EKS-MEG-00207

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00207

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	354.6	2.6E-106	4	237	234

Status

Unreviewed

Ensembl Protein

ENSMGAP00000004562

UniProt Accession

G1MZR4;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000004698	ENSMGAP00000004562	ENSMGAT00000005282

Organism

Meleagris gallopavo

Functional Description

Protein Length

942

Protein Sequence
(FASTA)

AVSLKTGLEV AIKMIDKKAM HKVGMVQRVQ NEVKIHCQLK HPSILELYNY FEDSNYVYLI 60

LEMCHNGEMS RYIKNRKKPF SEDEARHFLH QIITGMLYLH SHGILHRDLT LSNLLLTSNM 120

NVKIADFGLA TQLKMPHEKH YTMCGTPNYI SPEIATRSPH GLESDVWSLG CMFYTLLIGK 180

PPFDTDTVKN TLNKVVLADY EMPAFLSREA QDLIHKLLRK NPADRLSLSS VLDHPFMSRC 240

SSARSKDSGT SEDSMDSGNA TISTTFTGSS SISSSGCLKE KKKLLVGQPL PNKITFFPKN 300

KNPGNASSVN GSGSFHQWGI QGKETGTSGR GRVMQLAEER PHSRYLRRAH SSDRSGTSHS 360

QTQGISNVIE RCHSMELLSK PIGGTRENTE CFSPASSYTD MGEIFKEKTS GSSGSFEGQI 420

SPPVKDQPHS NFLYPMKPPL GLLEQKSQAE TMQQWLGSMQ TNTQLRPPED LTGNSNAHGG 480

FRYHLDMQQD ALRNGWNTLK DIRNHDASHD YSHSLNQRNP NKYIPEALCQ SEKVQTSSCG 540

LWPASEQNQA WGKELSARQK PTLRSIVSPL SAYRLKPIRQ KTKNAVVSIL DTGEVCMEFI 600

KEHHSQEFVK EVLRISCDGN MIAVYHPNEG RGFLLDDRPP IPPEDSCMYS FDNLPEKYWK 660

KYQYAAKFVQ LVRTKTPKVT FYTRYAKCML MENSPPADVE ICFYDGAKVH KTAGITRVIE 720

KSGKSFTLKG ENETGLKKEM QVYMDHANEG HRICLALESA ILEEEKRSES LPFFPIIVGR 780

KPGNTESPKA VLPLLDNTNC SKEVTALDRN TAASSTPVQT PNCTPPLQLV YNLLVLTANA 840

AESTCSSVYQ TECSPNSAQL IKSVFVKNVG WASQLTSGAV WVQFNDGSQL VAQAGVSSIT 900

YTNPDGQTTR YGENDKLPEY IKEKLHCLSS ILVMFTNPTD PH 942

Nucleotide Sequence
(FASTA)

