EKS-MEG-00012
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00012
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph259.22.4E-77617777161
StatusUnreviewed
Ensembl ProteinENSMGAP00000004751
UniProt AccessionG1N053;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA2
Gene Synonyms/Alias EPHA2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000004855ENSMGAP00000004751ENSMGAT00000005472
OrganismMeleagris gallopavo
Functional Description
Protein Length778
Protein Sequence
(FASTA)
TNPAVPDFPS WGNSSCSPLM VPFSPLPTVV LLDFAKAQGE LGWLTQPYGK GWDLQQHVLN 60
DSGIYIYAVC SVLQGEQENW LRTNWIYRSE AQRIFIELKF TVRDCNSFPG GGGSCKETFN 120
LFYAESDVDY GTNFQKRQFK KIDTIAPDEI TVQEDFETRN VKLNVEVRSV GPLRRKGFYL 180
AFQDLGACVS LLSVRVYYKT CPAVLRGLAV FPETVAGADS QQLAKVQGAC VEHAVADRVP 240
MLHCNMDGEW LVPIEQCQCQ AGYEAAGEQC QACPPGTFKA EVSLSGCQPC PAHTLPSSAA 300
ADACPCQDGY FRAPTDPAAM PCTRPPSPPR SVIALGLGAT VQLRWSPPSD RGGRQDVTYS 360
ITCEQCLSES GECQPCDGGI RYSQPPQGLV GTGVTVTDLE PHINYTFTVE ARNGVSAFSP 420
LRSVASTSIS VNHTEPPQVT SVSLNGQTAT SLVLSWTVPP RQQSWVWKYE VTYSKKTDEN 480
SYSVLRCEGT SVTIPKLSPG TAYVVRVQAL TKDGHGAFSL EHEFETLPEE AESMASAAVI 540
SGSVTGVIFV VFVLTVLLYV LRRRRRNSPS RQSPEDVYFS KSDQLKPLKT YVDPHTYEDP 600
NQAMLKFTTE ISPSSITRQK VIGAAGEFGE VYKGTLKQGK KEVPVAIKTL KVGYTEKQRV 660
DFLSEASIMG QFCHHNIIRL EGSSLTDKPF MIVTEYMENG ALDKFLREKD GQFCVIQLVG 720
MLRGIAAGMK YLANMNYVHR DLAARNILVN SNLVCKVSDF GLSRVLEDDP EATYTTSV 778
Nucleotide Sequence
(FASTA)
ACAAACCCAG CCGTGCCAGA TTTCCCCTCC TGGGGGAATT CCAGCTGCAG CCCACTAATG 60
GTCCCTTTCT CTCCTCTTCC CACAGTTGTC CTGCTAGATT TCGCCAAGGC TCAAGGGGAG 120
CTGGGCTGGC TCACCCAGCC CTATGGCAAA GGGTGGGACC TGCAGCAGCA CGTGCTGAAC 180
GACTCTGGGA TCTACATCTA CGCGGTGTGC AGCGTGCTGC AGGGCGAGCA GGAGAACTGG 240
CTGCGCACCA ACTGGATCTA CCGCAGCGAG GCGCAGCGCA TCTTCATCGA GCTCAAATTC 300
ACCGTCCGCG ACTGCAACAG CTTCCCTGGA GGCGGCGGCT CCTGCAAGGA GACCTTCAAC 360
CTCTTCTATG CTGAATCTGA CGTTGACTAT GGCACCAATT TCCAGAAGCG ACAGTTCAAG 420
AAGATTGACA CCATTGCTCC GGATGAGATC ACGGTGCAAG AAGACTTTGA GACGCGCAAC 480
GTCAAACTCA ACGTGGAGGT TCGCTCGGTG GGACCTCTGC GCCGGAAAGG TTTCTACCTG 540
GCTTTTCAGG ACCTGGGGGC CTGCGTGTCC CTGCTGTCTG TGCGGGTGTA CTACAAGACG 600
TGCCCAGCTG TGCTGCGGGG CCTGGCGGTG TTCCCCGAGA CGGTGGCAGG CGCTGACTCC 660
CAGCAGCTGG CGAAGGTGCA GGGTGCCTGC GTGGAGCACG CGGTGGCTGA CAGGGTGCCG 720
ATGCTGCACT GCAACATGGA TGGAGAGTGG TTGGTGCCCA TCGAGCAGTG CCAGTGCCAG 780
GCTGGCTACG AGGCGGCGGG AGAGCAATGT CAAGCATGTC CCCCCGGCAC CTTCAAGGCT 840
GAGGTGTCCC TGAGTGGCTG CCAGCCCTGC CCTGCTCACA CGCTGCCATC CTCGGCCGCC 900
GCTGACGCAT GTCCCTGCCA GGATGGGTAC TTCCGTGCCC CCACCGACCC GGCTGCCATG 960
CCCTGCACCC GTCCTCCTTC ACCCCCCCGC AGCGTCATAG CTCTTGGGCT GGGGGCCACC 1020
GTGCAGCTGC GTTGGTCGCC TCCCAGTGAC AGGGGTGGTC GGCAGGATGT CACCTACAGC 1080
ATCACCTGTG AGCAGTGCTT GTCTGAGAGT GGAGAGTGCC AGCCCTGCGA TGGGGGAATC 1140
CGCTACTCGC AGCCCCCCCA GGGGCTGGTG GGGACAGGGG TAACAGTCAC CGACCTGGAG 1200
CCCCACATCA ACTACACCTT CACCGTCGAA GCTCGAAACG GCGTCTCAGC CTTCAGCCCG 1260
CTCCGCAGCG TGGCCAGCAC CAGCATCAGC GTCAACCACA CGGAGCCGCC CCAGGTGACG 1320
TCGGTGAGCC TGAACGGACA AACAGCCACC AGCTTGGTCC TCTCCTGGAC GGTGCCACCA 1380
CGGCAGCAGA GCTGGGTCTG GAAATATGAA GTCACCTACA GCAAGAAGAC AGATGAGAAC 1440
AGCTACTCGG TGCTGCGCTG TGAGGGCACC TCTGTCACCA TCCCCAAGCT GTCCCCTGGC 1500
ACTGCCTACG TGGTGCGGGT CCAGGCGCTC ACCAAGGATG GCCATGGCGC CTTCAGCCTC 1560
