EKS-MEG-00027
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00027
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak293.31.5E-878021043242
StatusUnreviewed
Ensembl ProteinENSMGAP00000005183
UniProt AccessionG1N138;
Protein Name
Protein Synonyms/Alias
Gene NameJAK2
Gene Synonyms/Alias JAK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000005291ENSMGAP00000005183ENSMGAT00000005914
OrganismMeleagris gallopavo
Functional Description
Protein Length1053
Protein Sequence
(FASTA)
GIMPVYHNMF ALMSETDRVW YPPNHIFHVD EATRLMLLYR IRFYFPHWYC NGTSRAYRYG 60
IIRGSESPVL DDLVMSYLFA QWTGQQIHVW VLVRRICQTT FNSCGPAQLD NMPLLRDCGI 120
LPFLYPNQIL LRTFLDMCFW WVFLDFRFNI HMAVRLSATV FISMFNLLIS TCQNIKVITV 180
LCTSNLVCSI LSEEFVTSLP SELAEKTEMV FTICLIASLG MKSSLQQHTQ FIRSLNLFLR 240
IELLFVAVLY LELKQKLITS TNWSVLINKF SGDLSEAEFQ SLREALSFVS LIDGYYRLTA 300
DAHHYLCKEV APPSVLENIQ SNCHGPIFMD FAINKLKKAG NQTGFYVLRC SPKDFKKYFL 360
TFAIERITGT EYMPQNQKRQ RKESLIVLGF GMQLFKLFQI IWCLLCQHVL RISAIITQSH 420
SSIDLVPREK VAYMAFLTSS AESYQIYSTL PQVPSCFLSM IFGDLLMEES LGQGTFTKIF 480
KGIRKEVGDY GQLHQTEVLL KVLDKVHRNY SEKSLFFHVV SYSSSKIGDY KHLRIMLLCT 540
VLCLPEDILV QEYVKFGSLD TYLKKNKNVI NILWKLEVAK QLALAMHFLE DKGLVHGNVC 600
AKNILLIREE DRKSGNLPFI KLSDPGISIT VLPRDILLER IPWVPPECIE NPKQLSLATD 660
KWSFGTTLWE ICSGGDKPLS ALDSSRKLQF YEDRHQLPAP NWTELANLIN NCMDYEPDFR 720
PSFRAIIRDL NSLFTPDYEL LTENDMLPNI RTGALGFSGA FEDRDPTQFE ERHLKFLQQL 780
GKRKVFYVES IHQERLNISS AELHHSTEEH LRDFEREIEI LKSLQHDNIV KYKGVCYSAV 840
KGRRNLRLIM EYLPYGSLRD YLQKHKERLD HKKLLLYASQ ICKGMEYLGT KRYVHRDLAT 900
RNILVENENR VKIGDFGLTK VLPQDKEYYK VKEPGESPIF WYAPESLTES KFSVASDVWS 960
FGVVLYELFT YIEKSKSPPA EFMRMIGNDK QGQMIVFHLI ELLKNNGRLP RPDGCPDEIY 1020
AIMKECWNNN VTQRPTFRDL AQRVDQIRDN MGG 1053
Nucleotide Sequence
(FASTA)
GGTATCATGC CGGTCTATCA TAATATGTTT GCACTCATGA GTGAAACAGA TAGAGTTTGG 60
TATCCTCCAA ATCACATTTT CCACGTAGAT GAAGCAACCA GACTAATGCT ACTGTACCGG 120
ATAAGGTTTT ATTTTCCCCA CTGGTATTGC AATGGCACAA GCAGAGCATA TCGCTATGGC 180
ATTATTCGGG GTTCAGAAAG CCCTGTTCTT GATGATCTTG TCATGTCTTA CCTATTTGCA 240
CAGTGGACTG GGCAACAAAT ACATGTGTGG GTACTTGTTA GAAGGATTTG TCAAACCACA 300
TTCAATTCAT GTGGGCCTGC TCAGTTGGAC AATATGCCAC TGTTGAGAGA TTGTGGTATA 360
TTACCTTTTT TATACCCAAA TCAAATATTA CTAAGAACAT TCTTGGACAT GTGTTTTTGG 420
TGGGTGTTCT TGGACTTCCG TTTTAATATT CATATGGCTG TAAGACTCTC AGCTACAGTA 480
TTTATAAGTA TGTTTAATCT TCTCATATCA ACTTGCCAGA ATATTAAAGT AATTACGGTC 540
TTGTGTACAT CAAACTTAGT ATGTTCAATA TTGTCAGAGG AATTTGTAAC TTCATTACCT 600
TCTGAATTGG CGGAAAAGAC TGAAATGGTT TTTACAATCT GTTTAATAGC CTCGCTAGGA 660
ATGAAAAGCT CCCTGCAGCA ACATACTCAA TTTATAAGAA GTTTAAACTT GTTCTTAAGG 720
ATTGAATTGC TTTTTGTTGC AGTTTTATAC CTAGAGCTGA AGCAGAAACT GATTACTTCA 780
ACAAATTGGA GTGTACTGAT AAACAAATTT AGTGGAGACT TGTCAGAGGC TGAATTTCAG 840
TCTTTAAGAG AAGCACTCTC CTTTGTATCG TTAATTGATG GATATTACAG ATTAACTGCA 900
GATGCCCACC ATTATCTCTG CAAAGAAGTA GCACCACCAT CAGTGCTTGA AAATATACAA 960
