCGGAGCAG CCCAATGGCA TCATCCTAGA CTACGAACTG 1380
CGCTATTACG AGAAGGACCA CAACGAGTAC AATTCCTCCA TGGCCCGCAG TCAGACCAAC 1440
ACGGCCCGGC TGGAGGGGCT GCGCCCCGGC ATGGTGTACG TGGTGCAAGT GAGAGCGAGG 1500
ACGGTGGCTG GCTATGGGAA GTACAGTGGG AAGATGTGCT TCCAGACACT GACTGATGCA 1560
GATGACTACA AGTCTGAGCT GAGGGAGCAG CTGCCATTGA TTGCGGGGTC TGCAGCGGCC 1620
GGCGTGGTCT TCATCGTCTC ACTGGTGGCC ATTTCCATAG TCTGCAGCAG GAAGCGAGCG 1680
TACAGCAAGG AGGCGGTGTA CAGCGATAAG CTGCAGCACT ACAGCACTGG GAGAGGAATG 1740
AAGATTTACA TTGACCCCTT CACTTATGAG GACCCCAATG AGGCAGTGCG TGAGTTCGCC 1800
AAGGAGATTG ACGTCTCCTT TGTGAAGATT GAAGAGGTCA TTGGAGCAGG GGAGTTTGGA 1860
GAGGTGTACA AAGGCCGCCT GAAGTTGCCT GGCAAGCGGG AGATCTACGT GGCCATCAAA 1920
ACACTGAAGG CTGGCTACTC AGAGAAGCAG CGTCGGGATT TCCTGAGCGA AGCCAGCATC 1980
ATGGGGCAGT TTGACCACCC CAACATCATC CGGCTGGAAG GGGTGGTGAC CAAGAGCCGA 2040
CCAGTCATGA TTATCACAGA GTTCATGGAG AATGGGGCCC TGGACTCGTT CCTGCGGCAA 2100
AATGACGGGC AGTTCACGGT GATCCAGCTG GTGGGGATGC TCAGAGGGAT TGCTGCTGGG 2160
ATGAAGTACC TGGCAGAGAT GAACTATGTC CACAGGGATC TGGCGGCCAG GAACATTCTT 2220
GTCAACAGCA ACCTGGTGTG CAAAGTGTCA GACTTTGGCC TCTCACGCTA CCTGCAGGAC 2280
GACACGTCTG ATCCCACCTA CACCAGTTCC TTGGGTGGGA AGATCCCTGT GCGATGGACA 2340
GCACCGGAGG CGATTGCGTA TCGCAAGTTC ACGTCAGCCA GTGATGTCTG GAGCTATGGC 2400
ATCGTCATGT GGGAGGTGAT GTCGTTTGGG GAGAGGCCCT ACTGGGACAT GTCCAACCAG 2460
GACGTCATCA ATGCCATCGA GCAGGACTAC CGGCTCCCGC CGCCCATGGA CTGCCCGGCT 2520
GCTCTGCACC AGCTGATGCT GGACTGCTGG CAGAAGGACC GCAACACCCG GCCTCGCTTC 2580
GCCGAGATTG TCAACACCCT CGACAAGATG ATCCGCAACC CGGCAAGCCT CAAAACTGTG 2640
GCTACCATCA CCGCTGTGCC TTCTCAGCCC CTCCTCGACC GCTCTATCCC TGATTTCACT 2700
GCCTTTACCT CAGTAGAAGA CTGGCTGAGC GCCGTCAAGA TGAGCCAGTA TAGAGACAAC 2760
TTCCTGAGCG CTGGATTCAC CTCCCTCCAG CTGGTTGCCC AGATGACATC TGAAGACCTC 2820
TTGAGAATAG GAGTAACTCT GGCTGGGCAC CAGAAGAAGA TCCTGAACAG CATCCAGTCC 2880
ATGCGCGTGC AGATGAGTCA GTCTCCGACC TCGATGGCGT GA 2922
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGev++Grlklpgkrei+vaiktlkag++ekqrrdflseasi+Gqfdhp
Q: 608   VKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHP  667
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtks+pvmi+te+mengaldsflr++dgqftviqlvgmlrGia+gmkyl++m
Q: 668   NIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEM  727
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr l+dd+ +++yt+s ggkip+rwtapeaiay
Q: 728   NYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTsDPTYTSSlGGKIPVRWTAPEAIAY  787
         *******************************99999*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasdvwsyGiv+wev+s+Gerpywdmsnqdvi+aie++yrlpppmdcpaal+qlml
Q: 788   RKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLML  847
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqkdr++rp+f++iv++l
Q: 848   DCWQKDRNTRPRFAEIVNTL  867
         *****************975
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVYKGRL KLPGKREIYV AIKTLKAGYS EKQRRDFLSE ASIMGQFDHP 60
NIIRLEGVVT KSRPVMIITE FMENGALDSF LRQNDGQFTV IQLVGMLRGI AAGMKYLAEM 120
NYVHRDLAAR NILVNSNLVC KVSDFGLSRY LQDDTSDPTY TSSLGGKIPV RWTAPEAIAY 180
RKFTSASDVW SYGIVMWEVM SFGERPYWDM SNQDVINAIE QDYRLPPPMD CPAALHQLML 240
DCWQKDRNTR PRFAEIVNTL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00006
EKS-BOT-00012
EKS-CAJ-00005
EKS-CAF-00006
EKS-CAP-00013
EKS-CIS-00001
EKS-FEC-00003
EKS-GAM-00002
EKS-GAG-00006
EKS-GAA-00007
EKS-GOG-00005
EKS-ICT-00005
EKS-MAM-00005
EKS-MIM-00001
EKS-MOD-00007
EKS-MUM-00006
EKS-MUP-00006
EKS-MYL-00006
EKS-NOL-00005
EKS-ORN-00008
EKS-ORC-00006
EKS-ORL-00006
EKS-OTG-00004
EKS-PAT-00006
EKS-PES-00006
EKS-POA-00004
EKS-RAN-00006
EKS-TAG-00013
EKS-TAR-00007
EKS-XET-00003
EKS-XIM-00006
Gene Ontology
GO:0030424; C:axon
GO:0031901; C:early endosome membrane
GO:0005887; C:integral to plasma membrane
GO:0045121; C:membrane raft
GO:0005524; F:ATP binding
GO:0008046; F:axon guidance receptor activity
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0007411; P:axon guidance
GO:0031589; P:cell-substrate adhesion
GO:0030010; P:establishment of cell polarity
GO:0061351; P:neural precursor cell proliferation
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0046328; P:regulation of JNK cascade
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013