EKS-MEG-00014

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00014

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	531.8	2.2E-160	969	1236	268

Status

Unreviewed

Ensembl Protein

ENSMGAP00000005159

UniProt Accession

G1N117;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

INSR

Gene Synonyms/Alias

INSR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000005184	ENSMGAP00000005159	ENSMGAT00000005890

Organism

Meleagris gallopavo

Functional Description

Protein Length

1328

Protein Sequence
(FASTA)

VCRSMDIRNN LTRLSLLENC TVIEGHLQIL LMFKTKPEDF RELSFPKLTM ITDYLLLFRV 60

YGLESLKGLF PNLTVIRGTH LFFNYALVIF EMVHLKEIGL YNLMNITRGA VRIEKNNELC 120

YLSTIDWSRI LDSVEDNYII ANKDDKEECG DVCPGTVKGK SSCPPTVING IFIERCWTHD 180

RCQRVCPPAC KSQGCTSDGQ CCHSECLGDC TEPNNAERCV ACRNFYLDGR CVETCPPGHY 240

RFEGWRCVTF SFCQELHNKC KSARESGCHV IHNNECVHEC PSGYIMNSSN LHCTPCAGPC 300

PKVCDYGKEK TIDSVTSAQE LRGCTVVNGS LVINIRGGNN IAAELEANLG LIEEISGYLK 360

IRRSYALVSL SFFRKLHLIR GETLEAGNYS FYALDNQNLR QLWDWSKHNL TIARGKLFFH 420

YNPKLCLSEI HKMEEISGTK GRQERNDIAL KTNGDQASCE NELLKFSSIR TSHDKILLKW 480

EPYWPPDFRD LLGFMLFYKE APYQNVTEFD GQDACGSNSW TVVDVDPPPR SNEPKAQAQP 540

GWLLRGLKPW TQYAVFVKTL VTFSDERRTY GAKSEIIYVQ TNATVPSVPL DPISVSNSSS 600

QIILKWKPPS EPNGNITHYL VFWQQQAEDS ELYELDYCLK GLKLPSRTWS PPFESEDPQK 660

YNQSESEDVS GECCSCPKTD SQIQKELEES AFRKTFENYL HNEVFVPRPS RKRRDLGSIA 720

NATVVIPTIP SSPNSSAAAS ESAEEQKPFE KVKFKESLVI SGLRHFTGYR IELHACNHDA 780

QESRCSVAAY VSARTMPEAK ADDIVGPVTH ELVEKNTVHL KWQEPKEPNG LIVLYEVNYG 840

RLGEAEEAHF CVSRKHFASE QGCKLRGLQP GNYSVRIRAT SLAGNGSWTE PTYFYVADYL 900

NAQPNIAVII VPIIFAIIIA GIIGAAYVLV KKRQTEGPTG PLYASSNPEY LSASDVYVPD 960

EWEVPREKIT LLRELGQGSF GMVYEGIAKD IVKGELETRV AVKTVNESAS LRERIEFLNE 1020

ASVMKGFSCH HVVRLLGVVS KGQPTLVVME LMAHGDLKSY LRSLRPDAEN NPGRPPPTLR 1080

EMIQMAAEIA DGMAYLNAKK FVHRDLAARN CMVAEDFTVK IGDFGMTRDI YETDYYRKGG 1140

KGLLPVRWMA PESLKDGVFT TYSDVWSFGV VLWEISSLAE QPYQGLSNEQ VLKFVMDGGY 1200

LDQPDNCPER LHNLMQMCWQ YNPKMRPTFI EVIEMLKEDL HPSFQEVSFF YSEENKPLET 1260

EEYEMDFENM ESIPLDPSSY TQRDKALGRD NGPSMALKGN YEEHIPYTHM NGGKKNGRIL 1320

SMPRSSPS 1328

Nucleotide Sequence
(FASTA)

