EKS-MEG-00211

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00211

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	464.9	1.1E-139	208	521	314

Status

Unreviewed

Ensembl Protein

ENSMGAP00000003439

UniProt Accession

G1MX88;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK3

Gene Synonyms/Alias

DYRK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000003702	ENSMGAP00000003439	ENSMGAT00000004141

Organism

Meleagris gallopavo

Functional Description

Protein Length

586

Protein Sequence
(FASTA)

MAPCAAQRVR VETTRPTGPA RGEKARFGDG LYDSYMRIDQ LRYQESANEE HSPSGLPSLG 60

RSNVCSNKLA MKDHPLSGSQ VKVEQLFEDS GNRRSSTLQS AGITCSERSL PSLTKDKSIE 120

SLSTSKGGSS SSKAHKAVSQ APEQAVKQYK HQLSAYEQQE IFNFSEIYFV GPAAKKRQGV 180

IGGPNNGGYD DDQGSYIHVP HDHLAYRYEV LKIIGKGSFG QVAKVYDHKL HQHLALKMVR 240

NEKRFHRQAA EEIRILEHLK KQDKTGSMNV IHMLESFTFR NHICMTFELL SMNLYELIKR 300

NKFQGFSIQL VRKFAHSILQ CLDALYRNKI IHCDLKPENI LLKQQGRSGI KVIDFGSSCF 360

EHQRVYTYIQ SRFYRAPEVI LGSRYGMPID MWSFGCILVE LLTGYPLFPG EDEGDQLACM 420

MELLGMPPQK LLDQSKRAKN FINSKGHPRY CTVTTHADGR VTLNGSRSRR GKVRGAPGNK 480

DWVTALKGCD DPLFIEFLKE CLSWDPAVRM TPSQALRHPW ICKRTPKPPS TDKTSSKRIS 540

SYTSSFTGIG SKLPPVVGVA NKLRANLTSD ANGSIPLCTV LPKLVS 586

Nucleotide Sequence
(FASTA)

