EKS-MEG-00188

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00188

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	335.3	1.6E-100	1	226	226

Status

Unreviewed

Ensembl Protein

ENSMGAP00000002902

UniProt Accession

G1MW18;

Protein Name

Protein Synonyms/Alias

Gene Name

SIK3

Gene Synonyms/Alias

SIK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000003173	ENSMGAP00000002902	ENSMGAT00000003592

Organism

Meleagris gallopavo

Functional Description

Protein Length

1282

Protein Sequence
(FASTA)

VAIKIIDKTQ LDEENLKKIF REVQIMKMLC HPHIIRLYQV METERMIYLV TEYASGGEIF 60

DHLVAHGRMA EKEARRKFKQ IVAAVNFCHC RNIVHRDLKA ENLLLDANLN IKIADFGFSN 120

IFTPGQLLKT WCGSPPYAAP ELFEGKEYDG PKVDIWSLGV VLYVLVCGAL PFDGSTLQNL 180

RARVLSGKFR IPFFMSTECE HLIRHMLVLD PSKRLSMDQI CKHKWMKLGE ADAEFDRLIA 240

ECQHLKTERQ MEPLNEDVLL AMAEMGLDKE RTIQSLRADA YDHYSAIYSL LCDRLKRHKN 300

LRIAPSPSIP RTVTFPTSAN IQQTEQAGNT MNINVPQVQL INPENQIVET DGTMNLDSDE 360

GEEPSPEALV RYLSMRRHTV GVADPRTEVM EDLQKLLPGF PRVTPQAPFL QVTPNVNFMH 420

NVLPRQNLQP TGQLEYKEQS LLQPPTLQLL NGMGPLGRRA SDGGANIQLH AQQLLKRPRG 480

PSPLVTMTPA VPAVTPVDEE SSDGEPDQEA VQRYLANRSK RHTLAMTNPT AEIPPDLQRQ 540

LGQQSFRPRA WAPHLVPDQH RSIYKDSNTL HLPTERFSPV RRFSDGAASI QAFKAHLEKM 600

GNNSSIKQLQ QECEQLQKMY GGHMDERTLE KTQQQHMLYQ QEQHHQILHQ QIQDCIRPPQ 660

PSPPLQAQCE NQPALLTHQL QRLRIQPSSP PPNHPNNHLF RQPNSSPPPV SSSVLQPHGA 720

ASQSQFQGMP SHNTIFPQSG NCSPPPTMGL TCLALQQQSQ AQQVTIQVQE PGDMVSNNLL 780

QGASVAGQGM SSHTRGMSIS PSANQIQMQH RANLMASLTY GHRQLSKQLS ADSAESHSLN 840

VYRNPPTNYD QVHLHPHLFP EQPRVSPSNY SPSGGVGFPP AQQALKVPQL DQYPNFPQNA 900

HQQQQHYTAS ALQQALLSPT PPDYSRHQQV PHILQGLLSP RHSLTGHTDM RLPQAEFAQL 960

IKRRQQQQQQ QQQQQQDFQE LFRHMSQGDA GNMGTSMGQS LSERQSLSLP YQSADTYHPQ 1020

NSPQHLLKIR AQECIQQVPA SVPPHGYIHQ PALFHSESME EDCACEGARD SFPDSKNSNT 1080

LTKGCHETPL LVNAGGHGDP ESLLGTANHV QEHQYRHQPA AGFSRNKVPS RESVVGNCMD 1140

RSSPGQAMQV PDHNGLGYPA RPASSEHPRP RTLQRHHTIQ NSDDAYVQLD NLPGMSLMAG 1200

KALSSARMSD AVLSQSSLMA SQQLRDRESE ECGESLEGQE HPNLGDGNQH LNTSCYPSTC 1260

ITDVLLSYKH PEVPFGMEQA GV 1282

Nucleotide Sequence
(FASTA)

