EKS-MEG-00001
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00001
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph520.35.0E-157629886258
StatusUnreviewed
Ensembl ProteinENSMGAP00000004448
UniProt AccessionG1MZI2;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA4
Gene Synonyms/Alias EPHA4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000004608ENSMGAP00000004448ENSMGAT00000005165
OrganismMeleagris gallopavo
Functional Description
Protein Length994
Protein Sequence
(FASTA)
RQCLQSVYFS FICCRFISGS SSELSPLSSC PGGINELQYK PLAGRLLAFG LCVHEWEEVS 60
IMDEKNTPIR TYQVCNVMEP SQNNWLRTDW IPREGAQRVY IEIKFTLRDC NSLPGVMGTC 120
KETFNLYYYE SNNDKERFIR ESQFAKIDTI AADESFTQVD IGDRIMKLNT EVRDVGPLSK 180
KGFYLAFQDV GACIALVSVR VFYKKCPLTV RNLAQFPDTI TGADTSSLVE VRGSCVNNSE 240
EKDVPKMYCG ADGEWLVPIG NCLCNAGYEE RNGECQACKI GYYKALSTDV ACAKCPPHSY 300
SIWEGSTSCT CDRGFFRAEN DAASMPCTRP PSAPQNLISN VNETSVNLEW SAPQNKGGRE 360
DISYNVVCKR CGAGEPSRCR SCGSGVHFSP QQNGLKTTKV SITDLLAHTN YTFEVWAVNG 420
VSKHNPSQDQ AVSVTVTTNQ AAPSPIALIQ AKEITRHSVA LAWLEPDRPN GVILEYEVKY 480
YEKDQNERSY RIVKTASRNT DIKGLNPLTS YVFHVRARTA AGYGDFSGPF EFTTNTVPSP 540
IIGDGTNPTV LLVSVAGSVV LVVILIAAFV ISRRRSKYSK AKQEADEEKH LNQEHFCLAG 600
VRTYVDPFTY EDPNQAVREF AKEIDASCIK IEKVIGVGEF GEVCSGRLKV PGKREICVAI 660
KTLKAGYTDK QRRDFLSEAS IMGQFDHPNI IHLEGVVTKC KPVMIITEYM ENGSLDAFLR 720
KNDGRFTVIQ LVGMLRGIGS GMKYLSDMSY VHRDLAARNI LVNSNLVCKV SDFGMSRVLE 780
DDPEAAYTTR GGKIPIRWTA PEAIAYRKFT SASDVWSYGI VMWEVMSYGE RPYWDMSNQD 840
VIKAIEEGYR LPPPMDCPIA LHQLMLDCWQ KERSDRPKFG QIVNMLDKLI RNPNSLKRTG 900
SESSRPSTAL LDPSSPEFSA VVSVSDWLQA IKMERYKDNF TAAGYTTLEA VVHMNQDDLA 960
RIGITAIAHQ NKILSSVQAM RTQMQQMHGR MVPV 994
Nucleotide Sequence
(FASTA)
AGACAGTGCT TGCAAAGCGT TTATTTTAGC TTCATATGCT GCAGATTTAT TTCAGGCAGC 60
AGCAGTGAAC TCTCTCCTTT ATCTTCCTGC CCTGGAGGAA TTAATGAATT GCAGTATAAA 120
CCCTTGGCAG GGAGACTGCT TGCGTTTGGT TTGTGTGTCC ACGAATGGGA GGAAGTAAGC 180
ATAATGGATG AGAAAAACAC TCCGATCCGC ACCTACCAGG TTTGCAATGT GATGGAGCCC 240
AGTCAGAATA ACTGGTTACG AACTGATTGG ATTCCCCGCG AGGGGGCTCA GAGGGTATAT 300
ATTGAAATCA AGTTCACACT GAGAGACTGC AACAGCCTGC CAGGTGTCAT GGGAACTTGC 360
AAAGAGACTT TCAACCTCTA TTACTATGAA TCAAACAATG ACAAGGAGCG TTTTATTCGA 420
GAGAGCCAGT TTGCCAAGAT CGACACCATC GCTGCTGATG AGAGCTTCAC CCAGGTGGAC 480
ATTGGCGACA GGATCATGAA GCTGAATACA GAGGTGCGGG ATGTGGGACC TCTCAGCAAG 540
AAAGGGTTTT ACTTGGCTTT CCAGGACGTC GGTGCCTGCA TTGCTTTGGT GTCTGTTCGT 600
GTCTTCTATA AGAAGTGCCC ACTGACAGTT CGAAACCTGG CGCAGTTTCC AGACACCATT 660
ACCGGGGCTG ATACATCCTC TCTGGTGGAG GTTCGTGGCT CCTGTGTCAA CAACTCGGAA 720
