EKS-MEG-00242
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00242
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR101.63.9E-29694801108
StatusUnreviewed
Ensembl ProteinENSMGAP00000003570
UniProt AccessionG1MXJ5;
Protein Name
Protein Synonyms/Alias
Gene NameERBB4
Gene Synonyms/Alias ERBB4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000003739ENSMGAP00000003570ENSMGAT00000004274
ENSMGAG00000003739ENSMGAP00000003579ENSMGAT00000004283
OrganismMeleagris gallopavo
Functional Description
Protein Length801
Protein Sequence
(FASTA)
AVCAGTENKL SSLSDLEQQY RALRKYYENC EVVMGNLEIT SIEHNRDLSF LRSIREVTGY 60
VLVALNQFEY LPLENLRIVR GTKLYEDRYA LAIFLNYRKD GNFGLRELGL KNLTEILNGG 120
VYVGQNKFLC FADTIHWQDI VRNPWASNFT LVPTNGSSGC GRCHKSCTGR CWGPTENHCQ 180
TLTKTVCAEQ CDGRCYGPYV SDCCRECAGG CSGPKDTDCF ACMNFNDSGA CVTQCPQTFV 240
YNPTTFQLEH NHNAKYTYGA FCVKKCPHNF VVDSSSCVRA CPSSKMEVEE NGIKMCKPCT 300
DICPKACDGI GTGSLVSAQT VDSSNIDKFI NCTKINGNLI FLVTGIHGDP YHTIAAINPE 360
KLNIFQTVRE ITGYLNIQSW PENMTDFRVF SNLVTIGGRA LYSGLSLLIL KQQGITSLQF 420
QSLKQISAGN IYITDNSNLC YYHTVNWTSL FSTPSQKTVI HRNKKAENCT ADGMVCNELC 480
SSDGCWGPGP DQCLSCKRFI RGRTCIESCN LYDGEFREFA NGSVCVECDP QCEKMEDNMI 540
TCYGPGPDHC TKCFHFKDGP NCVEKCPDGL QGANSFIFKY ADEDRECHPC HPNCTQGCRG 600
PASHDCIYYP WTRQSTLPQH ARTPLIAAGV IGGLFIIVIM GLTFAVYVRR KSIKKKRALR 660
RFLETEVRPL LCASAVAATA LGNAAHLKTC HLQRKFVIGD LCVVTVSKGS TVPETFHCGH 720
AIALLSQAEA LTGSLLLFQE ALIMASMDHP HLVRLLGVCL SPTIQLVTQL MPHGCLLDYV 780
HEHKDNIGSQ LLLNWCVQIA K 801
Nucleotide Sequence
(FASTA)
GCAGTGTGTG CTGGCACAGA GAACAAGCTG AGCTCCCTCT CTGACCTGGA GCAGCAGTAC 60
CGGGCCCTGC GCAAGTACTA TGAGAACTGC GAGGTAGTTA TGGGCAACCT GGAAATCACC 120
AGCATCGAGC ACAACAGAGA CCTCTCCTTC CTGAGGTCTA TCAGAGAAGT CACAGGCTAT 180
GTTTTGGTGG CTTTGAATCA GTTTGAATAC CTGCCACTGG AGAACCTGCG CATCGTTCGT 240
GGGACCAAGC TCTATGAAGA CCGATACGCT CTGGCAATAT TTCTTAACTA CAGAAAGGAT 300
GGTAATTTTG GACTCAGGGA ACTTGGCTTG AAGAACTTGA CAGAAATACT GAATGGAGGG 360
GTGTATGTTG GCCAGAACAA ATTTCTTTGC TTCGCAGACA CCATTCATTG GCAGGATATC 420
GTGCGTAACC CCTGGGCCTC CAACTTCACT TTGGTTCCAA CGAATGGCAG CTCAGGATGT 480
GGTCGATGCC ACAAGTCCTG CACAGGCCGA TGCTGGGGAC CCACGGAGAA TCACTGCCAG 540
ACCTTAACAA AGACAGTGTG TGCAGAGCAG TGTGATGGAC GGTGCTACGG GCCCTACGTC 600
AGTGACTGCT GCCGGGAGTG CGCTGGAGGC TGTTCTGGAC CCAAAGACAC TGATTGCTTT 660
GCCTGCATGA ATTTCAATGA TAGCGGAGCA TGTGTCACAC AGTGCCCCCA GACATTTGTG 720
TACAATCCTA CTACCTTCCA ACTGGAACAT AATCACAATG CCAAGTACAC GTACGGGGCT 780
TTCTGCGTCA AGAAGTGCCC ACACAACTTT GTGGTAGATT CCAGCTCTTG TGTCCGTGCA 840
TGTCCAAGCT CCAAGATGGA GGTTGAAGAG AATGGTATTA AGATGTGTAA GCCCTGCACT 900
GACATTTGTC CTAAAGCGTG TGATGGCATT GGAACAGGGA GCTTAGTGTC AGCTCAGACA 960
GTGGATTCCA GCAACATTGA CAAGTTCATA AACTGTACTA AGATCAATGG CAACCTGATC 1020
TTCCTTGTTA CTGGGATTCA TGGGGATCCA TATCACACAA TCGCTGCAAT TAATCCTGAG 1080
AAATTAAATA TTTTCCAAAC AGTGAGAGAG ATAACAGGGT ATTTGAACAT ACAGTCATGG 1140
CCTGAGAACA TGACTGACTT CAGGGTGTTT TCTAACTTGG TTACTATTGG TGGAAGAGCT 1200
CTGTATAGTG GCCTTTCCTT ACTCATCCTG AAGCAGCAAG GCATTACCTC TTTACAGTTC 1260
CAGTCCTTGA AGCAGATCAG TGCTGGTAAC ATCTACATAA CAGACAACAG CAATTTATGC 1320