GTTGCTATAA AGATAATTGA TAAGACACAG CTGGATGAAG AGAATCTGAA GAAGATATTT 60

AGAGAAGTTC AGATCATGAA GATGCTCTGC CATCCACATA TCATCAGGTT ATATCAGGTT 120

ATGGAGACAG AGAGGATGAT TTATCTAGTG ACAGAGTATG CTAGCGGAGG GGAAATATTT 180

GATCACTTGG TGGCCCACGG GCGCATGGCG GAGAAGGAAG CTCGGAGGAA GTTCAAGCAA 240

ATCGTGGCTG CTGTCAACTT CTGTCACTGC CGTAACATAG TTCACAGAGA TCTCAAAGCA 300

GAAAATCTTC TTCTGGATGC TAACCTTAAC ATCAAAATAG CAGACTTTGG GTTCAGTAAC 360

ATCTTCACAC CTGGCCAGCT GCTAAAAACG TGGTGTGGGA GTCCTCCCTA TGCTGCCCCA 420

GAGCTCTTCG AGGGGAAGGA ATACGATGGG CCCAAGGTTG ACATTTGGAG TCTCGGCGTG 480

GTGCTGTACG TGTTGGTCTG TGGTGCTCTG CCCTTTGATG GGAGCACGCT GCAGAATCTG 540

CGGGCCAGGG TGCTCAGCGG GAAGTTTCGC ATTCCATTCT TCATGTCCAC AGAATGTGAA 600

CATCTGATCC GCCACATGCT GGTCTTGGAC CCAAGTAAGC GGCTCTCAAT GGACCAGATC 660

TGCAAACACA AGTGGATGAA GCTTGGGGAA GCTGATGCAG AGTTTGATAG GCTGATAGCA 720

GAATGTCAGC ACCTGAAGAC AGAGAGGCAG ATGGAGCCAC TGAACGAGGA TGTGTTGTTA 780

GCAATGGCAG AAATGGGGCT GGACAAGGAA CGCACAATTC AGTCATTAAG AGCTGATGCT 840

TACGATCACT ACAGTGCAAT CTACAGCCTG CTCTGTGACC GCCTGAAGAG GCACAAGAAT 900

CTGCGCATTG CCCCATCTCC AAGTATACCA CGGACAGTGA CCTTCCCCAC CTCTGCTAAC 960

ATCCAGCAGA CAGAACAGGC AGGCAATACC ATGAACATCA ATGTGCCACA AGTCCAGCTC 1020

ATCAACCCTG AAAACCAAAT TGTGGAGACT GATGGAACGA TGAACTTGGA CAGCGATGAA 1080

GGGGAAGAAC CATCACCTGA AGCTCTGGTC CGTTACCTCT CAATGAGAAG GCACACGGTT 1140

GGAGTAGCTG ACCCACGGAC GGAGGTCATG GAAGATTTGC AGAAGCTCCT GCCTGGCTTT 1200

CCTCGTGTCA CTCCTCAGGC TCCATTCCTG CAGGTGACCC CAAACGTGAA CTTCATGCAC 1260

AATGTGCTGC CTAGGCAGAA CCTGCAGCCC ACGGGTCAGC TGGAGTACAA GGAGCAGTCC 1320

CTGCTGCAGC CCCCCACTCT GCAACTGTTG AATGGCATGG GCCCTCTGGG GCGGAGAGCA 1380

TCCGATGGTG GAGCTAACAT CCAGCTACAT GCACAGCAAC TGCTGAAACG TCCTCGAGGT 1440

CCATCTCCTC TAGTCACTAT GACTCCAGCC GTCCCAGCTG TCACTCCCGT GGACGAGGAG 1500

AGCTCTGATG GGGAGCCAGA TCAGGAAGCT GTGCAGAGAT ACTTGGCAAA TAGGTCAAAA 1560

AGGCACACTC TGGCAATGAC CAACCCTACA GCTGAAATCC CTCCAGACTT GCAGAGGCAG 1620

CTAGGACAGC AGTCCTTCCG ACCCCGGGCT TGGGCTCCAC ACCTGGTACC CGATCAGCAC 1680

CGTTCTATTT ACAAGGACTC CAACACTCTG CACCTCCCCA CCGAACGCTT CTCCCCGGTT 1740

CGGCGCTTCT CTGACGGTGC TGCCAGCATC CAGGCTTTCA AAGCCCACCT GGAGAAGATG 1800

GGCAATAACA GTAGCATCAA ACAGCTTCAG CAGGAATGTG AACAGCTTCA GAAGATGTAT 1860

GGTGGGCACA TGGATGAGAG GACACTGGAG AAGACACAGC AGCAACACAT GCTGTACCAG 1920

CAAGAGCAGC ACCATCAGAT TCTTCATCAG CAAATCCAGG ACTGTATCCG GCCACCTCAG 1980

CCATCTCCAC CCTTGCAAGC TCAATGTGAA AACCAGCCAG CTCTGCTCAC TCACCAGCTT 2040

CAGAGGTTAC GGATTCAGCC ATCCAGCCCG CCCCCAAATC ACCCTAATAA CCACCTCTTC 2100

AGGCAACCAA ACAGCAGCCC ACCTCCTGTG AGCAGCAGCG TGCTGCAGCC CCACGGTGCA 2160

GCCTCCCAGT CGCAGTTCCA AGGGATGCCG TCCCACAACA CGATCTTCCC ACAGTCTGGT 2220

AACTGTTCCC CTCCCCCAAC CATGGGGCTG ACATGTCTGG CCCTGCAGCA GCAGTCCCAG 2280

GCCCAGCAGG TCACCATCCA AGTGCAGGAA CCCGGCGACA TGGTCAGCAA CAACCTCCTG 2340

CAAGGGGCCT CTGTGGCCGG GCAGGGCATG TCCTCCCACA CCCGGGGTAT GTCCATCAGC 2400

CCCAGTGCCA ACCAGATCCA GATGCAGCAC CGCGCCAACC TGATGGCCTC CCTCACCTAT 2460

GGCCACAGGC AGCTGTCCAA GCAGCTCAGC GCCGACAGCG CCGAGTCGCA CAGTCTGAAC 2520

GTGTACAGGA ATCCCCCCAC CAACTACGAC CAGGTGCACT TACACCCCCA CCTGTTCCCA 2580

