EKS-MEG-00240
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00240
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR490.39.6E-148180436257
StatusUnreviewed
Ensembl ProteinENSMGAP00000002437
UniProt AccessionH9H0G6;
Protein Name
Protein Synonyms/Alias
Gene NameERBB2
Gene Synonyms/Alias ERBB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000002808ENSMGAP00000002437ENSMGAT00000003115
OrganismMeleagris gallopavo
Functional Description
Protein Length704
Protein Sequence
(FASTA)
VASCNLLDGA IREHTNGTRC LPCHPECQPQ NGTETCFGSD ADQCVACAHY KDGQQCVRRC 60
PSGVKVDASF VPIWKYPDEE GVCQLCPTNC THSCTIRDED GCPVDQKPSQ VTSIIAGVVG 120
ALLVVVLLLI TVVCVKRRRQ QERKHTMRRL LQETELVEPL TPSGALPNQA QMRILKETEL 180
KKVKVLGSGA FGTVYKGIWI PDGESVKIPV AIKVLRENTS PKANKEILDE AYVMAGGSPY 240
VSRLLGICLT STVQLVTQLM PYGCLLDYVR ENKDRIGSQD LLNWCVQIAK GMSYLEEVRL 300
VHRDLAARNV LVKSPNHVKI TDFGLARLLD IDETEYHADG GKVPIKWMAL ESILRRRFTH 360
QSDVWSYGVT VWELMTFGAK PYDGIPAREI PDLLEKGERL PQPPICTIDV YMIMVKCWMI 420
DSECRPKFRE LVTEFSRMAR DPQRFVVIQN DMIGLPSSMD STFYRALLEE EDMDDLVDAE 480
EYLVPHQGFF SAETSTAYRS RISSTRSTAE TPADTTEGEE SAAFPFPPQS LAEGPECPVP 540
EALEVDVGAK GALPSPPATR YSEDPTALPG DESEGLDPEG FTTPAPHTTM PEYVNQAGER 600
PSPPRQPCAP PSPPDKPKGH QGKNGLIKDT KHPFLGPFGR AVENPEYLAP PGPVPTAFSQ 660
AFDNPYYWNQ DPPKAGSPEG GPSSTPAAEN PEYLGLAEPE DVAV 704
Nucleotide Sequence
(FASTA)
GTGGCCTCCT GCAACCTGCT GGATGGTGCC ATCCGGGAGC ACACCAACGG CACACGCTGC 60
CTGCCCTGCC ACCCTGAGTG CCAGCCACAG AACGGCACCG AGACCTGCTT TGGATCGGAC 120
GCGGATCAGT GCGTGGCGTG TGCGCACTAC AAGGATGGGC AGCAGTGTGT GCGGCGCTGC 180
CCCAGCGGGG TGAAGGTGGA CGCCTCCTTT GTGCCCATCT GGAAGTACCC GGACGAGGAG 240
GGGGTCTGCC AGCTCTGCCC CACCAACTGC ACCCACTCGT GCACCATCCG GGATGAGGAC 300
GGCTGCCCCG TGGACCAGAA GCCGAGCCAG GTGACGTCCA TCATTGCTGG TGTGGTGGGG 360
GCTCTGCTGG TCGTCGTCCT TCTGCTCATC ACCGTCGTCT GCGTCAAGCG CCGGCGGCAG 420
CAGGAGAGGA AGCACACCAT GCGGCGGCTG CTGCAGGAGA CCGAGCTGGT GGAGCCGCTG 480
ACGCCCAGCG GGGCGCTTCC CAACCAAGCG CAGATGCGCA TCCTCAAGGA GACGGAGTTG 540
AAGAAAGTGA AGGTTTTGGG CTCTGGCGCT TTCGGCACTG TCTATAAGGG CATCTGGATC 600
CCCGACGGGG AGAGCGTGAA GATCCCGGTG GCCATCAAGG TGTTGCGGGA GAACACCTCG 660
CCCAAAGCCA ACAAGGAGAT CCTGGATGAA GCCTACGTGA TGGCCGGGGG CAGCCCCTAT 720
GTGTCGCGGC TGCTGGGCAT CTGCCTGACC TCCACGGTGC AGCTGGTGAC GCAGCTGATG 780
CCCTACGGCT GCTTGTTGGA CTACGTGCGG GAGAACAAGG ACCGCATCGG CTCCCAGGAC 840
CTGCTCAACT GGTGTGTGCA GATCGCCAAG GGGATGAGCT ACCTGGAGGA GGTGCGGCTG 900
GTGCACCGTG ACCTGGCTGC TCGCAATGTC CTGGTCAAGA GCCCCAACCA CGTCAAAATC 960
ACAGACTTCG GGCTGGCACG GCTGCTTGAT ATCGACGAGA CTGAGTACCA TGCTGACGGG 1020
GGCAAGGTCC CCATCAAGTG GATGGCGCTG GAGTCCATCC TGCGCCGGCG CTTCACCCAC 1080
CAGAGCGACG TCTGGAGCTA CGGTGTCACT GTGTGGGAGC TGATGACCTT CGGGGCAAAA 1140
CCGTACGATG GGATCCCAGC AAGGGAGATC CCCGACCTGC TGGAGAAAGG CGAGCGGCTG 1200