ATGGCACCGT GCGCTGCTCA ACGAGTCCGG GTGGAAACAA CCCGCCCGAC CGGGCCGGCC 60

CGAGGAGAAA AGGCCAGGTT TGGAGACGGA TTATATGACT CCTATATGAG GATAGATCAG 120

CTTAGGTACC AAGAGTCTGC AAATGAAGAG CACAGCCCCT CAGGACTGCC TTCCCTTGGG 180

AGATCTAACG TTTGTAGCAA CAAACTTGCA ATGAAGGATC ACCCTCTGAG TGGGAGCCAG 240

GTCAAAGTGG AACAATTGTT TGAGGACTCT GGGAACAGGA GGAGTAGTAC CCTTCAGTCT 300

GCAGGAATTA CTTGTTCAGA AAGATCTCTT CCTTCCCTGA CAAAAGATAA AAGCATAGAG 360

AGCTTAAGCA CTTCTAAAGG TGGCAGCAGT TCCTCAAAAG CCCACAAAGC CGTTTCCCAG 420

GCTCCAGAAC AAGCTGTCAA ACAGTACAAG CATCAATTAT CTGCGTATGA GCAGCAAGAG 480

ATATTTAACT TCTCTGAGAT TTACTTTGTG GGTCCAGCTG CAAAGAAGAG GCAAGGAGTG 540

ATTGGTGGAC CCAACAACGG AGGTTATGAT GATGACCAAG GCAGCTACAT TCATGTGCCC 600

CACGACCATC TCGCTTACCG CTATGAAGTG CTCAAAATCA TTGGCAAGGG CAGTTTTGGA 660

CAAGTTGCTA AAGTCTATGA TCACAAACTC CACCAGCATT TAGCCTTAAA GATGGTTCGT 720

AATGAAAAGA GATTCCATCG GCAAGCAGCA GAAGAAATCC GGATCCTGGA GCACCTGAAG 780

AAGCAGGATA AAACTGGCAG TATGAACGTT ATTCACATGC TGGAAAGCTT CACCTTTCGG 840

AACCACATCT GTATGACCTT TGAACTCTTG AGTATGAACT TGTACGAGCT GATAAAAAGA 900

AATAAGTTCC AGGGCTTCAG CATCCAGCTG GTGCGCAAGT TTGCTCACTC TATACTGCAG 960

TGCTTGGATG CTCTCTATAG AAACAAAATC ATACACTGTG ACTTGAAGCC GGAAAATATC 1020

CTCCTCAAAC AGCAAGGGAG GAGTGGAATC AAGGTTATAG ATTTTGGGTC CAGCTGTTTT 1080

GAGCACCAAA GAGTCTACAC GTACATTCAG TCTCGATTTT ATCGAGCACC GGAGGTAATT 1140

CTAGGGAGTC GCTATGGGAT GCCCATAGAT ATGTGGAGTT TTGGCTGTAT TCTGGTGGAG 1200

CTATTGACTG GATACCCTCT TTTTCCTGGA GAGGACGAGG GAGACCAATT GGCTTGTATG 1260

ATGGAACTTC TTGGAATGCC CCCTCAGAAG CTTTTGGATC AATCCAAGCG AGCCAAGAAC 1320

TTTATCAACT CCAAGGGTCA TCCTCGCTAC TGCACTGTAA CTACACATGC AGATGGAAGA 1380

GTGACCCTCA ACGGGAGCCG ATCGCGCAGG GGAAAAGTGC GAGGTGCTCC AGGGAACAAG 1440

GACTGGGTGA CAGCACTGAA AGGCTGCGAC GATCCCTTGT TCATAGAGTT CTTAAAGGAA 1500

TGTCTCAGCT GGGACCCTGC TGTGCGCATG ACTCCAAGTC AAGCTTTAAG GCACCCCTGG 1560

ATTTGCAAAC GAACACCCAA ACCACCCAGC ACTGATAAAA CCTCCAGTAA AAGGATTTCT 1620

AGCTACACGA GTTCCTTCAC AGGAATTGGT TCCAAGTTGC CTCCTGTGGT CGGGGTAGCA 1680

AACAAGCTGA GGGCTAACTT AACATCCGAT GCCAATGGCA GTATACCTTT ATGTACTGTG 1740

CTGCCGAAGC TGGTCAGCTA G 1761

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl++igkGsfgqV+k++d+k ++++a+k+++n+krf+rqa+eE++iLe+l+k+dk+ +

Q: 208   YEVLKIIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS  267

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le+f+frnh+c++fells+nLyel+k+nkf+g+s++lvrk+a++il++L++L++

Q: 268   MNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSIQLVRKFAHSILQCLDALYR  327

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         +kiiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg +y

Q: 328   NKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQR-VYTYIQSRFYRAPEVILGSRYG  386

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iDmWS+Gc+l+El+tG+pLfpGe+e dqla+++e+lg+pp+kll+++k+ak+f+++k+

Q: 387   MPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGMPPQKLLDQSKRAKNFINSKG  446

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +p+y+++t+++d +++l+ ++++++k r ap++k++++alk ++d lf+++lk++l++dp

Q: 447   HPRYCTVTTHADGRVTLNGSRSRRGKVRGAPGNKDWVTALKGCDDPLFIEFLKECLSWDP  506

         ************************************************************

S: 301   akRitpkealkhpfv  315

         a R+tp++al+hp++

Q: 507   AVRMTPSQALRHPWI  521

         **************7

Domain Sequence
(FASTA)

YEVLKIIGKG SFGQVAKVYD HKLHQHLALK MVRNEKRFHR QAAEEIRILE HLKKQDKTGS 60

MNVIHMLESF TFRNHICMTF ELLSMNLYEL IKRNKFQGFS IQLVRKFAHS ILQCLDALYR 120

NKIIHCDLKP ENILLKQQGR SGIKVIDFGS SCFEHQRVYT YIQSRFYRAP EVILGSRYGM 180

PIDMWSFGCI LVELLTGYPL FPGEDEGDQL ACMMELLGMP PQKLLDQSKR AKNFINSKGH 240

PRYCTVTTHA DGRVTLNGSR SRRGKVRGAP GNKDWVTALK GCDDPLFIEF LKECLSWDPA 300

VRMTPSQALR HPWI 314

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013