EKS-MEG-00181

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00181

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	402.9	4.6E-121	23	309	287

Status

Unreviewed

Ensembl Protein

ENSMGAP00000005328

UniProt Accession

G1N1F1;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPKAPK5

Gene Synonyms/Alias

MAPKAPK5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000005400	ENSMGAP00000005328	ENSMGAT00000006061

Organism

Meleagris gallopavo

Functional Description

Protein Length

476

Protein Sequence
(FASTA)

VGRKSDPKKL LYETSILEEY NINWTQKLGA GISGPVSNTR VCVKKSSQER FALKILLDRP 60

KARNEVRLHM MCATHPNIVQ IIEVYANSVQ FPHESSPRAR LLIVMEMMEG GELFHRISQH 120

RHFTEKQASQ VTKQIALALQ HCHSLNIAHR DLKPENLLFK DNSLDAPVKL CDFGFAKVDQ 180

GDLMTPQFTP YYVAPQQQVL EAQRRHQKEK SGIIPTSPTP YTYNKSCDLW SLGVIIYVML 240

CGYPPFYSKH HSRTIPKDMR KKIMTGSFEF PEEEWSQISE MAKDIVRKLL KVKPEERLTI 300

EGVLDHPWLN STEALDNILP SAQLMMDKAM VAGIQQAHAE QLANMRIQDL KVSLKPLHSV 360

NNPILRKRKL LGTKPKDGVY IHDPENGSND SNVALEKLRD VIAQCILPQA GENEDEKLNE 420

VMQEAWKYNR ECKLLRDTLQ SFSWNGRGFT DKVDRLKLAE IVKQVIEEQT NSHDSQ 476

Nucleotide Sequence
(FASTA)

