EKS-MEG-00085
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00085
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec448.54.5E-135366616251
StatusUnreviewed
Ensembl ProteinENSMGAP00000005140
UniProt AccessionG1N100;
Protein Name
Protein Synonyms/Alias
Gene NameITK
Gene Synonyms/Alias ITK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000005218ENSMGAP00000005140ENSMGAT00000005871
OrganismMeleagris gallopavo
Functional Description
Protein Length623
Protein Sequence
(FASTA)
MNNCVLLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKSKLAY YEHRHGKKKT LKGSVELSRI 60
KCVEIVKSDI IIPCQYKYPF QIVHDNYILY VFAPNRESRQ RWVFTLKEET RSNNSLVSKY 120
HPDFWIDGKW RCCAQTEKMA VGCIEYDPTK TASKKPLPPT PEDNWKSLLN TKETLVMAIY 180
DYEAQNPQEL TLQYNEEYHV IDSSEEHWWL IQDKNGHEGY VPSSYLAEKS PDNLQIYEWY 240
NKNISRSKAE MLLRDEGREG AFMVRDSRQP GMYTVSVFTK ALSTDNNPVI KHYHINETTD 300
FPKRYYLAEK HVFDCIPELI NYHQHNAGGL VTRLRYAVSS WKKKAPITAG LSYESTGKLV 360
INPSELTRVQ EIGSGQFGVV YLGYWLEKTK VAIKTIREGA MSEEDFIEEA KVLMKLSHPK 420
LVQLYGVCFE NTPICLVFEF MEHGCLSDYL RSQRGSFSKE TLLGMCLDVC EGMAYLEQNS 480
VIHRDLAARN CLVGESHVVK VSDFGMSRIV LDDQYTSSTG TKFPVKWSAP EVFSYSNYST 540
KSDVWSFGVL MWEVFSEGKM PYENRTNGEV VEEINAGFRL YKPKLASKSI YEVMSHCWSM 600
RKEDRPSFSL LLYQLSEISE FDL 623
Nucleotide Sequence
(FASTA)
ATGAATAACT GTGTGCTCCT GGAAGAGCAG CTGATCAAAA AATCTCAGCA GAAGAGAAGA 60
ACTTCACCCT CCAACTTTAA AGTGCGCTTC TTTGTCTTAA CCAAATCTAA GCTGGCTTAC 120
TATGAACATC GCCATGGGAA AAAAAAGACT TTGAAGGGTT CTGTGGAACT TTCCAGGATT 180
AAATGTGTAG AAATTGTGAA AAGTGACATC ATCATCCCCT GCCAATATAA ATATCCTTTC 240
CAGATTGTCC ATGATAACTA CATCCTCTAC GTGTTCGCAC CCAACCGTGA GAGCCGGCAG 300
AGATGGGTCT TTACACTGAA GGAAGAAACC AGGAGCAACA ACAGTTTGGT CTCAAAGTAT 360
CATCCAGATT TCTGGATAGA TGGCAAGTGG AGATGCTGTG CTCAGACAGA GAAGATGGCA 420
GTTGGCTGTA TAGAGTATGA CCCCACCAAA ACTGCCTCAA AGAAGCCTCT TCCTCCAACT 480
CCTGAAGATA ACTGGAAATC ACTGCTAAAC ACAAAGGAAA CCTTAGTCAT GGCCATATAC 540
GACTATGAAG CCCAGAATCC GCAGGAGCTG ACGTTACAGT ACAATGAGGA ATATCATGTG 600
ATTGACAGCT CTGAGGAACA TTGGTGGCTG ATTCAAGATA AGAATGGGCA TGAAGGCTAT 660
GTGCCAAGTA GCTACCTGGC GGAAAAATCA CCCGATAACC TGCAAATATA TGAATGGTAC 720
AATAAGAACA TCAGCAGAAG CAAAGCAGAA ATGCTCCTCA GGGATGAGGG TAGAGAAGGT 780
GCCTTCATGG TGAGAGATTC GAGGCAGCCT GGCATGTACA CAGTCTCTGT TTTCACCAAA 840
GCATTGAGTA CGGATAACAA CCCTGTTATA AAACATTACC ACATCAATGA GACAACTGAC 900
TTTCCCAAGA GATACTATTT GGCAGAAAAA CACGTCTTCG ACTGCATCCC TGAACTCATC 960
AACTACCACC AGCACAATGC AGGAGGTCTT GTTACTCGTT TGCGGTATGC AGTGTCTTCT 1020
TGGAAGAAAA AGGCCCCAAT CACTGCAGGG CTGAGCTATG AATCAACAGG AAAATTGGTC 1080
ATTAATCCCT CTGAGCTCAC CCGTGTTCAG GAAATAGGCA GTGGTCAGTT TGGGGTGGTT 1140
TACCTTGGCT ACTGGTTGGA GAAGACAAAA GTTGCCATAA AGACCATTCG TGAAGGAGCG 1200
ATGTCTGAAG AGGATTTCAT CGAGGAGGCT AAGGTCTTGA TGAAGCTGTC TCACCCCAAA 1260
CTAGTTCAGC TTTATGGAGT GTGCTTTGAG AACACTCCCA TATGCCTGGT GTTTGAGTTC 1320
ATGGAGCATG GCTGCTTGTC TGACTACCTC AGGAGCCAGC GGGGCAGTTT TTCAAAAGAA 1380
