EKS-MEG-00303
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00303
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src438.07.5E-132191440250
StatusUnreviewed
Ensembl ProteinENSMGAP00000004565
UniProt AccessionG3X8M0;
Protein Name
Protein Synonyms/Alias
Gene NameLCK
Gene Synonyms/Alias LCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000004710ENSMGAP00000004565ENSMGAT00000005285
ENSMGAG00000004710ENSMGAP00000017883ENSMGAT00000019449
OrganismMeleagris gallopavo
Functional Description
Protein Length455
Protein Sequence
(FASTA)
SPPCSPLQDK LVVALYDYEP THDGDLGLKQ GEKLRVLEES GEWWKAQSLT TGQEGLIPHN 60
FVAMVNSLEP EPWFFKNLSR KDAERQLLAS GNTHGSFLIR ESETSKGSYS LSVRDFDQNQ 120
GETVKHYKIR NMDNGGYYIS PRVTFSSLHE LVEYYSSSSD GLCTRLGKPC RTQKPQKPWW 180
QDEWEVPRES LKLVEKLGAG QFGEVWMGYY NGHTKVAIKN LKQGSMSPSA FLAEANLMKN 240
LQHPRLVRLY AVVTKEPIYI ITEYMEKGSL VDFLKTSEGI KLSINKLLDM AAQIAEGMAF 300
IEAKNYIHRD LRAANILVSE ALCCKIADFG LARLIEDNEY TAREGAKFPI KWTAPEAINY 360
GTFTIKSDVW SFGILLTEIV TYGRIPYPGM TNPEVIQNLE RGYRMPQPDN CPRELYELMM 420
LCWKEQPEER PTFEYMKSVL EDFFTATEGQ YQQQP 455
Nucleotide Sequence
(FASTA)
TCTCCGCCGT GCTCCCCACT GCAAGACAAG CTCGTGGTGG CCCTGTATGA CTATGAACCC 60
ACTCACGATG GGGACCTGGG ACTTAAGCAG GGCGAGAAGC TGCGCGTCCT GGAAGAGAGC 120
GGAGAGTGGT GGAAGGCGCA GTCGCTCACC ACAGGCCAGG AGGGTTTGAT CCCCCACAAC 180
TTCGTGGCCA TGGTGAACAG CCTGGAGCCG GAGCCGTGGT TCTTCAAGAA CCTCAGCCGC 240
AAGGATGCAG AGCGGCAGCT GCTGGCGTCG GGCAACACGC ATGGCTCCTT CCTCATCCGG 300
GAGAGCGAGA CCTCCAAAGG CTCCTACTCG CTGTCAGTGA GGGACTTCGA CCAGAACCAG 360
GGTGAGACAG TGAAGCACTA CAAGATTCGC AACATGGACA ATGGCGGGTA CTACATCTCT 420
CCCCGGGTCA CCTTCAGCAG CCTGCACGAG CTGGTGGAGT ATTACTCAAG CAGCTCGGAT 480
GGGCTGTGCA CCCGCCTCGG CAAGCCCTGC CGGACACAGA AGCCGCAGAA GCCGTGGTGG 540
CAGGATGAGT GGGAGGTGCC GCGAGAGTCA CTGAAGCTGG TGGAGAAGCT GGGAGCCGGG 600
CAATTTGGAG AAGTCTGGAT GGGTTACTAC AATGGCCACA CCAAGGTAGC CATCAAGAAC 660
CTGAAGCAGG GCAGCATGTC CCCCAGCGCC TTCCTGGCAG AGGCCAACCT GATGAAGAAC 720
CTGCAGCACC CGCGGCTGGT GCGGCTCTAT GCCGTGGTGA CCAAGGAGCC CATCTACATC 780
ATCACAGAGT ACATGGAGAA GGGCAGCCTG GTGGACTTCC TCAAGACCTC AGAGGGCATC 840
AAGCTCAGCA TCAACAAACT GCTGGACATG GCTGCACAGA TTGCCGAAGG CATGGCCTTC 900
ATCGAAGCCA AGAACTACAT CCACCGTGAC CTGCGGGCTG CCAACATCCT GGTGTCGGAG 960
GCTCTGTGCT GCAAAATCGC CGACTTCGGG CTGGCGCGCC TTATTGAGGA CAATGAGTAC 1020
ACAGCACGAG AAGGGGCTAA ATTCCCCATT AAGTGGACGG CACCGGAGGC TATTAATTAT 1080
GGCACGTTCA CCATCAAGTC TGACGTCTGG TCCTTCGGCA TCCTTCTCAC TGAGATCGTT 1140
ACCTACGGCC GGATCCCATA TCCAGGGATG ACCAACCCCG AGGTGATCCA GAACCTGGAG 1200
