EKS-MEG-00223

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00223

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	412.0	1.0E-123	193	481	289

Status

Unreviewed

Ensembl Protein

ENSMGAP00000004236

UniProt Accession

G1MZ11;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2B

Gene Synonyms/Alias

ACVR2B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000004400	ENSMGAP00000004236	ENSMGAT00000004949

Organism

Meleagris gallopavo

Functional Description

Protein Length

515

Protein Sequence
(FASTA)

LTSPWVGLNI IYSQALNFAS GPGHGEAETR ECIYYNANWE LEKTNQSGVE RCEGEKDKRL 60

HCYASWRNNS GSIELVKKGC WLDDFNCYDR QECVATEENP QVFFCCCEGN YCNEKFTHLP 120

EVTGPEVIYE PPPPTPSLLN ILVYSLLPIA VLSVAILLAF WMYRHRKPPY GHVDINEDPG 180

PPPPSPLVGL KPLQLLEIKA RGRFGCVWKA QLMNDYVAVK IFPIQDKQSW QSEREIFNTP 240

GMKHENLLQF IAAEKRGTNL ETELWLITAF HDKGSLTDYL KGNIISWNEL CHVAETMARG 300

LSYLHEDVPW CKGEGHKPAI AHRDFKSKNV LLKNDLTAVL ADFGLAVRFE PGKPPGDTHG 360

QVGTRRYMAP EVLEGAINFQ RDAFLRIDMY AMGLVLWELV SRCRAVDGPV DEYMLPFEEE 420

IGQHPSLEDL QEVVVHKKMR PIFKDHWLKH PGLAQLCVTI EECWDHDAEA RLSAGCVEER 480

IAQIRKSVNG TTSDCLVSIV TSVTNVDLPP KESSI 515

Nucleotide Sequence
(FASTA)