TACTACCACA CAGTCAACTG GACCAGTCTT TTCAGCACAC CCAGCCAAAA GACGGTGATT 1380
CATCGAAATA AAAAGGCAGA GAACTGCACT GCTGATGGAA TGGTGTGTAA TGAGTTATGC 1440
TCAAGTGATG GCTGCTGGGG GCCAGGACCA GACCAGTGTC TCTCCTGCAA GCGCTTCATC 1500
AGGGGGAGGA CCTGCATAGA ATCTTGTAAC CTGTATGACG GGGAATTTCG AGAGTTTGCA 1560
AATGGTTCTG TTTGTGTGGA GTGTGATCCC CAATGTGAGA AGATGGAAGA CAACATGATC 1620
ACATGCTATG GGCCGGGGCC TGACCACTGC ACAAAGTGTT TCCATTTTAA GGATGGTCCG 1680
AACTGTGTGG AGAAATGTCC TGATGGTTTA CAGGGGGCCA ACAGTTTCAT TTTCAAATAT 1740
GCCGATGAGG ATCGTGAGTG CCATCCGTGC CATCCAAATT GCACCCAAGG GTGTAGAGGT 1800
CCAGCTAGTC ATGACTGCAT TTACTATCCA TGGACACGAC AGTCCACTTT ACCACAACAT 1860
GCTAGAACAC CTTTGATTGC TGCGGGAGTT ATTGGTGGCC TCTTCATCAT CGTCATCATG 1920
GGCCTGACGT TTGCTGTGTA CGTTCGACGC AAGAGCATTA AAAAGAAGAG AGCGCTGCGG 1980
AGGTTCCTGG AGACTGAGGT GAGGCCTCTG CTGTGTGCAA GTGCTGTGGC TGCAACTGCA 2040
CTGGGAAATG CAGCACATCT AAAGACGTGC CACCTCCAGA GGAAATTTGT TATAGGTGAC 2100
CTCTGTGTTG TCACAGTCTC CAAGGGCAGC ACAGTGCCAG AAACGTTTCA CTGTGGCCAT 2160
GCTATTGCAC TCTTGAGTCA AGCTGAAGCA TTAACTGGGT CACTTCTTTT GTTTCAGGAA 2220
GCTCTCATCA TGGCCAGCAT GGATCACCCA CACCTGGTGA GACTCCTGGG TGTCTGCTTG 2280
AGCCCGACCA TCCAGCTTGT CACTCAGCTG ATGCCTCATG GCTGCCTGCT GGATTATGTT 2340
CATGAACATA AGGACAATAT TGGCTCCCAG CTTCTGCTAA ACTGGTGTGT CCAAATAGCA 2400
AAG 2403
Domain Profile
S: 3     klkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldhan  62
         ++ v+G  +  tv kG  +pe+       ai  l+++     +  l +eal++as+dh++
Q: 694   RKFVIGDLCVVTVSKGSTVPET--FHCGHAIALLSQAEALTGSLLLFQEALIMASMDHPH  751
         5567788888899999999975..5677899999999999999999**************
S: 63    lvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiak  112
         lvrllg+cls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiak
Q: 752   LVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAK  801
         *************************************************8
Domain Sequence
(FASTA)
RKFVIGDLCV VTVSKGSTVP ETFHCGHAIA LLSQAEALTG SLLLFQEALI MASMDHPHLV 60
RLLGVCLSPT IQLVTQLMPH GCLLDYVHEH KDNIGSQLLL NWCVQIAK 108
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>
EKS-AIM-00279
EKS-BOT-00300
EKS-CAJ-00303
EKS-CAF-00303
EKS-DAR-00650
EKS-EQC-00288
EKS-GAG-00250
EKS-HOS-00303
EKS-LAC-00313
EKS-MAM-00300
EKS-MOD-00291
EKS-MUM-00328
EKS-MUP-00294
EKS-NOL-00273
EKS-ORN-00387
EKS-ORA-00263
EKS-ORC-00279
EKS-OTG-00306
EKS-PAT-00282
EKS-PES-00266
EKS-POA-00290
EKS-RAN-00313
EKS-SUS-00266
EKS-TAG-00313
EKS-VIP-00031
Gene Ontology
GO:0016323; C:basolateral plasma membrane
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0044212; F:transcription regulatory region DNA binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0045165; P:cell fate commitment
GO:0016477; P:cell migration
GO:0043066; P:negative regulation of apoptotic process
GO:0008285; P:negative regulation of cell proliferation
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:2000366; P:positive regulation of STAT protein import into nucleus
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0030334; P:regulation of cell migration
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
Prosites
Prints
Created Date20-Feb-2013