EKS-MEG-00094

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00094

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	425.6	5.5E-128	422	679	258

Status

Unreviewed

Ensembl Protein

ENSMGAP00000002402

UniProt Accession

G1MUY8;

Protein Name

Protein Synonyms/Alias

Gene Name

MST1R

Gene Synonyms/Alias

MST1R;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000002710	ENSMGAP00000002402	ENSMGAT00000003079

Organism

Meleagris gallopavo

Functional Description

Protein Length

729

Protein Sequence
(FASTA)

RVQGSTALSG FIFVEPRISI LHPSFGPQGG GTLMSLRGTH LSAGSSWRVT INGSECPLDG 60

QPSQGNGEIQ CTTPAASSLG AAPVALWIDG EEFLAPLPFE YRPDPSVLAI VPNCSYGGSM 120

LTLIGTHLDS VYRAKIQFEG GGGGKTEATE CEGPQSPDWL LCCSPAFPVE TKPVPGNLSV 180

LLDGAAGRWL FRLRYFPRPQ MFPFGQQGER YQLKPGDNEV KVNQLGLDSL AGCMNITMTV 240

GGRDCHPNVL KNEVTCRVPR DVDLSPAGPL CRICVNGACQ ALGLVLSASS LDMAASLALG 300

TGVTFLVCCI LAAVLLRWRW RKRRGTENLE LLVHSARSEH PITIQHPNVD YREVPVLPVA 360

DSPGLARPHA HFAGAGAGAD AAGGGSPVPL LRTTSCCLED LRPELLEEVK DILIPEERLI 420

THRSRVIGRG HFGSVYHGTY MDPLLGNLHC AVKSLHRITD LEEVEEFLRE GILMKSFHHP 480

QVLSLLGVCL PRHGLPLVVL PYMRHGDLRH FIRAQERSPT VKELIGFGLQ VALGMEYLAQ 540

KKFVHRDLAA RNCMLDETLT VKVADFGLAR DVFGKEYYSI RQHRHAKLPV KWMALESLQT 600

QKFTTKSDVW SFGVLMWELL TRGASPYPEV DPYDMARYLL RGRRLPQPQP CPDTLYGVML 660

SCWAPTPEER PSFSGLVCEL KRVLASLEGE RYVNLAVTYV NLESSPPFPR GQLPDSEDEE 720

DEEDEEDEE 729

Nucleotide Sequence
(FASTA)

