EKS-MEG-00269

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00269

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	301.4	4.4E-90	246	497	252

Status

Unreviewed

Ensembl Protein

ENSMGAP00000002867

UniProt Accession

G1MVZ4;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK2

Gene Synonyms/Alias

PAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000003166	ENSMGAP00000002867	ENSMGAT00000003555

Organism

Meleagris gallopavo

Functional Description

Protein Length

521

Protein Sequence
(FASTA)

MSDNGELEDK PPAPPVRMSS YGGKDPLSAN HSLKPLPSVP EERKPRNKII SIFSSTEKGS 60

KKKEKERPEI SPPSDFEHTI HVGFDAVTGE FTGMPEQWAR LLQTSNITKL EQKKNPQAVL 120

DVLKFYDSKD TAKQKYLSFS APEKDGFPSG TPTTNAKGSE PSTAVADDDD DDEEAPPPII 180

APRPDHTKSI YTRSVIDPIP APAGDASVDG GTKSGDKQKK KTKMSDEEIM EKLRTIVSIG 240

DPKKKYTRYE KIGQGASGTV FTAIDVATGQ EVTVCALFCI KMPSPHSTLF SLLDASKLID 300

PNTKLFRRSY LVGDELFVVM EYLAGGSLTD VVTETCMDEA QIAAVCRECL QALEFLHANQ 360

VIHRDIKSDN VLLGMDGSVK LTDFGFCAQI TPEQSKRSTM VGTPYWMAPE VVTRKAYGPK 420

VDIWSLGIMA IEMVEGEPPY LNENPLRALY LIATNGTPEL QNPEKLSPIF RDFLNRCLEM 480

DVEKRGSAKE LLQHPFLKLA KPLSSLTPLI LAAKEAMKSN R 521

Nucleotide Sequence
(FASTA)