CTGACTTCGC CTTGGGTTGG GTTGAATATT ATCTATTCCC AGGCTTTGAA TTTTGCTTCA 60

GGACCAGGTC ACGGGGAGGC AGAGACGAGG GAATGTATTT ACTACAATGC CAACTGGGAG 120

CTGGAGAAGA CCAACCAGAG CGGCGTGGAG CGCTGCGAGG GGGAGAAGGA CAAGCGGCTC 180

CACTGCTACG CCTCTTGGAG AAACAACTCG GGATCCATCG AGCTGGTGAA GAAAGGCTGC 240

TGGTTAGATG ACTTCAACTG TTATGACAGG CAGGAGTGCG TAGCCACAGA AGAAAACCCT 300

CAAGTGTTTT TCTGCTGCTG CGAGGGCAAC TACTGCAATG AGAAATTCAC CCACTTGCCT 360

GAAGTAACCG GCCCAGAAGT CATATATGAG CCGCCACCAC CAACGCCCTC CCTGCTTAAC 420

ATCCTGGTGT ACTCTCTGCT GCCCATTGCT GTCCTGTCAG TGGCCATCCT CCTGGCCTTC 480

TGGATGTATC GGCACCGCAA GCCTCCCTAC GGGCACGTTG ACATCAATGA GGACCCCGGC 540

CCACCACCTC CTTCTCCCCT GGTTGGCCTA AAACCTCTAC AGCTCCTGGA GATCAAAGCC 600

AGGGGACGCT TCGGCTGCGT GTGGAAGGCT CAGCTGATGA ATGACTACGT AGCAGTGAAA 660

ATCTTCCCAA TTCAGGATAA GCAATCTTGG CAGAGTGAGA GGGAGATTTT CAATACTCCT 720

GGCATGAAGC ATGAAAACCT TTTGCAATTT ATCGCAGCAG AGAAAAGAGG GACAAACCTA 780

GAGACAGAGC TCTGGCTGAT CACAGCGTTC CATGACAAGG GCTCTCTCAC GGATTATCTG 840

AAGGGCAATA TCATCAGCTG GAACGAGCTC TGCCATGTTG CAGAAACCAT GGCCCGTGGC 900

TTGTCTTACC TCCATGAGGA CGTCCCGTGG TGCAAGGGTG AAGGACACAA ACCTGCTATA 960

GCACACAGGG ACTTCAAGAG TAAAAACGTC TTGCTGAAGA ACGACTTAAC GGCAGTGCTA 1020

GCTGATTTTG GTCTTGCTGT ACGGTTTGAA CCTGGAAAAC CTCCAGGGGA CACTCATGGA 1080

CAGGTGGGAA CAAGGAGGTA TATGGCTCCT GAAGTGTTAG AGGGAGCAAT CAACTTCCAA 1140

CGGGATGCTT TCCTGAGAAT AGACATGTAC GCAATGGGAC TGGTATTATG GGAGTTAGTC 1200

TCCAGATGTA GAGCAGTTGA TGGTCCAGTG GATGAATACA TGCTGCCTTT TGAAGAAGAA 1260

ATAGGTCAGC ACCCATCCCT CGAGGACCTG CAAGAAGTGG TGGTTCACAA GAAGATGCGC 1320

CCCATCTTCA AGGATCATTG GCTGAAACAC CCTGGCTTGG CGCAGCTCTG CGTGACCATC 1380

GAAGAGTGCT GGGACCACGA CGCAGAGGCT CGGCTCTCGG CAGGCTGTGT CGAGGAGCGC 1440

ATTGCTCAGA TCCGCAAATC CGTAAACGGC ACTACCTCGG ACTGCCTTGT CTCCATCGTG 1500

ACGTCCGTCA CCAACGTGGA CTTGCCGCCC AAAGAGTCCA GTATCTAA 1548

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l++++vAvKif+ +d++sw++E+ei++t+ ++hen+lqfia

Q: 193   LQLLEIKARGRFGCVWKAQLMNDYVAVKIFPIQDKQSWQSEREIFNTPGMKHENLLQFIA  252

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ ++++tel+l+t++h+kgsL+dyLk ++++++el+++a+++a+Gl++LHe+++++k

Q: 253   AEKRGTNLETELWLITAFHDKGSLTDYLKGNIISWNELCHVAETMARGLSYLHEDVPWCK  312

         ************************************************************

S: 121   g.kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

         g  +KpaiaHRD+kskN+l+k+dlt+++aD+GLa+++e  k   d  ++ qvGt+RYmaP

Q: 313   GeGHKPAIAHRDFKSKNVLLKNDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAP  370

         *99***************************************888..79***********

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         Evle+a+n+++ +af r+D+Y++gLvlWE++sRc++vd+ v+ey+lpfee++g++Psle+

Q: 371   EVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCRAVDGPVDEYMLPFEEEIGQHPSLED  429

         **********9.9***********************************************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++evvv+kk+rP ++++w k++ l++l+ ++eecWd+d+eaRl+a +v++r+

Q: 430   LQEVVVHKKMRPIFKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERI  481

         *************************************************985

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL MNDYVAVKIF PIQDKQSWQS EREIFNTPGM KHENLLQFIA 60

AEKRGTNLET ELWLITAFHD KGSLTDYLKG NIISWNELCH VAETMARGLS YLHEDVPWCK 120

GEGHKPAIAH RDFKSKNVLL KNDLTAVLAD FGLAVRFEPG KPPGDTHGQV GTRRYMAPEV 180

LEGAINFQRD AFLRIDMYAM GLVLWELVSR CRAVDGPVDE YMLPFEEEIG QHPSLEDLQE 240

VVVHKKMRPI FKDHWLKHPG LAQLCVTIEE CWDHDAEARL SAGCVEERI 289

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005737	; C:cytoplasm
GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004712	; F:protein serine/threonine/tyrosine kinase activity
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0032147	; P:activation of protein kinase activity
GO:0030509	; P:BMP signaling pathway
GO:0030073	; P:insulin secretion
GO:0035265	; P:organ growth
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0009749	; P:response to glucose stimulus
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013