AGCAATTGCC ATGGACCAAT TTTCATGGAC TTTGCTATCA ATAAACTGAA GAAGGCAGGT 1020
AATCAGACTG GCTTCTACGT TCTTCGTTGC AGTCCTAAAG ATTTTAAAAA ATACTTCCTC 1080
ACATTTGCTA TTGAGAGAAT CACTGGCACA GAATATATGC CCCAAAATCA AAAAAGGCAG 1140
AGGAAAGAGA GTTTGATAGT TTTGGGGTTT GGAATGCAAC TGTTCAAACT ATTCCAGATT 1200
ATCTGGTGCT TGTTATGTCA GCATGTCTTG AGGATATCTG CTATAATTAC ACAATCTCAT 1260
TCCAGTATTG ATCTTGTTCC AAGGGAAAAA GTAGCATACA TGGCTTTTCT TACTAGTTCT 1320
GCAGAAAGCT ATCAGATTTA CTCAACACTG CCGCAAGTTC CTTCATGTTT TCTCAGCATG 1380
ATATTTGGAG ATTTGTTAAT GGAAGAGAGT CTTGGACAGG GCACATTTAC AAAGATTTTC 1440
AAAGGTATAA GGAAAGAAGT GGGAGACTAT GGCCAGCTCC ATCAAACTGA AGTTCTTTTA 1500
AAGGTTCTGG ATAAAGTCCA TAGAAACTAC TCTGAGAAAT CTCTTTTTTT TCATGTAGTG 1560
TCTTATTCTT CCAGTAAAAT TGGAGATTAT AAGCACCTAA GAATCATGTT ACTATGTACA 1620
GTGCTATGCT TACCAGAAGA TATCCTTGTA CAAGAATATG TGAAATTTGG ATCTTTGGAC 1680
ACATATTTGA AAAAGAACAA AAATGTTATT AATATCTTGT GGAAACTGGA AGTTGCCAAA 1740
CAGTTGGCAT TAGCCATGCA TTTTCTGGAG GATAAAGGCC TTGTTCATGG GAATGTCTGT 1800
GCAAAGAACA TCTTGCTTAT CAGGGAGGAG GACAGGAAGT CTGGAAACCT TCCTTTTATA 1860
AAACTAAGTG ATCCTGGCAT CAGTATCACA GTTTTGCCAA GAGACATTCT TCTTGAGAGA 1920
ATACCATGGG TTCCACCTGA ATGTATTGAG AACCCCAAAC AACTAAGCCT AGCTACAGAT 1980
AAGTGGAGTT TTGGTACCAC TTTATGGGAA ATCTGCAGTG GAGGAGATAA ACCTCTGAGC 2040
GCTCTCGATT CTTCAAGAAA ACTACAGTTT TATGAAGATA GACACCAGCT TCCTGCCCCC 2100
AACTGGACAG AGCTAGCAAA TCTTATAAAC AACTGTATGG ATTATGAGCC AGATTTCAGG 2160
CCATCATTTA GGGCAATTAT ACGTGACTTG AACAGTTTGT TCACTCCTGA TTATGAGTTA 2220
CTGACAGAAA ATGATATGTT GCCGAATATA CGAACTGGAG CTCTTGGATT TTCTGGGGCC 2280
TTTGAAGATC GGGACCCAAC ACAATTTGAA GAGAGACATC TTAAGTTTTT ACAGCAACTT 2340
GGCAAAAGAA AGGTTTTTTA TGTTGAATCC ATTCACCAGG AGAGGCTTAA TATTTCCAGT 2400
GCAGAGCTGC ATCATAGTAC AGAGGAGCAC CTTAGGGACT TTGAAAGAGA AATTGAAATA 2460
CTTAAATCTC TGCAGCATGA TAACATTGTT AAATATAAAG GAGTTTGCTA CAGTGCAGTA 2520
AAAGGTCGTA GGAATCTGAG GTTAATTATG GAATATCTAC CGTATGGAAG TTTACGGGAT 2580
TATCTGCAGA AACACAAAGA GAGATTGGAT CACAAAAAGC TTTTACTATA TGCATCTCAG 2640
ATATGCAAGG GCATGGAATA TCTGGGTACA AAAAGATATG TTCACCGGGA TTTAGCAACA 2700
AGAAATATCT TAGTGGAGAA TGAGAACAGA GTTAAAATTG GAGATTTTGG ATTGACTAAA 2760
GTCTTGCCAC AAGATAAGGA GTACTACAAA GTGAAAGAAC CTGGTGAAAG CCCTATATTT 2820
TGGTATGCTC CAGAGTCTCT GACAGAGAGC AAATTTTCCG TGGCTTCAGA TGTATGGAGT 2880
TTTGGTGTGG TCTTGTATGA ACTCTTCACT TACATTGAAA AGAGCAAAAG TCCACCAGCT 2940
GAATTCATGC GCATGATTGG CAATGATAAA CAAGGGCAGA TGATTGTATT TCATTTGATA 3000
GAGCTTTTGA AGAACAATGG ACGACTTCCA AGACCAGATG GATGCCCTGA TGAGATTTAT 3060
GCTATCATGA AAGAATGTTG GAACAATAAT GTTACTCAGC GGCCCACCTT TAGGGATCTT 3120
GCTCAGCGAG TGGATCAAAT AAGGGACAAC ATGGGTGGAT GA 3162
Domain Profile
S: 35    vLkesgedisrdfkreaeilsqlshehivklkgvcvaegen....rlVmeyvesGsLdiy  90
          L++s+e++ rdf+re+eil++l+h++ivk+kgvc++  +     rl+mey+++GsL++y
Q: 802   ELHHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAVKGrrnlRLIMEYLPYGSLRDY  861
         5899******************************8765433334****************