GTTTGCAGAA GCATGGACAT CCGCAACAAC CTGACCCGGC TGAGCTTGCT GGAGAACTGC 60

ACGGTGATTG AGGGCCACTT GCAAATACTG CTGATGTTTA AAACCAAGCC TGAAGATTTC 120

CGCGAGCTCA GCTTCCCCAA ACTGACTATG ATTACAGACT ACTTGCTTCT GTTCCGTGTG 180

TACGGCCTGG AGAGCTTAAA GGGCCTCTTC CCCAACCTCA CGGTGATCCG AGGAACCCAT 240

CTGTTCTTTA ACTACGCGCT GGTCATCTTC GAGATGGTTC ACCTGAAGGA GATCGGCCTC 300

TACAACCTGA TGAACATCAC GCGCGGCGCC GTGCGCATCG AGAAGAACAA CGAGCTGTGC 360

TACCTGTCCA CCATCGACTG GTCGAGGATT TTGGACTCCG TCGAGGACAA CTACATCATC 420

GCCAACAAGG ACGACAAGGA GGAGTGCGGA GATGTGTGTC CAGGAACCGT GAAAGGGAAA 480

AGCAGCTGCC CGCCCACCGT CATCAACGGC ATCTTCATCG AGCGCTGCTG GACCCACGAC 540

CGCTGCCAGA GAGTTTGCCC ACCCGCCTGC AAGTCCCAGG GCTGCACGTC GGACGGGCAG 600

TGCTGTCACA GCGAGTGCCT CGGGGACTGC ACCGAGCCCA ACAACGCGGA GCGCTGCGTG 660

GCGTGCCGCA ACTTCTACCT GGACGGGAGG TGCGTGGAGA CGTGCCCACC TGGGCACTAC 720

CGCTTCGAGG GCTGGCGCTG CGTCACCTTC AGCTTCTGCC AGGAGCTGCA CAACAAGTGC 780

AAGAGCGCCC GCGAGTCGGG CTGCCACGTC ATCCACAACA ACGAGTGCGT CCACGAGTGC 840

CCGTCGGGGT ACATCATGAA TTCCAGCAAC TTGCACTGCA CTCCTTGTGC AGGGCCCTGT 900

CCAAAGGTTT GTGACTATGG GAAAGAGAAG ACTATTGATT CGGTGACGTC GGCACAGGAG 960

CTCCGTGGCT GCACAGTTGT TAATGGAAGC TTGGTTATAA ATATCCGTGG AGGAAATAAC 1020

ATAGCAGCTG AGCTAGAAGC GAATCTTGGC TTGATAGAAG AAATCTCAGG TTACCTAAAA 1080

ATCCGCCGGT CTTATGCCTT GGTTTCTCTT TCTTTTTTTC GTAAACTACA TCTGATTAGA 1140

GGAGAAACAT TAGAAGCTGG AAATTATTCA TTCTATGCCT TGGACAACCA GAATCTTCGC 1200

CAGCTCTGGG ACTGGAGTAA ACACAACCTC ACGATAGCAC GAGGCAAACT CTTCTTCCAT 1260

TATAATCCCA AACTGTGTCT GTCAGAAATC CACAAGATGG AGGAGATCTC TGGGACTAAG 1320

GGGCGTCAGG AGAGGAACGA CATCGCCCTG AAGACAAACG GTGACCAAGC TTCATGTGAG 1380

AACGAATTGC TGAAGTTCTC TTCCATCAGA ACATCTCATG ACAAGATCCT ATTGAAGTGG 1440

GAGCCATATT GGCCTCCTGA TTTCCGTGAC CTCCTGGGAT TTATGCTCTT TTACAAAGAG 1500

GCTCCATACC AAAACGTGAC GGAGTTTGAT GGGCAGGATG CCTGCGGCTC CAACAGCTGG 1560

ACAGTGGTGG ACGTGGACCC ACCGCCGCGG TCCAACGAGC CCAAAGCCCA GGCCCAGCCA 1620

GGCTGGCTGC TGCGGGGCCT GAAGCCATGG ACACAGTATG CTGTGTTTGT TAAAACTCTG 1680

GTCACCTTCT CAGATGAACG AAGGACATAC GGTGCGAAGA GTGAGATCAT CTACGTCCAG 1740

ACCAACGCTA CAGTTCCGTC AGTCCCGTTA GATCCAATTT CTGTTTCCAA CTCTTCATCC 1800

CAAATCATCC TGAAGTGGAA GCCGCCCTCA GAGCCCAATG GCAACATCAC GCACTACCTG 1860

GTGTTCTGGC AGCAGCAGGC AGAAGACAGT GAGCTTTATG AACTCGATTA CTGCTTAAAG 1920

GGATTAAAAC TGCCCTCAAG GACGTGGTCT CCTCCTTTTG AATCTGAAGA TCCTCAGAAG 1980

TATAACCAAA GTGAAAGTGA GGATGTCAGT GGAGAATGTT GTTCCTGTCC TAAAACCGAC 2040

