EKS-MEG-00176

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00176

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	377.8	2.3E-113	66	365	300

Status

Unreviewed

Ensembl Protein

ENSMGAP00000002615

UniProt Accession

G1MVE8;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K2

Gene Synonyms/Alias

MAP2K2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000002951	ENSMGAP00000002615	ENSMGAT00000003295

Organism

Meleagris gallopavo

Functional Description

Protein Length

396

Protein Sequence
(FASTA)

FCPANRGQTF SGPSQTDAPI ISCRANLVDL QKKLEELELD EQQKKRLEAF LTQKAKVGEL 60

KDDDFERISE LGAGNGGVVT KVQHKPSGLI MARKLVSLIH LEIKPAIRNQ IIRELQVLHE 120

CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS LDQVLKEAKR IPEEILGKVS IAVLRGLAYL 180

REKHQIMHRD VKPSNILVNS RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY 240

SVQSDIWSMG LSLVELSIGR YPIPPPDSKE LEAIFGRPMV DGAEGESHSV SPRARPPGRP 300

ISGHGMDNRP AMAIFELLDY IVNEPPPKLP NGVFTQDFQE FVNKCLIKNP AERADLKMLM 360

NHTFIKRSEV EEVDFAGWLC KTLRLNQPST PTRAAV 396

Nucleotide Sequence
(FASTA)

TTTTGCCCCG CCAACAGAGG ACAGACTTTC TCTGGACCCT CACAGACTGA TGCCCCCATC 60

ATCTCCTGCA GGGCTAATCT GGTGGACCTT CAGAAGAAGC TCGAGGAGCT GGAGCTGGAT 120

GAGCAGCAAA AGAAGCGTTT GGAAGCTTTC CTCACTCAGA AAGCCAAAGT GGGAGAGCTG 180

AAGGATGATG ACTTTGAGCG GATCTCTGAG CTGGGGGCTG GCAATGGTGG TGTGGTCACC 240

AAAGTGCAAC ACAAACCCTC AGGGCTCATT ATGGCACGGA AGCTTGTCAG CTTGATTCAT 300

CTAGAAATCA AACCAGCCAT CAGGAATCAG ATCATCCGAG AGCTGCAGGT GCTGCATGAG 360

TGTAATTCCC CATATATTGT GGGTTTCTAT GGAGCCTTCT ACAGCGATGG AGAGATTTCC 420

ATCTGCATGG AGCACATGGA TGGTGGCTCC CTGGATCAAG TGTTGAAAGA AGCCAAAAGA 480

ATTCCTGAAG AAATACTGGG GAAAGTCAGT ATAGCGGTTC TGAGAGGTTT GGCCTATCTG 540

AGAGAGAAGC ACCAAATCAT GCACAGAGAT GTGAAGCCTT CCAACATCCT GGTTAACTCT 600

CGAGGAGAGA TTAAGCTGTG TGATTTTGGG GTCAGTGGTC AGCTCATTGA CTCCATGGCA 660

AACTCTTTTG TGGGAACTCG GTCCTACATG TCTCCTGAGC GGTTGCAGGG CACTCATTAC 720

TCAGTCCAGT CCGACATCTG GAGCATGGGT CTGTCACTGG TGGAGCTTTC TATTGGAAGG 780

TATCCAATAC CCCCACCAGA CTCCAAGGAA CTGGAAGCAA TATTTGGCCG TCCTATGGTG 840

GATGGGGCAG AGGGAGAATC TCACAGCGTC TCGCCGCGGG CCAGACCCCC AGGACGCCCC 900

ATCAGTGGCC ATGGAATGGA CAACCGACCT GCAATGGCCA TTTTTGAACT GCTGGACTAT 960

ATAGTTAATG AGCCACCTCC CAAGTTGCCA AATGGAGTTT TTACGCAAGA TTTCCAGGAG 1020

TTTGTAAATA AATGCTTAAT TAAGAATCCA GCGGAACGGG CAGATTTGAA GATGCTGATG 1080

AATCACACCT TCATCAAGCG TTCTGAAGTG GAGGAGGTGG ATTTCGCCGG CTGGCTCTGC 1140

AAAACATTGA GGTTAAACCA GCCCAGCACA CCCACCCGTG CTGCCGTGTG A 1191

Domain Profile

S: 2     ekleelGaGnggvVekvlhkksgkilavK...tirleikkeeqkqilrelevlkkssnsp  58

         e+++elGaGnggvV+kv+hk+sg i+a+K    i+leik+++++qi+rel+vl+++ nsp

Q: 66    ERISELGAGNGGVVTKVQHKPSGLIMARKlvsLIHLEIKPAIRNQIIRELQVLHEC-NSP  124

         789**************************6656789********************.***

S: 59    yivkfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleyl  118

         yiv+fyGaf+s+g++sicme+mdg+sld+vlk+    +kripe++lgk+++av+++l+yl

Q: 125   YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKE----AKRIPEEILGKVSIAVLRGLAYL  180

         ********************************9....79*********************

S: 119   keklkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkk  178

         +ek++i+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++

Q: 181   REKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-TH  239

         *********************************************************.**

S: 179   YsvksdvWslGltlvelatgrypyeklke...............................  207

         Ysv+sd+Ws+Gl+lvel +gryp++++++

Q: 240   YSVQSDIWSMGLSLVELSIGRYPIPPPDSkeleaifgrpmvdgaegeshsvsprarppgr  299

         ***************************999******************************

S: 208   ..............ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkel  253

                       i+ell++ivne+ppklp+  f+++fqefv+kCl+k+++eR++lk+l

Q: 300   pisghgmdnrpamaIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADLKML  359

         ************************************************************

S: 254   lkhafi  259

         ++h+fi

Q: 360   MNHTFI  365

         ****97

Domain Sequence
(FASTA)

ERISELGAGN GGVVTKVQHK PSGLIMARKL VSLIHLEIKP AIRNQIIREL QVLHECNSPY 60

IVGFYGAFYS DGEISICMEH MDGGSLDQVL KEAKRIPEEI LGKVSIAVLR GLAYLREKHQ 120

IMHRDVKPSN ILVNSRGEIK LCDFGVSGQL IDSMANSFVG TRSYMSPERL QGTHYSVQSD 180

IWSMGLSLVE LSIGRYPIPP PDSKELEAIF GRPMVDGAEG ESHSVSPRAR PPGRPISGHG 240

MDNRPAMAIF ELLDYIVNEP PPKLPNGVFT QDFQEFVNKC LIKNPAERAD LKMLMNHTFI 300

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005778	; C:peroxisomal membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:2000147	; P:positive regulation of cell motility

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013