GTAGGCAGAA AATCTGACCC AAAAAAGTTG CTTTATGAAA CCTCCATTTT AGAGGAGTAC 60

AACATTAACT GGACTCAGAA GCTGGGAGCT GGGATCAGTG GCCCTGTTAG TAATACCAGA 120

GTCTGCGTGA AAAAATCCTC TCAAGAACGC TTTGCACTGA AAATCCTTCT TGATCGTCCA 180

AAAGCTAGAA ATGAGGTACG TCTGCACATG ATGTGTGCAA CACATCCAAA TATTGTTCAA 240

ATTATTGAAG TTTATGCTAA CAGTGTGCAG TTCCCACATG AATCCAGCCC GAGGGCTCGG 300

CTCCTAATTG TAATGGAGAT GATGGAAGGG GGAGAGCTAT TTCACAGAAT CAGCCAGCAC 360

CGGCACTTTA CTGAGAAGCA AGCAAGCCAA GTAACAAAGC AGATAGCTTT GGCTTTGCAG 420

CATTGCCACT CACTAAACAT TGCACATAGA GACCTCAAGC CCGAGAATCT CCTCTTCAAG 480

GATAACTCTT TGGATGCACC TGTTAAACTG TGTGACTTTG GGTTTGCCAA AGTAGACCAA 540

GGTGACTTGA TGACACCACA GTTCACTCCA TATTACGTAG CACCTCAGCA ACAGGTATTG 600

GAGGCACAAA GGCGGCATCA GAAAGAAAAA TCTGGTATTA TCCCCACCTC TCCAACACCT 660

TACACATACA ACAAGAGCTG TGACTTGTGG TCCCTGGGTG TCATTATTTA CGTGATGCTG 720

TGTGGATACC CTCCGTTTTA CTCCAAACAC CACAGTCGGA CAATTCCAAA GGACATGCGG 780

AAAAAGATCA TGACAGGAAG TTTTGAATTT CCAGAGGAAG AGTGGAGCCA GATCTCAGAG 840

ATGGCAAAAG ACATTGTGCG AAAGTTGCTG AAGGTCAAAC CAGAGGAGCG GCTGACCATC 900

GAAGGTGTGC TGGACCATCC CTGGCTCAAC TCCACTGAGG CACTGGATAA CATCCTACCT 960

TCTGCCCAGC TGATGATGGA CAAGGCAATG GTTGCAGGGA TACAACAGGC TCATGCAGAA 1020

CAACTTGCAA ACATGAGAAT CCAAGACCTC AAAGTCAGTC TCAAACCCCT TCACTCTGTG 1080

AACAACCCTA TCCTGCGCAA AAGGAAATTA CTGGGCACTA AGCCAAAGGA TGGCGTTTAC 1140

ATCCACGACC CGGAGAATGG AAGTAATGAT TCCAACGTGG CTCTGGAAAA GCTCAGAGAT 1200

GTGATTGCTC AGTGCATTCT ACCACAGGCT GGAGAGAATG AGGATGAGAA GCTGAATGAA 1260

GTGATGCAGG AGGCGTGGAA GTATAATCGG GAGTGTAAGT TGCTGCGAGA CACTCTTCAG 1320

AGCTTCAGCT GGAATGGCAG AGGATTTACA GATAAAGTGG ATCGACTAAA ACTGGCAGAA 1380

ATAGTAAAAC AAGTTATTGA AGAGCAGACA AACTCCCATG ACTCTCAATA G 1431

Domain Profile

S: 2     lteevlGeGisgkv...lecvkkktgekyalkilkdrkkvrrevelhvqasghkniveli  58

         +++++lG+Gisg v   + cvkk+++e++alkil dr+k+r+ev+lh+++++h+niv++i

Q: 23    NWTQKLGAGISGPVsntRVCVKKSSQERFALKILLDRPKARNEVRLHMMCATHPNIVQII  82

         689*********9933346*****************************************

S: 59    dvfensfe......dekrlllvlekleGGellsriqerkaftekeasevvkdiasalkfl  112

         +v++ns++      +++rll+v+e++eGGel++ri+++++ftek+as+v+k+ia al+++

Q: 83    EVYANSVQfphessPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALQHC  142

         *******99999999*********************************************

S: 113   hskniahrDlkpenlLyeskeknapvklcDfglaketeeeeelktpcltaeyvaPe..vl  170

         hs niahrDlkpenlL+++++ +apvklcDfg+ak   ++ +l+tp++t++yvaP+  vl

Q: 143   HSLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK--VDQGDLMTPQFTPYYVAPQqqVL  200

         ***********************************..89****************555**

S: 171   eaekee.............allydksCDlWslGvilyillcGypPfyskk.graiskklk  216

         ea++++             +++y+ksCDlWslGvi+y++lcGypPfysk+ +r+i+k+++

Q: 201   EAQRRHqkeksgiiptsptPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHhSRTIPKDMR  260

         ****999*****************************************9979********

S: 217   eriqegkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         ++i++g++efPeeeWs++se+akd++rklLk++p+erltie vl+hpw+

Q: 261   KKIMTGSFEFPEEEWSQISEMAKDIVRKLLKVKPEERLTIEGVLDHPWL  309

         ************************************************6

Domain Sequence
(FASTA)

NWTQKLGAGI SGPVSNTRVC VKKSSQERFA LKILLDRPKA RNEVRLHMMC ATHPNIVQII 60

EVYANSVQFP HESSPRARLL IVMEMMEGGE LFHRISQHRH FTEKQASQVT KQIALALQHC 120

HSLNIAHRDL KPENLLFKDN SLDAPVKLCD FGFAKVDQGD LMTPQFTPYY VAPQQQVLEA 180

QRRHQKEKSG IIPTSPTPYT YNKSCDLWSL GVIIYVMLCG YPPFYSKHHS RTIPKDMRKK 240

IMTGSFEFPE EEWSQISEMA KDIVRKLLKV KPEERLTIEG VLDHPWL 287

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0032007	; P:negative regulation of TOR signaling cascade
GO:0046777	; P:protein autophosphorylation
GO:0007265	; P:Ras protein signal transduction
GO:0006417	; P:regulation of translation
GO:0090400	; P:stress-induced premature senescence

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013