EKS-MEG-00045

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00045

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	415.6	7.6E-125	4	287	284

Status

Unreviewed

Ensembl Protein

ENSMGAP00000002614

UniProt Accession

G1MVE7;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK1

Gene Synonyms/Alias

CDK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000002968	ENSMGAP00000002614	ENSMGAT00000003294

Organism

Meleagris gallopavo

Functional Description

Protein Length

303

Protein Sequence
(FASTA)

MEDYTKIEKI GEGTYGVVYK GRHKTTGQVV AMKKIRLESE EEGVPSTAIR EISLLKELRH 60

PNIVCLQDVL MQDARLYLIF EFLSMDLKKY LDAIPSGQYL DRSRVKTYLY QILQGIVFCH 120

SRRVLHRDLK PQNLLIDDKG VIKLADFGLA RAFGIPVRVY THEVVTLWYR SPEVLLGSAR 180

YSTPVDIWSI GTIFAELATK KPLFHGDSEI DQLFRIFRAL GTPNNDVWPD VESLQDYKNT 240

FPKWKPGSLG THVQNLDEDG LDLLSKMLIY DPAKRISGKM ALKHPYFDDL DKSILPANLI 300

KKF 303

Nucleotide Sequence
(FASTA)

ATGGAGGATT ACACAAAGAT AGAGAAGATT GGGGAAGGTA CCTATGGTGT TGTGTATAAA 60

GGGCGCCACA AAACTACAGG CCAAGTGGTT GCAATGAAGA AAATACGTCT AGAAAGTGAG 120

GAGGAAGGTG TTCCAAGTAC TGCTATCCGA GAAATTTCTT TATTAAAAGA ACTGCGTCAT 180

CCCAATATAG TCTGTCTTCA GGATGTTCTT ATGCAGGATG CAAGGCTATA CCTCATTTTT 240

GAATTCCTTT CCATGGACCT CAAGAAATAC TTGGATGCTA TTCCATCTGG CCAATATTTG 300

GATCGTTCAC GTGTTAAGAC TTACCTGTAT CAGATCCTGC AAGGTATCGT CTTCTGCCAT 360

TCAAGACGAG TTCTGCACAG AGATTTAAAA CCTCAGAATC TTCTAATAGA TGACAAAGGG 420

GTGATTAAAC TGGCAGATTT TGGATTGGCT CGAGCCTTTG GAATTCCAGT GCGAGTATAC 480

ACTCATGAAG TAGTGACACT GTGGTACAGG TCTCCAGAGG TTCTGCTAGG ATCTGCTCGT 540

TATTCCACTC CTGTAGATAT ATGGAGCATA GGTACCATAT TTGCAGAGTT AGCAACTAAA 600

AAGCCACTTT TCCATGGGGA CTCAGAGATT GACCAGCTCT TCAGAATCTT CAGAGCATTA 660

GGGACACCCA ACAATGATGT GTGGCCTGAC GTGGAATCCT TGCAAGACTA TAAAAACACT 720

TTCCCAAAAT GGAAACCTGG CAGCTTGGGA ACACATGTCC AAAACTTAGA TGAGGATGGA 780

CTCGATCTGT TGTCTAAAAT GTTAATTTAT GATCCTGCAA AAAGAATTTC TGGCAAAATG 840

GCCTTGAAGC ACCCATACTT CGATGATTTG GACAAATCTA TTCTTCCTGC TAATCTGATT 900

AAGAAATTCT AA 912

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y+k+ekigeGtyg+vyk+++k+tg+vvA+Kkirle+e+egvp+ta+rEisllkel+h+ni

Q: 4     YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI  63

         89**********************************************************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkk.klsleevkslllqlleglaylHsn  119

         v L++v++ ++++lyL+fefl++dLkk+l++ ++  +l++++vk++l+q+l+g+ ++Hs+

Q: 64    VCLQDVLM-QDARLYLIFEFLSMDLKKYLDAIPSGqYLDRSRVKTYLYQILQGIVFCHSR  122

         ********.99********************9876599**********************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

         ++lHRDlKpqNlLi+++g++klaDfGlaraf+ p++ yt+evvTlwYr+Pe+Llg+ +Ys

Q: 123   RVLHRDLKPQNLLIDDKGVIKLADFGLARAFGIPVRVYTHEVVTLWYRSPEVLLGSARYS  182

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfp  239

         t vDiWs+g i+ael+t+kplf+g+seidql+rif+ lgtp+++vwp+v++l++yk++fp

Q: 183   TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNDVWPDVESLQDYKNTFP  242

         ************************************************************

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         k+k+ +l ++v++l+e++ldll+k+l +dp+kRis k al+h+yf

Q: 243   KWKPGSLGTHVQNLDEDGLDLLSKMLIYDPAKRISGKMALKHPYF  287

         ********************************************9

Domain Sequence
(FASTA)

YTKIEKIGEG TYGVVYKGRH KTTGQVVAMK KIRLESEEEG VPSTAIREIS LLKELRHPNI 60

VCLQDVLMQD ARLYLIFEFL SMDLKKYLDA IPSGQYLDRS RVKTYLYQIL QGIVFCHSRR 120

VLHRDLKPQN LLIDDKGVIK LADFGLARAF GIPVRVYTHE VVTLWYRSPE VLLGSARYST 180

PVDIWSIGTI FAELATKKPL FHGDSEIDQL FRIFRALGTP NNDVWPDVES LQDYKNTFPK 240

WKPGSLGTHV QNLDEDGLDL LSKMLIYDPA KRISGKMALK HPYF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0030496	; C:midbody
GO:0005634	; C:nucleus
GO:0005876	; C:spindle microtubule
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0007095	; P:mitotic cell cycle G2/M transition DNA damage checkpoint
GO:0034501	; P:protein localization to kinetochore

KEGG

mgp:100549676

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013