CGCGGCTACC GCATGCCGCA GCCGGACAAC TGCCCGCGGG AGCTGTACGA ACTGATGATG 1260
CTGTGCTGGA AGGAGCAGCC CGAGGAGCGG CCCACCTTCG AGTACATGAA GAGTGTGCTG 1320
GAGGACTTCT TCACCGCCAC CGAGGGACAA TACCAGCAGC AGCCG 1365
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lklv+klG+GqfGevw+g+++g++kva+k lk+g++sp+afl+ea+++k+l+h++lv+ly
Q: 191   LKLVEKLGAGQFGEVWMGYYNGHTKVAIKNLKQGSMSPSAFLAEANLMKNLQHPRLVRLY  250
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePiyi+te+m+kGsl+dflk++eg kl+++kl+d+aaq+aeGma++e+kn+ihr
Q: 251   AVVTK-EPIYIITEYMEKGSLVDFLKTSEGIKLSINKLLDMAAQIAEGMAFIEAKNYIHR  309
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+e l++k+adfGlarlied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 310   DLRAANILVSEALCCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDV  369
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillteivt+G++PypGmtn ev++++ergyr+p+p++cp+elyel++ cwk++pee
Q: 370   WSFGILLTEIVTYGRIPYPGMTNPEVIQNLERGYRMPQPDNCPRELYELMMLCWKEQPEE  429
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe++++vl
Q: 430   RPTFEYMKSVL  440
         *******9875
Domain Sequence
(FASTA)
LKLVEKLGAG QFGEVWMGYY NGHTKVAIKN LKQGSMSPSA FLAEANLMKN LQHPRLVRLY 60
AVVTKEPIYI ITEYMEKGSL VDFLKTSEGI KLSINKLLDM AAQIAEGMAF IEAKNYIHRD 120
LRAANILVSE ALCCKIADFG LARLIEDNEY TAREGAKFPI KWTAPEAINY GTFTIKSDVW 180
SFGILLTEIV TYGRIPYPGM TNPEVIQNLE RGYRMPQPDN CPRELYELMM LCWKEQPEER 240
PTFEYMKSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00347
EKS-BOT-00370
EKS-CAF-00371
EKS-CAP-00402
EKS-DAR-00750
EKS-DIO-00065
EKS-EQC-00361
EKS-ERE-00004
EKS-FEC-00358
EKS-GAM-00223
EKS-GAA-00453
EKS-GOG-00391
EKS-HOS-00376
EKS-ICT-00351
EKS-LAC-00385
EKS-LOA-00383
EKS-MIM-00060
EKS-MOD-00357
EKS-MUM-00403
EKS-MUP-00365
EKS-MYL-00368
EKS-OCP-00080
EKS-ORN-00480
EKS-ORA-00322
EKS-ORC-00349
EKS-ORL-00441
EKS-OTG-00374
EKS-PES-00333
EKS-PEM-00194
EKS-POA-00359
EKS-RAN-00384
EKS-SAH-00340
EKS-SOA-00006
EKS-SUS-00324
EKS-TAR-00475
EKS-TEN-00466
EKS-TUT-00115
EKS-XET-00485
EKS-XIM-00468
Gene Ontology
GO:0005794; C:Golgi apparatus
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0050853; P:B cell receptor signaling pathway
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045588; P:positive regulation of gamma-delta T cell differentiation
GO:0010628; P:positive regulation of gene expression
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0050856; P:regulation of T cell receptor signaling pathway
GO:0051209; P:release of sequestered calcium ion into cytosol
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013