GCGGTATCCC TGAAAACCGG CCTGGAAGTG GCTATCAAAA TGATAGACAA AAAAGCCATG 60

CACAAAGTGG GAATGGTACA GAGGGTTCAG AACGAGGTGA AAATCCATTG TCAGTTAAAG 120

CATCCATCTA TTCTTGAGCT TTATAACTAT TTTGAAGATA GCAACTATGT GTACTTGATA 180

CTTGAAATGT GTCACAATGG TGAAATGAGT AGATACATAA AGAATAGAAA GAAACCCTTT 240

TCAGAAGATG AAGCCCGACA CTTCTTGCAT CAAATTATCA CCGGTATGCT GTATCTTCAT 300

TCTCATGGAA TACTGCATCG GGACCTCACC CTTTCCAATC TTTTACTCAC CAGTAACATG 360

AACGTCAAGA TTGCTGACTT TGGACTAGCA ACTCAGTTGA AAATGCCTCA TGAAAAGCAT 420

TATACCATGT GTGGAACTCC TAATTACATT TCTCCAGAGA TAGCCACGAG GAGTCCACAT 480

GGACTTGAGT CTGATGTGTG GTCTTTGGGC TGTATGTTTT ACACTCTTCT TATTGGAAAG 540

CCACCTTTTG ACACTGACAC AGTGAAGAAC ACACTGAATA AAGTAGTATT AGCAGATTAC 600

GAAATGCCAG CCTTTTTGTC CAGAGAGGCA CAAGACCTTA TACATAAATT ACTTCGCAAA 660

AATCCAGCAG ATCGTTTGAG TCTTTCCTCT GTGTTGGATC ATCCTTTTAT GTCTAGGTGT 720

AGCTCTGCAC GGAGCAAAGA TTCAGGAACT TCGGAAGATT CCATGGACAG TGGAAATGCT 780

ACCATCTCTA CTACTTTTAC AGGCTCTTCC AGCATCAGTA GCAGTGGCTG CTTGAAGGAA 840

AAAAAGAAGC TGTTAGTGGG ACAGCCGCTC CCAAATAAAA TAACTTTTTT TCCTAAAAAC 900

AAGAATCCGG GTAATGCTTC ATCTGTCAAT GGGAGTGGTT CTTTTCATCA GTGGGGAATT 960

CAAGGGAAAG AAACTGGCAC AAGTGGCAGG GGAAGAGTCA TGCAACTTGC TGAAGAGAGA 1020

CCACATTCCC GCTACCTCCG AAGAGCCCAC TCCTCAGATA GGTCTGGCAC ATCCCACAGT 1080

CAGACTCAAG GAATATCAAA TGTCATTGAG AGGTGTCACT CCATGGAACT GCTTTCCAAG 1140

CCTATAGGAG GAACGAGGGA AAACACAGAA TGCTTTTCGC CTGCAAGCAG CTATACTGAT 1200

ATGGGAGAAA TATTTAAGGA AAAGACTTCT GGTAGTTCTG GCTCTTTTGA AGGGCAAATA 1260

TCTCCACCTG TAAAAGATCA ACCACACTCA AATTTTCTCT ATCCAATGAA GCCCCCTCTT 1320

GGTTTGTTAG AGCAGAAGTC CCAGGCTGAA ACCATGCAGC AGTGGCTTGG AAGCATGCAG 1380

ACAAATACTC AGCTGAGGCC ACCTGAAGAC CTGACTGGTA ACAGTAATGC ACATGGAGGC 1440

TTTCGGTATC ATCTGGATAT GCAGCAAGAT GCACTGAGAA ATGGATGGAA CACCTTGAAG 1500

GATATACGGA ATCATGATGC ATCCCATGAT TATTCACATT CTTTGAATCA GAGAAACCCA 1560

AACAAATACA TTCCCGAAGC TCTCTGCCAA TCTGAAAAAG TTCAGACATC TTCATGTGGC 1620

CTTTGGCCAG CTTCAGAGCA AAACCAAGCG TGGGGCAAAG AACTATCAGC ACGTCAGAAA 1680

CCTACACTGC GAAGTATAGT GTCACCTCTC AGTGCTTACA GGCTAAAACC AATCAGGCAA 1740

AAAACAAAAA ATGCAGTGGT GAGCATTCTA GATACTGGGG AGGTGTGTAT GGAGTTTATA 1800

AAAGAACACC ATTCACAAGA ATTTGTGAAA GAAGTTCTCA GAATATCTTG TGATGGAAAT 1860

ATGATTGCAG TTTATCACCC GAATGAAGGA AGAGGCTTCC TTCTTGACGA CAGGCCGCCC 1920

ATTCCTCCTG AAGACAGCTG TATGTACAGT TTTGACAATT TGCCAGAAAA GTACTGGAAA 1980

AAGTACCAGT ATGCAGCCAA GTTTGTGCAG TTAGTGAGAA CAAAAACCCC CAAAGTTACA 2040

TTCTACACAA GATATGCCAA GTGCATGTTG ATGGAAAATT CACCTCCTGC AGATGTTGAA 2100

ATATGTTTTT ATGATGGAGC AAAGGTACAC AAGACAGCTG GTATAACTCG TGTGATTGAA 2160