GAGAAGGACG TGCCAAAAAT GTACTGCGGG GCAGATGGTG AATGGCTGGT ACCCATTGGC 780
AACTGTCTGT GCAATGCTGG CTATGAAGAA CGCAATGGTG AATGCCAAGC TTGCAAAATC 840
GGATACTACA AGGCGCTTTC GACAGATGTT GCGTGTGCCA AATGCCCGCC TCACAGCTAC 900
TCCATCTGGG AAGGCTCTAC CTCCTGCACC TGCGATCGGG GCTTTTTCCG AGCTGAAAAT 960
GATGCTGCAT CCATGCCCTG CACTCGCCCT CCATCTGCAC CCCAGAACCT GATTTCTAAT 1020
GTCAATGAGA CATCGGTGAA CTTGGAGTGG AGCGCCCCAC AGAACAAGGG AGGACGGGAG 1080
GACATCTCCT ACAACGTGGT GTGCAAGCGC TGCGGGGCAG GGGAGCCCAG CCGCTGCCGG 1140
TCCTGTGGCA GTGGTGTGCA TTTCAGCCCC CAGCAGAACG GGCTGAAAAC CACGAAGGTT 1200
TCCATCACTG ACCTCCTGGC ACACACCAAC TACACCTTTG AGGTCTGGGC AGTGAATGGA 1260
GTGTCCAAGC ACAACCCCAG CCAGGACCAA GCCGTGTCGG TCACTGTGAC AACTAACCAA 1320
GCAGCACCAT CCCCAATTGC ATTAATCCAG GCTAAAGAGA TAACGAGGCA CAGTGTTGCC 1380
TTGGCGTGGC TGGAACCTGA CAGGCCAAAT GGAGTCATCC TGGAGTACGA AGTCAAATAC 1440
TATGAAAAGG ACCAAAACGA GCGCAGCTAT CGCATTGTGA AGACAGCCTC CAGGAATACT 1500
GACATCAAAG GTTTGAACCC CCTAACTTCA TATGTATTTC ATGTGCGAGC CAGGACAGCA 1560
GCAGGATACG GAGACTTCAG TGGGCCGTTT GAGTTCACAA CTAACACAGT TCCTTCCCCC 1620
ATCATTGGCG ATGGTACCAA TCCCACAGTG CTGCTTGTTT CAGTGGCTGG CAGTGTTGTT 1680
CTTGTGGTCA TTCTCATTGC AGCCTTTGTC ATCAGCAGGA GGCGCAGCAA ATACAGTAAG 1740
GCTAAACAAG AGGCAGATGA GGAGAAGCAT TTGAACCAAG AACATTTCTG CCTTGCAGGT 1800
GTCAGAACAT ATGTGGATCC TTTTACATAT GAGGATCCAA ATCAAGCTGT GAGGGAATTT 1860
GCCAAAGAAA TTGATGCCTC CTGCATAAAG ATTGAGAAAG TTATTGGTGT GGGGGAATTT 1920
GGTGAAGTAT GCAGTGGACG ACTCAAAGTT CCAGGAAAAA GAGAGATCTG TGTGGCTATC 1980
AAGACTCTAA AAGCTGGTTA CACTGACAAA CAACGGAGAG ACTTCCTGAG TGAGGCCAGC 2040
ATCATGGGAC AATTTGACCA CCCCAATATC ATCCACTTGG AAGGTGTTGT TACTAAATGT 2100
AAACCGGTGA TGATCATAAC CGAGTACATG GAGAATGGCT CCTTGGATGC CTTCCTCCGG 2160
AAGAATGATG GCAGATTTAC AGTAATCCAG TTGGTGGGGA TGCTTCGTGG CATCGGCTCA 2220
GGAATGAAGT ATCTGTCTGA CATGAGCTAT GTGCATCGGG ATCTAGCTGC TCGAAACATT 2280
CTGGTCAACA GCAACTTGGT CTGCAAAGTG TCTGACTTCG GCATGTCCCG TGTCCTGGAA 2340
GATGACCCTG AGGCAGCTTA TACCACACGG GGTGGCAAGA TCCCCATCCG GTGGACTGCA 2400
CCAGAGGCAA TTGCCTACCG TAAATTTACA TCAGCCAGTG ACGTGTGGAG CTATGGCATC 2460
GTCATGTGGG AAGTGATGTC CTATGGAGAG AGACCTTACT GGGATATGTC CAATCAAGAC 2520
GTTATTAAAG CCATTGAGGA AGGGTATCGG TTGCCACCCC CAATGGACTG CCCCATTGCT 2580
CTCCATCAGC TGATGTTAGA CTGCTGGCAG AAGGAACGCA GCGACAGACC TAAATTTGGA 2640
CAGATTGTCA ACATGCTGGA CAAACTCATC CGCAACCCTA ACAGCCTGAA GAGGACAGGC 2700
AGCGAGAGCT CCAGACCCAG CACAGCCCTG CTGGATCCCA GCTCCCCGGA GTTCTCGGCG 2760
GTTGTTTCTG TCAGTGACTG GCTCCAAGCC ATTAAAATGG AGCGATACAA GGATAACTTC 2820
ACAGCTGCTG GCTATACCAC CCTAGAGGCT GTGGTGCATA TGAACCAGGA CGACCTGGCC 2880
