EKS-MEG-00026

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00026

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	296.0	2.2E-88	553	824	272

Status

Unreviewed

Ensembl Protein

ENSMGAP00000002803

UniProt Accession

G1MVV3;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

TYK2

Gene Synonyms/Alias

TYK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000003029	ENSMGAP00000002803	ENSMGAT00000003490

Organism

Meleagris gallopavo

Functional Description

Protein Length

1025

Protein Sequence
(FASTA)

GEEQWWSDGS RAPSAEEICV ELARRLGISP RCAALFALYD APSRTWLPPN HRFGAMEDRD 60

RRLHFRIRFY FRNWHGMNEA EPAVFRHAPR HNEGTGEKPR GTAVLDRASF QYLFEQGKFD 120

FINDAASLTD FQSEQEVQRF KNESLGMAVL HLCHIALRGG RCLEEVARKY SFKACIPRSF 180

RLQIQQSSAV TRLRMKNVFR KFVRRFQRHT VGAGTLTEED VMFKYLATLE LLAPRFGTER 240

FAVLSLDVSN EGEKAQPCGN GGHEMAERGD AAAPGDSSVS HEVLVSGTTG IQWRPVPSEQ 300

SVEVISHRGY FGRRSRRKDP EPPAPPEPPW VHFCDFQEIT HIVVQDCRVC VHRQDNKCME 360

VLLPSHPSAL SFISLLDGYF RLTADSNHYL CHDVAPPRLV MSILNGIHGP MQEEFVFAKL 420

RQEEHEEGLY VLRWSVLDFD RVILAVAKRD PAVPGGLQFR QFRIQKKGSS FVLEGWEREF 480

PTVRALLDAL QGCTLRSGED SFTVKRCCLP KPGEISDLLI TTQKVKDNAK RILNLTQLSF 540

HQIRKDEITQ PQRAHLGQGT RTNIYDGVLN VRGAAGPDEA EYFSTEQNNN SDGREMHVVL 600

KVLDPTHRDI ALAFFETASL MSQVSHVHLA FVHGVCVRGS ENIMVEEFVE HGPLDVLLRK 660

EKGRVPVGWK ITVAKQLASA LSYLEDKSLV HGNVCAKNVL LARTGLGDGT QPFVKLSDPG 720

VSFTALTREE RVDRIPWIAP ECIQDVGNLH PAADKWSFGT TLLEICFDAD VPLKERTPAE 780

KERFYEKKHR LPEPSCQDLA ALIQQCLSYA PAERPSFRTV LRDLTQLQPH SLMDVSSVNP 840

DLTVSDPTVF QKRYLKKIRE LGEGHFGKVG LYCYDPTNDG TGEMVAVKSL KAGCSPQLLA 900

SWKKEIAILK TLYHENIVKY KGCCSEQGMV GTPWGRPQQQ LGGAEKGIWG VSMVEFWDVS 960

QNIVGGMAYL HSLHYIHRDL AARNVLLESD RRVKIGDFGL AKALPHGCDY YRVRDDGDSP 1020

VFWWA 1025

Nucleotide Sequence
(FASTA)