CCGCAGCCGC CCATCTGCAC CATCGACGTC TACATGATCA TGGTGAAATG CTGGATGATC 1260
GACTCCGAGT GCCGGCCCAA GTTCCGTGAG CTGGTCACCG AGTTCTCCCG CATGGCCCGC 1320
GACCCCCAGC GCTTTGTGGT CATCCAGAAC GACATGATTG GGCTGCCCAG CTCCATGGAT 1380
AGCACCTTCT ACCGGGCGCT GCTGGAGGAG GAGGACATGG ACGACCTGGT GGATGCTGAG 1440
GAGTACCTGG TCCCTCACCA GGGCTTCTTC AGTGCTGAGA CCTCCACTGC CTACCGCAGC 1500
CGCATCTCCT CCACGCGGAG CACGGCAGAG ACCCCAGCCG ACACAACGGA GGGCGAGGAA 1560
TCAGCTGCCT TCCCCTTTCC ACCGCAGAGC CTGGCGGAGG GGCCAGAGTG CCCTGTGCCA 1620
GAGGCTCTGG AGGTGGATGT TGGGGCCAAA GGAGCCCTGC CGAGCCCCCC AGCCACACGG 1680
TACAGCGAGG ACCCCACTGC GCTGCCAGGT GATGAGAGCG AGGGTCTGGA CCCCGAGGGC 1740
TTCACCACCC CAGCTCCCCA TACCACTATG CCAGAGTACG TGAATCAGGC TGGGGAGCGG 1800
CCATCGCCCC CCCGGCAGCC CTGCGCACCG CCGTCCCCCC CAGACAAGCC CAAGGGCCAC 1860
CAAGGCAAGA ACGGGCTCAT CAAGGACACC AAGCACCCCT TCCTGGGGCC CTTTGGCCGC 1920
GCCGTGGAGA ACCCTGAGTA CCTGGCCCCC CCCGGGCCGG TCCCTACCGC CTTCAGCCAG 1980
GCCTTTGACA ACCCCTACTA CTGGAACCAG GACCCCCCCA AAGCCGGGAG CCCTGAGGGT 2040
GGTCCCAGCT CCACGCCGGC AGCTGAGAAC CCCGAGTACC TGGGTTTGGC TGAGCCTGAG 2100
GACGTTGCTG TGTAG 2115
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lkk+kvlGsGafGtvykGiwip+ge+vkipvaikvl+e+t++kanke+ldea+v+a   +
Q: 180   LKKVKVLGSGAFGTVYKGIWIPDGESVKIPVAIKVLRENTSPKANKEILDEAYVMAG-GS  238
         69*****************************************************98.79
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+qlvtql+p+Gclldyvre+kd++Gsq+llnwcvqiakGmsylee 
Q: 239   PYVSRLLGICLTSTVQLVTQLMPYGCLLDYVRENKDRIGSQDLLNWCVQIAKGMSYLEEV  298
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+r++
Q: 299   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF  358
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGakpydgipa+eipdllekGerl+qppictidvym++vkcw
Q: 359   THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCW  418
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mid+e+rpkf+el++efs
Q: 419   MIDSECRPKFRELVTEFS  436
         ****************96
Domain Sequence
(FASTA)
LKKVKVLGSG AFGTVYKGIW IPDGESVKIP VAIKVLRENT SPKANKEILD EAYVMAGGSP 60
YVSRLLGICL TSTVQLVTQL MPYGCLLDYV RENKDRIGSQ DLLNWCVQIA KGMSYLEEVR 120
LVHRDLAARN VLVKSPNHVK ITDFGLARLL DIDETEYHAD GGKVPIKWMA LESILRRRFT 180
HQSDVWSYGV TVWELMTFGA KPYDGIPARE IPDLLEKGER LPQPPICTID VYMIMVKCWM 240
IDSECRPKFR ELVTEFS 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Callithrix jacchus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Pelodiscus sinensis"; ?>
EKS-CAJ-00305
EKS-GAG-00252
EKS-HOS-00305
EKS-MAM-00302
EKS-PES-00267
Gene Ontology
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
KEGG
InterPros
IPR021157; Cyt_c1_TM_anchor_C.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00261; FU; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013