AGGATTGGGA TCACTGCCAT CGCGCACCAG AACAAGATCT TGAGCAGCGT TCAAGCCATG 2940
CGCACCCAAA TGCAACAGAT GCACGGCAGG ATGGTGCCCG TCTGA 2985
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         +kiekviG GefGevcsGrlk+pgkrei+vaiktlkag+t+kqrrdflseasi+Gqfdhp
Q: 629   IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHP  688
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         nii+leGvvtk+kpvmi+teymeng+ld+flrk+dg+ftviqlvgmlrGi+sgmkylsdm
Q: 689   NIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDM  748
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         +yvhrdlaarnilvnsnlvckvsdfG+srvledd+eaaytt+ggkipirwtapeaiayrk
Q: 749   SYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRK  808
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvwsyGiv+wev+syGerpywdmsnqdvikaieegyrlpppmdcp al+qlmldc
Q: 809   FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDC  868
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wqk+r++rpkf qiv++l
Q: 869   WQKERSDRPKFGQIVNML  886
         ***************985
Domain Sequence
(FASTA)
IKIEKVIGVG EFGEVCSGRL KVPGKREICV AIKTLKAGYT DKQRRDFLSE ASIMGQFDHP 60
NIIHLEGVVT KCKPVMIITE YMENGSLDAF LRKNDGRFTV IQLVGMLRGI GSGMKYLSDM 120
SYVHRDLAAR NILVNSNLVC KVSDFGMSRV LEDDPEAAYT TRGGKIPIRW TAPEAIAYRK 180
FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG YRLPPPMDCP IALHQLMLDC 240
WQKERSDRPK FGQIVNML 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00001
EKS-ANC-00001
EKS-BOT-00001
EKS-CAF-00001
EKS-CAP-00001
EKS-CIS-00002
EKS-DAR-00001
EKS-EQC-00001
EKS-FEC-00001
EKS-GAG-00001
EKS-GAA-00001
EKS-GOG-00001
EKS-HOS-00002
EKS-ICT-00001
EKS-LAC-00002
EKS-LOA-00001
EKS-MAM-00001
EKS-MOD-00001
EKS-MUM-00001
EKS-MUP-00001
EKS-MYL-00001
EKS-NOL-00001
EKS-ORN-00001
EKS-ORA-00001
EKS-ORC-00001
EKS-ORL-00001
EKS-OTG-00005
EKS-PAT-00001
EKS-PES-00001
EKS-PEM-00004
EKS-POA-00001
EKS-PRC-00001
EKS-PTV-00001
EKS-RAN-00001
EKS-SAH-00001
EKS-TAG-00001
EKS-TAR-00001
EKS-TAS-00001
EKS-TEN-00006
EKS-XET-00002
EKS-XIM-00001
Gene Ontology
GO:0030424; C:axon
GO:0030425; C:dendrite
GO:0031901; C:early endosome membrane
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0043507; P:positive regulation of JUN kinase activity
GO:2001108; P:positive regulation of Rho guanyl-nucleotide exchange factor activity
GO:0046777; P:protein autophosphorylation
GO:0032314; P:regulation of Rac GTPase activity
GO:0032317; P:regulation of Rap GTPase activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR011510; SAM_2.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF07647; SAM_2; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013