ATGTCTGACA ACGGAGAACT GGAAGACAAG CCACCAGCTC CTCCTGTGCG GATGAGCAGC 60

TATGGGGGAA AGGACCCGTT GTCTGCCAAC CACAGCTTGA AACCTCTGCC CTCCGTACCA 120

GAAGAGAGAA AACCTAGGAA TAAAATCATC TCCATATTCT CTAGCACTGA AAAAGGAAGC 180

AAGAAGAAGG AAAAGGAACG ACCAGAAATC TCCCCGCCGT CAGACTTTGA GCATACTATC 240

CATGTTGGCT TTGATGCTGT CACTGGAGAG TTCACTGGAA TGCCAGAGCA ATGGGCTCGG 300

TTGCTACAGA CCTCAAATAT CACCAAGTTA GAACAGAAGA AAAACCCTCA GGCGGTACTA 360

GATGTGCTGA AATTCTACGA CTCCAAAGAC ACAGCAAAAC AGAAATATCT GAGCTTTTCT 420

GCTCCAGAAA AAGATGGTTT CCCTTCAGGA ACACCAACGA CCAACGCCAA AGGTTCAGAG 480

CCATCAACAG CTGTGGCGGA TGATGATGAT GATGATGAAG AAGCACCACC TCCTATTATT 540

GCTCCGCGCC CAGATCACAC GAAATCGATT TATACACGGT CTGTAATTGA CCCCATCCCT 600

GCACCAGCTG GTGACGCTTC TGTTGACGGT GGGACAAAGT CAGGTGATAA GCAGAAGAAG 660

AAGACCAAAA TGTCAGATGA AGAGATCATG GAAAAACTAC GTACTATTGT GAGCATAGGT 720

GATCCCAAGA AAAAATACAC CAGATATGAA AAAATTGGGC AAGGGGCTTC AGGTACAGTT 780

TTCACAGCTA TTGATGTGGC TACTGGGCAG GAGGTAACAG TGTGTGCCTT GTTTTGTATT 840

AAAATGCCCT CTCCGCATTC TACTCTGTTT TCACTACTTG ATGCCTCCAA ACTCATTGAC 900

CCAAACACTA AGCTATTCAG AAGAAGTTAC CTCGTAGGAG ATGAACTGTT TGTGGTGATG 960

GAATATCTAG CTGGAGGCTC ACTAACAGAT GTGGTCACGG AAACGTGTAT GGATGAAGCA 1020

CAGATTGCTG CTGTTTGCAG AGAGTGCTTG CAAGCGCTTG AGTTCCTCCA TGCCAACCAG 1080

GTCATCCATA GAGATATAAA GAGCGACAAC GTGCTGCTAG GAATGGATGG ATCAGTTAAA 1140

CTAACCGACT TTGGTTTCTG TGCTCAGATC ACCCCAGAGC AGAGCAAGCG CAGCACTATG 1200

GTTGGAACTC CTTACTGGAT GGCTCCTGAA GTCGTCACAC GGAAAGCCTA TGGCCCTAAA 1260

GTGGATATCT GGTCCCTAGG CATCATGGCT ATTGAGATGG TGGAAGGAGA ACCCCCGTAC 1320

CTCAATGAAA ACCCCCTGAG GGCCTTATAT TTGATAGCAA CTAATGGCAC ACCAGAGCTT 1380

CAGAACCCTG AGAAACTGTC CCCAATATTT CGGGATTTCT TAAACCGATG TTTGGAGATG 1440

GATGTTGAGA AAAGAGGATC AGCCAAAGAA TTGCTACAGC ATCCCTTCTT GAAACTGGCC 1500

AAACCTCTGT CTAGCTTGAC GCCACTGATC CTGGCAGCCA AAGAAGCAAT GAAGAGTAAC 1560

CGCTAA 1566

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         y+ +e+ig+Ga+g+v++a ++ tg+ v++  + + k ++ ++    +   +kl +pn

Q: 246   YTRYEKIGQGASGTVFTAIDVATGQEVTVCALFCIKMPSPHSTLFSLLDASKLIDPNTKL  305

         7889**************************9999999777777777777888889*****

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +  s+l+ +el++vmeylagGsl+d+v+   ++ ++E qia+++re+l+aLe+lH+++vi

Q: 306   FRRSYLVGDELFVVMEYLAGGSLTDVVT---ETCMDEAQIAAVCRECLQALEFLHANQVI  362

         ****************************...9****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180

         Hrdik++n+Ll ++g+VkL+dfg++aq++ +++kr+t+vgtpywmAPEv++  +k Y  k

Q: 363   HRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT--RKAYGPK  420

         ***************************************************..9******

S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240

         +DiwslGI+aie++egepP+ +++pl+al++i++n +p+l++++k+s+ f++f+++cl+

Q: 421   VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEM  480

         ************************************************************

S: 241   npekRpsasellkhkFl  257

         ++ekR sa+ell+h+Fl

Q: 481   DVEKRGSAKELLQHPFL  497

         ****************7

Domain Sequence
(FASTA)

YTRYEKIGQG ASGTVFTAID VATGQEVTVC ALFCIKMPSP HSTLFSLLDA SKLIDPNTKL 60

FRRSYLVGDE LFVVMEYLAG GSLTDVVTET CMDEAQIAAV CRECLQALEF LHANQVIHRD 120

IKSDNVLLGM DGSVKLTDFG FCAQITPEQS KRSTMVGTPY WMAPEVVTRK AYGPKVDIWS 180

LGIMAIEMVE GEPPYLNENP LRALYLIATN GTPELQNPEK LSPIFRDFLN RCLEMDVEKR 240

GSAKELLQHP FL 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030296	; F:protein tyrosine kinase activator activity
GO:0043066	; P:negative regulation of apoptotic process
GO:2001271	; P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:0018105	; P:peptidyl-serine phosphorylation
GO:2001238	; P:positive regulation of extrinsic apoptotic signaling pathway
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013