EKS-MEG-00233

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00233

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	351.5	1.9E-105	840	1107	268

Status

Unreviewed

Ensembl Protein

ENSMGAP00000002484

UniProt Accession

G1MV50;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1

Gene Synonyms/Alias

BUB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000002837	ENSMGAP00000002484	ENSMGAT00000003163
ENSMGAG00000002837	ENSMGAP00000018274	ENSMGAT00000018439

Organism

Meleagris gallopavo

Functional Description

Protein Length

1140

Protein Sequence
(FASTA)

LDRCLFYRSY EAQIQNYQGN DPLEPWDRYV RWVQGSLPPH EQQKRLPRLL EQLVKAFLTD 60

EKYRQDGRFV NCCIKLAEFI NPPCVYFDYL CGQGIGTNIS AFYIAWAQQL VKEGLVQCAV 120

SVVQKGLRNQ AQPQENLQQL YWETDQRLLL GNMNFCAATV KPLQTSNAEN QMASTSVCLD 180

SLGSCSSSKR SEVTANCYTA NSSGIDFSSS YNLTCVTYIS KSEVLPTSLS SAVECKQVAM 240

YDKNLLICEG SELSFEELRA NRYFKKYERF KRQKEQEEEE KEFVRKKEAA VLELQALQQK 300

LEQLTQLTKS LEETRLEPAP TTFVAPNKTV SRLQYLTSTD TWHNLKYIMK RILIVKPQRL 360

ISPLRVLLNV HPHVALNATL QQNWMAPCQS SSLVPDQPQS STLLSKSLTL ESAKPSGHWM 420

TSTSLIKTPY KKDAITTQQE LSARTIEDLG TGLRVRMRTK LSRAGNASFA SGNASQATPN 480

TSLGGAMQAT PFKVQPSPTV HTKEALGFLM DVFQTPVFPE SPPLEESEEQ FEAFFCKSVC 540

REEQELDGTL KTNVVAPVVP MFSIFEDEEE KENNGIPPPK SKTEEPRNIG ERPLTDCTEE 600

ETRTPEFLQD DCIVWNASCT NKTLASCPNN TRDFTEAARL VSTPFNYLSV RSRPALEDKG 660

KIVNASGLEH QIQCFSPPYL CPRSKKASKN DLQQMDLEFS EELHKKAKTK KLSVINAEIY 720

SPALKHIAKQ GECQGNAITA AASHKLHEQI TTSRAEYSSS LGVDKTSHEK LSRTEQDSRT 780

ARTGGASEVL VENPWDKELI CKFLSELPKP LSTYTNYFEW KSVLPPIQAR AELHLGSLSV 840

CVDSLVGEGA FAQVYQASVL NASDPRNNQK VIFKVQKPAN PWEFYIATQL VERLDPSIHH 900

LYIHLYSAHF FQNGSILIGE LYNYGTLLNA INIYKKLPEK VMPQAFVVYF AVKILHMVEE 960

LHSCKIIHGD IKPDNFMLGE RFLDNDTCDI DDLSHGLTLI DLGQSIDMKL FPEGTAFTAK 1020

CETSGFQCIE MLTQKPWNYQ TDYFGIAATV YCMLFGTYMQ VKNESGVWKP EGSFRRLVNA 1080

EVWKEFFDIM LNIPNCQSLP SLSALRNRLK DLFCKSYAKE IKLLRRRLVV LLIEHKRSRK 1140

Nucleotide Sequence
(FASTA)

