EKS-MEG-00048

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00048

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	377.5	3.1E-113	377	662	286

Status

Unreviewed

Ensembl Protein

ENSMGAP00000019192

UniProt Accession

G1MUI7;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK11A

Gene Synonyms/Alias

CDK11A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000002561	ENSMGAP00000019192	ENSMGAT00000018734
ENSMGAG00000002561	ENSMGAP00000002200	ENSMGAT00000002874

Organism

Meleagris gallopavo

Functional Description

Protein Length

734

Protein Sequence
(FASTA)

SDDRDSKRDS LEEGELRDHR MEITIRNSPY RREDSMEDRG EEDDSLAIKP PQQMSRKEKT 60

HHRKDEKRKE KRRHRSHSAE GKHARVKEKE REHERRKRHR EEQDKARREW ERQKRREMAR 120

EHSRRERDRL EQLERERERK IREQQKEQRE QKERERRAEE RRKEREARRE VSAHHRTVRE 180

EYGDKVKMRP WSRSPLRQQR DKPEQADSRK PVKEEKPEER DPLSDLQDIS DSERKTSSAE 240

YSLYRSESGS GSEEEEEESS SEGSEEEGEE EEEEEEETGS NSEEVSEQSA EEVSEEEMSE 300

EEERENGNHI PVESRFDRDS AGSEVEEEEV GEGSPQSNAM TEGDYVPDSP ASSPIELKQE 360

LPKYLPALQG CRSVEEFQCL NRIEEGTYGV VYRAKDKKTD EIVALKRLKM EKEKEGFPIT 420

SLREINTILK AQHLNIVTVR EIVVGSNMDK IYIVMNYVEH DLKSLMETMK QPFLPGEVKT 480

LMIQLLRGVK HLHDNWILHR DLKTSNLLLS HSGILKVGDF GLAREYGSPL KPYTPVVVTL 540

WYRAPELLLG AKEYSTAIDM WSVGCIFGEL LTQKPLFPGK SEIDQINKVF KDLGTPSEKI 600

WPGYNELPAV KKMTFTEYPY NNLRKRFGAL LSDQGFDLMN NFLTYYPARR ITAEDGLKHE 660

YFRETPLPID PSMFPTWPAK SEQQRVKRGT SPRPPEGGLG YSQLGDDDLK DTGFHLTTTN 720

QGASAAGPGF SLKF 734

Nucleotide Sequence
(FASTA)

