EKS-MEG-00204
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00204
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Abl557.43.2E-168215466252
StatusUnreviewed
Ensembl ProteinENSMGAP00000005430
UniProt AccessionG1N1M4;
Protein Name
Protein Synonyms/Alias
Gene NameABL1
Gene Synonyms/Alias ABL1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000005488ENSMGAP00000005430ENSMGAT00000006163
OrganismMeleagris gallopavo
Functional Description
Protein Length1090
Protein Sequence
(FASTA)
ALQRPVVSDF EPQGLSEAAR WNSKENLLSC PSENDPHLFV ALYDFVASGD NTLSITKGEK 60
LRVLGYNHNG EWCEAQTKNG QGWVPSNYIT PVNSLEKHSW YHGPVSRNAA EYLLSSGING 120
SFLVRESESS PGQRSISLRY EGRVYHYRIN TASDGKLYVS SESRFNTLAE LVHHHSTVAD 180
GLITTLHYPA PKRNKPTIYG VSPNYDKWEI ERTDITMKHK LGGGQYGEVY EGVWKKYSLT 240
VAVKTLKEDT MEVEEFLKEA AVMKEIKHPN LVQLLGVCTR EPPFYIITEF MTYGNLLDYL 300
RECNRQEVNA VVLLYMATQI SSAMEYLEKK NFIHRDLAAR NCLVGENHLV KVADFGLSRL 360
MTGDTYTAHA GAKFPIKWTA PESLAYNKFS IKSDVWAFGV LLWEIATYGM SPYPGIDLSQ 420
VYELLEKDYR MERPEGCPEK VYELMRACWQ WSPSDRPSFA EIHQAFETMF QESSISDEVE 480
KELGKKGMRS VVSNFLQAPE LPTKTRTSRR AAESKDVNEG LETAHARGQG ECDPLDHEPA 540
VSPLLPRKER VALESSLNED ERLLPKDKKP NLFSALIKKK KKTAPTPPKR SSSFREMDGH 600
SDRRAGGEEE CRDAGNGAFI APPTEAADPS KFQSPSNGAG VTNGVVAGNS GFLSPHLRKK 660
SSTMSSSRGV AGEEESSSNS SKRFLRSCSA SCVPHGAKDT EWKSVTLPRD LQSTGRQFDS 720
STFGGHKSEK PALPRKRANE AKTDIAVRGT VTPPPRLLKK NEETTDDVFK DAESSPGSSP 780
PTLTPKLGRR QPAVPPSSSV LHKDDGVKSS ALGTTATMDQ GSAAKPNSAA FAGANKASVE 840
EPRLRRLKQT SELAGKDKGK LSKLKPAPPV PMSSSSVGKP GKVSHSPSHE AATDVVSGPK 900
SKQLTQVADA VSSEAVKPNQ SGEGVKKLGI PSVPKPQSST KLLMSTATSA ASSSSVPSAP 960
AFIPLISTRV SLRKTRQPPE RIASGTITKG VVLESTEALR LAISKNSEQM ASHSTVLEAG 1020
KNLYTFCVSY VDSIQQMRNK FAFREAINKL ENNLRELQIC PATAGSGSAA TQDFSKLLSS 1080
VKEISDIVQR 1090
Nucleotide Sequence
(FASTA)
GCCCTCCAGA GGCCAGTCGT GTCAGATTTT GAGCCCCAGG GGTTGAGTGA AGCTGCTCGC 60
TGGAACTCCA AGGAGAACCT CCTGTCCTGT CCCAGTGAAA ATGACCCTCA CCTCTTTGTT 120
GCACTGTATG ATTTTGTGGC GAGTGGGGAC AACACTCTCA GCATAACTAA AGGTGAAAAG 180
CTTCGTGTCC TGGGCTACAA CCATAATGGT GAATGGTGTG AGGCTCAAAC GAAGAATGGA 240
CAAGGCTGGG TACCCAGCAA CTACATCACC CCAGTGAACA GTTTGGAGAA ACATTCCTGG 300
TACCATGGAC CAGTGTCACG TAATGCTGCT GAGTACCTCC TGAGCAGTGG CATCAATGGC 360
AGCTTTCTCG TGCGAGAGAG TGAGAGCAGT CCAGGACAGA GATCAATTTC ACTGCGCTAC 420
GAAGGAAGGG TGTACCACTA CAGAATAAAC ACTGCGTCCG ATGGGAAGCT GTACGTCTCT 480
TCAGAGAGCC GCTTCAACAC CTTGGCAGAG TTGGTCCATC ATCATTCAAC GGTAGCAGAT 540
GGGCTCATCA CCACTTTGCA CTACCCGGCG CCCAAGCGCA ACAAGCCCAC CATTTACGGG 600
GTGTCTCCAA ACTATGACAA GTGGGAGATA GAGAGAACTG ACATCACTAT GAAGCACAAG 660
CTGGGCGGCG GGCAGTATGG AGAGGTGTAT GAAGGAGTCT GGAAGAAGTA CAGCCTCACA 720
GTGGCTGTGA AGACCCTAAA GGAGGATACC ATGGAGGTGG AAGAGTTCTT GAAAGAAGCT 780
GCAGTAATGA AGGAGATCAA GCATCCGAAC TTGGTGCAAT TATTAGGGGT GTGCACACGG 840
GAACCTCCTT TCTACATCAT CACGGAGTTC ATGACTTACG GGAATCTGTT GGATTATCTG 900
CGTGAGTGCA ACCGGCAGGA GGTCAATGCG GTGGTGCTGC TGTACATGGC AACCCAGATC 960