AAATCAGGGA AATCCTTCAC TTTGAAAGGA GAAAATGAAA CGGGTTTGAA GAAGGAAATG 2220

CAAGTATATA TGGATCATGC AAATGAGGGA CATCGCATAT GCCTTGCACT GGAATCTGCT 2280

ATTTTGGAAG AAGAAAAAAG GAGTGAAAGT CTTCCATTTT TTCCAATAAT TGTTGGAAGA 2340

AAACCTGGCA ATACTGAATC TCCAAAGGCT GTACTGCCTC TGTTGGACAA CACCAACTGT 2400

TCAAAAGAAG TTACGGCACT GGATAGAAAT ACAGCTGCCA GTTCTACTCC TGTTCAAACT 2460

CCAAACTGTA CTCCTCCACT ACAGTTGGTG TATAATCTGT TGGTCTTAAC AGCCAATGCT 2520

GCTGAAAGTA CGTGCTCCTC TGTTTATCAG ACAGAATGCA GCCCAAATTC AGCTCAACTT 2580

ATAAAATCAG TCTTTGTGAA AAATGTTGGT TGGGCTTCAC AGCTGACCAG TGGAGCAGTA 2640

TGGGTTCAGT TTAATGATGG ATCCCAACTG GTAGCCCAAG CAGGTGTTTC TTCTATCACT 2700

TACACCAATC CAGATGGCCA GACAACTAGG TATGGAGAAA ATGATAAGTT GCCAGAATAC 2760

ATCAAAGAGA AGTTGCACTG TCTGTCTTCT ATTCTTGTGA TGTTTACCAA TCCAACTGAT 2820

CCCCACTGA 2829

Domain Profile

S: 21    letkevfavkvvpksllakekqrekvekeieihrslkhknivklyeffedkenvylvlel  80

         l+t+ ++a+k+++k++++k  + ++v++e++ih++lkh++i++ly++fed+++vyl+le+

Q: 4     LKTGLEVAIKMIDKKAMHKVGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLILEM  63

         689999******************************************************

S: 81    csrrslaellkrr.kaltepevryylrqivsglkylhekrilhrdlklgnlflneelevk  139

         c+++++ +++k+r k+++e e+r++l+qi++g++ylh++ ilhrdl+l+nl+l+++++vk

Q: 64    CHNGEMSRYIKNRkKPFSEDEARHFLHQIITGMLYLHSHGILHRDLTLSNLLLTSNMNVK  123

         ***********99899********************************************

S: 140   igdfGlatrlekeeerkktlcGtPnyiaPevlskkghslevdiWslGcilytllvGkPPf  199

         i+dfGlat+l++++e+++t+cGtPnyi+Pe+++++ h+le+d+WslGc++ytll+GkPPf

Q: 124   IADFGLATQLKMPHEKHYTMCGTPNYISPEIATRSPHGLESDVWSLGCMFYTLLIGKPPF  183

         ************************************************************

S: 200   etkelketyekikkaeyslPsslskeaksliakllkkePeerpsleevlkdefl  253

         +t+++k+t++k++ a+y++P+ ls+ea++li+kll+k+P++r+sl++vl+++f+

Q: 184   DTDTVKNTLNKVVLADYEMPAFLSREAQDLIHKLLRKNPADRLSLSSVLDHPFM  237

         ****************************************************98

Domain Sequence
(FASTA)

LKTGLEVAIK MIDKKAMHKV GMVQRVQNEV KIHCQLKHPS ILELYNYFED SNYVYLILEM 60

CHNGEMSRYI KNRKKPFSED EARHFLHQII TGMLYLHSHG ILHRDLTLSN LLLTSNMNVK 120

IADFGLATQL KMPHEKHYTM CGTPNYISPE IATRSPHGLE SDVWSLGCMF YTLLIGKPPF 180

DTDTVKNTLN KVVLADYEMP AFLSREAQDL IHKLLRKNPA DRLSLSSVLD HPFM 234

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005814	; C:centriole
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0007099	; P:centriole replication
GO:0046601	; P:positive regulation of centriole replication

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013