EKS-MEG-00053

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00053

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	341.2	3.4E-102	2	280	279

Status

Unreviewed

Ensembl Protein

ENSMGAP00000003475

UniProt Accession

G3UQR4;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK9

Gene Synonyms/Alias

CDK9;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000003747	ENSMGAP00000018005	ENSMGAT00000018932
ENSMGAG00000003747	ENSMGAP00000003475	ENSMGAT00000004179

Organism

Meleagris gallopavo

Functional Description

Protein Length

337

Protein Sequence
(FASTA)

SQRKETGKKL ALKKVLMENE KEGFPITALR EIKILQLLKH ENVVNLIEIC RTKASPYNRC 60

KGSIYLVFDF CEHDLAGLLS NTHVKFTLSE IKKVMQMLLN GLYYIHRNKI LHRDMKAANV 120

LITRDGVLKL ADFGLARAFS LAKNSQPNRY TNRVVTLWYR PPELLLGERD YGPPIDLWGG 180

GCIMAEMWTR SPIMQGNTEQ HQLTLISQLC GSITPEVWPN VDKYELYQKL ELPKGQKRKV 240

KDRLKAYVKD PYALDLIDKL LVLDPAQRID SDDALNHDFF WSDPMPSDLK NMLSTHNQSM 300

FEYLAPPRRR GGHMPQQPAN QGRNPAATNQ TEFDRVF 337

Nucleotide Sequence
(FASTA)

TCACAGAGAA AGGAAACTGG AAAGAAGTTG GCTCTAAAAA AGGTGTTGAT GGAAAATGAG 60

AAGGAGGGGT TCCCCATCAC AGCTCTGCGA GAGATTAAAA TCCTCCAGCT GCTCAAGCAT 120

GAGAATGTGG TGAACCTCAT AGAAATCTGT AGGACCAAAG CCTCTCCATA CAACCGCTGC 180

AAGGGAAGTA TCTACCTGGT GTTTGACTTC TGTGAGCACG ACCTGGCTGG CCTTCTCAGC 240

AACACCCACG TCAAGTTCAC GCTCTCAGAG ATCAAGAAAG TTATGCAGAT GCTATTGAAT 300

GGACTTTATT ACATCCACAG GAACAAGATC TTGCATCGAG ACATGAAAGC TGCAAACGTT 360

CTGATCACGC GGGATGGAGT CCTGAAGCTC GCAGACTTTG GGCTGGCTCG AGCTTTCAGC 420

CTGGCTAAGA ACAGCCAGCC AAATCGCTAC ACCAACCGTG TTGTGACTCT GTGGTATCGG 480

CCACCAGAGC TGCTGCTAGG GGAGCGGGAC TACGGGCCCC CCATTGACCT GTGGGGTGGA 540

GGCTGCATCA TGGCAGAGAT GTGGACCCGC AGCCCCATCA TGCAGGGGAA CACGGAGCAG 600

CACCAGCTCA CCCTCATTAG CCAGCTCTGC GGATCCATCA CGCCAGAGGT CTGGCCGAAT 660

GTGGATAAGT ATGAGCTGTA CCAGAAGCTG GAGCTCCCCA AGGGTCAGAA GCGCAAGGTG 720

AAGGATCGCC TGAAGGCCTA CGTCAAGGAC CCCTATGCAC TCGACCTCAT CGACAAGCTG 780

CTGGTGCTGG ACCCGGCCCA ACGCATCGAC AGCGATGATG CGCTGAACCA CGACTTCTTC 840

TGGTCAGACC CCATGCCCTC GGACCTCAAA AACATGCTGT CCACCCACAA CCAGTCCATG 900

TTCGAGTACC TGGCCCCGCC ACGCAGGAGG GGTGGGCACA TGCCCCAGCA GCCAGCAAAC 960

CAGGGCAGGA ACCCTGCGGC TACCAACCAG ACTGAGTTTG ACAGGGTGTT T 1011

Domain Profile

S: 19    kdketgevvAlKkirlekekegvpitalrEisllkelkhknivkLlevva.......kdk  71

         ++ketg+++AlKk+ +e+ekeg+pitalrEi++l+ lkh+n+v+L+e++        + k

Q: 2     QRKETGKKLALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRtkaspynRCK  61

         5799**********************************************9999998888

S: 72    kklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnkilHRDlKpqNl  131

          ++yLvf+f+e+dL+ ll++++  k++l+e+k+++++ll+gl y+H+nkilHRD+K++N+

Q: 62    GSIYLVFDFCEHDLAGLLSNTHV-KFTLSEIKKVMQMLLNGLYYIHRNKILHRDMKAANV  120

         9********************99.************************************

S: 132   LiskegklklaDfGlaraf....ssplktytkevvTlwYraPelLlgakeYstavDiWsv  187

         Li+++g+lklaDfGlaraf    +s+ ++yt++vvTlwYr+PelLlg+++Y+  +D+W+

Q: 121   LITRDGVLKLADFGLARAFslakNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGG  180

         *******************7776555557*******************************

S: 188   gcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksfpkkkkkkl  246

         gci+ae++tr+p++qg++e++ql+ i++l+g+++ +vwp+v k++ y+  ++pk +k+k+

Q: 181   GCIMAEMWTRSPIMQGNTEQHQLTLISQLCGSITPEVWPNVDKYELYQkLELPKGQKRKV  240

         ************************************************8899**9999**

S: 247   kekvkklkek..aldllekllaldpkkRisakealqhkyf  284

         k+++k++ ++  aldl++kll ldp++Ri++++al+h++f

Q: 241   KDRLKAYVKDpyALDLIDKLLVLDPAQRIDSDDALNHDFF  280

         ****988766579*************************98

Domain Sequence
(FASTA)

QRKETGKKLA LKKVLMENEK EGFPITALRE IKILQLLKHE NVVNLIEICR TKASPYNRCK 60

GSIYLVFDFC EHDLAGLLSN THVKFTLSEI KKVMQMLLNG LYYIHRNKIL HRDMKAANVL 120

ITRDGVLKLA DFGLARAFSL AKNSQPNRYT NRVVTLWYRP PELLLGERDY GPPIDLWGGG 180

CIMAEMWTRS PIMQGNTEQH QLTLISQLCG SITPEVWPNV DKYELYQKLE LPKGQKRKVK 240

DRLKAYVKDP YALDLIDKLL VLDPAQRIDS DDALNHDFF 279

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016605	; C:PML body
GO:0005524	; F:ATP binding
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0017069	; F:snRNA binding
GO:0044212	; F:transcription regulatory region DNA binding
GO:0071345	; P:cellular response to cytokine stimulus
GO:0071157	; P:negative regulation of cell cycle arrest
GO:0006282	; P:regulation of DNA repair
GO:0031056	; P:regulation of histone modification
GO:0043111	; P:replication fork arrest

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013