TCTTCAGCCA TGGAGTACCT GGAGAAGAAA AACTTCATCC ACAGGGACCT CGCTGCCAGA 1020
AATTGCCTTG TAGGGGAGAA CCACTTGGTG AAGGTGGCAG ACTTTGGCCT GAGCAGGCTG 1080
ATGACAGGTG ACACGTACAC TGCCCACGCT GGGGCCAAGT TCCCGATCAA GTGGACAGCA 1140
CCAGAGAGCC TGGCCTACAA CAAGTTCTCC ATTAAATCTG ACGTCTGGGC CTTTGGTGTT 1200
CTGCTTTGGG AAATTGCGAC CTATGGCATG TCCCCTTACC CTGGGATCGA CCTGTCTCAA 1260
GTCTATGAGC TGCTGGAGAA AGACTACCGC ATGGAGCGCC CTGAAGGCTG TCCTGAGAAA 1320
GTATATGAGC TCATGAGAGC ATGCTGGCAG TGGAGCCCCT CCGACAGGCC TTCCTTTGCT 1380
GAGATCCATC AGGCGTTTGA GACGATGTTT CAGGAATCCA GCATATCAGA TGAGGTGGAG 1440
AAGGAATTGG GAAAGAAGGG CATGAGGAGT GTAGTGAGCA ATTTCCTTCA GGCCCCAGAG 1500
TTACCAACCA AGACACGAAC GTCGAGGAGA GCTGCTGAAA GCAAAGATGT GAACGAGGGC 1560
TTGGAGACTG CACATGCACG AGGCCAGGGG GAATGTGACC CTCTGGACCA TGAACCCGCT 1620
GTTTCTCCTT TGCTGCCACG GAAGGAGAGA GTGGCCCTGG AGAGCAGTTT GAATGAAGAT 1680
GAGAGGCTGC TTCCAAAAGA CAAAAAGCCC AACTTGTTCA GTGCCCTTAT CAAGAAGAAG 1740
AAGAAGACTG CCCCTACCCC TCCAAAACGG AGCAGCTCCT TCCGAGAGAT GGATGGCCAC 1800
TCGGACCGCA GGGCGGGTGG GGAGGAGGAG TGCAGGGATG CTGGCAATGG AGCTTTCATT 1860
GCTCCTCCCA CAGAAGCAGC TGACCCCTCC AAGTTTCAGA GCCCAAGCAA TGGGGCTGGT 1920
GTCACCAATG GGGTCGTCGC TGGGAACTCT GGGTTTTTGT CTCCCCACTT AAGGAAGAAG 1980
TCCAGCACAA TGAGCAGCAG CCGGGGGGTG GCTGGTGAGG AGGAGAGCAG TTCCAACTCC 2040
AGCAAGCGTT TCTTAAGGTC CTGCTCAGCC TCCTGTGTGC CCCACGGTGC AAAGGACACG 2100
GAGTGGAAAT CTGTGACTCT GCCTCGGGAT CTGCAGTCCA CAGGACGCCA GTTTGATTCC 2160
TCCACTTTTG GGGGACACAA AAGCGAAAAG CCAGCGCTGC CTCGAAAGCG GGCAAACGAG 2220
GCCAAGACTG ACATTGCTGT CAGGGGGACA GTGACCCCCC CTCCACGGCT GCTTAAGAAA 2280
AACGAAGAGA CCACTGATGA TGTGTTCAAA GATGCGGAGT CGAGTCCTGG CTCCAGCCCA 2340
CCCACTCTGA CTCCAAAACT TGGCCGTAGG CAACCCGCCG TCCCCCCTTC CTCCAGCGTG 2400
CTGCACAAGG ACGATGGAGT CAAATCCAGT GCCTTAGGTA CCACTGCGAC AATGGACCAA 2460
GGTTCTGCTG CCAAACCCAA CTCTGCTGCA TTTGCAGGTG CCAACAAAGC TTCTGTCGAG 2520
GAGCCGCGGC TGAGGAGGCT CAAGCAGACC TCAGAGTTGG CAGGGAAGGA CAAAGGGAAG 2580
TTATCGAAGC TGAAGCCAGC CCCTCCGGTT CCAATGTCTT CATCCTCTGT TGGCAAGCCT 2640
GGAAAAGTAT CTCACAGTCC CAGCCATGAA GCGGCAACAG ATGTGGTGTC TGGTCCTAAA 2700
TCCAAACAGT TGACTCAGGT TGCAGATGCT GTGAGCAGTG AAGCTGTCAA GCCAAACCAG 2760
TCAGGGGAAG GTGTGAAAAA GCTAGGGATC CCTTCTGTAC CAAAGCCCCA GTCCTCCACA 2820
AAGCTGCTGA TGAGCACAGC AACCTCCGCT GCCTCTTCCT CGTCTGTACC CTCTGCCCCA 2880
GCCTTCATCC CTCTCATATC CACCAGGGTC TCTCTGCGGA AGACCCGTCA GCCCCCGGAG 2940
AGGATTGCCA GCGGCACCAT CACCAAAGGG GTGGTGCTGG AAAGCACCGA GGCTCTACGG 3000
CTCGCCATTA GCAAGAACTC TGAACAAATG GCGAGCCACA GCACTGTCTT GGAGGCTGGC 3060
AAGAACCTCT ACACCTTCTG CGTGAGCTAC GTGGACTCCA TACAGCAGAT GAGGAACAAA 3120
TTTGCCTTTC GGGAGGCCAT CAATAAGCTG GAGAACAACC TGCGAGAGCT TCAGATCTGC 3180
CCAGCGACGG CTGGCAGCGG CTCTGCGGCC ACGCAGGACT TTAGCAAACT GCTCAGTTCT 3240
GTGAAAGAAA TCAGCGACAT TGTTCAGAGG TAG 3273
Domain Profile
S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60
         i+mkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmke+khpnlvql
Q: 215   ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQL  274