S: 91    LrkkkealslsslldvakqlakameYLedkklvhrdvaarnvLveresnegtppfvklsd  150
         L+k+ke+l++++ll +a+q++k+meYL++k++vhrd+a+rn+Lve+e++      vk++d
Q: 862   LQKHKERLDHKKLLLYASQICKGMEYLGTKRYVHRDLATRNILVENENR------VKIGD  915
         *************************************************......*****
S: 151   pglakavnqd.eYylvreerdsripwlapeclseaknlstasdvWsFgvtlyellt.csk  208
         +gl+k+++qd eYy v+e+++s+i+w+ape+l+e+k +s+asdvWsFgv+lyel+t ++k
Q: 916   FGLTKVLPQDkEYYKVKEPGESPIFWYAPESLTESK-FSVASDVWSFGVVLYELFTyIEK  974
         ************************************.***********************
S: 209   gesp....lrsesle........rklelleekerlpkpk.cpaelaelmtnclsyepsqr  255
         ++sp    +r+++++        +++ell+++ rlp+p+ cp+e++ +m++c++++ +qr
Q: 975   SKSPpaefMRMIGNDkqgqmivfHLIELLKNNGRLPRPDgCPDEIYAIMKECWNNNVTQR  1034
         ********999999999*******************************************
S: 256   psFrailed  264
         p+Fr+++++
Q: 1035  PTFRDLAQR  1043
         *****9775
Domain Sequence
(FASTA)
ELHHSTEEHL RDFEREIEIL KSLQHDNIVK YKGVCYSAVK GRRNLRLIME YLPYGSLRDY 60
LQKHKERLDH KKLLLYASQI CKGMEYLGTK RYVHRDLATR NILVENENRV KIGDFGLTKV 120
LPQDKEYYKV KEPGESPIFW YAPESLTESK FSVASDVWSF GVVLYELFTY IEKSKSPPAE 180
FMRMIGNDKQ GQMIVFHLIE LLKNNGRLPR PDGCPDEIYA IMKECWNNNV TQRPTFRDLA 240
QR 242
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00026
EKS-ANC-00025
EKS-BOT-00031
EKS-CAJ-00030
EKS-CAF-00031
EKS-CAP-00032
EKS-DAR-00042
EKS-EQC-00028
EKS-FEC-00028
EKS-GAM-00013
EKS-GAG-00025
EKS-GAA-00046
EKS-GOG-00030
EKS-HOS-00032
EKS-ICT-00027
EKS-LAC-00033
EKS-LOA-00030
EKS-MAM-00031
EKS-MOD-00030
EKS-MUM-00032
EKS-MUP-00032
EKS-MYL-00032
EKS-NOL-00029
EKS-ORN-00046
EKS-ORA-00025
EKS-ORC-00031
EKS-ORL-00043
EKS-OTG-00031
EKS-PAT-00029
EKS-PES-00027
EKS-POA-00028
EKS-PTV-00030
EKS-RAN-00032
EKS-SAH-00029
EKS-TAG-00028
EKS-TAR-00046
EKS-TEN-00052
EKS-XET-00030
EKS-XIM-00044
Gene Ontology
GO:0005901; C:caveola
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0020037; F:heme binding
GO:0035401; F:histone kinase activity (H3-Y41 specific)
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0030154; P:cell differentiation
GO:0060396; P:growth hormone receptor signaling pathway
GO:0035722; P:interleukin-12-mediated signaling pathway
GO:0008285; P:negative regulation of cell proliferation
GO:0043392; P:negative regulation of DNA binding
GO:0010811; P:positive regulation of cell-substrate adhesion
GO:0050727; P:regulation of inflammatory response
GO:0046677; P:response to antibiotic
GO:0007262; P:STAT protein import into nucleus
GO:0033209; P:tumor necrosis factor-mediated signaling pathway
GO:0007260; P:tyrosine phosphorylation of STAT protein
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693; Tyr_kinase_non-rcpt_Jak2.
Pfam
PF07714; Pkinase_Tyr; 2.
SMARTs
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR01823; JANUSKINASE.
PR01825; JANUSKINASE2.
PR00109; TYRKINASE.
Created Date20-Feb-2013