ACCCTCCTGG GAATGTGCCT AGATGTGTGC GAAGGAATGG CTTATCTGGA ACAAAATTCT 1440
GTCATCCACA GAGACCTGGC TGCTAGGAAC TGCCTGGTGG GGGAATCTCA TGTGGTCAAA 1500
GTGTCTGACT TTGGGATGTC AAGGATTGTT CTTGACGATC AGTATACCAG CTCCACAGGG 1560
ACCAAGTTTC CAGTTAAATG GTCTGCCCCA GAGGTTTTCT CCTACAGTAA CTACAGCACC 1620
AAATCAGATG TTTGGTCATT TGGAGTGCTG ATGTGGGAGG TCTTCAGCGA AGGCAAAATG 1680
CCCTATGAGA ATCGCACCAA TGGAGAAGTG GTGGAAGAAA TCAATGCAGG GTTTCGGCTC 1740
TACAAGCCCA AGTTGGCCTC CAAGTCTATT TATGAGGTGA TGAGCCACTG CTGGAGCATG 1800
AGGAAAGAAG ACCGCCCATC CTTTTCTCTT CTGCTTTATC AGCTGAGTGA AATCTCTGAG 1860
TTTGATCTGT AA 1872
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt ++e+gsgqfgvv lg+w +k++vaik+i+egamseedfieeakv+mklshpklvqly
Q: 366   LTRVQEIGSGQFGVVYLGYWLEKTKVAIKTIREGAMSEEDFIEEAKVLMKLSHPKLVQLY  425
         5779********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc +++pi++v+e++e+gcl++ylr+++++++ke+ll mc dvcegm+yle++s+ihrd
Q: 426   GVCFENTPICLVFEFMEHGCLSDYLRSQRGSFSKETLLGMCLDVCEGMAYLEQNSVIHRD  485
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+e++vvkvsdfg++r vlddqy+ss+g+kfpvkws+pev+sys+ys+ksdvw
Q: 486   LAARNCLVGESHVVKVSDFGMSRIVLDDQYTSSTGTKFPVKWSAPEVFSYSNYSTKSDVW  545
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevfsegk+pye+++n evve+++ g+rly+pklask++yevm +cw+ + e+r
Q: 546   SFGVLMWEVFSEGKMPYENRTNGEVVEEINAGFRLYKPKLASKSIYEVMSHCWSMRKEDR  605
         ************************************************************
S: 241   ptfkellsale  251
         p+f+ ll +l+
Q: 606   PSFSLLLYQLS  616
         *******9885
Domain Sequence
(FASTA)
LTRVQEIGSG QFGVVYLGYW LEKTKVAIKT IREGAMSEED FIEEAKVLMK LSHPKLVQLY 60
GVCFENTPIC LVFEFMEHGC LSDYLRSQRG SFSKETLLGM CLDVCEGMAY LEQNSVIHRD 120
LAARNCLVGE SHVVKVSDFG MSRIVLDDQY TSSTGTKFPV KWSAPEVFSY SNYSTKSDVW 180
SFGVLMWEVF SEGKMPYENR TNGEVVEEIN AGFRLYKPKL ASKSIYEVMS HCWSMRKEDR 240
PSFSLLLYQL S 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00101
EKS-ANC-00099
EKS-BOT-00110
EKS-CAJ-00111
EKS-CAF-00112
EKS-CAP-00105
EKS-CIS-00119
EKS-DAR-00357
EKS-EQC-00108
EKS-FEC-00105
EKS-GAG-00090
EKS-GAA-00128
EKS-GOG-00111
EKS-HOS-00113
EKS-ICT-00105
EKS-LAC-00114
EKS-LOA-00106
EKS-MAM-00105
EKS-MOD-00106
EKS-MUM-00112
EKS-MUP-00113
EKS-MYL-00124
EKS-NOL-00103
EKS-OCP-00072
EKS-ORA-00089
EKS-ORC-00102
EKS-ORL-00125
EKS-OTG-00112
EKS-PAT-00100
EKS-PES-00093
EKS-POA-00103
EKS-RAN-00108
EKS-SAH-00102
EKS-TAG-00138
EKS-TAR-00137
EKS-TEN-00127
EKS-XET-00091
EKS-XIM-00129
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543; F:phospholipid binding
GO:0007202; P:activation of phospholipase C activity
GO:0002250; P:adaptive immune response
GO:0035556; P:intracellular signal transduction
GO:0050852; P:T cell receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR013315; Spectrin_alpha_SH3.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR01887; SPECTRNALPHA.
PR00109; TYRKINASE.
Created Date20-Feb-2013