         89**********************************************************
S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120
         lgvctreppfyiitefm+ygnlldylre++r+ev+avvllymatqissameylekknfih
Q: 275   LGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIH  334
         ************************************************************
S: 121   rdlaarnclvgenklvkvadfglsrlmkedtytahagakfpikwtapeslaynkfsiksd  180
         rdlaarnclvgen+lvkvadfglsrlm++dtytahagakfpikwtapeslaynkfsiksd
Q: 335   RDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSD  394
         ************************************************************
S: 181   vwafgvllweiatygmspypgidlsqvyellekgyrmerpegcppkvyelmracwkwsps  240
         vwafgvllweiatygmspypgidlsqvyellek+yrmerpegcp+kvyelmracw+wsps
Q: 395   VWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWSPS  454
         ************************************************************
S: 241   drpsfaeihqal  252
         drpsfaeihqa+
Q: 455   DRPSFAEIHQAF  466
         *********986
Domain Sequence
(FASTA)
ITMKHKLGGG QYGEVYEGVW KKYSLTVAVK TLKEDTMEVE EFLKEAAVMK EIKHPNLVQL 60
LGVCTREPPF YIITEFMTYG NLLDYLRECN RQEVNAVVLL YMATQISSAM EYLEKKNFIH 120
RDLAARNCLV GENHLVKVAD FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNKFSIKSD 180
VWAFGVLLWE IATYGMSPYP GIDLSQVYEL LEKDYRMERP EGCPEKVYEL MRACWQWSPS 240
DRPSFAEIHQ AF 252
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00218
EKS-ANC-00228
EKS-BOT-00257
EKS-CAE-00214
EKS-CAJ-00243
EKS-CAF-00245
EKS-CAP-00293
EKS-CII-00141
EKS-CIS-00017
EKS-DAR-00593
EKS-DAN-00005
EKS-DRM-00121
EKS-EQC-00230
EKS-FEC-00244
EKS-GAG-00198
EKS-GAA-00320
EKS-GOG-00256
EKS-HOS-00245
EKS-ICT-00225
EKS-LAC-00270
EKS-LOA-00268
EKS-MAM-00261
EKS-MIM-00012
EKS-MOD-00237
EKS-MUM-00242
EKS-MUP-00256
EKS-MYL-00237
EKS-NOL-00240
EKS-ORN-00335
EKS-ORA-00227
EKS-ORC-00244
EKS-ORL-00286
EKS-OTG-00264
EKS-PAT-00226
EKS-PES-00229
EKS-PEM-00134
EKS-POA-00230
EKS-PTV-00011
EKS-RAN-00272
EKS-SAH-00243
EKS-SUS-00223
EKS-TAG-00253
EKS-TAR-00332
EKS-TAS-00010
EKS-TEN-00297
EKS-TUT-00026
EKS-XET-00314
EKS-XIM-00328
Gene Ontology
GO:0005730; C:nucleolus
GO:0048471; C:perinuclear region of cytoplasm
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0030145; F:manganese ion binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0030036; P:actin cytoskeleton organization
GO:0006975; P:DNA damage induced protein phosphorylation
GO:0071901; P:negative regulation of protein serine/threonine kinase activity
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0051353; P:positive regulation of oxidoreductase activity
GO:0051726; P:regulation of cell cycle
GO:2001020; P:regulation of response to DNA damage stimulus
GO:0042770; P:signal transduction in response to DNA damage
KEGG
InterPros
IPR015015; F-actin_binding.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF08919; F_actin_bind; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00808; FABD; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013