GAGCAGCCTC GTGTTTCCCC CAGTAACTAC AGCCCATCAG GAGGAGTTGG GTTTCCTCCA 2640

GCTCAGCAAG CTCTCAAAGT CCCACAGCTT GACCAGTATC CCAATTTCCC TCAAAATGCA 2700

CATCAGCAAC AACAGCACTA CACTGCATCG GCACTACAGC AAGCACTGTT GTCCCCAACA 2760

CCTCCTGACT ACAGCCGACA CCAGCAGGTA CCGCACATCC TCCAGGGACT TCTTTCTCCC 2820

CGTCACTCTC TCACGGGGCA CACGGACATG CGGCTGCCCC AGGCAGAATT TGCACAGCTC 2880

ATCAAACGAC GGCAGCAGCA GCAGCAACAG CAGCAGCAGC AGCAGCAAGA TTTTCAAGAG 2940

TTGTTCAGGC ACATGAGTCA AGGGGATGCT GGAAACATGG GCACCAGCAT GGGACAGAGC 3000

CTGTCGGAGC GTCAGTCGTT GTCTTTGCCT TATCAGAGTG CTGACACCTA TCATCCACAG 3060

AACAGCCCCC AGCATCTCTT AAAAATCAGG GCGCAAGAAT GTATCCAGCA GGTACCTGCG 3120

TCAGTGCCAC CACATGGATA CATACACCAG CCAGCTCTGT TCCACTCGGA GAGCATGGAG 3180

GAGGACTGTG CGTGCGAGGG CGCCAGGGAC AGCTTTCCAG ACAGTAAGAA TTCAAACACA 3240

TTGACCAAAG GTTGCCACGA GACCCCTCTG CTTGTAAATG CAGGAGGGCA CGGGGACCCA 3300

GAATCTTTGC TAGGAACTGC TAATCACGTT CAGGAGCATC AATACAGACA TCAGCCCGCT 3360

GCTGGATTCA GTAGGAATAA GGTGCCCAGC AGAGAGTCCG TCGTAGGGAA CTGTATGGAC 3420

AGGAGCTCCC CTGGCCAAGC CATGCAGGTG CCTGACCACA ACGGGCTGGG CTACCCAGCA 3480

CGGCCGGCGT CCAGTGAGCA CCCGCGGCCC CGCACCCTGC AGAGACATCA CACCATCCAG 3540

AATAGTGATG ATGCCTACGT GCAGTTAGAT AACCTGCCTG GGATGAGTTT AATGGCAGGA 3600

AAAGCGCTCA GCTCTGCTCG GATGTCTGAT GCCGTCCTCA GCCAGTCGTC GCTCATGGCC 3660

AGCCAGCAGC TGCGTGACAG GGAGAGTGAG GAATGTGGGG AAAGTTTGGA AGGTCAAGAG 3720

CATCCCAACC TAGGTGATGG CAACCAGCAT CTAAACACCT CTTGTTACCC ATCGACATGT 3780

ATCACAGATG TCCTACTGAG CTACAAGCAC CCAGAGGTGC CCTTTGGGAT GGAGCAGGCA 3840

GGGGTGTAA 3849

Domain Profile

S: 27    vavKiikkkklseeslekikrEieilkklkhpniikllevietkkklylvleyasggeLf  86

         va+Kii+k++l+ee+l+ki+rE++i+k+l hp+ii+l++v+et++++ylv+eyasgge+f

Q: 1     VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  60

         8***********************************************************

S: 87    dyieekgrlkekearklfkqlvsavkYlhskgivHrDlKpeNllldkkenikiaDFGlan  146

         d+++++gr+ ekear+ fkq+v+av+++h ++ivHrDlK+eNllld++ nikiaDFG++n

Q: 61    DHLVAHGRMAEKEARRKFKQIVAAVNFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  120

         ************************************************************

S: 147   lfkegklletfcGsppYaaPellkgkkYegpkvDvWslGvvLyalvtgklPfdeenlkel  206

         +f++g+ll+t+cGsppYaaPel++gk+Y+gpkvD+WslGvvLy+lv+g+lPfd+++l++l

Q: 121   IFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNL  180

         ************************************************************

S: 207   lekilkgkleipkklskelesLlrklLvvdpekRatieeilkhewl  252

         ++++l+gk++ip+ +s+e+e+L+r++Lv dp+kR+++++i kh+w+

Q: 181   RARVLSGKFRIPFFMSTECEHLIRHMLVLDPSKRLSMDQICKHKWM  226

         *********************************************8

Domain Sequence
(FASTA)

VAIKIIDKTQ LDEENLKKIF REVQIMKMLC HPHIIRLYQV METERMIYLV TEYASGGEIF 60

DHLVAHGRMA EKEARRKFKQ IVAAVNFCHC RNIVHRDLKA ENLLLDANLN IKIADFGFSN 120

IFTPGQLLKT WCGSPPYAAP ELFEGKEYDG PKVDIWSLGV VLYVLVCGAL PFDGSTLQNL 180

RARVLSGKFR IPFFMSTECE HLIRHMLVLD PSKRLSMDQI CKHKWM 226

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013