GGGGAGGAGC AATGGTGGAG TGATGGGAGC AGAGCGCCGA GCGCTGAGGA GATCTGCGTG 60

GAGTTGGCAC GGCGCCTCGG CATCTCCCCC CGCTGCGCGG CGCTGTTCGC GCTGTACGAT 120

GCACCTTCCA GGACCTGGCT GCCACCCAAC CACCGCTTCG GTGCCATGGA GGACCGTGAC 180

CGCCGCCTGC ACTTCCGCAT CCGGTTCTAC TTCCGGAACT GGCATGGCAT GAACGAGGCG 240

GAGCCGGCCG TCTTCCGCCA TGCGCCGCGG CACAACGAGG GCACCGGAGA GAAACCGCGC 300

GGCACAGCCG TGCTCGACAG GGCATCCTTC CAGTATCTGT TTGAGCAGGG AAAATTCGAC 360

TTCATTAACG ATGCAGCATC ATTAACGGAC TTCCAGTCGG AGCAGGAAGT GCAGCGCTTC 420

AAAAATGAGA GCCTGGGCAT GGCCGTGCTG CACCTCTGCC ACATCGCCCT CCGCGGCGGC 480

CGCTGCCTCG AGGAGGTGGC ACGGAAATAC AGCTTCAAGG CATGCATCCC GCGCTCCTTC 540

CGGCTCCAGA TCCAGCAGAG CAGCGCCGTG ACGCGGCTCC GAATGAAGAA CGTCTTCCGG 600

AAGTTCGTGC GGCGCTTCCA GCGGCACACA GTGGGCGCGG GGACGCTGAC GGAAGAGGAC 660

GTCATGTTCA AATATTTGGC CACTTTGGAG CTGCTGGCCC CCCGCTTCGG CACCGAGCGC 720

TTCGCCGTGC TCTCCTTGGA CGTCTCCAAC GAAGGGGAGA AGGCGCAGCC CTGCGGCAAT 780

GGGGGGCACG AGATGGCGGA GCGCGGGGAC GCGGCGGCCC CAGGGGACTC TTCGGTCAGC 840

CATGAGGTTC TGGTCAGCGG TACCACTGGG ATCCAGTGGC GGCCCGTGCC CAGCGAGCAG 900

AGCGTTGAGG TCATCTCCCA CCGCGGATAT TTCGGGCGGA GGAGCAGACG GAAGGATCCG 960

GAACCCCCGG CACCGCCGGA GCCCCCATGG GTGCACTTCT GTGACTTCCA AGAGATCACC 1020

CACATCGTCG TCCAGGACTG CAGGGTCTGC GTCCACCGGC AGGACAACAA GTGCATGGAG 1080

GTTCTCCTCC CATCCCACCC GAGCGCTCTC TCCTTCATCT CACTGCTGGA CGGATACTTC 1140

CGACTGACGG CCGACTCCAA CCACTACCTG TGCCACGATG TGGCCCCACC GCGCCTCGTC 1200

ATGAGCATCC TCAACGGCAT CCACGGCCCC ATGCAGGAGG AGTTTGTCTT CGCCAAACTG 1260

CGTCAGGAGG AGCACGAGGA GGGGCTCTAC GTCCTCCGCT GGAGCGTCCT CGACTTCGAT 1320

AGGGTGATTC TGGCCGTGGC AAAGAGGGAC CCCGCTGTGC CGGGAGGCCT CCAGTTCCGC 1380

CAGTTCCGCA TCCAGAAGAA GGGCAGCTCC TTCGTGCTGG AGGGCTGGGA GCGTGAATTC 1440

CCCACCGTGC GGGCGCTGCT GGACGCCCTC CAGGGCTGCA CGCTGCGCTC CGGCGAAGAC 1500

AGCTTCACGG TGAAGCGGTG CTGCCTGCCC AAACCGGGAG AGATCTCGGA TCTGCTGATC 1560

ACCACGCAGA AGGTGAAGGA CAACGCGAAG CGGATCCTCA ACCTGACCCA GCTCAGCTTC 1620

CACCAGATCC GCAAGGACGA GATCACTCAG CCTCAGCGAG CCCACCTGGG CCAGGGCACC 1680

CGCACCAACA TCTACGACGG CGTCCTGAAC GTCCGCGGCG CCGCCGGGCC CGACGAGGCC 1740

GAATACTTCT CCACCGAACA GAACAACAAC AGCGACGGCC GCGAGATGCA CGTGGTGCTC 1800

AAAGTGTTGG ACCCCACCCA CCGTGACATC GCCCTGGCGT TTTTCGAGAC AGCCAGCTTG 1860

ATGAGCCAAG TGTCGCACGT CCACCTGGCC TTCGTGCACG GCGTCTGCGT GCGGGGATCC 1920

GAGAATATCA TGGTGGAGGA GTTTGTGGAG CACGGCCCTC TGGACGTCCT CCTGCGGAAG 1980

GAGAAGGGCA GAGTCCCCGT GGGGTGGAAG ATCACAGTGG CCAAGCAGCT GGCCAGCGCC 2040

CTGAGCTACC TGGAGGACAA GAGCCTGGTG CACGGCAACG TGTGTGCCAA GAACGTCCTG 2100

CTGGCGCGGA CGGGGTTGGG TGATGGCACG CAGCCCTTCG TCAAGCTCAG CGACCCCGGG 2160

GTCAGCTTCA CCGCGCTGAC CCGAGAAGAA CGGGTGGATC GGATCCCATG GATCGCCCCA 2220

GAATGCATTC AGGACGTGGG GAACCTCCAC CCGGCCGCCG ACAAGTGGAG CTTCGGCACC 2280

ACACTGCTGG AGATCTGCTT CGACGCCGAC GTCCCCCTGA AGGAGCGTAC CCCGGCCGAG 2340