TCTCAGATCC AGAAGGAGCT GGAGGAGTCT GCTTTCCGCA AGACCTTTGA GAACTACCTT 2100

CACAATGAGG TGTTCGTCCC CAGGCCATCA AGGAAGAGAA GAGACCTGGG CTCCATAGCA 2160

AATGCCACCG TGGTGATCCC CACCATCCCG TCCTCTCCAA ACTCTTCTGC AGCCGCATCT 2220

GAGAGTGCTG AGGAACAGAA ACCTTTTGAA AAAGTGAAGT TCAAGGAGTC CCTGGTGATC 2280

TCCGGGCTGC GGCACTTCAC AGGATATCGC ATTGAGCTCC ATGCCTGTAA CCACGATGCT 2340

CAGGAGTCCC GGTGCAGCGT TGCAGCTTAC GTCAGTGCCA GGACCATGCC AGAAGCTAAG 2400

GCAGATGACA TCGTTGGTCC AGTCACCCAT GAACTGGTTG AAAAAAACAC CGTGCATTTG 2460

AAGTGGCAGG AACCCAAGGA GCCAAATGGC CTTATTGTGC TGTATGAAGT GAATTACGGC 2520

CGTCTGGGGG AAGCAGAGGA AGCGCACTTC TGCGTGTCCC GAAAGCACTT TGCCAGCGAG 2580

CAGGGCTGCA AACTGCGTGG GCTGCAGCCT GGAAACTACA GCGTGCGGAT CCGAGCGACG 2640

TCGCTGGCTG GGAACGGCTC CTGGACAGAG CCCACCTACT TCTATGTGGC TGATTACTTG 2700

AACGCTCAGC CTAACATTGC TGTTATAATT GTTCCGATTA TTTTTGCCAT AATCATTGCT 2760

GGAATTATTG GAGCTGCTTA CGTGCTCGTG AAAAAGAGAC AAACTGAAGG ACCAACGGGG 2820

CCACTCTACG CGTCCTCTAA CCCCGAATAC CTCAGTGCCA GTGATGTGTA CGTTCCTGAT 2880

GAGTGGGAGG TCCCACGGGA AAAGATCACT CTGCTCCGTG AGCTGGGCCA GGGCTCGTTT 2940

GGAATGGTGT ACGAGGGGAT TGCCAAGGAC ATCGTGAAGG GAGAGCTGGA GACCCGCGTG 3000

GCTGTGAAAA CGGTGAACGA GTCGGCCAGC CTGCGGGAGC GCATTGAGTT CCTCAACGAA 3060

GCCTCTGTGA TGAAAGGCTT CAGCTGCCAT CACGTGGTTC GCCTCCTCGG GGTGGTCTCC 3120

AAGGGCCAAC CCACGCTGGT GGTCATGGAG TTAATGGCAC ATGGGGACTT GAAAAGCTAC 3180

CTCCGCTCTC TGAGACCCGA TGCTGAGAAT AACCCTGGTC GTCCACCACC GACGCTGAGA 3240

GAAATGATCC AGATGGCTGC AGAGATCGCC GATGGCATGG CCTACCTGAA TGCCAAAAAG 3300

TTTGTTCACA GAGATCTGGC AGCTCGGAAC TGCATGGTTG CAGAGGACTT CACTGTAAAA 3360

ATTGGAGACT TCGGCATGAC CAGAGATATC TACGAGACGG ATTATTACCG AAAGGGCGGC 3420

AAAGGACTTC TGCCTGTGCG CTGGATGGCG CCCGAATCGT TGAAGGACGG CGTGTTCACA 3480

ACCTACTCAG ATGTGTGGTC ATTTGGTGTT GTCCTCTGGG AGATAAGCAG CTTAGCAGAG 3540

CAGCCGTATC AGGGACTCTC CAACGAACAG GTGCTGAAGT TTGTGATGGA TGGAGGATAC 3600

CTGGATCAGC CGGACAACTG CCCGGAGAGG CTGCACAACC TGATGCAGAT GTGCTGGCAG 3660

TACAACCCCA AGATGCGCCC CACCTTCATT GAGGTCATCG AGATGCTGAA GGAGGATTTG 3720

CACCCCAGCT TCCAAGAGGT TTCCTTCTTC TACAGCGAGG AGAACAAACC TCTGGAAACA 3780

GAGGAGTATG AGATGGACTT CGAGAACATG GAGAGCATCC CCCTCGATCC CTCCTCGTAC 3840

ACACAGAGGG ACAAAGCCCT GGGGAGGGAC AATGGGCCCT CCATGGCCCT CAAGGGGAAC 3900

TACGAGGAGC ACATACCTTA CACTCACATG AACGGTGGCA AGAAGAACGG GCGGATCCTC 3960

TCCATGCCCA GGTCGAGTCC TTCCTAA 3987

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+llrelGqGsfGmvyeG+akd+vkge etrva+ktvne+as reriefl+easvmk f+