TCGGATGATA GGGATTCAAA GCGGGATTCT CTTGAAGAGG GGGAGCTGAG AGATCACCGC 60

ATGGAGATCA CGATCCGCAA TTCGCCGTAC CGCAGGGAGG ACTCCATGGA GGACAGAGGA 120

GAAGAAGATG ATTCCTTGGC TATAAAACCA CCACAGCAAA TGTCACGGAA AGAAAAAACC 180

CATCATAGAA AAGATGAGAA GAGGAAAGAG AAACGGAGAC ACCGCAGTCA TTCAGCAGAA 240

GGGAAACATG CCAGAGTGAA GGAGAAAGAA CGGGAACACG AGCGTAGGAA GAGGCATAGA 300

GAAGAGCAGG ATAAGGCCCG ACGTGAGTGG GAAAGGCAGA AACGGAGAGA AATGGCGAGG 360

GAGCATTCCA GGAGGGAGAG AGATCGTCTG GAGCAACTTG AGAGAGAACG AGAGAGAAAA 420

ATCAGAGAGC AGCAGAAAGA ACAAAGGGAG CAAAAAGAGC GTGAGAGGAG AGCTGAAGAA 480

AGGCGTAAGG AGCGGGAAGC CAGAAGAGAA GTTTCTGCAC ACCATAGAAC AGTGAGGGAA 540

GAATATGGAG ACAAAGTGAA AATGAGACCC TGGAGTCGCA GCCCATTACG ACAGCAGAGA 600

GACAAGCCTG AGCAAGCAGA TAGCAGGAAA CCAGTGAAAG AAGAGAAACC AGAAGAAAGA 660

GACCCTCTTT CAGACTTGCA AGACATCAGT GACAGTGAAA GAAAAACAAG CTCAGCTGAA 720

TACTCATTGT ACAGATCAGA GTCTGGGTCA GGCTCAGAAG AAGAGGAAGA AGAGTCGAGC 780

AGTGAAGGAT CTGAGGAAGA GGGAGAAGAA GAGGAGGAGG AGGAGGAGGA GACAGGGAGC 840

AATTCTGAGG AGGTGTCTGA GCAGTCAGCT GAAGAGGTGA GCGAAGAAGA AATGAGTGAA 900

GAGGAAGAAC GAGAGAATGG AAACCACATC CCAGTTGAGT CGAGGTTTGA TCGCGATTCA 960

GCGGGCAGTG AGGTTGAGGA AGAGGAGGTG GGGGAGGGCA GCCCTCAGTC CAACGCCATG 1020

ACGGAAGGAG ACTATGTTCC TGACTCACCT GCTTCTTCCC CTATTGAACT GAAACAGGAG 1080

CTTCCTAAAT ATCTTCCTGC ACTTCAGGGG TGTCGTAGTG TGGAGGAGTT TCAGTGTTTG 1140

AACAGGATTG AAGAGGGAAC ATACGGTGTG GTGTACAGAG CAAAAGACAA AAAGACTGAT 1200

GAAATTGTGG CTCTGAAGCG ACTGAAAATG GAGAAGGAAA AGGAAGGCTT CCCCATTACT 1260

TCTCTCAGAG AAATAAATAC TATTCTGAAA GCACAACACC TAAATATCGT CACAGTCAGA 1320

GAAATCGTTG TAGGTAGTAA TATGGATAAA ATCTATATTG TTATGAACTA CGTAGAACAT 1380

GATCTCAAGA GTCTGATGGA AACAATGAAG CAACCATTTC TACCAGGTGA AGTGAAAACC 1440

TTGATGATCC AGTTACTACG AGGAGTCAAG CATCTTCATG ACAACTGGAT ACTTCACCGG 1500

GACTTGAAAA CTTCCAACCT GCTGCTCAGT CATTCAGGAA TTTTAAAGGT TGGAGATTTT 1560

GGATTGGCCC GAGAATATGG ATCTCCTCTG AAGCCTTACA CACCAGTGGT GGTGACACTT 1620

TGGTACAGGG CTCCGGAGTT GTTGCTTGGA GCCAAGGAAT ATTCAACAGC GATAGACATG 1680

TGGTCAGTAG GGTGTATCTT TGGAGAACTC TTAACTCAGA AACCACTGTT TCCAGGGAAG 1740

TCGGAAATTG ATCAGATTAA CAAAGTTTTT AAGGATCTAG GTACTCCAAG TGAAAAAATC 1800

TGGCCTGGTT ACAATGAGCT GCCAGCAGTG AAGAAGATGA CATTCACGGA ATATCCCTAC 1860

AATAATCTAC GCAAGAGATT TGGAGCACTC CTCTCTGATC AGGGCTTTGA TCTAATGAAC 1920

AACTTTTTGA CGTACTACCC AGCCAGAAGA ATTACTGCTG AAGATGGTTT GAAGCACGAG 1980

TATTTCCGTG AGACTCCCCT TCCTATTGAC CCCTCCATGT TTCCTACATG GCCAGCCAAA 2040

AGTGAACAAC AAAGGGTGAA ACGTGGCACC AGCCCCCGCC CACCCGAGGG AGGCCTTGGC 2100

TACAGTCAGT TGGGCGATGA TGATCTGAAA GACACCGGTT TTCATCTGAC CACCACGAAT 2160

CAAGGAGCAT CTGCTGCTGG GCCTGGATTC AGCCTCAAGT TTTAA 2205

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         +++l++i+eGtyg+vy+akdk+t+e+vAlK++++ekekeg+pit+lrEi+++ + +h ni

Q: 377   FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHLNI  436

         7899********************************************************

S: 61    vkLlevva.kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsn  119

         v++ e+v+ ++ +k+y+v++++e+dLk+l++++k+  + + evk+l++qll+g+++lH+n

Q: 437   VTVREIVVgSNMDKIYIVMNYVEHDLKSLMETMKQ-PFLPGEVKTLMIQLLRGVKHLHDN  495

         *******95666***********************.9999********************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

         +ilHRDlK++NlL+s++g+lk++DfGlar+++splk yt++vvTlwYraPelLlgakeYs

Q: 496   WILHRDLKTSNLLLSHSGILKVGDFGLAREYGSPLKPYTPVVVTLWYRAPELLLGAKEYS  555

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksf  238

         ta+D+Wsvgci+ ellt+kplf+gkseidq++++fk lgtpsek+wp++++lp +k ++f

Q: 556   TAIDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYNELPAVKkMTF  615

         ********************************************************99**

S: 239   pkkkkkklkekvkklkek.aldllekllaldpkkRisakealqhkyf  284

         +++++++l++++ +l ++ ++dl++++l++ p++Ri+a++ l+h+yf

Q: 616   TEYPYNNLRKRFGALLSDqGFDLMNNFLTYYPARRITAEDGLKHEYF  662

         ************8877554***************************9

Domain Sequence
(FASTA)

FQCLNRIEEG TYGVVYRAKD KKTDEIVALK RLKMEKEKEG FPITSLREIN TILKAQHLNI 60

VTVREIVVGS NMDKIYIVMN YVEHDLKSLM ETMKQPFLPG EVKTLMIQLL RGVKHLHDNW 120

ILHRDLKTSN LLLSHSGILK VGDFGLAREY GSPLKPYTPV VVTLWYRAPE LLLGAKEYST 180

AIDMWSVGCI FGELLTQKPL FPGKSEIDQI NKVFKDLGTP SEKIWPGYNE LPAVKKMTFT 240

EYPYNNLRKR FGALLSDQGF DLMNNFLTYY PARRITAEDG LKHEYF 286

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006915	; P:apoptotic process
GO:0007088	; P:regulation of mitosis

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013