CGTGTCCAGG GATCCACCGC CCTCAGCGGC TTCATCTTTG TGGAACCCCG CATCAGCATC 60

CTGCACCCCA GCTTCGGTCC CCAGGGCGGT GGCACCCTTA TGTCCCTCCG TGGCACTCAC 120

CTCTCAGCGG GGAGCAGCTG GCGGGTGACG ATCAATGGCT CCGAGTGTCC CCTGGATGGG 180

CAGCCCAGCC AGGGCAACGG GGAGATCCAG TGCACAACTC CTGCTGCCAG CAGCCTGGGT 240

GCAGCCCCTG TGGCCCTGTG GATCGATGGC GAGGAGTTCC TGGCCCCACT GCCTTTCGAG 300

TACCGCCCCG ACCCCTCCGT TTTGGCCATC GTCCCCAACT GCAGCTATGG GGGCTCGATG 360

CTCACCCTCA TCGGCACCCA CCTGGACTCA GTGTATCGTG CCAAGATCCA ATTTGAAGGC 420

GGCGGCGGTG GGAAGACCGA AGCCACGGAG TGTGAGGGAC CACAGTCGCC CGACTGGCTG 480

CTGTGCTGCA GCCCAGCCTT CCCCGTCGAG ACCAAGCCGG TGCCTGGGAA TCTGAGCGTG 540

CTGCTGGATG GGGCTGCTGG CCGCTGGCTG TTCCGCCTGC GCTATTTCCC CCGGCCTCAG 600

ATGTTCCCCT TCGGGCAGCA GGGTGAGCGG TACCAACTCA AACCCGGCGA TAATGAGGTT 660

AAAGTGAATC AATTGGGGCT GGACTCCTTG GCTGGGTGTA TGAACATCAC CATGACCGTG 720

GGGGGCCGGG ACTGCCACCC CAACGTGCTG AAGAATGAGG TGACGTGCCG CGTGCCTCGC 780

GACGTGGACC TGTCCCCGGC GGGGCCCCTG TGCAGGATCT GCGTGAATGG CGCCTGCCAG 840

GCACTGGGTT TGGTGCTGTC TGCCTCCTCG CTGGACATGG CCGCCAGCCT GGCCCTGGGC 900

ACTGGTGTCA CCTTCCTTGT CTGCTGCATC CTGGCCGCTG TGCTGCTCCG CTGGCGCTGG 960

AGGAAGAGGA GGGGGACGGA GAACCTGGAG CTGCTGGTGC ACTCTGCCCG GAGTGAGCAC 1020

CCCATCACCA TCCAGCACCC CAACGTTGAC TACAGAGAAG TGCCAGTGCT GCCTGTTGCA 1080

GACAGCCCCG GCCTGGCCAG GCCCCATGCA CACTTTGCCG GTGCCGGTGC TGGAGCTGAT 1140

GCTGCCGGCG GTGGCTCCCC GGTGCCGCTG CTCAGGACCA CGTCTTGCTG CCTGGAGGAC 1200

CTGCGGCCAG AGCTGCTAGA GGAGGTGAAG GACATCCTCA TCCCCGAGGA GCGGCTCATC 1260

ACCCACCGCA GCCGCGTCAT CGGCAGAGGG CACTTTGGCA GTGTGTACCA TGGCACCTAC 1320

ATGGACCCGC TGCTGGGCAA CCTGCACTGT GCCGTCAAGT CCCTGCACCG TATCACAGAC 1380

CTGGAGGAGG TGGAAGAGTT CCTGCGCGAG GGCATCCTGA TGAAGAGCTT CCACCACCCG 1440

CAGGTGCTCT CGTTGCTGGG TGTCTGCCTG CCCCGCCACG GGCTGCCCCT CGTCGTCCTG 1500

CCCTACATGC GCCATGGGGA CCTGCGCCAC TTCATCCGCG CCCAGGAGCG GAGCCCCACG 1560

GTGAAGGAGC TCATCGGCTT CGGGCTCCAG GTGGCCTTGG GCATGGAGTA CTTGGCCCAG 1620

AAAAAATTTG TGCACCGGGA CCTGGCGGCC AGGAACTGCA TGCTGGACGA GACGCTGACA 1680

GTGAAGGTGG CTGACTTCGG GCTGGCGCGG GATGTGTTCG GCAAGGAGTA CTACAGCATC 1740

CGGCAGCACC GGCACGCCAA GCTGCCCGTC AAGTGGATGG CGCTGGAGAG CCTACAGACC 1800

CAAAAATTCA CTACTAAGTC AGATGTGTGG TCCTTTGGGG TGCTCATGTG GGAGCTGCTG 1860

ACGCGGGGTG CATCGCCGTA CCCCGAGGTG GACCCCTATG ACATGGCCCG CTATCTGCTG 1920

CGGGGTCGGC GCCTGCCGCA GCCCCAGCCC TGCCCCGATA CGCTGTATGG GGTGATGCTG 1980

AGCTGCTGGG CACCCACACC CGAGGAGCGG CCGTCCTTCT CAGGGCTGGT GTGTGAGCTC 2040

AAGCGTGTGC TGGCCTCACT GGAGGGTGAG CGCTACGTCA ACCTGGCCGT CACCTACGTC 2100

AACCTGGAGA GCAGCCCTCC TTTCCCCAGG GGGCAGCTGC CCGACAGTGA GGATGAGGAG 2160

GATGAAGAGG ATGAGGAGGA TGAAGAG 2187

Domain Profile

S: 2     dkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhpn  61

         + ++viG+GhfG vy+g+++d+   + ++avksl+ritd+e+veeflreg++mk ++hp+

Q: 422   HRSRVIGRGHFGSVYHGTYMDPLLGNLHCAVKSLHRITDLEEVEEFLREGILMKSFHHPQ  481

         6789********************************************************

S: 62    vlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylask  121

         vlsllG++l+ +glplvvlpym++Gdl++fir +er++tvk+l++f+lqva gmeyla+k

Q: 482   VLSLLGVCLPRHGLPLVVLPYMRHGDLRHFIRAQERSPTVKELIGFGLQVALGMEYLAQK  541

         ************************************************************

S: 122   kfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqtf  181

         kfvhrdlaarnc+lde+ltvkvadfGlardv+ ke+y+ +++r+a+lpvkw+aleslqt+

Q: 542   KFVHRDLAARNCMLDETLTVKVADFGLARDVFGKEYYSIRQHRHAKLPVKWMALESLQTQ  601

         ************************************************************

S: 182   kqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvml  241

         k fttksdvwsfGvl+welltrga+py+ev+++d+  yl +grrl++p+ cpd+ly vml

Q: 602   K-FTTKSDVWSFGVLMWELLTRGASPYPEVDPYDMARYLLRGRRLPQPQPCPDTLYGVML  660

         *.**********************************************************

S: 242   kcwkakpaerpqfsdlvsi  260

         +cw ++p+erp+fs lv+

Q: 661   SCWAPTPEERPSFSGLVCE  679

         ****************986

Domain Sequence
(FASTA)

HRSRVIGRGH FGSVYHGTYM DPLLGNLHCA VKSLHRITDL EEVEEFLREG ILMKSFHHPQ 60

VLSLLGVCLP RHGLPLVVLP YMRHGDLRHF IRAQERSPTV KELIGFGLQV ALGMEYLAQK 120

KFVHRDLAAR NCMLDETLTV KVADFGLARD VFGKEYYSIR QHRHAKLPVK WMALESLQTQ 180

KFTTKSDVWS FGVLMWELLT RGASPYPEVD PYDMARYLLR GRRLPQPQPC PDTLYGVMLS 240

CWAPTPEERP SFSGLVCE 258

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0001725	; C:stress fiber
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0043406	; P:positive regulation of MAP kinase activity
GO:0051897	; P:positive regulation of protein kinase B signaling cascade

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01833	; TIG; 1.

SMARTs

SM00429	; IPT; 2.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013