TTAGACCGTT GTTTGTTTTA CAGAAGTTAC GAGGCGCAGA TTCAAAACTA CCAGGGGAAC 60

GACCCGCTGG AGCCGTGGGA CAGGTACGTG CGGTGGGTGC AGGGCTCGCT GCCGCCTCAC 120

GAACAACAGA AGCGCCTGCC GCGTCTCCTG GAGCAGCTTG TGAAGGCGTT CCTGACCGAC 180

GAGAAGTATC GCCAGGACGG TAGATTTGTG AACTGCTGCA TTAAGCTGGC AGAGTTCATC 240

AATCCTCCTT GCGTGTATTT TGACTACCTG TGTGGTCAGG GAATTGGCAC AAACATCTCT 300

GCCTTCTATA TTGCTTGGGC TCAGCAACTT GTAAAAGAAG GCCTCGTGCA GTGTGCAGTG 360

TCTGTTGTTC AAAAAGGACT TCGCAACCAG GCACAGCCAC AAGAGAACCT GCAACAGCTG 420

TATTGGGAGA CAGACCAACG GTTATTGCTG GGAAATATGA ACTTTTGTGC TGCTACTGTA 480

AAACCACTTC AAACTTCAAA TGCTGAAAAT CAAATGGCAT CTACATCTGT CTGTCTGGAT 540

TCTCTGGGAT CTTGTTCATC TTCCAAAAGG TCTGAGGTTA CAGCTAACTG TTATACAGCT 600

AATTCTTCAG GAATAGATTT CTCAAGTTCT TACAACTTGA CGTGTGTTAC ATACATCTCT 660

AAATCTGAAG TTCTTCCTAC ATCGTTGTCT TCTGCTGTGG AATGCAAACA GGTTGCAATG 720

TATGATAAAA ACCTGCTCAT TTGTGAGGGC TCTGAACTTT CATTTGAGGA GCTGAGAGCC 780

AACCGATACT TCAAGAAATA CGAGCGTTTC AAAAGGCAAA AAGAACAGGA AGAGGAAGAG 840

AAGGAGTTCG TGAGGAAAAA AGAAGCAGCT GTCCTCGAAC TGCAAGCCCT GCAGCAGAAG 900

CTGGAACAGC TCACTCAGCT CACCAAAAGC TTGGAGGAAA CTAGGCTGGA ACCAGCACCT 960

ACAACATTCG TTGCACCAAA TAAGACAGTG TCAAGGCTGC AATATCTGAC TAGCACAGAT 1020

ACCTGGCATA ATTTGAAATA CATAATGAAG AGAATTTTAA TTGTTAAACC TCAAAGATTG 1080

ATATCGCCTC TGAGAGTCCT CTTAAATGTA CATCCACATG TGGCACTCAA TGCAACTCTG 1140

CAGCAGAACT GGATGGCACC TTGCCAGAGC TCAAGTCTGG TACCAGATCA ACCTCAGTCA 1200

AGTACTTTGT TATCAAAATC TCTTACACTG GAGTCAGCAA AACCATCTGG CCACTGGATG 1260

ACATCAACCT CCCTGATAAA AACGCCATAC AAGAAGGACG CAATCACAAC TCAACAGGAG 1320

CTTTCTGCCA GAACTATCGA GGACCTGGGG ACAGGCCTTA GAGTAAGAAT GAGGACAAAG 1380

CTATCTAGAG CTGGAAATGC TTCCTTTGCT TCTGGAAATG CTTCTCAGGC TACACCAAAC 1440

ACCTCTCTGG GAGGAGCAAT GCAAGCAACA CCATTCAAAG TGCAACCTTC ACCAACAGTT 1500

CATACAAAAG AAGCATTGGG CTTTCTAATG GATGTATTTC AAACACCTGT CTTCCCTGAA 1560

TCACCTCCTC TAGAAGAAAG TGAGGAGCAA TTTGAAGCCT TTTTCTGCAA AAGTGTTTGT 1620

AGGGAAGAGC AGGAGCTTGA TGGAACCTTG AAAACTAACG TCGTCGCCCC CGTTGTGCCC 1680

ATGTTTTCTA TCTTTGAAGA TGAAGAGGAA AAGGAGAACA ATGGGATTCC ACCACCAAAA 1740

AGCAAGACAG AAGAGCCCAG AAATATTGGA GAGCGTCCCT TGACTGACTG CACAGAAGAA 1800

GAGACAAGGA CACCAGAGTT CTTGCAGGAT GATTGTATAG TGTGGAATGC GTCATGTACC 1860

AATAAAACAT TAGCTTCCTG TCCAAACAAC ACAAGAGACT TTACAGAAGC TGCCCGACTT 1920

GTATCAACAC CGTTTAATTA CCTGTCAGTG CGTTCACGGC CAGCTTTGGA GGACAAAGGT 1980

AAAATAGTGA ATGCTTCAGG CTTAGAGCAT CAAATTCAGT GCTTCTCACC TCCGTATCTG 2040

TGCCCTAGGA GCAAAAAAGC TTCCAAGAAT GACTTGCAGC AAATGGATTT GGAATTTTCT 2100

GAAGAACTGC ATAAGAAGGC AAAAACTAAG AAGCTAAGTG TTATTAATGC AGAGATATAT 2160

AGCCCTGCTC TTAAACACAT TGCAAAACAA GGAGAGTGTC AAGGAAATGC CATCACTGCA 2220

GCTGCTTCTC ACAAATTACA CGAGCAGATT ACCACTAGTA GAGCTGAATA TTCTTCATCT 2280

CTTGGGGTGG ACAAGACTTC CCATGAAAAA CTGTCCAGAA CTGAGCAGGA CAGCAGGACA 2340

GCCAGGACTG GTGGAGCTTC AGAAGTCCTT GTTGAGAACC CTTGGGATAA GGAATTGATT 2400

TGCAAATTCT TATCAGAGCT CCCTAAGCCA CTCAGTACAT ATACCAACTA TTTTGAATGG 2460

AAATCTGTTC TTCCACCTAT CCAAGCGAGG GCTGAACTCC ATCTTGGTTC CCTCTCAGTC 2520

TGTGTGGACA GCTTGGTTGG AGAAGGAGCT TTTGCTCAAG TCTACCAGGC TTCTGTTCTG 2580