AAAGAGCGTT TCTATGAGAA AAAGCACCGC CTGCCTGAGC CGTCCTGCCA GGACCTGGCT 2400

GCCCTCATCC AGCAATGCCT GAGCTACGCG CCCGCCGAGC GACCGTCCTT CCGTACCGTC 2460

CTGCGGGACC TGACCCAGCT GCAGCCCCAC AGCCTCATGG ACGTCTCCTC CGTCAACCCT 2520

GACCTGACTG TGTCCGACCC CACCGTCTTC CAGAAGCGTT ACCTGAAAAA GATCCGCGAG 2580

CTGGGGGAGG GTCACTTTGG CAAGGTGGGC CTCTACTGCT ACGACCCCAC CAACGACGGG 2640

ACGGGTGAGA TGGTGGCTGT GAAGTCCCTG AAGGCCGGCT GCAGCCCACA GCTGTTGGCC 2700

AGCTGGAAGA AGGAGATCGC CATCCTGAAG ACCCTCTACC ACGAGAACAT CGTCAAATAC 2760

AAGGGCTGCT GCAGCGAGCA GGGTATGGTG GGAACACCAT GGGGCCGCCC CCAACAACAG 2820

CTTGGGGGTG CTGAGAAGGG AATTTGGGGG GTTTCTATGG TTGAGTTTTG GGATGTCTCA 2880

CAGAACATTG TTGGGGGCAT GGCCTACCTG CACTCCCTGC ACTACATCCA CCGGGACCTG 2940

GCAGCCCGCA ATGTGCTGCT GGAAAGCGAC CGCCGTGTCA AGATCGGCGA CTTCGGCCTG 3000

GCCAAAGCGC TGCCCCACGG CTGCGATTAT TACCGCGTGC GCGACGACGG CGACAGCCCC 3060

GTCTTCTGGT GGGCC 3075

Domain Profile

S: 4     iesLgkgtftkvfevre..................daegdsteeevalkvLkesgedisr  45

           +Lg+gt+t+++ + +                  ++++d +e  v+lkvL++ ++di+

Q: 553   RAHLGQGTRTNIYDGVLnvrgaagpdeaeyfsteqNNNSDGREMHVVLKVLDPTHRDIAL  612

         579*************99999**9999988876433666666677***************

S: 46    dfkreaeilsqlshehivklkgvcvaegenrlVmeyvesGsLdiyLrkkkealslsslld  105

         +f+++a+++sq+sh h+++++gvcv+++en++V+e+ve+G+Ld+ Lrk+k ++++ +++

Q: 613   AFFETASLMSQVSHVHLAFVHGVCVRGSENIMVEEFVEHGPLDVLLRKEKGRVPVGWKIT  672

         ************************************************************

S: 106   vakqlakameYLedkklvhrdvaarnvLveresn.egtppfvklsdpglakavnqdeYyl  164

         vakqla+a++YLedk+lvh++v+a+nvL++r +  +gt+pfvklsdpg++ ++      l

Q: 673   VAKQLASALSYLEDKSLVHGNVCAKNVLLARTGLgDGTQPFVKLSDPGVSFTA------L  726

         **********************************9******************......*

S: 165   vreerdsripwlapeclseaknlstasdvWsFgvtlyelltcskgesplrseslerklel  224

         +reer +ripw+apec+++  nl  a+d+WsFg+tl+e+  c + + pl+++++++k+++

Q: 727   TREERVDRIPWIAPECIQDVGNLHPAADKWSFGTTLLEI--CFDADVPLKERTPAEKERF  784

         ***************************************..*******************

S: 225   leekerlpkpkcpaelaelmtnclsyepsqrpsFrailedl  265

         +e+k+rlp+p+c+ +la l+++clsy p +rpsFr++l+dl

Q: 785   YEKKHRLPEPSCQ-DLAALIQQCLSYAPAERPSFRTVLRDL  824

         *************.*************************98

Domain Sequence
(FASTA)

RAHLGQGTRT NIYDGVLNVR GAAGPDEAEY FSTEQNNNSD GREMHVVLKV LDPTHRDIAL 60

AFFETASLMS QVSHVHLAFV HGVCVRGSEN IMVEEFVEHG PLDVLLRKEK GRVPVGWKIT 120

VAKQLASALS YLEDKSLVHG NVCAKNVLLA RTGLGDGTQP FVKLSDPGVS FTALTREERV 180

DRIPWIAPEC IQDVGNLHPA ADKWSFGTTL LEICFDADVP LKERTPAEKE RFYEKKHRLP 240

EPSCQDLAAL IQQCLSYAPA ERPSFRTVLR DL 272

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045	; Tyr_kinase_non-rcpt_TYK2_N.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR00109	; TYRKINASE.
PR01827	; YKINASETYK2.

Created Date

20-Feb-2013