EKS-MEG-00119

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00119

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	512.3	2.9E-154	89	383	295

Status

Unreviewed

Ensembl Protein

ENSMGAP00000002083

UniProt Accession

G1MU99;

Protein Name

Protein Synonyms/Alias

Gene Name

STK38

Gene Synonyms/Alias

STK38;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000002482	ENSMGAP00000002083	ENSMGAT00000002756

Organism

Meleagris gallopavo

Functional Description

Protein Length

469

Protein Sequence
(FASTA)

MAMTGPTPCS SMSNHTKERV TMTKVTLENF YSNLIAQHEE REMRQKKLEQ MMEEEGLKDE 60

EKRIRRSAHA QKETEFLRLK RTRLGLEDFE SLKVIGRGAF GEVRLVQKKD TGHVYAMKIL 120

RKADMLEKEQ VGHIRAERDI LVEADSLWVV KMFYSFQDKL NLYLIMEFLP GVGDMMTLLM 180

KKDTLTEEET QFYIAETVLA IDSIHQLGFI HRDIKPDNLL LDSKGHVKLS DFGLCTGLKK 240

AHRTEFYRNL NHSLPSDFTF QNMNSKRKAE TWKRNRRQLA FSTVGTPDYI APEVFMQTGY 300

NKLCDWWSLG VIMYEMLIGY PPFCSETPQE TYKKVMNWKE TLTFPPEVPI SDKAKDLILR 360

FCCEWEHRIG ASGVEEIKSN PFFEGVDWEH IRERPAAISI EIKSIDDTSN FDEFPESDIL 420

KPTVLSVATS NHPETDYKNK DWVFINYTYK RFEGLTARGA IPSYMKAGK 469

Nucleotide Sequence
(FASTA)

ATGGCCATGA CCGGCCCGAC GCCGTGCTCC TCTATGAGCA ACCACACCAA GGAGCGGGTG 60

ACGATGACGA AGGTGACGCT GGAGAACTTC TACAGCAACC TCATAGCACA GCACGAAGAG 120

CGAGAGATGA GACAAAAGAA GCTAGAACAA ATGATGGAAG AAGAAGGCTT GAAAGATGAG 180

GAGAAAAGGA TCAGGAGATC AGCACATGCA CAGAAGGAGA CCGAGTTCCT TCGCCTGAAG 240

AGAACAAGGC TCGGCCTGGA GGACTTCGAG TCTTTAAAAG TAATAGGCAG AGGAGCTTTT 300

GGAGAGGTGC GTCTCGTCCA GAAGAAAGAC ACGGGCCACG TTTATGCCAT GAAAATCCTG 360

CGTAAAGCTG ATATGCTGGA GAAAGAGCAG GTTGGCCACA TCCGTGCTGA GCGGGACATC 420

CTTGTGGAAG CAGACAGCCT GTGGGTAGTG AAGATGTTCT ATAGCTTTCA GGATAAGCTG 480

AACCTCTACC TTATCATGGA GTTCCTGCCT GGAGTAGGTG ATATGATGAC ACTCTTGATG 540

AAAAAAGACA CGCTAACAGA AGAAGAGACA CAGTTCTATA TAGCTGAGAC TGTGCTTGCC 600

ATTGATTCTA TTCATCAGCT GGGCTTTATC CATCGAGATA TCAAACCAGA CAACCTTCTT 660

CTGGACAGCA AGGGCCACGT GAAACTGTCA GATTTTGGTC TGTGCACTGG ACTGAAGAAA 720

GCCCATAGAA CAGAGTTCTA TAGGAACCTG AACCATTCCC TTCCCAGTGA CTTCACCTTC 780

CAGAACATGA ATTCCAAACG GAAAGCAGAG ACGTGGAAGA GAAACAGACG GCAGTTGGCT 840

TTTTCTACTG TGGGGACTCC GGATTACATT GCTCCTGAAG TTTTCATGCA GACGGGCTAC 900

AACAAGCTCT GTGACTGGTG GTCGCTGGGG GTCATCATGT ATGAGATGCT GATTGGTTAT 960

CCACCTTTCT GTTCTGAGAC TCCTCAAGAA ACTTACAAGA AAGTAATGAA TTGGAAAGAG 1020

ACCCTCACGT TTCCTCCAGA AGTCCCAATA TCTGACAAAG CCAAGGACCT TATTTTAAGA 1080

TTTTGCTGTG AATGGGAGCA CAGAATTGGT GCATCTGGTG TGGAGGAAAT AAAGAGTAAT 1140

CCGTTCTTTG AAGGGGTTGA TTGGGAGCAT ATAAGGGAGA GACCTGCTGC AATTTCAATA 1200

GAAATTAAAA GCATTGATGA TACCTCAAAC TTTGATGAAT TTCCAGAATC TGATATCCTT 1260

AAGCCAACAG TCTTATCAGT GGCAACAAGC AACCACCCAG AGACAGACTA CAAGAACAAG 1320

GACTGGGTTT TCATCAATTA CACCTACAAG CGTTTTGAGG GCCTGACAGC CCGAGGAGCA 1380

ATACCATCCT ACATGAAAGC AGGAAAGTAA 1410

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         fe+lkvig+GafGevrlv+kkdt++vya+kilrk+d+l+k+qv h++aerdil+eads w

Q: 89    FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLW  148

         899*********************************************************

S: 61    vvklyysfqdkenlylvmeylPG.GdlmtllikkeilkeelarfyiaelvlavesvhklG  119

         vvk++ysfqdk nlyl+me+lPG Gd+mtll+kk++l+ee+++fyiae+vla++s+h+lG

Q: 149   VVKMFYSFQDKLNLYLIMEFLPGvGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLG  208

         ***********************9************************************

S: 120   fihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddleaseelkvle  179

         fihrd+kPdnll+d+kGh+kl+dfGlctGlkk+hr+e+y++l+++ ++d+ ++    +++

Q: 209   FIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQ----NMN  264

         **************************************************555....555

S: 180   rrkk....kknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyemlvGypPfl  235

         +++k    k+nrr+la+s+vGtpdyiapev++++gynklcdwWslGvi+yeml+GypPf+

Q: 265   SKRKaetwKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFC  324

         55544556****************************************************

S: 236   aetpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdeikkhpff  294

         +etpqetykkv+nwketl+fp+ev++s++akdli r+++++e+r+g++Gv+eik++pff

Q: 325   SETPQETYKKVMNWKETLTFPPEVPISDKAKDLILRFCCEWEHRIGASGVEEIKSNPFF  383

         **********************************************************9

Domain Sequence
(FASTA)

FESLKVIGRG AFGEVRLVQK KDTGHVYAMK ILRKADMLEK EQVGHIRAER DILVEADSLW 60

VVKMFYSFQD KLNLYLIMEF LPGVGDMMTL LMKKDTLTEE ETQFYIAETV LAIDSIHQLG 120

FIHRDIKPDN LLLDSKGHVK LSDFGLCTGL KKAHRTEFYR NLNHSLPSDF TFQNMNSKRK 180

AETWKRNRRQ LAFSTVGTPD YIAPEVFMQT GYNKLCDWWS LGVIMYEMLI GYPPFCSETP 240

QETYKKVMNW KETLTFPPEV PISDKAKDLI LRFCCEWEHR IGASGVEEIK SNPFF 295

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0070688	; C:MLL5-L complex
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0043407	; P:negative regulation of MAP kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013