GAGCATGAGT TTGAGACATT ACCTGAGGAA GCTGAGTCCA TGGCATCGGC TGCCGTCATC 1620
AGTGGCTCTG TCACCGGTGT CATCTTTGTT GTCTTCGTCC TCACTGTTCT ACTCTACGTC 1680
CTCCGGAGGA GGAGGAGGAA CTCTCCATCG CGCCAGTCCC CCGAGGATGT CTACTTCTCC 1740
AAGTCTGACC AGTTGAAGCC CCTCAAGACC TACGTTGACC CACACACCTA TGAAGACCCC 1800
AACCAAGCCA TGCTCAAGTT CACCACTGAG ATCTCGCCAT CCTCCATCAC CCGCCAGAAG 1860
GTCATCGGCG CCGCAGGAGA ATTCGGGGAG GTCTACAAGG GCACCCTGAA GCAGGGCAAG 1920
AAGGAGGTGC CGGTGGCCAT CAAGACGCTC AAGGTGGGCT ACACGGAGAA GCAGCGTGTG 1980
GACTTCCTGA GTGAGGCCAG CATCATGGGG CAGTTCTGTC ACCACAACAT CATCCGCCTC 2040
GAGGGGTCGT CTCTAACAGA CAAACCCTTC ATGATCGTCA CAGAGTACAT GGAAAACGGC 2100
GCGTTGGACA AATTCCTGCG GGAAAAAGAT GGGCAGTTCT GCGTCATCCA GCTGGTGGGC 2160
ATGCTGCGGG GCATCGCAGC GGGCATGAAG TACTTGGCCA ACATGAACTA CGTGCACCGG 2220
GACTTGGCTG CACGCAACAT CCTGGTCAAC AGCAACCTGG TCTGCAAGGT GTCCGACTTT 2280
GGGCTGTCGA GGGTGCTGGA GGATGACCCC GAAGCCACCT ATACCACCAG TGTA 2334
Domain Profile
S: 2     kiekviGa.GefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         + +kviGa GefGev++G+lk+ gk+e++vaiktlk g+tekqr+dflseasi+Gqf h+
Q: 617   TRQKVIGAaGEFGEVYKGTLKQ-GKKEVPVAIKTLKVGYTEKQRVDFLSEASIMGQFCHH  675
         6789**9549**********96.7************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleG     kp mivteymengald+flr+kdgqf viqlvgmlrGia+gmkyl++m
Q: 676   NIIRLEGSSLTDKPFMIVTEYMENGALDKFLREKDGQFCVIQLVGMLRGIAAGMKYLANM  735
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaaytts  162
         +yvhrdlaarnilvnsnlvckvsdfGlsrvledd+ea+ytts
Q: 736   NYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTS  777
         ****************************************96
Domain Sequence
(FASTA)
TRQKVIGAAG EFGEVYKGTL KQGKKEVPVA IKTLKVGYTE KQRVDFLSEA SIMGQFCHHN 60
IIRLEGSSLT DKPFMIVTEY MENGALDKFL REKDGQFCVI QLVGMLRGIA AGMKYLANMN 120
YVHRDLAARN ILVNSNLVCK VSDFGLSRVL EDDPEATYTT S 161
KeywordATP-binding; Complete proteome; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00009
EKS-ANC-00009
EKS-BOT-00008
EKS-CAF-00010
EKS-CAP-00007
EKS-EQC-00010
EKS-FEC-00007
EKS-HOS-00011
EKS-ICT-00009
EKS-LOA-00010
EKS-MAM-00009
EKS-MAE-00001
EKS-MUM-00010
EKS-MUP-00010
EKS-MYL-00011
EKS-NOL-00009
EKS-OCP-00002
EKS-ORA-00008
EKS-ORC-00009
EKS-OTG-00010
EKS-PAT-00012
EKS-PES-00008
EKS-POA-00010
EKS-RAN-00009
EKS-SAH-00008
EKS-SUS-00007
Gene Ontology
GO:0005925; C:focal adhesion
GO:0005887; C:integral to plasma membrane
GO:0031256; C:leading edge membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
GO:0032863; P:activation of Rac GTPase activity
GO:0006915; P:apoptotic process
GO:0060326; P:cell chemotaxis
GO:0051898; P:negative regulation of protein kinase B signaling cascade
GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane
GO:0043491; P:protein kinase B signaling cascade
GO:0045765; P:regulation of angiogenesis
GO:0043535; P:regulation of blood vessel endothelial cell migration
GO:0033628; P:regulation of cell adhesion mediated by integrin
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0010591; P:regulation of lamellipodium assembly
GO:0070848; P:response to growth factor stimulus
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR019931; LPXTG-motif_cell_wall_anchor.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS50847; GRAM_POS_ANCHORING; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013