AATGCCAGTG ACCCTAGAAA CAATCAGAAA GTAATATTCA AGGTCCAGAA ACCTGCCAAT 2640

CCTTGGGAAT TCTACATAGC AACCCAACTG GTAGAAAGGC TCGATCCAAG TATACATCAT 2700

CTTTATATCC ACCTTTATTC TGCTCATTTC TTTCAAAATG GAAGTATTTT GATTGGTGAG 2760

CTCTATAACT ATGGAACTTT GCTGAATGCC ATAAACATTT ACAAAAAGCT TCCTGAAAAG 2820

GTGATGCCTC AAGCATTTGT AGTCTACTTT GCTGTAAAAA TTCTTCATAT GGTAGAAGAA 2880

CTCCATAGCT GCAAAATCAT TCATGGTGAC ATTAAACCCG ATAATTTCAT GCTTGGAGAA 2940

AGGTTTCTGG ACAACGATAC GTGTGACATA GATGATCTCT CTCATGGCCT GACACTCATT 3000

GATTTGGGAC AGAGTATAGA CATGAAACTC TTTCCTGAAG GAACTGCATT TACTGCAAAG 3060

TGTGAAACAT CTGGGTTCCA GTGTATCGAA ATGCTGACCC AGAAACCATG GAACTACCAG 3120

ACAGACTACT TTGGCATTGC AGCAACAGTC TACTGCATGC TGTTTGGTAC TTACATGCAA 3180

GTGAAGAATG AAAGTGGTGT CTGGAAGCCT GAAGGATCCT TCAGAAGGCT TGTCAATGCT 3240

GAGGTGTGGA AAGAGTTCTT TGACATCATG CTAAACATAC CAAATTGCCA GAGCCTGCCT 3300

TCTTTATCCG CTTTGCGCAA CAGACTGAAG GACTTATTTT GCAAGTCATA TGCAAAGGAA 3360

ATAAAGCTCC TTAGGAGAAG ACTTGTTGTG TTGCTCATAG AGCACAAACG GTCACGAAAG 3420

TAG 3423

Domain Profile

S: 1     leiekeigeGayakvykaeh....dsksgelvalKvekpansWefYIclqlkeRlkeeel  56

         ++++ ++geGa+a+vy+a      d +++++v+ Kv+kpan+WefYI +ql eRl  +++

Q: 840   VCVDSLVGEGAFAQVYQASVlnasDPRNNQKVIFKVQKPANPWEFYIATQLVERLD-PSI  898

         5899**************999888899****************************9.78*

S: 57    lksiieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkiv  116

         ++ +i+++sa+ fq++s+l+ e+++ygtll++in +k+  +kvm+++ vv+++v++l++v

Q: 899   HHLYIHLYSAHFFQNGSILIGELYNYGTLLNAINIYKKLPEKVMPQAFVVYFAVKILHMV  958

         ************************************************************

S: 117   eklHeveIiHgDlkPdnfllgnrimdkad..kdkeekglkliDfgrsiDmkllpdgtkfk  174

         e+lH+++IiHgD+kPdnf+lg+r+ d+     d+ ++gl liD+g+siDmkl+p+gt+f+

Q: 959   EELHSCKIIHGDIKPDNFMLGERFLDNDTcdIDDLSHGLTLIDLGQSIDMKLFPEGTAFT  1018

         ************************99987225688899**********************

S: 175   gkaktdafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkqkikrll  234

         +k++t++f+cieml+ k+w+Yq+D+fg+aa+++++lfg+y++v++e+g wk++ +++rl+

Q: 1019  AKCETSGFQCIEMLTQKPWNYQTDYFGIAATVYCMLFGTYMQVKNESGVWKPEGSFRRLV  1078

         ************************************************************

S: 235   kkelwekiferlLNisdastlpsleelve  263

         + e+w+++f+ +LNi+++++lpsl  l++

Q: 1079  NAEVWKEFFDIMLNIPNCQSLPSLSALRN  1107

         **************************994

Domain Sequence
(FASTA)

VCVDSLVGEG AFAQVYQASV LNASDPRNNQ KVIFKVQKPA NPWEFYIATQ LVERLDPSIH 60

HLYIHLYSAH FFQNGSILIG ELYNYGTLLN AINIYKKLPE KVMPQAFVVY FAVKILHMVE 120

ELHSCKIIHG DIKPDNFMLG ERFLDNDTCD IDDLSHGLTL IDLGQSIDMK LFPEGTAFTA 180

KCETSGFQCI EMLTQKPWNY QTDYFGIAAT VYCMLFGTYM QVKNESGVWK PEGSFRRLVN 240

AEVWKEFFDI MLNIPNCQSL PSLSALRN 268

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000777	; C:condensed chromosome kinetochore
GO:0000780	; C:condensed nuclear chromosome, centromeric region
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007063	; P:regulation of sister chromatid cohesion
GO:0071173	; P:spindle assembly checkpoint

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013