Q: 969   ITLLRELGQGSFGMVYEGIAKDIVKGELETRVAVKTVNESASLRERIEFLNEASVMKGFS  1028

         789*********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvskgqp+lvvmelm++Gdlksylrslrp++en+++++pp+l ++iqmaae

Q: 1029  CHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPDAENNPGRPPPTLREMIQMAAE  1088

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+akkfvhrdlaarncmvaed+tvkiGdfGmtrdiyetdyyrkggkgllpvrw

Q: 1089  IADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1148

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         m+peslkdGvft+ sdvwsfGvvlwei +laeqpyqGlsneqvlkfv+dgg+l++p+ncp

Q: 1149  MAPESLKDGVFTTYSDVWSFGVVLWEISSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCP  1208

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

         e+l++lm++cwqynpk+rp+f+e++e+l

Q: 1209  ERLHNLMQMCWQYNPKMRPTFIEVIEML  1236

         *************************975

Domain Sequence
(FASTA)

ITLLRELGQG SFGMVYEGIA KDIVKGELET RVAVKTVNES ASLRERIEFL NEASVMKGFS 60

CHHVVRLLGV VSKGQPTLVV MELMAHGDLK SYLRSLRPDA ENNPGRPPPT LREMIQMAAE 120

IADGMAYLNA KKFVHRDLAA RNCMVAEDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180

MAPESLKDGV FTTYSDVWSF GVVLWEISSL AEQPYQGLSN EQVLKFVMDG GYLDQPDNCP 240

ERLHNLMQMC WQYNPKMRPT FIEVIEML 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0005899	; C:insulin receptor complex
GO:0005524	; F:ATP binding
GO:0005525	; F:GTP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0032148	; P:activation of protein kinase B activity
GO:0071363	; P:cellular response to growth factor stimulus
GO:0007186	; P:G-protein coupled receptor signaling pathway
GO:0008286	; P:insulin receptor signaling pathway
GO:0030335	; P:positive regulation of cell migration
GO:0048639	; P:positive regulation of developmental growth
GO:0045740	; P:positive regulation of DNA replication
GO:0045725	; P:positive regulation of glycogen biosynthetic process
GO:0045821	; P:positive regulation of glycolysis
GO:0043410	; P:positive regulation of MAPK cascade
GO:0045840	; P:positive regulation of mitosis
GO:0045429	; P:positive regulation of nitric oxide biosynthetic process
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0060267	; P:positive regulation of respiratory burst
GO:0046777	; P:protein autophosphorylation
GO:0045995	; P:regulation of embryonic development
GO:0006355	; P:regulation of transcription, DNA-dependent

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 2.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013